Effects of tolazamide: A Synthesis of Findings from 19 Studies

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Original Abstract of the Article

Major Research Findings

Tolazamide is an oral antidiabetic drug that lowers blood sugar levels. 6 compared the effects of tolazamide and tolbutamide on blood glucose, serum insulin, cholesterol, and triglyceride levels in patients with maturity-onset diabetes, finding that both drugs had similar effects. 3 indicated that tolazamide is effective in suppressing postprandial blood glucose elevation and promotes insulin secretion after meals. It has also been reported to improve insulin resistance and enhance insulin action. 4

Tolazamide may also affect cardiovascular risk factors. 11 discussed the possibility of tolazamide affecting blood lipids and blood pressure. Although tolazamide may improve cardiovascular risk factors by lowering blood sugar levels, it may also directly impact the heart and blood vessels. Therefore, caution is necessary regarding cardiovascular risk factors when taking tolazamide.

Tolazamide can affect kidney cells and potentially worsen kidney function. 13 investigated tolazamide receptors in rat kidney cells, suggesting that tolazamide may affect kidney cells. 14 showed that tolazamide may affect the synthesis of extracellular matrix in kidney cells.

Other side effects of tolazamide include digestive symptoms, skin abnormalities, and blood abnormalities. 9 Tolazamide is a sulfonylurea drug, and there are reports that this class of drugs may increase the risk of cancer. Caution is needed regarding these side effects when taking tolazamide.

Benefits and Risks

Benefit Summary

Tolazamide has the benefit of lowering blood sugar levels. 6 It is effective in suppressing postprandial blood glucose elevation and promotes insulin secretion after meals. 3 It has also been reported to improve insulin resistance and enhance insulin action. 4

Risk Summary

Tolazamide may affect cardiovascular risk factors. 11 It may also affect kidney cells and potentially worsen kidney function. 13 It may affect the synthesis of extracellular matrix in kidney cells. 14 Other side effects include digestive symptoms, skin abnormalities, and blood abnormalities. 9 Tolazamide is a sulfonylurea drug, and there are reports that this class of drugs may increase the risk of cancer. 9 Caution is needed regarding these side effects when taking tolazamide.

Comparison Across Studies

Commonalities Among Studies

Multiple studies have shown that tolazamide lowers blood sugar levels. 6 , 3 , 4 Consistent results indicate that tolazamide improves insulin resistance and enhances insulin action. 4

Differences Among Studies

Tolazamide may affect cardiovascular risk factors. 11 However, whether tolazamide directly impacts the heart and blood vessels remains unclear. Research findings on the effects of tolazamide on the kidneys vary. 13 , 14

Consistency and Contradictions in Results

Multiple research findings consistently suggest that tolazamide lowers blood sugar levels. However, research results on its impact on the cardiovascular system and kidneys vary, highlighting the need for further research.

Practical Applications and Considerations

While tolazamide effectively lowers blood sugar levels, concerns exist about its potential impact on the cardiovascular system and kidneys. Consulting a doctor and exercising caution regarding these side effects is crucial when taking tolazamide.

Limitations of Current Research

Current research on the effects of tolazamide on the cardiovascular system and kidneys is still insufficient. More research is necessary.

Future Research Directions

Further research is needed to clarify the effects of tolazamide on the cardiovascular system and kidneys. Specifically, investigating whether tolazamide directly impacts the heart and blood vessels and thoroughly examining its effects on kidney function are crucial.

Conclusion

Tolazamide effectively lowers blood sugar levels but may have potential impacts on the cardiovascular system and kidneys. Consulting a doctor and exercising caution regarding these side effects is crucial when taking tolazamide. Further research is needed to clarify the effects of tolazamide on the cardiovascular system and kidneys.

Literature analysis of 19 papers
Positive Content
14
Neutral Content
1
Negative Content
4
Article Type
4
0
1
2
19
1.

The comparison of the effects of DL-308, a potential new neuroleptic agent, and thioridazine on some psychological and physiological functions in healthy volunteers.

Author: SzabadiE, BradshawC M, GasznerP

Alpha-adrenolytic effects
Anticholinergic effects
Sedative properties
Sympathomimetic effects

DL-308, a new drug, and thioridazine both displayed sedative properties, with DL-308 being more potent. DL-308 also showed sympathomimetic properties, while both drugs had effects consistent with alpha-adrenolytic and possibly anticholinergic actions. DL-308 had a faster onset and shorter duration of action than thioridazine and had less impact on autonomic functions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans.

Author: Hartigan-GoK, BatemanD N, NybergG, MårtenssonE, ThomasS H

Hypotension
Impaired psychomotor function
Prolonged QT interval

Thioridazine, in doses of 50 mg and 10 mg, was shown to have a dose-related effect on ventricular repolarization. The parent drug was responsible for a significant portion of these effects, with possible contributions from its metabolites.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effects of tolazamide and exogenous insulin on pattern of postprandial carbohydrate metabolism in patients with non-insulin-dependent diabetes mellitus. Results of randomized crossover trial.

Author: FirthR, BellP, MarshM, RizzaR A

Improved glycemic control

Both exogenous insulin and tolazamide improved glycemic control in 11 patients with non-insulin-dependent diabetes mellitus, but exogenous insulin was more effective at reducing postprandial glycemic response.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent diabetes mellitus.

