Effective treatment of rheumatoid arthritis: A Synthesis of Findings from 39 Studies

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Original Abstract of the Article

Main Research Findings

Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and pain in the joints. Various approaches are used to treat RA, including drug therapy, physical therapy, and lifestyle modifications. Recent studies have shown that these approaches can be effective in improving RA symptoms and slowing disease progression. shows that drug therapy, specifically called DMARDs, can help reduce RA symptoms. demonstrates that physical therapy helps improve joint stiffness and pain caused by RA. suggests that lifestyle modifications, such as weight management and exercise, can help reduce RA symptoms and slow disease progression. These studies suggest that combining various approaches is crucial for treating RA.

Benefits and Risks

Benefits Summary

Various approaches are used to treat RA, including drug therapy, physical therapy, and lifestyle modifications. Recent studies have shown that these approaches can be effective in improving RA symptoms and slowing disease progression. shows that drug therapy, specifically called DMARDs, can help reduce RA symptoms. demonstrates that physical therapy helps improve joint stiffness and pain caused by RA. suggests that lifestyle modifications, such as weight management and exercise, can help reduce RA symptoms and slow disease progression. These studies suggest that combining various approaches is crucial for treating RA.

Risks Summary

Treating RA may involve risks of side effects. Drug therapy can lead to various side effects, including nausea, abdominal pain, rash, and liver dysfunction. Physical therapy may rarely cause side effects such as pain or muscle injury. Lifestyle modifications may be difficult to implement for individuals who struggle with exercise or experience high levels of stress. It is essential to consult with a physician and choose appropriate treatments to minimize these risks.

Comparison Between Studies

Similarities in Studies

Multiple studies have shown that various approaches, including drug therapy, physical therapy, and lifestyle modifications, can be helpful in treating RA. These approaches are often used in combination to reduce RA symptoms and slow disease progression.

Differences in Studies

Different studies have yielded varying results regarding the effectiveness of specific approaches for treating RA. While some studies showed specific drug therapies or physical therapies to be effective, others did not observe significant effects. Additionally, participant characteristics and study designs varied across studies, making it challenging to compare results.

Consistency and Contradictions in Results

Research findings on treating RA exhibit both consistency and contradictions. Some studies have shown specific drug therapies or physical therapies to be effective. However, other studies have indicated that these approaches do not yield significant results. These contradictions may be attributed to differences in methodologies and participant characteristics across studies.

Practical Implications and Considerations

Consulting a physician and choosing appropriate treatments is crucial to manage RA symptoms. Various approaches, including drug therapy, physical therapy, and lifestyle modifications, may be helpful. However, these approaches are not effective for everyone. Additionally, there are risks of side effects, so it is essential to follow physician guidance and implement them carefully.

Limitations of Current Research

There are limitations to research on treating RA. Many studies have been conducted with small sample sizes, making it difficult to generalize results. Additionally, many studies have focused on specific types of RA, making it challenging to apply results to other types of RA.

Future Research Directions

Further research is needed on treating RA. Specifically, studies with larger sample sizes and involving various types of RA are required. Research is also needed on the long-term effects of specific approaches in treating RA.

Conclusion

RA is a chronic autoimmune disease that affects many people worldwide. Various approaches are used to treat RA, including drug therapy, physical therapy, and lifestyle modifications. These approaches are often used in combination to reduce RA symptoms and slow disease progression. However, there are limitations to research on treating RA, and further research is needed. If you have RA symptoms, it is crucial to consult with a physician and choose appropriate treatments.

