Effective treatment of obsessive-compulsive disorder: A Synthesis of Findings from 129 Studies

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Original Abstract of the Article

Key Research Findings

Obsessive-compulsive disorder (OCD) is a chronic and often debilitating condition, with a significant impact on quality of life. Treatment typically involves a combination of pharmacotherapy and cognitive-behavioral therapy (CBT). 55 , 99 .

However, for some individuals, traditional treatments may not be entirely effective. Research explores various approaches to enhance treatment efficacy, including augmenting CBT with motivational interviewing and thought mapping. 51 For children and adolescents who haven't responded to CBT, adding medications like sertraline might be beneficial. 85 The study suggests that, in cases where the initial response to medications is partial, the addition of antipsychotics like risperidone, paliperidone, or aripiprazole to serotonin reuptake inhibitors (SRIs) can improve outcomes. 97

Research on alternative therapies for OCD includes brain stimulation techniques and deep brain stimulation (DBS). 102 , 91 While these options hold promise for treatment-resistant cases, further research is needed to understand their long-term effects and optimal application. The role of cognitive remediation therapy (CRT) in improving cognitive inflexibility and enhancing treatment outcomes in OCD remains under investigation. 104

Treatment Summary

Treatment approaches for OCD include a range of options, from medication to behavioral therapies and even neurosurgical interventions. 55 , 51 , 102 , 91 These treatments might be used individually or in combination, tailoring the approach to the individual's specific needs. 27 .

Benefits and Risks

Benefits Summary

Treatment for OCD can significantly reduce symptoms and, in some cases, lead to remission. 38 , 48 In addition, treatment can have positive effects on cognitive function. 60 .

Risks Summary

Pharmacotherapy can cause side effects, which vary depending on the specific medication. 99 , 63 CBT may lead to temporary increases in anxiety or distress. 51 Brain stimulation and DBS, although promising, carry potential risks of complications. 102 , 91 .

Comparison of Studies

Commonalities Across Studies

Numerous studies consistently highlight the effectiveness of pharmacotherapy and CBT in treating OCD. 55 , 48 , 93 .

Differences Across Studies

Variations exist in the effectiveness of different treatment approaches, the prevalence of side effects, and the specific types of OCD being addressed. 32 , 36 , 99 , 27 . For example, the effectiveness of CBT can vary based on the specific therapy modality and the individual's characteristics. Similarly, the effectiveness of pharmacotherapy depends on the specific medication and its dosage.

Consistency and Discrepancies in Findings

While the research consistently suggests the effectiveness of various treatment approaches, certain discrepancies exist. For instance, the efficacy of CBT can be influenced by specific therapy methods and patient characteristics. 32 , 36 .

Real-World Considerations

The choice of treatment for OCD should be individualized, considering the patient's unique symptoms, history, and preferences. 58 , 66 Close collaboration with a healthcare professional is crucial to ensure that the chosen treatment plan is appropriate. 125 .

Limitations of Current Research

Further research is necessary to address some limitations in our understanding of OCD treatment. For example, more long-term studies evaluating the sustainability of treatment effects are needed. 103 .

Future Directions for Research

Future research should focus on expanding our knowledge of long-term outcomes, exploring new treatment strategies, and optimizing existing therapies. 103 .

Conclusion

Obsessive-compulsive disorder is a treatable condition, with effective therapies available to manage symptoms. 13 However, treatment outcomes can vary greatly depending on the individual's specific circumstances. 58 Close consultation with a qualified healthcare professional is essential to select the most appropriate treatment plan. 125 If you're struggling with OCD, remember that you're not alone, and seeking professional help is a vital step toward recovery.

Treatment List

・Pharmacotherapy ・Cognitive-behavioral therapy (CBT) ・Motivational interviewing ・Thought mapping ・Brain stimulation ・Deep brain stimulation (DBS) ・Cognitive remediation therapy (CRT) ・Electrical stimulation

Keywords
Benefit Keywords
OCD treatment
1
Higher abstinence rates
Reduced OCD symptom severity
2
Significant improvement in obsessive-compulsive symptoms
3
OCD treatment
4
Improved understanding of OCD treatment response
5
Antidepressant efficacy
OCD treatment efficacy
6
Potential treatment
Refractory OCD
7
Prevented relapse of OCD
8
Improved understanding of the Y-BOCS
9
Improved OCD treatment
10
Improved compulsive behavior disorder treatment
11
Reduced OCD symptoms
Reduced anxiety
Reduced depression
12
Improved OCD treatment
13
Improved obsessive-compulsive disorder treatment
14
Improved OCD treatment
15
Improved OCD symptoms
16
OCD symptom reduction
17
Improved therapeutic response
OCD symptom reduction
18
Improved OCD treatment
19
Improved OCD treatment
20
Improved clinical outcome
OCD treatment
21
Improved recovery
Symptom reduction
23
Improved quality of life
Reduced OCD symptoms
24
Improved OCD treatment
25
Reduced relapse rates
26
Improved OCD symptoms
27
OCD treatment
28
OCD treatment
29
OCD treatment
30
OCD treatment
31
OCD treatment
32
Improved OCD treatment
33
Augmented drug response
OCD symptom reduction
34
Effective treatment for OCD
Improved treatment for high obsessional conviction
35
OCD treatment
36
Improved OCD treatment
37
Superior treatment outcome
38
OCD treatment
39
Reduced OCD symptoms
40
Improved OCD treatment
41
Improved OCD symptoms
42
Improved OCD treatment
43
Improved OCD treatment
44
Improved OCD treatment
46
Reduced OCD symptoms
47
OCD symptom relief
48
Reduced OCD symptoms
49
Improved MDD
Improved OCD
50
OCD treatment
51
OCD treatment
52
OCD treatment
53
Reduced trichotillomania symptoms
54
OCD treatment
55
Improved OCD
Improved depression
Improved quality of life
56
Reduced OCD symptoms
57
Early-onset OCD treatment
58
OCD treatment
59
Treatment of OCD
60
Improves obsessive signs
OCD treatment
61
Treatment of OCD
62
Treatment of OCD
63
OCD treatment response
64
OCD treatment
65
Anxiety treatment
OCD treatment
66
OCD symptom reduction
67
OCD symptom reduction
68
OCD treatment
69
Behavioral therapy
Serotonin-reuptake inhibitors
70
OCD treatment
71
Internet-based writing therapy
72
EX/RP efficacy
73
BD-OCD treatment
74
Improved OCD symptoms
75
Deep brain stimulation
76
Maximizes long-term outcome
Superior OCD outcomes
77
OCD treatment
78
CBT efficacy
SSRI efficacy
79
OCD treatment
80
OCD treatment
81
OCD treatment
82
OCD treatment
83
OCD treatment
84
OCD
SRT treatment
85
OCD treatment
86
OCD symptom reduction
87
OCD treatment
89
OCD treatment
91
OCD symptom improvement
92
OCD treatment
93
OCD treatment
94
Exposure therapy
OCD treatment
95
OCD treatment
iCBT
96
OCD treatment
97
OCD treatment
98
Improved OCD
Reduced symptoms
99
CBT
OCD treatment
100
BD-OCD treatment
101
OCD treatment
102
OCD treatment
103
Improved AN treatment
Improved OCD treatment
104
OCD treatment
105
OCD treatment
106
OCD treatment
107
OCD treatment
108
iCBT for OCD
109
OCD treatment
110
OCD treatment
111
OCD treatment
112
Improved OCD symptoms
113
Memantine for OCD
115
Treatment for OCD
116
Ketamine
OCD treatment
117
Cost-effective treatment
OCD treatment
118
OCD treatment
119
OCD treatment
120
OCD treatment
121
Therapeutic alliance in CBT for OCD
123
OCD treatment
124
OCD treatment
125
OCD treatment
126
OCD treatment
127
OCD treatment
128
OCD treatment
129
Risk Keywords
Side effects
7
Hoarding predicts poor response
16
Agitation
Insomnia
Nausea
Tremor
18
Adverse events
24
Comorbidity impact
26
OCD
Predominant obsessions
33
Obsessive-compulsive disorder
35
Obsessive-compulsive disorder
37
Limited evidence
40
Obsessive-compulsive disorder
41
Obsessive-compulsive disorder
43
Obsessive-compulsive disorder
44
Obsessive-compulsive disorder
46
Serious adverse events
47
Side effects
48
Adverse events
49
High dropout rate
50
Adverse effects
54
Forgetfulness
Word-finding problems
57
None
61
Treatment dropout
67
Obsessive-compulsive disorder
70
Obsessive-compulsive disorder
72
Poorer EX/RP outcome
73
Obsessive-compulsive disorder
76
Lack of pediatric data
79
Fear acquisition
Impaired inhibitory learning
88
Reduced libido
98
Inconsistent results
Underpowered studies
102
Anxiety
Depression
113
Impaired insight in OCD
114
Anxiety
Depression
Stress
118
Chronicity of OCD
122
OCD symptoms
127
Literature analysis of 129 papers
Positive Content
127
Neutral Content
1
Negative Content
1
Article Type
91
19
26
18
124
1.

Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder.

Author: HewlettW A, VinogradovS, AgrasW S

OCD treatment

Clomipramine and clonazepam were effective in reducing obsessive-compulsive disorder (OCD) symptoms compared to diphenhydramine, a control medication. Clonazepam was particularly effective in the first 3 weeks of treatment. Clonidine was ineffective.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

2.

The treatment of substance abusers diagnosed with obsessive-compulsive disorder: an outcome study.

Author: Fals-StewartW, SchaferJ

Higher abstinence rates
Reduced OCD symptom severity

A study of 60 substance abusers with OCD found that those receiving combined treatment for both conditions had longer treatment duration, greater reduction in OCD symptom severity, and higher abstinence rates at 12-month follow-up compared to those receiving only substance abuse treatment or an attention control group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Cognitive therapy with obsessive-compulsive disorder: a comparative evaluation.

Author: EmmelkampP M, BeensH

Significant improvement in obsessive-compulsive symptoms

Rational Emotive Therapy (RET) and exposure in vivo were both effective in treating obsessive-compulsive disorder, with similar outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A comparative study of family-based and patient-based behavioural management in obsessive-compulsive disorder.

