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The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors.

Author: BakerJillian G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the selectivity of beta-antagonists for different human beta-adrenoceptor subtypes. Most clinically used beta-blockers showed poor selectivity for beta1- over beta2-adrenoceptors, suggesting potential for developing more selective drugs to reduce side effects.
Paper Details　
Original Abstract of the Article :
Beta-adrenoceptor antagonists ("beta-blockers") are one of the most widely used classes of drugs in cardiovascular medicine (hypertension, ischaemic heart disease and increasingly in heart failure) as well as in the management of anxiety, migraine and glaucoma. Where known, the mode of action in car...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576008/

データ提供：米国国立医学図書館（NLM）

Beta-Adrenoceptor Antagonists: Understanding the Desert of Receptor Selectivity

Just as a camel navigates the desert with a keen sense of direction, understanding the selectivity of drugs is crucial for their effective and safe use. This study, like a meticulous guide mapping a complex terrain, investigates the selectivity of beta-adrenoceptor antagonists (beta-blockers) at different receptor subtypes. It's a quest to understand the intricate pathways of drug action within the body.

A Complex Landscape of Receptor Interactions

The study, like a detailed map, reveals that beta-blockers, commonly used for treating cardiovascular conditions, exhibit varying degrees of selectivity for different beta-adrenoceptor subtypes. This finding, like discovering a hidden oasis of knowledge, highlights the importance of understanding these differences for optimizing treatment and minimizing side effects.

Navigating the Desert of Drug Therapy

This research provides valuable insights into the selectivity of beta-blockers, emphasizing the need for a personalized approach to drug therapy. It's like a guide leading a traveler through a diverse landscape, ensuring the most effective and safe route for each individual. This study underscores the importance of ongoing research to develop more selective beta-blockers, minimizing unwanted side effects and enhancing treatment outcomes.

Dr.Camel's Conclusion

This study explores the complex landscape of beta-adrenoceptor selectivity, highlighting the importance of considering individual patient needs and the potential for developing more selective beta-blockers. It's a reminder that the desert of drug therapy requires continuous exploration and understanding to optimize treatment outcomes.

Date :
  1. Date Completed 2005-06-13
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

15655528

DOI: Digital Object Identifier

PMC1576008

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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