Keywords
Benefit Keywords
Good results
Less severe joint condition
1
Improved coping
Improved health status
Reduced pain
2
Improved rheumatoid arthritis treatment
3
Improved compliance
Improved joint protection
4
Enhanced efficacy
Improved RA treatment
Improved rheumatoid arthritis treatment
Reduced joint damage
5
Reduces disability
Relieves pain
6
Reduced joint pain
7
Benefit for joint activity
8
Clinical benefit with dietary manipulation
9
RA function improvement
RA pain improvement
11
Clinical improvement
Inhibited joint damage
12
Reduced macrophage infiltration
13
Improved RA symptoms
14
Ankylosing spondylitis treatment
Rheumatoid arthritis treatment
15
Rheumatoid arthritis treatment
16
RA joint destruction reduction
17
Inhibited radiographic progression
18
Improved RA treatment
19
Improved RA treatment
20
Improved disease activity
Reduced pain
21
RA pain relief
22
Anti-tumor necrosis factor agents
23
Improved RA management
Potential for CVD prevention
RA treatment
24
Biologic agents
25
Improved RA treatment
Potential for better outcomes
RA treatment
26
Omega-3 for RA
27
MRI response
RA symptom reduction
28
Inhibited radiographic progression
31
Biologics for RA
Improved disease evolution
No delayed wound healing
Reduced risk of post-operative surgical site infection
32
RA severity
periodontal treatment
33
Medicinal plants
Natural alternative
Potential for RA treatment
RA treatment
34
IL-1 antagonists
RA treatment
35
Improved clinical outcomes
Improved psychological status
36
DMARDs for rheumatoid arthritis
37
DMARDs for OA
38
CVD risk reduction
RA treatment
39
Risk Keywords
Complications
1
Corticosteroid dependence
Limited evidence
Need for replication
5
Adverse reactions
Higher toxicity
7
High toxicity
8
No therapeutic benefit
10
Osteoporotic fractures
12
Rheumatoid arthritis
23
Needs further research
Unclear benefits of TNFi
24
Rheumatoid arthritis
25
Needs further research
Unclear effectiveness and safety
26
psychosocial impact
30
RA patients
33
Needs further research
Potential for interactions
Side effects
Unclear effectiveness
34
Conflicting data
38
Literature analysis of 39 papers
Positive Content
35
Neutral Content
1
Negative Content
3
Article Type
23
6
13
8
38
1.

Long-term study of management of rheumatoid arthritis.

Author: MillionR, KellgrenJ H, PooleP, JaysonM I

Good results
Less severe joint condition
Complications

A 10-year study comparing a program of rest and medication with a program of maintained activity and medication for rheumatoid arthritis found no significant difference in overall outcomes, except that the steroid group showed better clinical and radiological outcomes for several joints.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effects of stress management on clinical outcomes in rheumatoid arthritis.

Author: ParkerJ C, SmarrK L, BuckelewS P, Stucky-RoppR C, HewettJ E, JohnsonJ C, WrightG E, IrvinW S, WalkerS E

Improved coping
Improved health status
Reduced pain

Stress management training produced significant improvements in helplessness, self-efficacy, coping, pain, and health status in patients with rheumatoid arthritis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

3.

[Combination therapy in early rheumatoid arthritis: the COBRA study].

Author: BoersM, VerhoevenA C, van der LindenS

Improved rheumatoid arthritis treatment

A study of early rheumatoid arthritis (RA) found that combining sulfasalazine, prednisolone, and methotrexate for the first six months (COBRA scheme) was more effective than sulfasalazine alone over 1.5 years. The combination treatment resulted in less disease activity, less joint damage, and fewer side effects, while costing the same or less. The study recommends more aggressive treatment for early RA with a reassessment of the use of corticosteroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Dutch

4.

Effects of patient education on compliance with basic treatment regimens and health in recent onset active rheumatoid arthritis.

Author: BrusH L, van de LaarM A, TaalE, RaskerJ J, WiegmanO

Improved compliance
Improved joint protection

Patient education improves compliance with physical exercise, energy conservation, and joint protection in patients with active, recent onset rheumatoid arthritis (RA). However, formal patient education does not improve health status. Compliance with sulphasalazine therapy is high regardless of formal education.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

The effects of dothiepin on subjects with rheumatoid arthritis and depression.

Author: AshG, DickensC M, CreedF H, JaysonM I, TomensonB

Reduces disability
Relieves pain

Dothiepin is effective in relieving pain, disability, and reducing early morning stiffness in rheumatoid arthritis patients. Its analgesic effect is independent of its antidepressant effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Azathioprine for rheumatoid arthritis.

Author: Suarez-AlmazorM E, SpoonerC, BelseckE

Reduced joint pain
Adverse reactions
Higher toxicity

Azathioprine may have a benefit for rheumatoid arthritis, but this evidence is based on a small number of patients from older trials. Its high risk-benefit ratio limits its recommendation over other DMARDs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Azathioprine for treating rheumatoid arthritis.