Author: MehtaM

OCD treatment

A study of 30 patients with obsessive-compulsive disorder found that a family-based treatment approach, involving a trained family member as cotherapist, was more effective in reducing anxiety, depression, obsessive symptoms, and improving social adjustment compared to treatment involving the patient alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Predictors of drug treatment response in obsessive-compulsive disorder.

Author: RavizzaL, BarzegaG, BellinoS, BogettoF, MainaG

Improved understanding of OCD treatment response

This study aims to identify clinical factors that predict how well people with obsessive-compulsive disorder (OCD) respond to medication. While medication is known to be effective for many with OCD, a significant number of patients don't respond well. This research seeks to understand why some individuals experience better outcomes with medication than others.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Efficacy of drug treatment in obsessive-compulsive disorder. A meta-analytic review.

Author: PiccinelliM, PiniS, BellantuonoC, WilkinsonG

Antidepressant efficacy
OCD treatment efficacy

Antidepressant drugs are effective in the short-term treatment of obsessive-compulsive disorder. Clomipramine and fluvoxamine had greater therapeutic efficacy than antidepressant drugs with no selective serotonergic properties.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Neurosurgical treatment for refractory obsessive-compulsive disorder: implications for understanding frontal lobe function.

Author: MindusP, RasmussenS A, LindquistC

Potential treatment
Refractory OCD
Side effects

This study explores neurosurgical interventions, specifically Gamma Knife capsulotomy, as a potential treatment for severe, treatment-resistant obsessive-compulsive disorder (OCD). While traditional medications and therapies are often effective, a small group of patients experience chronic, disabling symptoms. The study outlines the design of an ongoing placebo-controlled trial to evaluate the safety, effectiveness, and side effects of this neurosurgical approach. The authors propose that both drug treatments and neurosurgical interventions for OCD may work by influencing the balance of activity between different brain regions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Relapse prevention program for treatment of obsessive-compulsive disorder.

Author: HissH, FoaE B, KozakM J

Prevented relapse of OCD

In a study of 18 people with obsessive-compulsive disorder, those who received relapse prevention (RP) treatment after intensive behavior therapy showed fewer symptoms at 6 months compared to those who received attention-control therapy (AT). Both groups improved immediately after the initial therapy, but the RP group maintained their improvements, while the AT group saw a return of symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

9.

The Yale-Brown Obsessive-Compulsive Scale: measures of internal consistency.

Author: KimS W, DyskenM W, PheleyA M, HooverK M

Improved understanding of the Y-BOCS

This study examined the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) using data from 204 people with OCD. The analysis found that the scale has three distinct components: obsessive thoughts, compulsive behaviors, and resistance to those behaviors. The resistance component was not as sensitive to changes in symptoms as the other two components.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Diagnosis and fluoxetine treatment of compulsive behavior disorder of adults with mental retardation.

Author: BodfishJ W, MadisonJ T

Improved compulsive behavior disorder treatment

In a study of 16 individuals with intellectual disability and behavioral problems, those who met criteria for compulsive behavior disorder showed improvement after taking fluoxetine (7 out of 10). None of the comparison group showed improvement. The study also suggests that repetitive movements (stereotypies) may be related to compulsive behaviors and response to fluoxetine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

A comparison of behavioral group therapy and individual behavior therapy in treating obsessive-compulsive disorder.

Author: Fals-StewartW, MarksA P, SchaferJ

Reduced OCD symptoms
Reduced anxiety
Reduced depression

In a study of 93 people with obsessive-compulsive disorder (OCD), both individual and group behavioral therapy were equally effective in reducing OCD symptoms, depression, and anxiety at the end of treatment. Individual therapy led to faster symptom reduction, but both forms of therapy maintained their benefits at a 6-month follow-up.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Cognitive-behavioral treatment of obsessive thoughts: a controlled study.

Author: FreestonM H, LadouceurR, GagnonF, ThibodeauN, RhéaumeJ, LetarteH, BujoldA

Improved obsessive-compulsive disorder treatment

In a study of 29 people with obsessive-compulsive disorder (OCD) who did not engage in compulsive rituals, those who received cognitive-behavioral therapy showed significant improvement in their obsessions, overall functioning, and anxiety levels compared to those who waited for treatment. When those who initially waited for treatment later received therapy, both groups showed improvement. These improvements were maintained six months later. The study suggests that cognitive-behavioral therapy can be effective for people with OCD who only experience obsessive thoughts, a group that is often considered difficult to treat.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Self-directed treatment with minimal therapist contact: preliminary findings for obsessive-compulsive disorder.

Author: FritzlerB K, HeckerJ E, LoseeM C

Improved OCD treatment

A brief intervention for obsessive-compulsive disorder (OCD), involving five therapy sessions, self-directed exposure, and reading materials, was effective in improving OCD symptoms in nine participants. While symptoms remained stable during a 6-week waiting period, the group showed significant improvement after treatment. One-third of participants showed clinically significant improvement, demonstrating that brief interventions can be helpful for some individuals with OCD.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Hoarding and treatment response in 38 nondepressed subjects with obsessive-compulsive disorder.

Author: BlackD W, MonahanP, GableJ, BlumN, ClancyG, BakerP

Improved OCD symptoms
Hoarding predicts poor response

Patients with obsessive-compulsive disorder (OCD) who have hoarding symptoms are less likely to respond well to short-term treatment with paroxetine, placebo, or cognitive-behavioral therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Behavior therapy versus clomipramine for the treatment of obsessive-compulsive disorder in children and adolescents.

Author: de HaanE, HoogduinK A, BuitelaarJ K, KeijsersG P

OCD symptom reduction

Both behavior therapy and clomipramine were effective in treating obsessive-compulsive disorder in children and adolescents. Behavior therapy led to greater improvements on the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) than clomipramine, suggesting it is a viable alternative for treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Sertraline in children and adolescents with obsessive-compulsive disorder: a multicenter randomized controlled trial.

Author: MarchJ S, BiedermanJ, WolkowR, SaffermanA, MardekianJ, CookE H, CutlerN R, DominguezR, FergusonJ, MullerB, RiesenbergR, RosenthalM, SalleeF R, WagnerK D, SteinerH

Improved therapeutic response
OCD symptom reduction
Agitation
Insomnia
Nausea
Tremor

Sertraline is a safe and effective short-term treatment for children and adolescents with obsessive-compulsive disorder. In a randomized, double-blind, placebo-controlled trial, sertraline-treated patients showed significantly greater improvement than placebo-treated patients on the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS), the NIMH Global Obsessive Compulsive Scale (NIMH GOCS), and the CGI-I scales. 42% of patients receiving sertraline and 26% of patients receiving placebo were very much or much improved.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Electrical stimulation in anterior limbs of internal capsules in patients with obsessive-compulsive disorder.

Author: NuttinB, CosynsP, DemeulemeesterH, GybelsJ, MeyersonB

Improved OCD treatment

Four patients with chronic, treatment-resistant obsessive-compulsive disorder received chronic electrical stimulation instead of bilateral capsulotomy (a surgical procedure). Three out of the four patients showed positive results from the electrical stimulation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
LetterA written message for communication and exchange of information between individuals.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

The effect of fluvoxamine and behavior therapy on children and adolescents with obsessive-compulsive disorder.

Author: NezirogluF, Yaryura-TobiasJ A, WalzJ, McKayD

Improved OCD treatment

This study investigated whether adding behavioral therapy to medication for obsessive-compulsive disorder (OCD) would improve treatment outcomes. Behavioral therapy included exposure and response prevention, social skills training, cognitive therapy, and habit reversal. Medication included serotonin partial and specific reuptake blockers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Reactivity of serotonin in whole blood: relationship with drug response in obsessive-compulsive disorder.

Author: HumbleM, BejerotS, BergqvistP B, BengtssonF

Improved clinical outcome
OCD treatment

This study found that a fast decrease in whole blood serotonin levels was associated with poor clinical outcome in patients with obsessive-compulsive disorder treated with serotonin reuptake inhibitors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Insight and resistance in patients with obsessive-compulsive disorder.

Author: CatapanoF, SperandeoR, PerrisF, LanzaroM, MajM

This study examined insight and resistance in 93 patients with obsessive-compulsive disorder (OCD). 16% of patients did not recognize their obsessive thoughts and compulsive behaviors as unreasonable. Patients with poor insight had more severe OCD symptoms, a family history of mental illness, and a higher rate of childhood mental health issues. While 52% of patients with normal insight responded well to medication (SSRIs), none of those with poor insight showed improvement. This suggests that assessing insight and resistance in OCD patients can help predict treatment response to SSRIs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Cognitive versus behavior therapy in the group treatment of obsessive-compulsive disorder.

Author: McLeanP D, WhittalM L, ThordarsonD S, TaylorS, SöchtingI, KochW J, PatersonR, AndersonK W

Improved recovery
Symptom reduction

This study compared cognitive-behavioral therapy (CBT) and exposure and response prevention (ERP) for treating obsessive-compulsive disorder (OCD). Both treatments were more effective than no treatment. ERP was slightly more effective than CBT at the end of treatment and 3 months later. Both treatments led to similar improvements in beliefs, and the study suggests that the type of treatment might influence the best format for delivering therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Efficacy of sertraline in the long-term treatment of obsessive-compulsive disorder.

Author: KoranLorrin M, HackettElizabeth, RubinArkady, WolkowRobert, RobinsonDelbert

Improved quality of life
Reduced OCD symptoms
Adverse events

Sertraline demonstrated sustained efficacy among patients responding to treatment and was generally well tolerated during the 80-week study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Obsessive-compulsive symptom dimensions as predictors of compliance with and response to behaviour therapy: results from a controlled trial.

Author: Mataix-ColsDavid, MarksIsaac M, GreistJohn H, KobakKenneth A, BaerLee

Improved OCD treatment

This study examines the relationship between different types of obsessive-compulsive disorder (OCD) symptoms and treatment outcomes. It investigates whether different symptom dimensions, previously identified in research, affect how well people with OCD follow their behavioral therapy and respond to treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Impact of comorbidity on treatment response to paroxetine in pediatric obsessive-compulsive disorder: is the use of exclusion criteria empirically supported in randomized clinical trials?

