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Metformin reduces serum mullerian-inhibiting substance levels in women with polycystic ovary syndrome after protracted treatment.
Author: FlemingRichard, HarborneLyndal, LingDaniel, MacLaughlinDavid T, NormanJane, SattarNaveed, SeiferDavid B
Original Abstract of the Article :
OBJECTIVE: Assessment of ovarian responses to metformin treatment in obese women with polycystic ovary syndrome (PCOS). DESIGN: Prospective treatment with randomization to two doses of metformin. SETTING: University teaching hospital. PATIENT(S): Obese women (n = 82) with PCOS. INTERVENTION(S): ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.fertnstert.2004.05.098
データ提供:米国国立医学図書館(NLM)
Metformin for Polycystic Ovary Syndrome: A Delayed Response
Polycystic ovary syndrome (PCOS) is a common hormonal disorder that can impact fertility and overall health. Metformin, a medication typically used for type 2 diabetes, has shown promise in treating PCOS. This research investigated the effects of metformin on ovarian function in obese women with PCOS. The researchers observed changes in hormone levels, menstrual frequency, and Mullerian-inhibiting substance (MIS) levels over time. It's like observing the slow but steady growth of a desert flower, requiring time and patience to see its full bloom.
Metformin's Impact on PCOS: A Delayed Response
The study found that metformin led to improvements in menstrual frequency and a reduction in androstenedione levels within the first 4 months of treatment. However, the suppression of MIS levels required a more protracted treatment period, indicating that the effects of metformin on certain ovarian functions may not be immediately apparent. This suggests that a longer-term approach to metformin therapy might be necessary for optimal results.
Managing PCOS: A Journey of Patience and Persistence
This research highlights the importance of patience and persistence in managing PCOS. While metformin may not show immediate results, its long-term effects can be beneficial. It's a reminder that like a camel navigating a desert, we need to be prepared for a journey that may require time and effort to reach our destination.
Dr.Camel's Conclusion
This research underscores the importance of understanding the time course of metformin's effects on PCOS. It's a reminder that in the vast desert of medical treatment, some solutions require time and patience to manifest their full potential. By understanding the nuances of treatment, we can provide better care and support for patients with PCOS.
Date :
- Date Completed 2005-03-01
- Date Revised 2022-03-16
Further Info :
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