Author: Suarez-AlmazorM E, SpoonerC, BelseckE

Benefit for joint activity
High toxicity

Azathioprine appears to have a statistically significant benefit on disease activity in rheumatoid arthritis (RA) patients. However, this evidence is based on a small number of patients from older trials. Toxicity was significantly higher with azathioprine compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Diet therapy for rheumatoid arthritis. A controlled double-blind study of two different dietary regimens.

Author: Sarzi-PuttiniP, ComiD, BoccassiniL, MuzzupappaS, TurielM, PanniB, SalvaggioA

Clinical benefit with dietary manipulation

Dietary manipulation may provide some clinical benefit for rheumatoid arthritis (RA) patients, but no significant improvement was observed with a composite index. In a study of 50 patients, a diet high in unsaturated fats and low in saturated fats with hypoallergenic foods showed some improvement in certain variables, but only tender joint counts and ESR reached statistical significance after adjusting for weight variations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Lack of effect of doxycycline on disease activity and joint damage in patients with rheumatoid arthritis. A double blind, placebo controlled trial.

Author: van der LaanW, MolenaarE, RondayK, VerheijenJ, BreedveldF, GreenwaldR, DijkmansB, TeKoppeleJ

No therapeutic benefit

Doxycycline (50 mg twice a day) did not show any therapeutic benefit for rheumatoid arthritis (RA) patients in terms of disease activity or joint destruction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

One-year outcomes of a randomized controlled trial of an educational-behavioural joint protection programme for people with rheumatoid arthritis.

Author: HammondA, FreemanK

RA function improvement
RA pain improvement

This study examined the long-term effects of joint protection in people with early rheumatoid arthritis (RA). While joint protection has been shown to help reduce pain and improve function in the short-term, the long-term effects are uncertain. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial.

Author: van EverdingenAmalia A, JacobsJohannes W G, Siewertsz Van ReesemaDirk R, BijlsmaJohannes W J

Clinical improvement
Inhibited joint damage
Osteoporotic fractures

Low-dose prednisone (10mg/day) provided clinical benefit, especially in the first six months, for patients with early active rheumatoid arthritis who had not been treated with disease-modifying antirheumatic drugs. Radiologic joint damage progressed significantly less in the prednisone group compared to placebo. However, prednisone was associated with a higher incidence of osteoporotic fractures.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Effects of oral prednisolone on biomarkers in synovial tissue and clinical improvement in rheumatoid arthritis.

Author: GerlagDanielle M, HaringmanJasper J, SmeetsTom J M, ZwindermanA H, KraanMaarten C, LaudPeter J, MorganShethah, NashAnthony F P, TakPaul P

Reduced macrophage infiltration

Prednisolone therapy in rheumatoid arthritis (RA) is associated with a marked reduction in macrophage infiltration in synovial tissue, suggesting that synovial macrophage numbers could be used as a biomarker for clinical efficacy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Polyarticular corticosteroid injection versus systemic administration in treatment of rheumatoid arthritis patients: a randomized controlled study.

Author: FurtadoRita N V, OliveiraLeda M, NatourJamil

Improved RA symptoms

This study found that polyarticular intraarticular (IA) injection of triamcinolone hexacetonide was more effective than intramuscular (IM) corticosteroid in patients with rheumatoid arthritis (RA).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Etanercept exerts beneficial effects on articular cartilage biomarkers of degradation and turnover in patients with ankylosing spondylitis.

Author: MaksymowychWalter P, PooleA Robin, HiebertLori, WebbAlison, IonescuMirela, LobanokTatiana, KingLindsay, DavisJohn C

Ankylosing spondylitis treatment
Rheumatoid arthritis treatment

While medications that block TNF-alpha have been shown to improve symptoms and reduce joint damage in rheumatoid arthritis (RA), it is unknown if they have the same protective effect on joint damage in ankylosing spondylitis (AS). This study aims to investigate whether these medications impact biomarkers of cartilage damage in AS, as traditional X-ray imaging is not sensitive enough to detect subtle changes over time.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

16.

Effects of glucocorticoids on radiological progression in rheumatoid arthritis.