Author: GellerDaniel A, BiedermanJoseph, StewartS Evelyn, MullinBenjamin, FarrellColleen, WagnerKaren Dineen, EmslieGraham, CarpenterDavid

Reduced relapse rates
Comorbidity impact

Psychiatric comorbidity adversely impacted response to pharmacotherapy with paroxetine in pediatric OCD and significantly increased risk of relapse.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

A double-blind, placebo-controlled trial of olanzapine addition in fluoxetine-refractory obsessive-compulsive disorder.

Author: ShapiraNathan A, WardHerbert E, MandokiMiguel, MurphyTanya K, YangMark C K, BlierPierre, GoodmanWayne K

Improved OCD symptoms

This study evaluated the effectiveness of adding olanzapine to fluoxetine for treating obsessive-compulsive disorder (OCD). The results showed no additional benefit for adding olanzapine compared to extending the fluoxetine monotherapy trial.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

28.

Post-treatment effects of exposure therapy and clomipramine in obsessive-compulsive disorder.

Author: SimpsonH Blair, LiebowitzMichael R, FoaEdna B, KozakMichael J, SchmidtAndrew B, RowanVivienne, PetkovaEva, KjernistedKevin, HuppertJonathan D, FranklinMartin E, DaviesSharon O, CampeasRaphael

OCD treatment

This study found that people with obsessive-compulsive disorder (OCD) who responded to exposure and response prevention (EX/RP) therapy, with or without medication (clomipramine), were less likely to relapse 12 weeks after stopping treatment compared to those who only received medication. While the relapse rate for medication alone was lower than previously reported, those receiving EX/RP therapy fared significantly better.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

29.

Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial.

Author:

OCD treatment

Studies show that both short-term, specialized cognitive-behavioral therapy (CBT) and medications called selective serotonin reuptake inhibitors (SSRIs) can be effective for treating obsessive-compulsive disorder (OCD) in children and teenagers. However, we need more research to compare how well these treatments work on their own and when combined.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

30.

A multidimensional meta-analysis of psychotherapy and pharmacotherapy for obsessive-compulsive disorder.

Author: EddyKamryn T, DutraLissa, BradleyRebekah, WestenDrew

OCD treatment

This meta-analysis of OCD treatments found that behavioral and cognitive-behavioral therapies and various medications, particularly clomipramine and other serotonin reuptake inhibitors, lead to significant improvements in OCD symptoms. However, even after successful treatment, OCD symptoms often remain at moderate levels. There's a lack of research on the long-term effects of these treatments beyond one year. Future research should focus on including more patients with co-occurring conditions, examining long-term outcomes, and investigating combined therapy approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

31.

Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder.

Author: FoaEdna B, LiebowitzMichael R, KozakMichael J, DaviesSharon, CampeasRafael, FranklinMartin E, HuppertJonathan D, KjernistedKevin, RowanVivienne, SchmidtAndrew B, SimpsonH Blair, TuXin

OCD treatment

This study investigates how well clomipramine (a medication) and exposure and ritual prevention (a type of therapy) work individually and together in treating obsessive-compulsive disorder (OCD) in adults. While both clomipramine (a type of serotonin reuptake inhibitor) and exposure therapy are known to be helpful for OCD, we don't yet fully understand how effective they are compared to each other and when used together.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

32.

Treatment of obsessive-compulsive disorder: cognitive behavior therapy vs. exposure and response prevention.

Author: WhittalMaureen L, ThordarsonDana S, McLeanPeter D

OCD treatment

This study compared the effectiveness of individual cognitive-behavioral therapy (CBT) and exposure and response prevention (ERP) for obsessive-compulsive disorder (OCD). Both treatments showed similar improvement at the end of treatment and 3 months later. While a higher percentage of CBT participants achieved a full recovery, this difference was not statistically significant. The study compares its findings to previous research on group CBT and ERP, suggesting that individual CBT may be as effective as group CBT.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Risperidone and haloperidol augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder: a crossover study.

Author: LiXiaohua, MayRoberta S, TolbertLelland C, JacksonWarren T, FlournoyJames M, BaxterLewis R

Improved OCD treatment
OCD
Predominant obsessions

While serotonin reuptake inhibitors (SRIs) are the first-line treatment for OCD, about half of patients don't respond well to them alone. People with OCD who mainly experience obsessive thoughts are often harder to treat and may need additional therapies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Behavior therapy augments response of patients with obsessive-compulsive disorder responding to drug treatment.

Author: TenneijNienke H, van MegenHarold J G M, DenysDamiaan A J P, WestenbergHerman G M

Augmented drug response
OCD symptom reduction

This study found that addition of behavior therapy is beneficial for patients with obsessive-compulsive disorder (OCD) who have responded to drug treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Evaluation of an inference-based approach to treating obsessive-compulsive disorder.

Author: O'ConnorK P, AardemaF, BouthillierD, FournierS, GuayS, RobillardS, PélissierM C, LandryP, TodorovC, TremblayM, PitreD

Effective treatment for OCD
Improved treatment for high obsessional conviction
Obsessive-compulsive disorder

This study compared three treatments for obsessive-compulsive disorder (OCD): a cognitive appraisal model (CAM), exposure and response prevention (ERP), and an inference-based approach (IBA). All three treatments led to significant symptom reduction, but IBA was more effective for patients with strong belief in their obsessions compared to CAM. The study suggests that matching treatment to the level of conviction in obsessions (IBA for high conviction, CAM for low) may improve outcomes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

Treatment motivation, treatment expectancy, and helping alliance as predictors of outcome in cognitive behavioral treatment of OCD.

Author: VogelPatrick A, HansenBjarne, StilesTore C, GötestamK Gunnar

Improved OCD treatment
Obsessive-compulsive disorder

This study found that a positive relationship between the patient and therapist (helping alliance) was strongly linked to improvement in obsessive-compulsive symptoms after treatment. While expectations for treatment and motivation to change were not significant predictors of improvement, a positive alliance showed a trend toward significance even after a year.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

38.

Response versus remission in obsessive-compulsive disorder.

Author: SimpsonHelen Blair, HuppertJonathan D, PetkovaEva, FoaEdna B, LiebowitzMichael R

Superior treatment outcome

EX/RP (with or without CMI) can lead to superior treatment outcome compared with CMI alone in OCD patients without comorbid depression. However, many OCD patients who receive evidence-based treatment do not achieve remission.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Cognitive behaviour therapy and medication in the treatment of obsessive-compulsive disorder.

Author: O'ConnorK P, AardemaF, RobillardS, GuayS, PélissierM-C, TodorovC, BorgeatF, LeblancV, GrenierS, DoucetP

OCD treatment

CBT has a more specific antiobsessional effect than medication but CBT plus medication shows greatest overall clinical improvement in mood.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

Behavioural and cognitive behavioural therapy for obsessive compulsive disorder in children and adolescents.

Author: O'KearneyR T, AnsteyK J, von SandenC

Reduced OCD symptoms
Limited evidence

This review examined the overall efficacy of behavioral or cognitive-behavioral therapy (BT/CBT) for pediatric obsessive-compulsive disorder (OCD), its relative efficacy against psychopharmacology, and whether there are benefits in using BT/CBT combined with medication. The results showed that BT/CBT was promising for the treatment of OCD in children and adolescents, leading to better outcomes when combined with medication compared to medication alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Influence of co-morbid generalized anxiety disorder, panic disorder and personality disorders on the outcome of cognitive behavioural treatment of obsessive-compulsive disorder.

Author: HansenBjarne, VogelPatrick A, StilesTore C, GötestamK Gunnar

Improved OCD treatment
Obsessive-compulsive disorder

This study examined how having generalized anxiety disorder and/or panic disorder, and having any personality disorder, affected the outcomes of treatment for obsessive-compulsive disorder (OCD). Patients received either exposure and response prevention (ERP) with cognitive therapy (ERP+CT) or ERP with relaxation training (ERP+REL). People with generalized anxiety disorder and/or panic disorder showed less improvement with both treatment approaches, but those in the ERP+CT group showed significantly more improvement at the end of treatment and 12 months later than those in the ERP+REL group. However, this difference was not significant when only looking at patients who completed treatment. Those with certain personality disorders (Clusters A or B) showed significantly less improvement at 12 months, while those with Cluster C personality disorders showed better outcomes at the end of treatment with ERP+REL. The study suggests that combining ERP with cognitive therapy may be more beneficial for those with anxiety, and that personality disorders may impact treatment outcomes. Further research is needed to understand these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

Response of symptom dimensions in obsessive-compulsive disorder to treatment with citalopram or placebo.

Author: SteinDan J, AndersenElisabeth W, OveroKerstin Fredricson

Improved OCD symptoms

Citalopram shows good efficacy in treating obsessive-compulsive disorder. However, the symptom dimension of symmetry/hoarding may be less responsive to this medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

A randomized, controlled trial of cognitive-behavioral therapy for augmenting pharmacotherapy in obsessive-compulsive disorder.

Author: SimpsonHelen Blair, FoaEdna B, LiebowitzMichael R, LedleyDeborah Roth, HuppertJonathan D, CahillShawn, VermesDonna, SchmidtAndrew B, HembreeElizabeth, FranklinMartin, CampeasRaphael, HahnChang-Gyu, PetkovaEva

Improved OCD treatment
Obsessive-compulsive disorder

While serotonin reuptake inhibitors (SRIs) are approved to treat obsessive-compulsive disorder (OCD), many people with OCD who have tried SRIs still have significant symptoms. This study examines the effects of adding exposure and ritual prevention, a type of cognitive-behavioral therapy (CBT) for OCD, to SRI treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

44.

Escitalopram in obsessive-compulsive disorder: response of symptom dimensions to pharmacotherapy.

Author: SteinDan J, CareyPaul D, LochnerChristine, SeedatSoraya, FinebergNaomi, AndersenElisabeth W

Improved OCD treatment
Obsessive-compulsive disorder

This study investigated how different symptoms of obsessive-compulsive disorder (OCD) responded to 12 weeks of treatment with escitalopram or a placebo. Previous research has shown that different OCD symptoms are distinct and may respond differently to treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

Quetiapine addition to serotonin reuptake inhibitors in patients with severe obsessive-compulsive disorder: a double-blind, randomized, placebo-controlled study.

