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Effects of sulfonylureas, alpha-endosulfine counterparts, on glomerulosclerosis in type 1 and type 2 models of diabetes.

Author: BiedermanJason I, CortesPedro, GiannicoGiovanna, HassettClare, RankhaniyaRohit, VeraEdgard, YeeJerry

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Sulfonylurea receptors (SUR) are found in mesangial cells and isolated glomeruli. Alpha-endosulfine, the endogenous ligand of SUR, is upregulated by high glucose levels. This study investigated the effects of sulfonylureas, exogenous SUR ligands, on diabetic animals.
Paper Details　
Original Abstract of the Article :
Previously, we showed the expression of a unique sulfonylurea receptor (SUR) and its putative endogenous ligand, alpha-endosulfine, in mesangial cells and isolated glomeruli. Further, this ligand was up-regulated by high glucose concentration. To investigate the possible role of alpha-endosulfine up...See full text at original site
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引用元：
https://doi.org/10.1111/j.1523-1755.2005.67112.x

データ提供：米国国立医学図書館（NLM）

Sulfonylureas: A Potential Oasis in the Desert of Glomerulosclerosis

This study ventures into the realm of diabetes, a chronic condition that can lead to complications like glomerulosclerosis, a scarring of the kidneys. This research is like a camel caravan venturing into a desert oasis, seeking a solution to the challenges of diabetes-related kidney damage.

Unveiling the Mechanisms: Sulfonylureas and Glomerulosclerosis

The study investigated the potential role of sulfonylureas, a class of medications used to treat diabetes, in mitigating glomerulosclerosis in both type 1 and type 2 diabetes models. It’s like a scientific expedition, carefully examining the effects of these medications on kidney function. The study found that sulfonylureas may have a protective effect on the kidneys, potentially slowing down the progression of glomerulosclerosis.

Protecting the Kidneys: A Promising Approach to Diabetes Care

This research highlights the potential of sulfonylureas as a therapeutic strategy for managing diabetic kidney disease. It’s like finding a hidden spring in the desert, offering a potential solution to the challenges of this chronic condition. The study suggests that further research is needed to fully understand the mechanisms of action and optimize the use of sulfonylureas in managing diabetic kidney disease.

Dr.Camel's Conclusion

This study offers a glimmer of hope for individuals with diabetes, a condition that can lead to serious kidney complications. It's like discovering a hidden oasis in the desert, providing a potential solution for managing diabetic kidney disease and improving the overall well-being of those affected by this chronic condition.

Date :
  1. Date Completed 2005-06-09
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

15673303

DOI: Digital Object Identifier

10.1111/j.1523-1755.2005.67112.x

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English

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