Author: KirwanJ R, BijlsmaJ W J, BoersM, SheaB J

Rheumatoid arthritis treatment

This study notes that steroids (glucocorticoids) are commonly used in rheumatoid arthritis (RA) and have been shown to have short-term benefits. However, it raises the question of whether these steroids may also have a long-term effect in slowing the progression of joint damage in RA. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Similar effects of disease-modifying antirheumatic drugs, glucocorticoids, and biologic agents on radiographic progression in rheumatoid arthritis: meta-analysis of 70 randomized placebo-controlled or drug-controlled studies, including 112 comparisons.

Author: GraudalNiels, JürgensGesche

RA joint destruction reduction

Treatment with DMARDs, glucocorticoids, biologic agents, and combination agents significantly reduced radiographic progression at 1 year. A direct comparison between the combination of a biologic agent plus MTX and the combination of 2 DMARDs plus initial glucocorticoids revealed no difference.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

The effects of golimumab on radiographic progression in rheumatoid arthritis: results of randomized controlled studies of golimumab before methotrexate therapy and golimumab after methotrexate therapy.

Author: EmeryPaul, FleischmannRoy, van der HeijdeDésirée, KeystoneEdward C, GenoveseMark C, ConaghanPhilip G, HsiaElizabeth C, XuWeichun, BaratelleAnna, BeutlerAnna, RahmanMahboob U

Inhibited radiographic progression

Golimumab in combination with methotrexate (MTX) significantly inhibited radiographic progression in methotrexate-naive patients with rheumatoid arthritis (RA) compared to MTX alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Low-dose oral prednisone improves clinical and ultrasonographic remission rates in early rheumatoid arthritis: results of a 12-month open-label randomised study.

Author: MontecuccoCarlomaurizio, TodoertiMonica, SakellariouGarifallia, ScirèCarlo Alberto, CaporaliRoberto

Improved RA treatment

This study aims to compare the effectiveness of combining low-dose prednisone (PDN) with disease-modifying anti-rheumatic drugs (DMARDs) versus using DMARDs alone for treating early rheumatoid arthritis (RA). The study will also use ultrasound to assess the impact of these treatments on inflammation in the joints. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Association of joint space narrowing with impairment of physical function and work ability in patients with early rheumatoid arthritis: protection beyond disease control by adalimumab plus methotrexate.

Author: SmolenJosef S, van der HeijdeDésirée M, KeystoneEdward C, van VollenhovenRonald F, GoldringMary B, GuéretteBenoît, CifaldiMary A, ChenNaijun, LiuShufang, LandewéRobert B M

Improved RA treatment

This study investigates whether blocking tumor necrosis factor (TNF) in combination with methotrexate prevents joint damage in people with rheumatoid arthritis (RA). The researchers aimed to determine if this treatment slows down the erosion of bone (joint erosion; JE) or the narrowing of cartilage spaces (joint space narrowing; JSN), and if these changes in joint structure impact long-term outcomes as reported by patients. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Early effects of tocilizumab in the treatment of moderate to severe active rheumatoid arthritis: a one-week sub-study of a randomised controlled trial (Rapid Onset and Systemic Efficacy [ROSE] Study).

Author: YaziciYusuf, CurtisJeffrey R, InceAkgun, BarafHerbert S B, LepleyDenise M, DevenportJenny N, KavanaughArthur

Improved disease activity
Reduced pain

Tocilizumab was found to improve patient-reported disease activity, pain and DAS28 score as early as day 7 after the first infusion in patients with rheumatoid arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Systematic review and meta-analysis of effects of foot orthoses on pain and disability in rheumatoid arthritis patients.

Author: ConceiçãoCristiano Sena da, Gomes NetoMansueto, MendesSelena M D, SáKátia Nunes, BaptistaAbrahão Fontes

RA pain relief

Foot orthoses (FO) may improve pain in rheumatoid arthritis (RA) patients, but their impact on disability remains undetermined.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Down-titration and discontinuation strategies of tumor necrosis factor-blocking agents for rheumatoid arthritis in patients with low disease activity.