Author: KordonAndreas, WahlKarina, KochNicole, ZurowskiBartosz, AnlaufMatthias, VielhaberKirsten, KahlKai G, BroocksAndreas, VoderholzerUlrich, HohagenFritz

While serotonin reuptake inhibitors (SRIs) help many people with obsessive-compulsive disorder (OCD), about 40-60% don't respond. This study examined the effectiveness of adding quetiapine to SRI treatment for severe OCD in adults.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

46.

Individual versus group cognitive-behavioral treatment for obsessive-compulsive disorder: a controlled pilot study.

Author: JaurrietaNuria, Jimenez-MurciaSusana, MenchónJosé Manuel, Del Pino AlonsoM, SegalasCinto, Alvarez-MoyaEva M, LabadJavier, GraneroRoser, VallejoJulio

Improved OCD treatment
Obsessive-compulsive disorder

This study examined the effectiveness of group and individual cognitive-behavioral therapy (CBT) for obsessive-compulsive disorder (OCD), comparing both to a waitlist control group. Both group and individual CBT reduced anxiety and depression, but individual CBT was more effective at reducing OCD symptoms. However, the dropout rate was higher for individual CBT. People with rituals focused on symmetry and order showed less improvement in anxiety compared to those with other rituals. Overall, both types of CBT were more effective than waitlist, suggesting the value of CBT for OCD.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Subthalamic nucleus stimulation in severe obsessive-compulsive disorder.

Author: MalletLuc, PolosanMircea, JaafariNematollah, BaupNicolas, WelterMarie-Laure, FontaineDenys, du MontcelSophie Tezenas, YelnikJérôme, ChéreauIsabelle, ArbusChristophe, RaoulSylvie, AouizerateBruno, DamierPhilippe, ChabardèsStephan, CzerneckiVirginie, ArdouinClaire, KrebsMarie-Odile, BardinetEric, ChaynesPatrick, BurbaudPierre, CornuPhilippe, DerostPhilippe, BougerolThierry, BatailleBenoit, MatteiVianney, DormontDidier, DevauxBertrand, VérinMarc, HouetoJean-Luc, PollakPierre, BenabidAlim-Louis, AgidYves, KrackPaul, MilletBruno, PelissoloAntoine,

Reduced OCD symptoms
Serious adverse events

Stimulation of the subthalamic nucleus may reduce the symptoms of severe forms of OCD but is associated with a substantial risk of serious adverse events, including intracerebral hemorrhage and infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

Efficacy of treatments for patients with obsessive-compulsive disorder: a systematic review.

Author: ChoiYun-Jung

OCD symptom relief
Side effects

Administration of fluvoxamine or sertraline to patients for an adequate duration is recommended as the first-line prescription for OCD, and augmentation therapy with risperidone, olanzapine, or quetiapine is recommended for refractory OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients.

Author: VulinkNienke C C, DenysDamiaan, FluitmanSjoerd B A H A, MeinardiJantien C M, WestenbergHerman G M

Reduced OCD symptoms
Adverse events

Quetiapine added to citalopram was more effective than citalopram alone in reducing obsessive-compulsive disorder symptoms in treatment-naive or medication-free patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

Psychological treatment of obsessive-compulsive disorder in patients with major depression: a pilot randomized controlled trial.

Author: RectorNeil A, CassinStephanie E, RichterMargaret A

Improved MDD
Improved OCD
High dropout rate

Cognitive-behavioral therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD) in patients with comorbid major depressive disorder (MDD), but treatment dropout rates are high. Both standard CBT and integrated CBT resulted in significant improvements in OCD and MDD symptoms, but treatment effects were lower in the intent-to-treat sample.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

51.

A randomized clinical trial to examine enhancing cognitive-behavioral group therapy for obsessive-compulsive disorder with motivational interviewing and thought mapping.

Author: MeyerElisabeth, SouzaFernanda, HeldtElizeth, KnappPaulo, CordioliAristides, ShavittRoseli G, LeukefeldCarl

OCD treatment

Obsessive-compulsive disorder (OCD) is characterized by repeated thoughts and behaviors (rituals) that people do to try to control anxiety. Cognitive behavioral group therapy (CBGT) has been shown to be effective, but about 30% of patients don't improve. Some patients continue to do their rituals because they don't fully participate in CBGT, especially the exposure exercises. Therefore, it's important to encourage patients to fully engage in treatment and complete the exercises.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

52.

Does the therapy manual or the therapist matter most in treatment of obsessive-compulsive disorder? A randomized controlled trial of exposure with response or ritual prevention in 118 patients.

Author: van OppenPatricia, van BalkomAnton J L M, SmitJohannes H, SchuurmansJosien, van DyckRichard, EmmelkampPaul M G

OCD treatment

This study compared the effectiveness of four different approaches to delivering exposure and response prevention (ERP) therapy for obsessive-compulsive disorder (OCD). The study also aimed to examine how a therapist's experience and training might influence the effectiveness of treatment. The study compared the effectiveness of therapist-led ERP to patient-led ERP.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Moderators and predictors of response to cognitive-behavioral therapy augmentation of pharmacotherapy in obsessive-compulsive disorder.

Author: MaherM J, HuppertJ D, ChenH, DuanN, FoaE B, LiebowitzM R, SimpsonH B

OCD treatment

Cognitive-behavioral therapy (CBT) with exposure and response prevention (EX/RP) is an effective treatment for obsessive-compulsive disorder (OCD), but about half of patients don't respond well. This study explores factors that might predict or influence how well people respond to CBT when combined with medication, identifying variables associated with poorer treatment outcomes for OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

54.

A randomized, double-blind, placebo-controlled trial of olanzapine in the treatment of trichotillomania.

Author: Van AmeringenMichael, ManciniCatherine, PattersonBeth, BennettMark, OakmanJonathan

Reduced trichotillomania symptoms
Adverse effects

Olanzapine was safe and effective in treating primary trichotillomania, showing a significant improvement in symptoms and quality of life compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

55.

No effect of adding brief dynamic therapy to pharmacotherapy in the treatment of obsessive-compulsive disorder with concurrent major depression.

Author: MainaGiuseppe, RossoGianluca, RigardettoSylvia, Chiadò PiatSimone, BogettoFilippo

OCD treatment

This study investigates the effectiveness of adding brief dynamic therapy (BDT) to medication for obsessive-compulsive disorder (OCD) in patients who also have major depressive disorder (MDD). While BDT has shown promise for depression, its use with OCD has not been studied before.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

A randomized clinical trial of acceptance and commitment therapy versus progressive relaxation training for obsessive-compulsive disorder.

Author: TwohigMichael P, HayesSteven C, PlumbJennifer C, PruittLarry D, CollinsAngela B, Hazlett-StevensHolly, WoidneckMichelle R

Improved OCD
Improved depression
Improved quality of life

Acceptance and commitment therapy (ACT) was more effective than progressive relaxation training (PRT) in reducing OCD severity and improving quality of life.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

57.

Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder.

Author: DenysDamiaan, MantioneMariska, FigeeMartijn, van den MunckhofPepijn, KoerselmanFrank, WestenbergHerman, BoschAndries, SchuurmanRick

Reduced OCD symptoms
Forgetfulness
Word-finding problems

Bilateral deep brain stimulation of the nucleus accumbens showed promise as an effective and safe treatment for treatment-refractory obsessive-compulsive disorder (OCD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

58.

Obsessive-compulsive disorder in children and adolescents.

Author: WalitzaSusanne, MelfsenSiebke, JansThomas, ZellmannHenrike, WewetzerChristoph, WarnkeAndreas

Early-onset OCD treatment

Early-onset obsessive-compulsive disorder (OCD) affects 1% to 3% of children and adolescents, causing significant impairment and family conflict. This review discusses the symptoms, related conditions, underlying mechanisms, and progression of the disorder, as well as current diagnostic and treatment approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

59.

Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: the Pediatric OCD Treatment Study II (POTS II) randomized controlled trial.

Author: FranklinMartin E, SapytaJeffrey, FreemanJennifer B, KhannaMuniya, ComptonScott, AlmirallDaniel, MoorePhoebe, Choate-SummersMolly, GarciaAbbe, EdsonAubrey L, FoaEdna B, MarchJohn S

OCD treatment

In a 12-week randomized controlled trial of 124 children with OCD who had partial response to SRI use, those who received medication management plus CBT had a significantly greater response rate (68.6%) than those who received medication management only (30%) or medication management plus instructions in CBT (34%). This study suggests that CBT is an effective augmentation strategy for pediatric OCD patients who have not fully responded to SRI treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

60.

Do cognitive functions in obsessive-compulsive disorder change after treatment? A systematic review and a double case report.

Author: VandborgSanne Kjær, HartmannTue Borst, BennedsenBirgit Egedal, PedersenAnders Degn, EskildsenAnita, VidebechPoul Bror Hemming, ThomsenPer Hove

Treatment of OCD

Studies have shown that people with OCD have thinking problems related to specific brain areas. However, it is unclear whether these thinking difficulties improve after treatment. This study aims to determine if these thinking problems are temporary (state-dependent) or more persistent (trait-like) in OCD.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

61.

Comparison of eye movement desensitization and reprocessing with citalopram in treatment of obsessive-compulsive disorder.

Author: NazariHedayat, MomeniNahid, JarianiMojgan, TarrahiMohammad Javad

Improves obsessive signs
OCD treatment
None

EMDR was more effective than citalopram in improvement of OCD signs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

62.

Does anti-obsessional pharmacotherapy treat so-called comorbid depressive and anxiety states?

Author: ValerioCarolina, DinizJuliana Belo, FossaluzaVictor, de MathisMaria Alice, Belotto-SilvaCristina, JoaquimMarinês Alves, Miguel FilhoEurípedes Constantino, ShavittRoseli Gedanke

Treatment of OCD

This study aims to investigate how treating obsessive-compulsive disorder (OCD) affects other mental health conditions that are often present in people with OCD, such as depression, tics, and anxiety. The research focuses on whether treating OCD alone can also improve outcomes for these additional conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

63.

Evaluation of oral zinc sulfate effect on obsessive-compulsive disorder: a randomized placebo-controlled clinical trial.

