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Comparative drug effects and abuse liability of lorazepam, buspirone, and secobarbital in nondependent subjects.

Author: KaplanH L, RomachM K, SchneidermanJ F, SellersE M, SomerG R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lorazepam and secobarbital were more liked and produced greater drug effects compared to buspirone and placebo. Buspirone 20 mg was significantly less liked than other drugs.
Paper Details　
Original Abstract of the Article :
The pharmacologic effects of lorazepam (2 mg), buspirone (20 mg, 10 mg), secobarbital (100 mg), and placebo were compared in 15 male, experienced, intermittent nontherapeutic drug users. All drugs produced a "drug effect," however, buspirone 20 mg was significantly less liked than were lorazepam, se...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1573044

データ提供：米国国立医学図書館（NLM）

Comparing the Effects of Lorazepam, Buspirone, and Secobarbital in Nondependent Subjects

This research delves into the comparative effects and abuse liability of three different medications: lorazepam, buspirone, and secobarbital. These medications are commonly used for anxiety and sleep disorders, but their potential for abuse is a significant concern. The researchers conducted a study with 15 male subjects who were experienced nontherapeutic drug users. They compared the effects of each drug against placebo. The study aimed to understand the subjective effects, behavioral impairments, and potential for abuse liability of these medications. The researchers discovered that lorazepam produced the most pronounced effects, followed by secobarbital. Buspirone, on the other hand, was less liked and produced fewer pronounced effects.

Understanding the Abuse Liability of Different Medications

This study provides valuable insights into the potential for abuse of different medications, particularly lorazepam and secobarbital. The researchers' findings suggest that these medications have a greater likelihood of being abused compared to buspirone. This information is critical for healthcare professionals and policymakers who are working to prevent drug abuse.

Responsible Medication Use and Seeking Help

It's crucial to use all medications responsibly and under the guidance of a healthcare professional. If you have concerns about medication use or abuse, seeking professional help is essential. This study highlights the importance of understanding the potential for abuse of different medications and the need for careful monitoring and treatment.

Dr. Camel's Conclusion

Imagine a desert oasis offering a variety of refreshments. Lorazepam and secobarbital are like potent, but potentially addictive, beverages, while buspirone is like a refreshing, but less potent, fruit juice. This research helps us understand the different effects and potential risks of these 'drinks' and highlights the importance of choosing wisely and responsibly.

Date :
  1. Date Completed 1992-06-04
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1573044

DOI: Digital Object Identifier

1573044

Related Literature

Article Analysis
・Effects of buspirone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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