Author: van HerwaardenNoortje, den BroederAlfons A, JacobsWilco, van der MaasAatke, BijlsmaJohannes W J, van VollenhovenRonald F, van den BemtBart J F

Anti-tumor necrosis factor agents
Rheumatoid arthritis

While anti-TNF medications are effective for rheumatoid arthritis (RA), they can have side effects and are expensive. This study explores the effectiveness of reducing the dose of these medications (down-titration) compared to continuing the standard dose to determine if lower doses can still provide benefits while reducing potential side effects and costs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Coronary Artery Disease Evaluation in Rheumatoid Arthritis (CADERA): study protocol for a randomized controlled trial.

Author: ErhayiemBara, PavittSue, BaxterPaul, AndrewsJacqueline, GreenwoodJohn P, BuchMaya H, PleinSven

Improved RA management
Potential for CVD prevention
RA treatment
Needs further research
Unclear benefits of TNFi

People with rheumatoid arthritis (RA) have a higher risk of heart disease than the general population. While early treatment and tight control of RA are important, it's not yet clear whether using TNF inhibitors, a specific type of medication, to achieve remission in RA offers additional benefits for preventing heart disease compared to standard treatment.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Combination Therapy With and Without Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis: A Meta-Analysis of Randomized Trials.

Author: GraudalNiels, Hubeck-GraudalThorbjørn, FaurschouMikkel, BaslundBo, JürgensGesche

Biologic agents
Rheumatoid arthritis

This study compared the effectiveness of standard medications for rheumatoid arthritis (RA) with and without the addition of biologic drugs. Biologic drugs are significantly more expensive, costing about 100 times more than standard medications, but their effectiveness has not been proven to be superior.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

The Effect of Omega-3 Fatty Acids in Patients With Active Rheumatoid Arthritis Receiving DMARDs Therapy: Double-Blind Randomized Controlled Trial.

Author: RajaeiElham, MowlaKarim, GhorbaniAli, BahadoramSara, BahadoramMohammad, Dargahi-MalamirMehrdad

Omega-3 for RA

This study aims to evaluate the effects of omega-3 fatty acids on rheumatoid arthritis (RA) in patients already taking standard medications (DMARDs). The study will assess how omega-3s impact disease activity, remission rates, weight changes, and the need for pain relievers compared to a placebo group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Efficacy of VX-509 (decernotinib) in combination with a disease-modifying antirheumatic drug in patients with rheumatoid arthritis: clinical and MRI findings.

Author: GenoveseMark C, YangFang, ØstergaardMikkel, KinnmanNils

MRI response
RA symptom reduction

VX-509, in combination with stable disease-modifying antirheumatic drug therapy, reduced the signs and symptoms of rheumatoid arthritis in patients with an inadequate response to a DMARD alone.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Effects of Teriparatide on Joint Erosions in Rheumatoid Arthritis: A Randomized Controlled Trial.

Author: SolomonD H, KayJ, DuryeaJ, LuB, BolsterM B, YoodR A, HanR, BallS, ColemanC, LoE, WohlfahrtA, SuryM, YinM, YuZ, ZakA, GravalleseE M

This study aimed to investigate whether a medication that promotes bone growth (teriparatide) could help reduce the amount of joint erosion (bone damage) in people with rheumatoid arthritis (RA) who are already taking a type of medication that blocks inflammation (tumor necrosis factor inhibitor, TNFi).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Effects of biologic disease-modifying anti-rheumatic drugs on the radiographic progression of rheumatoid arthritis: a systematic literature review.

Author: CombeBernard, LulaSadiq, BooneCaroline, DurezPatrick

Inhibited radiographic progression

Biologic disease-modifying anti-rheumatic drugs (bDMARDs) are effective in inhibiting radiographic progression in patients with rheumatoid arthritis (RA) when used in combination with methotrexate (MTX). Combination therapy with a bDMARD and MTX had a significantly greater effect than placebo or MTX alone in slowing radiographic progression in patients with early, active or established RA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

A Systematic Review to Identify the Effects of Biologics in the Feet of Patients with Rheumatoid Arthritis.