Author: SayyahMehdi, OlapourAlireza, SaeedabadYashar shahhosseini, Yazdan ParastRezvan, MalayeriAlireza

Treatment of OCD

Obsessive-compulsive disorder (OCD) is common. While medications are available, many patients experience side effects, don't respond well, or stop responding over time. Adding safe supplements, such as trace elements, to medications may offer a solution to these challenges.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

64.

Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder.

Author: D'AlcanteCarina C, DinizJuliana B, FossaluzaVictor, BatistuzzoMarcelo C, LopesAntonio C, ShavittRoseli G, DeckersbachThilo, Malloy-DinizLeandro, MiguelEuripedes C, HoexterMarcelo Q

OCD treatment response

Patients with obsessive-compulsive disorder (OCD) with better cognitive and executive abilities at baseline were more likely to respond to either cognitive-behavioral therapy (CBT) or fluoxetine. Mental flexibility predicted response to treatment in opposite directions for CBT and fluoxetine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

65.

Efficacy of combination of fluoxetine and cognitive behavioral therapy and fluoxetine alone for the treatment of obsessive compulsive disorder.

Author: GiasuddinNoor Ahmed, NaharJhunu Shamsun, MorshedNahid Mahjabin, BalharaYatan Pal Singh, SobhanMohammad Abdus

OCD treatment

This study compared the effectiveness of fluoxetine (a medication) alone versus fluoxetine combined with cognitive behavioral therapy (CBT) in treating obsessive-compulsive disorder (OCD). Both treatments significantly reduced OCD symptoms, but the combination group showed a greater improvement starting at week 9 and continuing through week 13.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

66.

Cognitive behavior therapy for comorbid obsessive-compulsive disorder in high-functioning autism spectrum disorders: a randomized controlled trial.

Author: RussellAilsa J, JassiAmita, FullanaMiguel A, MackHilary, JohnstonKate, HeymanIsobel, MurphyDeclan G, Mataix-ColsDavid

Anxiety treatment
OCD treatment

Anxiety disorders, particularly obsessive-compulsive disorder (OCD), are common in people with autism spectrum disorders (ASD). Group therapy based on cognitive behavioral therapy (CBT) has been shown to help with anxiety in young people with ASD, but not specifically for OCD. One small study of individual CBT for OCD in adults with ASD showed promising results.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

67.

Behavioral versus cognitive treatment of obsessive-compulsive disorder: an examination of outcome and mediators of change.

Author: OlatunjiBunmi O, RosenfieldDavid, TartCandyce D, CottrauxJean, PowersMark B, SmitsJasper A J

OCD symptom reduction
Treatment dropout

Behavioral therapy for obsessive-compulsive disorder (OCD) may be more effective than cognitive therapy. This benefit is mediated by reductions in depressed mood and not necessarily by decreases in avoidance or responsibility.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

68.

Six-month follow-up of a randomized controlled trial augmenting serotonin reuptake inhibitor treatment with exposure and ritual prevention for obsessive-compulsive disorder.

Author: FoaEdna B, SimpsonHelen Blair, LiebowitzMichael R, PowersMark B, RosenfieldDavid, CahillShawn P, CampeasRaphael, FranklinMartin, HahnChang-Gyu, HembreeElizabeth A, HuppertJonathan D, SchmidtAndrew B, VermesDonna, WilliamsMonnica T

OCD symptom reduction

Augmenting SRIs with exposure and ritual prevention versus stress management training leads to better outcome after acute treatment and 24 weeks later. Greater improvement during the acute phase influences how well patients maintain their gains, regardless of treatment condition.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

69.

Treatment response, symptom remission, and wellness in obsessive-compulsive disorder.

Author: FarrisSamantha G, McLeanCarmen P, Van MeterPage E, SimpsonHelen Blair, FoaEdna B

OCD treatment

Obsessive-compulsive disorder (OCD) involves unwanted thoughts and repetitive behaviors. While the goal of treatment is to reduce symptoms and help people achieve a state of well-being, there are no widely accepted criteria to define what constitutes "wellness" in OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

70.

Behavioral therapy and serotonin reuptake inhibitor pharmacotherapy in the treatment of obsessive-compulsive disorder: a systematic review and meta-analysis of head-to-head randomized controlled trials.

Author: RomanelliRobert J, WuFrances M, GambaRyan, MojtabaiRamin, SegalJodi B

Behavioral therapy
Serotonin-reuptake inhibitors
Obsessive-compulsive disorder

This review examined research comparing behavioral therapy (exposure and response prevention, cognitive behavioral therapy) and serotonin-reuptake inhibitors (SRIs) for treating obsessive-compulsive disorder (OCD). The study aimed to determine the relative effectiveness of these approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

Excluding the typical patient: thirty years of pharmacotherapy efficacy trials for obsessive-compulsive disorder.

Author: OdlaugBrian L, WeinhandlEric, ManceboMaria C, MortensenErik L, EisenJane L, RasmussenSteven A, SchreiberLiana R N, GrantJon E

OCD treatment

While there have been successful medications for obsessive-compulsive disorder (OCD), many patients in clinical settings report that treatments aren't effective. This study examines the characteristics of people with OCD seeking treatment and compares them to the criteria used in medication trials, to understand potential reasons for the difference in outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, American Recovery and Reinvestment ActResearch and economic activity support funds provided under the American Recovery and Reinvestment Act of 2009.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

72.

No talking, just writing! Efficacy of an Internet-based cognitive behavioral therapy with exposure and response prevention in obsessive compulsive disorder.

Author: HerbstNirmal, VoderholzerUlrich, ThielNicola, SchaubRonja, KnaevelsrudChristine, StrackeSilke, HertensteinElisabeth, NissenChristoph, KülzAnne Katrin

Internet-based writing therapy
Obsessive-compulsive disorder

While cognitive behavioral therapy with exposure and response prevention (CBT with ERP) is the recommended treatment for obsessive-compulsive disorder (OCD), many patients don't receive it. This study evaluated an internet-based writing therapy that incorporates CBT with ERP principles to make treatment more accessible.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

73.

The impact of symptom dimensions on outcome for exposure and ritual prevention therapy in obsessive-compulsive disorder.

Author: WilliamsMonnica T, FarrisSamantha G, TurkheimerEric N, FranklinMartin E, SimpsonH Blair, LiebowitzMichael, FoaEdna B

EX/RP efficacy
Poorer EX/RP outcome

Exposure and ritual prevention (EX/RP) was effective for all symptom dimensions of obsessive-compulsive disorder (OCD), however it was less effective for unacceptable/taboo thoughts and hoarding than for other dimensions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

74.

Treatment of comorbid bipolar disorder and obsessive-compulsive disorder: a systematic review.

Author: AmerioA, OdoneA, MarchesiC, GhaemiS N

BD-OCD treatment

More than 20% of people with bipolar disorder (BD) also have obsessive-compulsive disorder (OCD), making treatment challenging. While medications called serotonin reuptake inhibitors (SSRIs) are the usual treatment for OCD, they can worsen mood swings in BD. The best way to treat both conditions together is still being determined.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

Deep brain stimulation for obsessive-compulsive disorder: systematic review and evidence-based guideline sponsored by the American Society for Stereotactic and Functional Neurosurgery and the Congress of Neurological Surgeons (CNS) and endorsed by the CNS and American Association of Neurological Surgeons.

Author: HamaniClement, PilitsisJulie, RughaniAnand I, RosenowJoshua M, PatilParag G, SlavinKonstantin S, AboschAviva, EskandarEmad, MitchellLaura S, KalkanisSteven,

Improved OCD symptoms

A systematic review of the literature evaluated the effectiveness of deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD). The review found that bilateral subthalamic nucleus DBS and bilateral nucleus accumbens DBS were more effective in improving OCD symptoms than sham treatment. However, insufficient evidence exists to recommend the use of unilateral DBS for OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

76.

Deep brain stimulation for treatment-refractory obsessive compulsive disorder: a systematic review.

Author: KohlSina, SchönherrDeva M, LuigjesJudy, DenysDamiaan, MuellerUlf J, LenartzDoris, Visser-VandewalleVeerle, KuhnJens

Deep brain stimulation
Obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) is a debilitating mental illness. While medications and therapy help many people, about 10% remain severely affected and don't respond to treatment. Deep brain stimulation is a treatment option for these individuals. This article reviews the research on deep brain stimulation for OCD, comparing different areas of the brain targeted for stimulation and their effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

Six-month outcomes from a randomized trial augmenting serotonin reuptake inhibitors with exposure and response prevention or risperidone in adults with obsessive-compulsive disorder.

Author: FoaEdna B, SimpsonHelen Blair, RosenfieldDavid, LiebowitzMichael R, CahillShawn P, HuppertJonathan D, BenderJames, McLeanCarmen P, MaherMichael J, CampeasRaphael, HahnChang-Gyu, ImmsPatricia, PintoAnthony, PowersMark B, RodriguezCarolyn I, Van MeterPage E, VermesDonna, WilliamsMonnica T

Maximizes long-term outcome
Superior OCD outcomes

Exposure and response prevention (EX/RP) was found to be more effective than risperidone in treating obsessive-compulsive disorder (OCD) in patients taking serotonin reuptake inhibitors (SRIs). After 6 months, 70% of patients in the EX/RP group met response criteria (Y-BOCS decrease ≥ 25%), compared to 20% of the risperidone group. Additionally, 50% of EX/RP patients achieved minimal symptoms (Y-BOCS ≤ 12), compared to only 5% in the risperidone group.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

78.

Mindfulness-based cognitive therapy in obsessive-compulsive disorder: protocol of a randomized controlled trial.

Author: KülzAnne Katrin, LandmannSarah, CludiusBarbara, HottenrottBirgit, RoseNina, HeidenreichThomas, HertensteinElisabeth, VoderholzerUlrich, MoritzSteffen

OCD treatment

Obsessive-compulsive disorder (OCD) is a debilitating condition that can be chronic without treatment. While cognitive behavioral therapy (CBT) with or without medication is often used, about a third of people with OCD don't respond well. This study examines whether mindfulness-based cognitive therapy (MBCT) can help people with OCD who have not responded well to CBT, to reduce their symptoms and develop a better way of coping.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

79.

