Effects of buspirone: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Major Research Findings

Buspirone is a non-benzodiazepine anxiolytic medication used for the treatment of anxiety disorders. Several studies have shown that buspirone is effective in reducing anxiety symptoms. 7 reported that in a double-blind trial comparing buspirone and diazepam, both medications showed comparable effectiveness in alleviating anxiety and depressive symptoms. Additionally, buspirone has been found to have less cognitive impairment and sedation compared to diazepam. 6 investigated the side effect profile of buspirone and concluded that sedation, lethargy, and depression were significantly less frequent and severe with buspirone compared to diazepam or clorazepate, and were comparable to placebo. 4 demonstrated that buspirone did not impair objective measures of daytime wakefulness or performance. Buspirone has also been found to have less psychological performance impairment compared to diazepam. 8 found that buspirone did not impair objective performance but caused drowsiness and fatigue, whereas diazepam impaired skills objectively, with less subjective impairment. Furthermore, buspirone has been suggested to have a lower risk of dependence and abuse compared to benzodiazepines. 2 found that buspirone was significantly less liked than lorazepam, secobarbital, or buspirone 10 mg, suggesting a lower potential for abuse. 1 also found that buspirone was as effective as diazepam in treating anxiety and also showed excellent antidepressant effects.

Benefits and Risks

Benefit Summary

Buspirone may be an effective treatment for anxiety disorders and has a lower risk of cognitive impairment, dependence, and abuse compared to benzodiazepines. 7 6 4 2 1

Risk Summary

Buspirone has been shown to have fewer side effects compared to diazepam, and also less sedation. 6 8 However, buspirone is metabolized by CYP3A4, and its use with CYP3A4 inducers such as rifampicin should be avoided. 13 Rifampicin was found to significantly decrease buspirone's plasma concentration, potentially reducing its effectiveness. 13 Buspirone may also have potential interactions with other medications.

Comparison Between Studies

Commonalities Between Studies

Multiple studies consistently demonstrate that buspirone is effective in reducing anxiety symptoms. Additionally, studies consistently suggest that buspirone has a lower risk of cognitive impairment, dependence, and abuse compared to benzodiazepines.

Differences Between Studies

Some differences exist in the findings regarding buspirone's effects and side effects. For example, 7 found that buspirone was as effective as diazepam in reducing anxiety, while 5 indicated that buspirone had weaker interactions with alcohol compared to diazepam. 11 found that buspirone had a lower discriminative stimulus effect compared to diazepam. These discrepancies may be due to variations in study design, participant characteristics, and dosage of the medication.

Consistency and Contradictions in Findings

The findings regarding buspirone's effectiveness in treating anxiety and its lower risk of cognitive impairment, dependence, and abuse compared to benzodiazepines are consistent across several studies. However, there are some contradictions in the findings regarding buspirone's specific effects and side effects. To address these inconsistencies, further research is needed.

Considerations for Real-World Application

While buspirone may be an effective treatment option for anxiety disorders, caution is advised when using it concurrently with CYP3A4 inducers like rifampicin. 13 Buspirone may also have potential interactions with other medications. It is crucial to consult with a healthcare professional and receive appropriate guidance regarding dosage and co-medications before starting buspirone treatment.

Limitations of Current Research

Research on buspirone is still insufficient. For example, research on the long-term safety and efficacy of buspirone is lacking. Additionally, more research is needed to determine which types of anxiety disorders buspirone is most effective for and the optimal dosage for maximum efficacy.

Future Research Directions

Future research should focus on investigating the long-term safety and efficacy of buspirone, identifying specific anxiety disorders for which it is most effective, determining the optimal dosage, and further studying its interactions with other medications.

Conclusion

Buspirone shows potential as a medication for treating anxiety disorders. It may be a safer alternative to benzodiazepines, with a lower risk of cognitive impairment, dependence, and abuse. However, it is important to be aware of potential interactions with medications like rifampicin. 13 Always consult with a healthcare professional for proper guidance on dosage and potential drug interactions before starting buspirone treatment.

Literature analysis of 13 papers
Positive Content
8
Neutral Content
2
Negative Content
3
Article Type
13
0
0
0
13
1.

The comparative efficacy of buspirone and diazepam in the treatment of anxiety.

Author: GoldbergH L, FinnertyR J

Antidepressant effects
Effective antianxiety agent

Buspirone is as effective as diazepam in treating anxiety neurosis and may have fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Comparative drug effects and abuse liability of lorazepam, buspirone, and secobarbital in nondependent subjects.

