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[The additive antiproteinuric effect of Enalapril and Losartan to normotensive patients with pathology proteinuria].

Author: CanepaC, De ReyesV, DieguezS M, LiernM, VallejosG

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
English AbstractA summary of a research paper/publication written in English for a wider audience.

Overview

This study evaluated the effectiveness of enalapril in reducing proteinuria and blood pressure in normotensive patients with proteinuria. Enalapril at two different doses significantly reduced proteinuria, and combined with losartan, further reduced proteinuria. Enalapril also significantly lowered blood pressure in all stages. No patients developed hyperkalemia, decreased glomerular filtration rate, or anemia.
Paper Details　
Original Abstract of the Article :
The proteinuria is frequently the initial insult to the kidney and it usually followed by a progressive decline in the glomerular filtration rate. The angiotensin II mediate by glomerular permeselective function via the opening of large pores after elevations in transmembrane pressure and by acting ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15683027

データ提供：米国国立医学図書館（NLM）

Enalapril and Losartan for Proteinuria: A Combined Approach

Proteinuria, the presence of excess protein in the urine, is a common indicator of kidney disease. This study investigates the effectiveness of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in reducing proteinuria in normotensive patients with kidney disease. The researchers evaluated the effects of Enalapril (an ACEI) alone and in combination with Losartan (an ARB) in patients with proteinuria and normal glomerular filtration rate. The study found that both Enalapril and the combination therapy significantly reduced proteinuria, suggesting a potential benefit for managing kidney disease.

A Potential Strategy for Managing Proteinuria

This study suggests that ACEIs and ARBs, particularly in combination, may be effective in reducing proteinuria and potentially slowing the progression of kidney disease. It's like using a combination of tools to clear a path through a dense desert, ensuring a smoother and safer journey forward.

Managing Kidney Disease: A Multi-faceted Approach

This study highlights the importance of a multi-faceted approach to managing kidney disease. The findings suggest that targeting the renin-angiotensin system through ACEIs and ARBs may be a valuable strategy for reducing proteinuria and improving renal function.

Dr.Camel's Conclusion

This study explores the potential benefits of ACEIs and ARBs in managing proteinuria, suggesting a promising strategy for preserving kidney function and slowing the progression of kidney disease. It's a reminder that managing kidney disease requires a comprehensive and personalized approach, just like navigating a complex desert ecosystem.
Date :
  1. Date Completed 2005-03-15
  2. Date Revised 2014-07-29
Further Info :

Pubmed ID

15683027

DOI: Digital Object Identifier

15683027

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・Side Effects of enalapril
SNS
PICO Info
in preparation
Languages

Spanish

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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