Assessment and management of treatment-refractory obsessive-compulsive disorder in children.

Author: BlochMichael H, StorchEric A

CBT efficacy
SSRI efficacy
Lack of pediatric data

Several pharmacological treatment options exist for children with refractory OCD symptoms. However, little evidence-based data exist to guide treatment for our most challenging pediatric OCD patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

80.

Electroconvulsive therapy for obsessive-compulsive disorder: a systematic review.

Author: FontenelleLeonardo F, CoutinhoEvandro S F, Lins-MartinsNatália M, FitzgeraldPaul B, FujiwaraHironobo, YücelMurat

OCD treatment

While advanced treatments like deep brain stimulation are not widely available for OCD, there is no comprehensive review to support the common belief that electroconvulsive therapy (ECT) is ineffective for OCD. This review aims to examine the available research on ECT for OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

Cognitive behavioral treatments of obsessive-compulsive disorder. A systematic review and meta-analysis of studies published 1993-2014.

Author: ÖstLars-Göran, HavnenAudun, HansenBjarne, KvaleGerd

OCD treatment

Obsessive-compulsive disorder (OCD) is a disabling condition that can be long-lasting without treatment. Cognitive behavioral therapy (CBT) is the most effective psychological treatment for OCD. This review found that CBT was significantly more effective than doing nothing or taking a placebo, and slightly better than antidepressants. While combining CBT with medication showed some benefit, it wasn't significantly better than CBT combined with a placebo. The review highlighted some methodological issues in the research and discussed how to improve future studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

82.

Repetitive Transcranial Magnetic Stimulation (rTMS) improves symptoms and reduces clinical illness in patients suffering from OCD--Results from a single-blind, randomized clinical trial with sham cross-over condition.

Author: HaghighiMohammad, ShayganfardMehran, JahangardLeila, AhmadpanahMohammad, BajoghliHafez, PirdehghanAzar, Holsboer-TrachslerEdith, BrandSerge

OCD treatment

While therapy and medication are used to treat obsessive-compulsive disorder (OCD), success can be mixed. This study examines whether repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive brain stimulation technique, can improve symptoms and reduce the severity of OCD in people who haven't responded well to traditional treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

83.

Neuroimaging of psychotherapy for obsessive-compulsive disorder: A systematic review.

Author: ThorsenAnders Lillevik, van den HeuvelOdile A, HansenBjarne, KvaleGerd

OCD treatment

Obsessive-compulsive disorder (OCD) involves intrusive thoughts, repetitive behaviors, anxiety, and difficulty shifting thoughts, which are linked to problems in specific brain circuits. While therapy that exposes people to their fears and prevents rituals has been shown to be effective, it's unclear how this affects the brain. This review found that successful therapy can reverse some of the brain changes associated with OCD, suggesting that both therapy and medication can lead to improved function, reduced symptoms, and brain changes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Highly efficacious cognitive-coping therapy for overt or covert compulsions.

Author: HuXian-Zhang, MaJian-Dong, HuangPing, ShanXiao-Wen, ZhangZhao-Hui, ZhangJian-Hong, OuyangHua, KouShao-Jie, LiZhi-Rong, WangShu-Fan, ZhaoHong-Zeng, WangHui, WangChang-Hong

OCD treatment

This study found that a combination of medication and cognitive-coping therapy (pCCT) was more effective in treating obsessive-compulsive disorder (OCD) than medication alone. Patients receiving pCCT had significantly lower symptom severity, higher response rates, and higher remission rates compared to those receiving medication plus psychological support. This was true for both patients with obvious compulsions and those with less obvious compulsions. These results suggest that pCCT could be a promising treatment option for adults with OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

85.

Sertraline Treatment of Nonresponders to Extended Cognitive-Behavior Therapy in Pediatric Obsessive-Compulsive Disorder.

Author: SkarphedinssonGudmundur, WeidleBernhard, IvarssonTord

OCD
SRT treatment

This observational study suggests that sertraline (SRT) treatment may be beneficial for a minority of children and adolescents with obsessive-compulsive disorder (OCD) who have failed two consecutive courses of cognitive-behavior therapy (CBT).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

86.

A systematic review and meta-analysis of self-help therapeutic interventions for obsessive-compulsive disorder: Is therapeutic contact key to overall improvement?

Author: PearcyCaitlin P, AndersonRebecca A, EganSarah J, ReesClare S

OCD treatment

Obsessive-compulsive disorder (OCD) can significantly impact quality of life, affecting work and relationships. Self-help programs are becoming more common for treating OCD, offering increased access to care. This study examines the effectiveness of self-help interventions for OCD in the context of professional therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

88.

Fear conditioning and extinction in pediatric obsessive-compulsive disorder.

Author: GellerDaniel A, McGuireJoseph F, OrrScott P, PineDaniel S, BrittonJennifer C, SmallBrent J, MurphyTanya K, WilhelmSabine, StorchEric A

Fear acquisition
Impaired inhibitory learning

This study investigated the differences in fear acquisition and extinction between youths with obsessive-compulsive disorder (OCD) and healthy controls. The study found that participants with OCD exhibited a stronger orienting SCR to initial stimuli, a larger SCR to the CS+, and a larger absolute magnitude of the unconditioned fear response. During extinction, OCD participants continued to exhibit a differential SCR to the CS+ and CS-, whereas HC participants exhibited diminished SCR to both stimuli.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

89.

Dissecting the Yale-Brown Obsessive-Compulsive Scale severity scale to understand the routes for symptomatic improvement in obsessive-compulsive disorder.

Author: CostaDaniel L da Conceição, BarbosaVeronica S, RequenaGuaraci, ShavittRoseli G, PereiraCarlos A de Bragança, DinizJuliana B

OCD treatment

This study examined how different aspects of obsessive-compulsive disorder (OCD) symptoms improved with the medication fluoxetine. It found that reductions in distress and increased control over symptoms occurred before improvements in the time spent on obsessions and compulsions or how much they interfered with daily life. This suggests that fluoxetine first helps reduce distress and increase control before addressing the amount of time and interference caused by OCD symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

90.

Low-intensity cognitive-behaviour therapy interventions for obsessive-compulsive disorder compared to waiting list for therapist-led cognitive-behaviour therapy: 3-arm randomised controlled trial of clinical effectiveness.

Author: LovellKarina, BowerPeter, GellatlyJudith, ByfordSarah, BeePenny, McMillanDean, ArundelCatherine, GilbodySimon, GegaLina, HardyGillian, ReynoldsShirley, BarkhamMichael, MottramPatricia, LidbetterNicola, PedleyRebecca, MolleJo, PeckhamEmily, Knopp-HofferJasmin, PriceOwen, ConnellJanice, HeslinMargaret, FoleyChristopher, PlummerFaye, RobertsChristopher

While cognitive behavioral therapy (CBT) is the recommended treatment for obsessive-compulsive disorder (OCD), access to therapists is limited. This study investigated the effectiveness of two forms of less intensive CBT, which can be delivered remotely, before more intensive treatment, for adults with OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

91.

Deep brain stimulation and treatment-resistant obsessive-compulsive disorder: A systematic review.

Author: Vázquez-BourgonJavier, MartinoJuan, Sierra PeñaMaría, Infante CeberioJon, Martínez MartínezM Ángeles, OcónRoberto, MenchónJosé Manuel, Crespo FacorroBenedicto, Vázquez-BarqueroAlfonso

OCD treatment

About 10% of people with obsessive-compulsive disorder (OCD) don't respond to medications. Deep brain stimulation (DBS), a neurosurgical technique that uses electrical stimulation to alter brain activity, has been explored as a treatment for severe and treatment-resistant OCD. This review examines the current research on the effectiveness and use of DBS for OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

92.

A randomized controlled trial comparing EMDR and CBT for obsessive-compulsive disorder.

Author: MarsdenZoe, LovellKarina, BloreDavid, AliShehzad, DelgadilloJaime

OCD symptom improvement

Eye movement desensitization and reprocessing (EMDR) and cognitive behavioral therapy (CBT) had comparable completion rates and clinical outcomes for obsessive-compulsive disorder (OCD).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

93.

A Systematic Review of Evidence-based Treatment Strategies for Obsessive- compulsive Disorder Resistant to first-line Pharmacotherapy.

Author: AlbertUmberto, MarazzitiDonatella, Di SalvoGabriele, SoliaFrancesca, RossoGianluca, MainaGiuseppe

OCD treatment

Antidepressants called serotonin reuptake inhibitors (SRIs) and cognitive-behavioral therapy (CBT) are the main treatments for obsessive-compulsive disorder (OCD). However, many people don't respond well to these first-line treatments. This research looks at various options for treating people with OCD who don't respond to standard treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Protocol for a Systematic Review and Meta-Analysis of Lithium, Anticonvulsive or atypical antipsychotic Drugs for Treatment of Refractory Obsessive-Compulsive Disorder.

Author: SoleimaniR, JalaliM M, KeshtkarA, JalaliS M

OCD treatment

Obsessive-compulsive disorder (OCD) is a mental health condition that causes significant distress. While some people respond well to antidepressants, about half don't see enough improvement. This review examines the effectiveness of mood stabilizers for treating OCD in people who haven't responded to other treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

95.

Behavioral avoidance predicts treatment outcome with exposure and response prevention for obsessive-compulsive disorder.

Author: WheatonMichael G, GershkovichMarina, GallagherThea, FoaEdna B, SimpsonH Blair

Exposure therapy
OCD treatment

People with OCD often avoid situations or activities related to their obsessive thoughts and compulsive behaviors. This study looks at how avoidance behaviors before treatment might affect the outcome of exposure and response prevention (EX/RP) therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

96.

Therapist-Assisted Internet-Based Cognitive Behavioral Therapy Versus Progressive Relaxation in Obsessive-Compulsive Disorder: Randomized Controlled Trial.

Author: KyriosMichael, AhernClaire, FassnachtDaniel B, NedeljkovicMaja, MouldingRichard, MeyerDenny

OCD treatment
iCBT

Obsessive-compulsive disorder (OCD) is a debilitating condition that can persist without treatment. Cognitive behavioral therapy (CBT) is effective but not always accessible. While internet-based CBT (iCBT) is becoming more popular, no study has directly compared it to a similar but non-treatment control group in a randomized controlled trial. This study aims to fill that gap in the research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

97.