Author: SellersE M, SchneidermanJ F, RomachM K, KaplanH L, SomerG R

Drug abuse potential

Lorazepam and secobarbital were more liked and produced greater drug effects compared to buspirone and placebo. Buspirone 20 mg was significantly less liked than other drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Buspirone and diazepam: comparison of subjective, psychomotor and biological effects.

Author: BoulengerJ P, SquillaceK, SimonP, HerrouM, LeymarieP, ZarifianE

Less severe effects
No psychomotor impairment

Buspirone, an anxiolytic drug, produced less severe subjective effects than diazepam, another anxiolytic, and did not impair psychomotor functioning. Diazepam, on the other hand, caused sleepiness, impaired central sensory processing, and delayed memory.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Buspirone: an anxiolytic without sedative effect.

Author: SeidelW F, CohenS A, BliwiseN G, DementW C

No daytime impairment

Buspirone did not impair daytime wakefulness or performance in volunteers with chronic insomnia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

5.

Effects of buspirone and diazepam, alone and in combination with alcohol, on skilled performance and evoked potentials.

Author: ErwinC W, LinnoilaM, HartwellJ, ErwinA, GuthrieS

Sedative effect
Alcohol interaction
Performance impairment

Buspirone, compared to diazepam, had lesser effects on skilled performance and evoked responses. Buspirone's effects were primarily sedative and short-lasting, while diazepam also impaired tracking and body balance. Both anxiolytics showed slight additive interactions with alcohol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

The side effect profile of buspirone in comparison to active controls and placebo.

Author: NewtonR E, CastenG P, AlmsD R, BenesC O, MarunyczJ D

Less impairment in psychomotor function
Less sedative-hypnotic side effects
Dizziness
Headache
Nervousness

Buspirone (20 mg) was less sedative and less likely to cause lethargy or depression than diazepam (20 mg) or clorazepate (24 mg). Other side effects were similar to those of benzodiazepines, with nervousness, headache, and dizziness occurring more frequently with buspirone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

A double-blind comparison of buspirone and diazepam in outpatients with generalized anxiety disorder.

Author: FeighnerJ P, MeridethC H, HendricksonG A

Effective for anxiety and depression
Fewer side effects
Improved cognition

Buspirone (16.5 mg/day) was comparable to diazepam (15 mg/day) in relieving anxiety and depression symptoms. Buspirone showed greater improvement in impaired cognition and confusion compared to diazepam, with fewer and less severe side effects, such as sedation and drowsiness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Acute effects of buspirone and alcohol on psychomotor skills.

Author: MattilaM J, ArankoK, SeppalaT

Drowsiness
Fatigue

Buspirone (10 and 20 mg) did not impair objective performance but caused drowsiness and fatigue. Lorazepam (2.5 mg) impaired skills objectively, with less subjective impairment, and interacted with alcohol. Buspirone did not interact with alcohol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Psychological effects of buspirone.

Author: LaderM

Improved psychological performance
Less physical sedation

Buspirone, a non-benzodiazepine anxiolytic, showed similar mental sedation to diazepam but less physical sedation. It produced less impairment in psychological performance and had minimal physiologic effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Assessment of the abuse liability of buspirone in recreational sedative users.

Author: ColeJ O, OrzackM H, BeakeB, BirdM, Bar-TalY

Not reinforcing

Buspirone, a new antianxiety drug, was evaluated for abuse potential in recreational sedative users. Buspirone at 40 mg caused sedation and dysphoria, while methaqualone caused euphoria and sedation. Buspirone did not show significant abuse liability.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

Discriminative stimulus effects of diazepam and buspirone in normal volunteers.

Author: RushC R, CritchfieldT S, TroisiJ R, GriffithsR R

Clumsiness
Drowsiness
Nervousness

Diazepam and buspirone are discriminable at doses lower than previously shown to be behaviorally active, and diazepam is relatively more discriminable than buspirone at commonly used clinical doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

Behavioral response to buspirone in cocaine and phencyclidine withdrawal.

Author: GianniniA J, LoiselleR H, GrahamB H, FoltsD J

Cocaine Withdrawal
PCP Withdrawal

Buspirone is a drug that was found to be effective in treating cocaine and phencyclidine (PCP) withdrawal.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Concentrations and effects of buspirone are considerably reduced by rifampicin.

Author: LambergT S, KivistöK T, NeuvonenP J

Reduced anxiolytic effect

Rifampicin significantly reduces the plasma concentrations and effects of buspirone, a non-benzodiazepine anxiolytic, likely due to increased CYP3A4-mediated metabolism.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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