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Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder.

Author: CampeasRafael, DaviesSharon, FoaEdna B, FranklinMartin E, HuppertJonathan D, KjernistedKevin, KozakMichael J, LiebowitzMichael R, RowanVivienne, SchmidtAndrew B, SimpsonH Blair, TuXin

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigates how well clomipramine (a medication) and exposure and ritual prevention (a type of therapy) work individually and together in treating obsessive-compulsive disorder (OCD) in adults. While both clomipramine (a type of serotonin reuptake inhibitor) and exposure therapy are known to be helpful for OCD, we don't yet fully understand how effective they are compared to each other and when used together.
Paper Details　
Original Abstract of the Article :
The purpose of the study was to test the relative and combined efficacy of clomipramine and exposure and ritual prevention in the treatment of obsessive-compulsive disorder (OCD) in adults. Serotonin reuptake inhibitors (SRIs) and cognitive behavior therapy by exposure and ritual prevention are both...See full text at original site
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引用元：
https://doi.org/10.1176/appi.ajp.162.1.151

データ提供：米国国立医学図書館（NLM）

Treating Obsessive-Compulsive Disorder: A Combined Approach

Obsessive-compulsive disorder (OCD) is a challenging mental health condition that can significantly impact a person's life. This study investigated the efficacy of two established treatments for OCD: clomipramine, a tricyclic antidepressant, and exposure and ritual prevention (ERP), a cognitive behavioral therapy. The researchers aimed to determine the relative and combined efficacy of these treatments.

The Power of Combination: A Synergistic Approach to OCD

The study found that both clomipramine and ERP were effective in treating OCD, with the combination therapy demonstrating the highest efficacy. The authors concluded that the combination of clomipramine and ERP provided a synergistic effect, leading to greater symptom reduction compared to either treatment alone. This finding suggests that combining medication and therapy can be a powerful strategy for managing OCD.

Navigating the Desert of OCD Treatment: Finding the Right Path

This study offers valuable insights for individuals struggling with OCD and their healthcare providers. The findings suggest that combining medication and therapy may be a more effective approach than using either treatment alone. It emphasizes the importance of personalized treatment plans, tailoring the approach to each individual's needs and preferences. This research, like a compass guiding us through the complexities of OCD treatment, helps us find the most effective path towards recovery.

Dr.Camel's Conclusion

This study provides strong evidence supporting the efficacy of combining clomipramine and ERP in the treatment of OCD. The findings suggest that this synergistic approach can lead to greater symptom reduction and improved outcomes for individuals with OCD. This research, like a refreshing oasis in the desert of mental health challenges, offers hope for a more effective and personalized approach to managing this complex disorder.

Date :
  1. Date Completed 2005-02-18
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

15625214

DOI: Digital Object Identifier

10.1176/appi.ajp.162.1.151

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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