Author: Ramos-PetersenLaura, NesterChristopher James, Reinoso-CoboAndres, Nieto-GilPilar, Ortega-AvilaAna Belen, Gijon-NogueronGabriel

Biologics for RA
Improved disease evolution
No delayed wound healing
Reduced risk of post-operative surgical site infection

This review of eight studies on rheumatoid arthritis (RA) found that using biologic medications for RA did not increase the risk of infections or delayed healing after foot surgery. The review also found that these medications were associated with positive effects on the progression of RA, as assessed through X-ray images.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Effects of non-surgical periodontal treatment in rheumatoid arthritis patients: A randomized clinical trial.

Author: NguyenVan Bich, NguyenThuy Thu, HuynhNam Cong-Nhat, NguyenKhoa Dinh, LeThu Anh, HoangHung Tu

RA severity
periodontal treatment
RA patients

Non-surgical periodontal treatment significantly reduced DAS28-CRP, disease activity classification, ESR, and ACPAs levels in serum of Vietnamese patients with rheumatoid arthritis (RA) and periodontal disease (PD). This treatment may help reduce RA severity in these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Anti-inflammatory natural products as potential therapeutic agents of rheumatoid arthritis: A systematic review.

Author: GandhiGopalsamy Rajiv, JothiGnanasekaran, MohanaThiruchenduran, VasconcelosAlan Bruno Silva, MontalvãoMonalisa Martins, HariharanGovindasamy, SridharanGurunagarajan, KumarPerumal Madan, GurgelRicardo Querioz, LiHua-Bin, ZhangJinming, GanRen-You

Medicinal plants
Natural alternative
Potential for RA treatment
RA treatment
Needs further research
Potential for interactions
Side effects
Unclear effectiveness

Rheumatoid arthritis (RA) is a chronic inflammatory disease that can severely affect movement and quality of life. Current treatments focus on suppressing inflammation in the joints, but often have side effects. Herbal remedies are being explored as potential alternative treatments for RA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Effectiveness and adverse effects of anakinra in treatment of rheumatoid arthritis: a systematic review.

Author: BedaiwiM K, AlmaghlouthI, OmairM A

IL-1 antagonists
RA treatment

This review examines the effectiveness and potential side effects of medications called interleukin-1 antagonists for treating rheumatoid arthritis (RA). These medications block the action of a protein called interleukin-1, which plays a role in inflammation. The review aims to assess the benefits and risks of these medications for RA patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Meta-Analyses on the Effects of Disease-Modifying Antirheumatic Drugs on the Most Relevant Patient-Reported Outcome Domains in Rheumatoid Arthritis.

Author: van den DikkenbergMarijke, Luurssen-MasurelNathalie, KuijperTjallingius Martijn, KokMarc-Redwart, HazesJohanna Maria Wilhelmina, de JongPascal Hendrik Pieter, Lopes-BarretoDeirisa, Weel-KoendersAngelique Elisabeth Adriana Maria

DMARDs for rheumatoid arthritis

This review aims to assess how medications for rheumatoid arthritis (DMARDs) impact patients' quality of life, focusing on areas such as pain, fatigue, limitations in daily activities, overall well-being, and ability to work or manage daily tasks. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

38.

Effect of disease-modifying anti-rheumatic drugs in osteoarthritis: A meta-analysis.

Author: MathieuSylvain, TournadreAnne, SoubrierMartin, SellamJérémie

DMARDs for OA
Conflicting data

Osteoarthritis (OA) involves inflammation, and while medications used for rheumatoid arthritis (DMARDs) might be helpful for OA, research has been inconsistent. This meta-analysis aimed to analyze existing studies to determine the overall effect of DMARDs (including methotrexate, hydroxychloroquine, TNF inhibitors, and IL-1 inhibitors) on OA.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

39.

Vascular effects of biologic and targeted synthetic antirheumatic drugs approved for rheumatoid arthritis: a systematic review.

Author: GerganovGeorgi, GeorgievTsvetoslav, DimovaMaria, ShivachevaTanya

CVD risk reduction
RA treatment

This study aims to investigate the impact of medications used to treat rheumatoid arthritis (RA) on the risk of cardiovascular disease (CVD). Because RA is linked to increased inflammation, and the medications used to treat RA can affect the immune system, the study seeks to understand how these medications might influence the risk of heart problems in people with RA. The abstract does not provide specific results, only the research question. Therefore, we cannot provide a summary of the study's findings.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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