A systematic review of the use of risperidone, paliperidone and aripiprazole as augmenting agents for obsessive-compulsive disorder.

Author: BrakouliasVlasios, StockingsEmily

OCD treatment

Risperidone, paliperidone and aripiprazole are supported by evidence as augmentation agents for OCD in adults. More studies are needed to assess predictors of response and detect any differential effects between the three agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

98.

Effects of atorvastatin on treatment-resistant obsessive-compulsive disorder: A double-blind randomized trial.

Author: RahimFakher, SayyahMehdi

OCD treatment
Reduced libido

Atorvastatin significantly reduced obsession subtotal score and total score on the Y-BOCS in patients with treatment-resistant OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

99.

Augmentation agents to serotonin reuptake inhibitors for treatment-resistant obsessive-compulsive disorder: A network meta-analysis.

Author: ZhouDong-Dong, ZhouXiao-Xin, LiYao, ZhangKai-Fu, LvZhen, ChenXiao-Rong, WanLi-Yang, WangWo, WangGao-Mao, LiDa-Qi, AiMing, KuangLi

Improved OCD
Reduced symptoms

Antipsychotic or glutamatergic agents may be effective augmentation agents for treatment-resistant obsessive-compulsive disorder. Topiramate, lamotrigine, aripiprazole, olanzapine, risperidone, memantine, and quetiapine are potential alternative augmentation drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

100.

Symptom Dimension Response in Children and Adolescents with Obsessive-Compulsive Disorder.

Author: McGuireJoseph F, TanPatricia Z, PiacentiniJohn

CBT
OCD treatment

This study found that exposure-based cognitive behavior therapy (CBT) was more effective than psychoeducation and relaxation training (PRT) for treating obsessive-compulsive disorder (OCD) in children and teens. Children with aggressive or checking behaviors were more likely to benefit from CBT. Both treatments were effective, but CBT was better at reducing overall distress. While hoarding symptoms improved more slowly, both treatments helped with these symptoms. However, children reported a slower reduction in distress over time, suggesting that therapists may need to use more reinforcement strategies to maintain progress.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

101.

Aripiprazole augmentation in treating comorbid bipolar disorder and obsessive-compulsive disorder: A systematic review.

Author: AmerioA, OdoneA, GhaemiS N

BD-OCD treatment

Having both bipolar disorder (BD) and obsessive-compulsive disorder (OCD) is common. While antidepressants are typically the first choice for OCD, they can worsen mood swings in BD. The best way to treat BD and OCD together is still being studied.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

102.

Brain Stimulation in Obsessive-Compulsive Disorder (OCD): A Systematic Review.

Author: RapinesiChiara, KotzalidisGeorgios D, FerracutiStefano, SaniGabriele, GirardiPaolo, Del CasaleAntonio

OCD treatment
Inconsistent results
Underpowered studies

Brain stimulation techniques, particularly deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS), may be effective for severely ill obsessive-compulsive disorder (OCD) patients unresponsive to drugs and/or behavioral therapy. While evidence is limited, low-frequency TMS over the supplementary motor area or the orbitofrontal cortex and DBS targeting the nucleus accumbens-ventral capsule or the subthalamic nucleus may be particularly effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

103.

Distinct trajectories of long-term symptom severity in pediatric obsessive-compulsive disorder during and after stepped-care treatment.

Author: JensenSanne, HøjgaardDavíð R M A, HybelKatja A, MortensenErik Lykke, SkarphedinssonGudmundur, MelinKarin, IvarssonTord, NissenJudith Becker, WeidleBernhard, ValderhaugRobert, TorpNor Christian, DahlKitty, ComptonScott, ThomsenPer Hove

OCD treatment

This study aims to identify different groups of children with OCD based on how well they respond to treatment with either cognitive behavioral therapy (CBT) or SSRI medications. The goal is to understand what factors predict long-term symptom severity in children with OCD, so that treatments can be better tailored to individual needs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

104.

Cognitive Remediation Therapy Does Not Enhance Treatment Effect in Obsessive-Compulsive Disorder and Anorexia Nervosa: A Randomized Controlled Trial.

Author: van PasselBoris, DannerUnna N, DingemansAlexandra E, AartsEmmeke, SternheimLot C, BeckerEni S, van ElburgAnnemarie A, van FurthEric F, HendriksGert-Jan, CathDaniëlle C

Improved AN treatment
Improved OCD treatment

While treatments for obsessive-compulsive disorder (OCD) and anorexia nervosa (AN) are helpful, they could be more effective. Both disorders often involve difficulty changing one's thoughts, known as cognitive inflexibility, which can hinder treatment engagement and outcomes. This study proposes cognitive remediation therapy (CRT) as a potential addition to existing therapies to improve this cognitive issue before starting disorder-specific treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

105.

What is the relationship between fear of self, self-ambivalence, and obsessive-compulsive symptomatology? A systematic literature review.

Author: GodwinTanya L, GodwinHayward J, SimondsLaura M

OCD treatment

This review examined studies exploring the connection between a person's fear of themselves, self-doubt, and obsessive-compulsive disorder (OCD) symptoms. The review found that fear of self and self-doubt are strong predictors of OCD symptoms, particularly obsessions and beliefs associated with OCD. The findings suggest that addressing self-doubt beliefs could be a crucial aspect of treating OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

106.

Intelligence quotient level and treatment of obsessive-compulsive disorders: Meta-analyses.

Author: HuLidan, HaoYouguo, LiuShudong, KangHongying, QinLi, ZengZhen, AbdelrahimMohamed E A, TanYouguo

OCD treatment

Obsessive-compulsive disorder (OCD) is a complex mental health condition that can affect thinking abilities. This study aims to see how IQ (intelligence) is related to OCD and to evaluate how well different treatments work for people with OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

107.

Effect of D-Cycloserine on the Effect of Concentrated Exposure and Response Prevention in Difficult-to-Treat Obsessive-Compulsive Disorder: A Randomized Clinical Trial.

Author: KvaleGerd, HansenBjarne, HagenKristen, AbramowitzJonathan S, BørtveitTore, CraskeMichelle G, FranklinMartin E, HasethSvein, HimleJoseph A, HystadSigurd, KristensenUnn Beate, LaunesGunvor, LundAnders, SolemStian, ÖstLars-Göran

OCD treatment

There aren't many effective treatments for people with severe OCD. Some experts believe that a medication called D-cycloserine (DCS) could make exposure and response prevention (ERP) therapy more effective, but this hasn't been tested in people with severe OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

108.

Treatment-Specific Associations Between Brain Activation and Symptom Reduction in OCD Following CBT: A Randomized fMRI Trial.

Author: NormanLuke J, MannellaKristin A, YangHuan, AngstadtMike, AbelsonJames L, HimleJoseph A, FitzgeraldKate D, TaylorStephan F

OCD treatment

This study aimed to understand if brain activity is linked to how well teenagers and adults with OCD respond to cognitive-behavioral therapy (CBT) compared to another type of therapy called stress management therapy (SMT). The study looked for differences in brain activity that might explain why some people respond better to CBT than others, and if these differences are specific to CBT or also occur with SMT.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

109.

Unguided Internet-based cognitive-behavioral therapy for obsessive-compulsive disorder: A randomized controlled trial.

Author: SchröderJohanna, WerkleNathalie, CludiusBarbara, JelinekLena, MoritzSteffen, WestermannStefan

iCBT for OCD

Many people with obsessive-compulsive disorder (OCD) don't seek professional help due to various barriers. This study explored the effectiveness of a self-guided online cognitive-behavioral therapy (iCBT) program that includes newer "third-wave" approaches for treating OCD symptoms. The study aimed to evaluate how well this program works without direct guidance from a therapist.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

111.

Cognitive behavioural therapy with exposure and response prevention in the treatment of obsessive-compulsive disorder: A systematic review and meta-analysis of randomised controlled trials.

Author: ReidJemma E, LawsKeith R, DrummondLynne, VismaraMatteo, GranciniBenedetta, MpavaendaDavis, FinebergNaomi A

OCD treatment

Cognitive behavioral therapy (CBT) that includes exposure and response prevention (ERP) is considered the best psychological treatment for obsessive-compulsive disorder (OCD). However, more research is needed to understand the effectiveness of this treatment and how different factors might influence outcomes for people with OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

112.

Examination of a brief computerized Cognitive Anxiety Sensitivity intervention on obsessive-compulsive symptoms.

Author: RainesAmanda M, KoscinskiBrandon, MathesBrittany M, PorteroAmberly K, AllanNicholas P, SchmidtNorman B

OCD treatment

While there are treatments for obsessive-compulsive disorder (OCD), many people don't get better or don't finish treatment. Researchers are trying to find factors that make treatment less effective, hoping to address them and improve outcomes. One factor is anxiety sensitivity (AS), which is a worry about the physical sensations of anxiety. This study aims to determine if reducing AS can help reduce OCD symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

113.

Effect of an Internet-Delivered Stepped-Care Program vs In-Person Cognitive Behavioral Therapy on Obsessive-Compulsive Disorder Symptoms in Children and Adolescents: A Randomized Clinical Trial.

Author: AspvallKristina, AnderssonErik, MelinKarin, NorlinLisa, ErikssonViktor, VigerlandSarah, JolstedtMaral, Silverberg-MörseMaria, WallinLena, SampaioFilipa, FeldmanInna, BottaiMatteo, LenhardFabian, Mataix-ColsDavid, SerlachiusEva

Improved OCD symptoms
Anxiety
Depression

Internet-delivered cognitive behavioral therapy (CBT) followed by in-person CBT as needed was compared to in-person CBT alone for 152 children and adolescents with obsessive-compulsive disorder. At 6 months, internet-delivered CBT was noninferior to in-person CBT, with a noninferiority margin of 4 points on the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). Both groups experienced increased anxiety and depressive symptoms, but there were only 2 unrelated serious adverse events.

Equivalence TrialA clinical trial designed to show that a new treatment is equivalent in efficacy/safety to an existing treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

114.