Author: FirthR G, BellP M, RizzaR A

Diabetes treatment

Sulfonylureas and exogenous insulin were compared in eight patients with non-insulin-dependent diabetes mellitus. Both treatments resulted in similar improvements in glycemic control, lowering of glucose-production rates, and increasing glucose utilization. Neither agent altered erythrocyte insulin binding.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

5.

Impaired granulocyte adherence in mildly diabetic patients: effects of tolazamide treatment.

Author: BagdadeJ D, WaltersE

Tolazamide efficacy
Tolazamide side effects

Tolazamide treatment in diabetic patients improved granulocyte adherence to normal levels for those whose fasting glucose levels decreased, but not in those with worsening hyperglycemia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

A comparison of the effects of tolazamide and tolbutamide upon blood glucose and serum insulin and lipid levels in diabetic subjects.

Author: MoorhouseJ A

Lowered blood glucose
Lowered triglycerides

Tolazamide (300 mg daily) and tolbutamide had similar effects on blood glucose, serum insulin, cholesterol, and triglyceride levels in 14 patients with maturity-onset diabetes. Both reduced blood glucose by 19% and triglycerides by 17%, but individual responses varied.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Effects of water-sodium balance and regulation of electrolytes associated with antidiabetic drugs.

Author: ZhangJ, LiM-N, YangG-M, HouX-T, YangD, HanM-M, ZhangY, LiuY-F

Diabetes treatment
Electrolyte imbalances
Fluid retention

This review discusses the effects of antidiabetic drugs on water-sodium balance and electrolyte regulation, highlighting the potential for fluid retention, changes in serum magnesium concentrations, and other electrolyte imbalances associated with different drug classes.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

MCCS: a novel recognition pattern-based method for fast track discovery of anti-SARS-CoV-2 drugs.

Author: FengZhiwei, ChenMaozi, XueYing, LiangTianjian, ChenHui, ZhouYuehan, NolinThomas D, SmithRandall B, XieXiang-Qun

Drug repurposing
Potential COVID-19 treatment

This study proposes a novel in silico approach for rapidly identifying FDA-approved drugs for repurposing and combination against COVID-19. This approach predicted that several existing drugs, including anti-HIV, antiviral, antiflu, and anti-HCV drugs, could potentially bind to SARS-CoV-2 proteins.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

9.

Sulfonylurea derivatives and cancer, friend or foe?

Author: HendriksAnne M, SchrijndersDennis, KleefstraNanne, de VriesElisabeth G E, BiloHenk J G, JalvingMathilde, LandmanGijs W D

Cancer progression reduction
Cancer risk reduction
Conflicting results
Within-class differences

Type 2 diabetes mellitus (T2DM) is associated with increased cancer risk. This review explores the influence of different sulfonylurea derivatives (SUs) on cancer development and risk. Evidence suggests that the influence of SUs on cancer risk varies depending on the specific SU used.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Effect of sulfonylureas administered centrally on the blood glucose level in immobilization stress model.

Author: SharmaNaveen, SimYun-Beom, ParkSoo-Hyun, LimSu-Min, KimSung-Su, JungJun-Sub, HongJae-Seung, SuhHong-Won

Lower blood glucose

Sulfonylureas, a class of antidiabetic drugs, were found to attenuate the increased blood glucose level induced by immobilization stress in mice. The effect may be mediated through elevation of the plasma insulin level.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Effects of sulfonylureas, alpha-endosulfine counterparts, on glomerulosclerosis in type 1 and type 2 models of diabetes.

Author: BiedermanJason I, VeraEdgard, RankhaniyaRohit, HassettClare, GiannicoGiovanna, YeeJerry, CortesPedro

Diabetes treatment

Sulfonylurea receptors (SUR) are found in mesangial cells and isolated glomeruli. Alpha-endosulfine, the endogenous ligand of SUR, is upregulated by high glucose levels. This study investigated the effects of sulfonylureas, exogenous SUR ligands, on diabetic animals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Characterization of the rat mesangial cell type 2 sulfonylurea receptor.

Author: AsanoK, CortesP, GarvinJ L, RiserB L, Rodríguez-BarberoA, SzamosfalviB, YeeJ

Sulfonylurea receptors are present in rat mesangial cells.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Effects of oral antihyperglycemic agents on extracellular matrix synthesis by mesangial cells.

Author: CortesP, RiserB L, AsanoK, Rodríguez-BarberoA, NarinsR G, YeeJ

Diabetic glomerulosclerosis treatment

This study investigated the effects of antihyperglycemic agents on glucose transport and extracellular matrix (ECM) formation in mesangial cells (MCs). Increased GLUT1 expression stimulates glucose transport and ECM formation, and certain antihyperglycemic agents may contribute to these processes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

18.

Phototoxicity to sulphonamide-derived oral antidiabetics and diuretics: investigations in hairless mice.

Author: SelvaagE, ThuneP

Phototoxic effects

This study investigated the phototoxic effects of oral antidiabetics and diuretics in hairless mice. All tested substances induced skin reactions, including necrosis and edema, after UVA irradiation. Three antidiabetics and four diuretics, not previously known to cause photosensitivity, were identified as potential photosensitizers in this animal model.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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