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Striatal dopaminergic D2 receptor occupancy and clinical efficacy in psychosis exacerbation: a 123I-IBZM study with ziprasidone and haloperidol.

Author: AguilarYolanda, AlvarezEnric, CarrióIgnasi, CatafauAna M, CorripioIluminada, MenaEsther, PerezVíctor, PuigdemontDolors

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ziprasidone, an atypical antipsychotic, induces lower striatal dopaminergic D2 receptor occupancy and fewer extrapyramidal side effects compared to haloperidol. High doses of ziprasidone may be more beneficial for patients with acute psychosis exacerbation, but caution should be taken regarding the potential for extrapyramidal side effects.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The aim of this study was to compare striatal dopaminergic D2 receptor occupancy (D2 RO) induced by ziprasidone and haloperidol and its relationship with clinical response and extrapyramidal side effects (EPS) in patients with acute psychosis exacerbation. METHOD: Twenty patients hospita...See full text at original site
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引用元：
https://doi.org/10.1016/j.pnpbp.2004.10.010

データ提供：米国国立医学図書館（NLM）

Striatal Dopaminergic D2 Receptor Occupancy: A Key to Understanding Antipsychotic Efficacy

Antipsychotic medications are essential for managing psychosis, but understanding their mechanisms of action and their relationship to clinical efficacy is crucial. This research investigates the relationship between striatal dopaminergic D2 receptor occupancy (D2 RO) and clinical efficacy in patients with acute psychosis exacerbation, comparing the effects of two antipsychotic medications, ziprasidone and haloperidol.

Comparing Antipsychotic Medications: D2 Receptor Occupancy and Clinical Response

The study found that haloperidol induced significantly higher D2 RO compared to ziprasidone, suggesting that these medications act through different mechanisms. While both medications were effective in managing psychotic symptoms, ziprasidone was associated with lower D2 RO and fewer extrapyramidal side effects (EPS).

Navigating the Desert of Psychosis: Finding the Right Antipsychotic

This research highlights the importance of understanding the specific mechanisms of action of different antipsychotic medications and their impact on D2 RO. It's like choosing the right path through a vast and potentially treacherous desert landscape; selecting an antipsychotic medication based on its D2 RO profile can help to optimize treatment efficacy and minimize the risk of side effects.

Dr. Camel's Conclusion

This study underscores the importance of considering D2 receptor occupancy when choosing antipsychotic medications. By understanding the relationship between D2 RO and clinical efficacy, we can select the most appropriate medication for individual patients, maximizing treatment effectiveness while minimizing the risk of unwanted side effects.

Date :
  1. Date Completed 2005-02-15
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

15610950

DOI: Digital Object Identifier

10.1016/j.pnpbp.2004.10.010

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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