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Neoadjuvant versus adjuvant systemic treatment in breast cancer: a meta-analysis.

Author: IoannidisJohn P A, MauriDavide, PavlidisNicholas

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

This study compared the outcomes of patients with breast cancer who received chemotherapy before surgery (neoadjuvant therapy) versus those who received chemotherapy after surgery (adjuvant therapy). The study aimed to determine if receiving chemotherapy before surgery, which has the potential to reduce the extent of surgery needed, had a significant impact on overall treatment outcomes.
Paper Details　
Original Abstract of the Article :
Interest in the use of preoperative systemic treatment in the management of breast cancer has increased because such neoadjuvant therapy appears to reduce the extent of local surgery required. We compared the clinical end points of patients with breast cancer treated preoperatively with systemic the...See full text at original site
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引用元：
https://doi.org/10.1093/jnci/dji021

データ提供：米国国立医学図書館（NLM）

Neoadjuvant vs. Adjuvant Therapy in Breast Cancer: A Tale of Two Treatments

The world of breast cancer treatment is a complex and ever-evolving landscape. This meta-analysis delves into the effectiveness of systemic treatment delivered before surgery (neoadjuvant therapy) compared to treatment delivered after surgery (adjuvant therapy). The analysis, based on a comprehensive review of randomized trials, aimed to determine which approach yielded better clinical outcomes for breast cancer patients. The results suggest that there is no clear advantage to either approach, with both neoadjuvant and adjuvant therapy demonstrating similar efficacy. This finding highlights the need for personalized treatment plans based on individual patient characteristics and tumor biology.

Two Paths in the Desert of Breast Cancer Treatment

This meta-analysis explores the effectiveness of two common approaches to systemic treatment in breast cancer: neoadjuvant therapy, where treatment is delivered before surgery, and adjuvant therapy, where treatment is delivered after surgery. The findings suggest that both approaches are equally effective, offering patients a choice in their treatment plan based on individual needs and preferences. This is a valuable insight that empowers patients to actively participate in their treatment decisions.

Navigating the Breast Cancer Landscape

This research underscores the importance of personalized treatment plans in breast cancer management. The findings suggest that both neoadjuvant and adjuvant therapy are effective treatment options, but the best approach for an individual patient depends on various factors, including tumor characteristics and personal preferences. It is crucial to consult with a healthcare professional to discuss all treatment options and make informed decisions based on your individual needs and circumstances.

Dr.Camel's Conclusion

This study highlights the complexity of breast cancer treatment, with no single approach being universally superior. The findings suggest that both neoadjuvant and adjuvant therapy can be effective, emphasizing the importance of personalized treatment plans based on individual patient characteristics and tumor biology.

Date :
  1. Date Completed 2005-02-15
  2. Date Revised 2023-07-18
Further Info :

Pubmed ID

15687361

DOI: Digital Object Identifier

10.1093/jnci/dji021

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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