Association between obsession, compulsion, depression and insight in obsessive-compulsive disorder: a meta-analysis.

Author: GanJun, HeJing, FuHong, ZhuXiongzhao

Impaired insight in OCD

This study examined differences in clinical characteristics and treatment outcomes between patients with obsessive-compulsive disorder (OCD) with poor insight (OCD-PI) and those with good insight (OCD-GI).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

115.

Memantine augmentation of sertraline in the treatment of symptoms and executive function among patients with obsessive-compulsive disorder: A double-blind placebo-controlled, randomized clinical trial.

Author: AskariSanaz, MokhtariSaba, ShariatSeyed Vahid, ShariatiBehnam, YarahmadiMasoomeh, ShalbafanMohammadreza

Memantine for OCD

This study investigated the effectiveness of memantine as an adjunct therapy to sertraline for improving symptoms and executive function in patients with obsessive-compulsive disorder (OCD), considering the limited response to current treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

116.

The causes and consequences of shame in obsessive-compulsive disorder.

Author: VisvalingamShanara, CroneCassandra, StreetSimon, OarElla L, GilchristPhilippe, NorbergMelissa M

Treatment for OCD

This study explored the role of shame in obsessive-compulsive disorder (OCD). People with OCD often engage in rituals or compulsions to relieve anxiety, but this study found that shame also plays a significant role, especially for disturbing obsessions related to violence or sex. Shame was linked to a greater desire to perform compulsions and avoid certain situations, even when controlling for anxiety. The researchers suggest that treatments for OCD should address shame in addition to anxiety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

117.

Ketamine in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review.

Author: BandeiraIgor D, Lins-SilvaDaniel H, CavenaghiVitor Breseghello, Dorea-BandeiraIngrid, Faria-GuimarãesDaniela, BarouhJudah L, Jesus-NunesAna Paula, BeanesGraziele, SouzaLucca S, LealGustavo C, SanacoraGerard, MiguelEuripedes C, SampaioAline S, QuarantiniLucas C

Ketamine
OCD treatment

Standard treatments for obsessive-compulsive disorder (OCD) include therapy and medication, but new and better treatments are needed. Research suggests that a brain chemical called glutamate plays a role in OCD. This opens the door for exploring ketamine, a medication that affects glutamate, as a potential treatment for OCD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

118.

Effect of Internet-Based vs Face-to-Face Cognitive Behavioral Therapy for Adults With Obsessive-Compulsive Disorder: A Randomized Clinical Trial.

Author: LundströmLina, FlygareOskar, AnderssonErik, EnanderJesper, BottaiMatteo, IvanovVolen Z, BobergJulia, PascalDiana, Mataix-ColsDavid, RückChristian

Cost-effective treatment
OCD treatment
Anxiety
Depression
Stress

This randomized clinical trial compared therapist-guided and unguided internet-based cognitive behavioral therapy (ICBT) to face-to-face CBT for adults with obsessive-compulsive disorder (OCD). Therapist-guided ICBT was inconclusive for noninferiority to face-to-face CBT, while unguided ICBT was not noninferior. However, both guided and unguided ICBT were cost-effective compared to face-to-face CBT.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

119.

Randomized trial of the efficacy of trial-based cognitive therapy for obsessive-compulsive disorder: preliminary findings.

Author: RodriguesEleonardo Pereira, FechineAna Jardel Batista, OliveiraAntonio César, MatosCristiane Francisca Ferreira, PassarelaCristiane de Medeiros, HemannyCurt, DiasFrancimeuda de Morais, BatistaJosé Wilson, AlbuquerqueLuciana de Carvalho Nogueira, SoaresMyrla Sirqueira, CoelhoPedro Evangelista, AraújoVanessa Pires de Carvalho, AyresZila Mendes, de OliveiraIrismar Reis

OCD treatment

Obsessive-compulsive disorder (OCD) is a common and disabling condition. While medications and therapies like CBT and ERP are used, new approaches are needed. Trial-based cognitive therapy (TBCT) is a newer therapy that focuses on changing negative thoughts. This study will compare the effectiveness of TBCT to ERP for treating OCD.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

120.

Evaluation of Inference-Based Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder: A Multicenter Randomized Controlled Trial with Three Treatment Modalities.

Author: AardemaFrederick, BouchardStéphane, KoszyckiDiana, LavoieMarc E, AudetJean-Sebastien, O'ConnorKieron

OCD treatment

Inference-based cognitive-behavioral therapy (I-CBT) is a specialized treatment for OCD that focuses on changing faulty thinking patterns that lead to obsessive thoughts and rituals. Unlike traditional CBT, it doesn't involve prolonged exposure to feared situations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

121.

Comparing the Effects of a Herbal Drug based on <i>Echium Amoenum</i> With Fluvoxamine in the Treatment of Adolescents with Obsessive-compulsive Disorder.

Author: NorasMohamad Reza, SoltanifarAtefeh, SalariRoshanak, JarahiLida, AbrishamiMaryam Hosseini

OCD treatment

Obsessive-compulsive disorder (OCD) is a serious mental health condition. While medications and cognitive-behavioral therapy are common treatments, about 30% of people don't respond well or fully recover. We need to explore natural products as potential treatments for OCD, to find safer and more effective approaches.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

122.

Symptom improvement and remission in untreated adults seeking treatment for obsessive-compulsive disorder: A systematic review and meta-analysis.

Author: MelkonianMaral, McDonaldSarah, ScottAmelia, KarinEyal, DearBlake F, WoottonBethany M

Chronicity of OCD

This study examined the course of obsessive-compulsive disorder (OCD) in people who didn't receive treatment, using data from control groups in clinical trials. The findings showed that, without treatment, OCD symptoms generally didn't improve significantly over an average of 10.9 weeks, and only 4% of participants saw their symptoms completely disappear. The study suggests that OCD, without treatment, is a chronic and persistent condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

123.

The therapeutic alliance in cognitive-behavioral therapy for obsessive-compulsive disorder: A systematic review and meta-analysis.

Author: StrappiniFrancesca, SocciValentina, SalianiAngelo Maria, GrossiGiuseppe, D'AriGiulia, DamatoTitti, PompiliNicole, AlessandriGuido, ManciniFrancesco

Therapeutic alliance in CBT for OCD

This systematic review and meta-analysis examined the effect of therapeutic alliance on treatment outcomes in Cognitive Behavioral Therapy (CBT) for patients with obsessive-compulsive disorder (OCD).

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

124.

Neurobiological outcomes of cognitive behavioral therapy for obsessive-compulsive disorder: A systematic review.

Author: PoliAndrea, PozzaAndrea, OrrùGraziella, ConversanoCiro, CiacchiniRebecca, PugiDaniele, AngeloNicole Loren, AngelettiLorenzo Lucherini, MiccoliMario, GemignaniAngelo

OCD treatment

Obsessive-compulsive disorder (OCD) involves repetitive thoughts and behaviors. Research suggests that certain brain regions are involved in these symptoms. This review will examine studies that looked at changes in brain activity before and after cognitive-behavioral therapy (CBT), the main therapy for OCD, to see how treatment affects these brain areas.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

125.

Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment.

Author: de OliveiraMarcos Vinícius Sousa, de BarrosPedro Macul Ferreira, de MathisMaria Alice, BoavistaRodrigo, ChaconPriscila, EchevarriaMarco Antonio Nocito, FerrãoYgor Arzeno, VattimoEdoardo Felippo de Queiroz, LopesAntônio Carlos, TorresAlbina Rodrigues, DinizJuliana Belo, FontenelleLeonardo F, RosárioMaria Conceição do, ShavittRoseli Gedanke, MiguelEurípedes Constantino, da SilvaRenata de Melo Felipe, CostaDaniel Lucas da Conceição

OCD treatment

This study updated the 2013 American Psychiatric Association guidelines for the treatment of obsessive-compulsive disorder (OCD) by reviewing new evidence on pharmacological treatments. The study confirmed that SSRIs remain the first-line treatment, and augmentation with low-dose risperidone or aripiprazole is the most evidence-based approach for SSRI-resistant OCD. The study also identified treatments considered ineffective or potentially harmful.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

126.

Economic Analyses of Obsessive-Compulsive Disorder Interventions: A Systematic Review.

Author: StrouphauerEmily R, MorrisOlivia J, SoileauKeaton J, WieseAndrew D, QuastTroy, GoodmanWayne K, ShethSameer A, WojcikKatharine D, GuzickAndrew G, StorchEric A

OCD treatment

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by repetitive thoughts and behaviors that cause distress. While therapy and medication are common treatments, other approaches might be more affordable in some cases. It's important to understand the cost-effectiveness of all treatment options for OCD to ensure that people receive the best care at a reasonable price.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

127.

Predictors of response to cognitive behavioural therapy (CBT) for individuals with obsessive-compulsive disorder (OCD): a systematic review.

Author: McDonaldSarah, MelkonianMaral, KarinEyal, DearBlake F, TitovNickolai, WoottonBethany M

OCD treatment
OCD symptoms

This systematic review found that some OCD-related pre-treatment variables (e.g., pre-treatment severity, past CBT treatment, and levels of avoidance) and during treatment variables (e.g., poor working alliance and low treatment adherence) may be important to consider when making treatment recommendations for OCD.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

128.

Efficacy and Cost-Effectiveness Analysis of Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: Randomized Controlled Trial.

Author: WuYiwen, LiXin, ZhouYuxin, GaoRui, WangKaifeng, YeHuiling, LyuNa, WangChun, ZhangNing, WangZhen, FanQing

OCD treatment

Obsessive-compulsive disorder (OCD) is a common and disabling condition. While online therapy (ICBT) is effective, there haven't been any studies comparing online therapy, in-person group therapy, and medication alone. This study will examine the effectiveness of each of these approaches.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

129.

A Meta-analysis of Transcranial Magnetic Stimulation in Obsessive-Compulsive Disorder.

Author: SteuberElizabeth R, McGuireJoseph F

OCD treatment

This meta-analysis examined the therapeutic benefit of repetitive transcranial magnetic stimulation (rTMS) in patients with obsessive-compulsive disorder (OCD), considering its potential as a treatment option for patients who don't respond to first-line therapies.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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