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Effects of oral prednisolone on biomarkers in synovial tissue and clinical improvement in rheumatoid arthritis.

Author: GerlagDanielle M, HaringmanJasper J, KraanMaarten C, LaudPeter J, MorganShethah, NashAnthony F P, SmeetsTom J M, TakPaul P, ZwindermanA H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Prednisolone therapy in rheumatoid arthritis (RA) is associated with a marked reduction in macrophage infiltration in synovial tissue, suggesting that synovial macrophage numbers could be used as a biomarker for clinical efficacy.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To create greater understanding of the changes in synovial tissue parameters that occur in conjunction with clinical response by using an effective therapy, in order to facilitate the planning of future studies with therapeutic agents for rheumatoid arthritis (RA). METHODS: Twenty-one pa...See full text at original site
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引用元：
https://doi.org/10.1002/art.20664

データ提供：米国国立医学図書館（NLM）

Prednisolone: A Beacon of Hope in the Desert of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects millions worldwide, causing pain, stiffness, and joint damage. This research explores the effects of prednisolone, a commonly used medication for RA, on synovial tissue biomarkers and clinical improvement.

The study investigated the impact of prednisolone on synovial tissue biomarkers in patients with active RA. The researchers found that prednisolone treatment led to significant reductions in macrophage infiltration, a key component of the inflammatory process in RA. They also observed trends towards reduced infiltration by T cells, plasma cells, and fibroblast-like synoviocytes.

Prednisolone: A Powerful Tool in the Fight Against RA

This study provides compelling evidence for the efficacy of prednisolone in treating RA. The observed reduction in macrophage infiltration suggests that prednisolone may play a crucial role in suppressing inflammation and slowing disease progression. The results also highlight the potential for synovial macrophage numbers to serve as a biomarker for clinical efficacy.

Managing RA: A Multifaceted Approach

While prednisolone shows promise in treating RA, it is important to remember that RA is a complex condition requiring a multifaceted approach. Lifestyle modifications, such as regular exercise and a healthy diet, along with other medications and therapies, are crucial for managing the disease effectively.

Dr. Camel's Conclusion

Just as a camel needs a strong and resilient body to survive a harsh desert journey, patients with RA need powerful tools to manage their disease. This research highlights the potential of prednisolone to combat inflammation and offer relief from the debilitating symptoms of RA. Remember, taking care of your health is a journey, not a destination, and finding the right combination of treatments is key to thriving in the face of adversity.

Date :
  1. Date Completed 2005-01-13
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

15593225

DOI: Digital Object Identifier

10.1002/art.20664

SNS
PICO Info
in preparation
Languages

English

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