Paper Details
- Home
- Paper Details
Characterization of monochloramine toxicity on PC12 cells and protective effect of tocopherol via antioxidative function.
Author: ChenZhihua, NikiEtsuo, PigaRosaria, SaitoYoshiro, YoshidaYasukazu
Original Abstract of the Article :
Monochloramine (NH(2)Cl) is a physiological oxidant produced by activated neutrophils. In the present work, we studied the underlying mechanism of cytotoxic effects of NH(2)Cl on an undifferentiated rat pheochromocytoma PC12 cell line and the protective effects of antioxidants. The cells treated wit...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1016/j.abb.2005.01.021
データ提供：米国国立医学図書館（NLM）
Monochloramine Toxicity: A Study of PC12 Cells and the Protective Effect of Tocopherol
This study investigates the cytotoxic effects of monochloramine (NH2Cl), a physiological oxidant produced by activated neutrophils, on rat pheochromocytoma PC12 cells. The researchers explored the underlying mechanisms of NH2Cl cytotoxicity and investigated the protective effects of various antioxidants, including alpha-tocopherol (alpha-Toc) and beta-tocopherol (beta-Toc). The findings provide insights into the role of oxidative stress in NH2Cl-induced cell death and the potential of tocopherols as protective agents.
Oxidative Stress and Cell Death: The Role of Tocopherols
The study found that NH2Cl induced apoptosis in PC12 cells, characterized by phosphatidylserine exposure and caspase activation. The researchers observed a loss of cellular glutathione and an increase in reactive oxygen species (ROS) in response to NH2Cl treatment. They found that alpha-Toc and beta-Toc, both antioxidants, exerted a protective effect against NH2Cl-induced cell death. The findings suggest that oxidative stress plays a significant role in NH2Cl-induced cytotoxicity and that tocopherols can mitigate these effects.
A Camel's Perspective: The Desert of Oxidative Stress
Like a camel enduring the harsh desert environment, cells are constantly exposed to oxidative stress. This study sheds light on the damaging effects of monochloramine on PC12 cells and the potential of antioxidants like tocopherols to protect against cell death. Understanding the mechanisms of oxidative stress and the protective roles of antioxidants is crucial for promoting cell health and longevity.
Dr.Camel's Conclusion
This study provides valuable insights into the cytotoxic effects of monochloramine and the protective role of tocopherols. The findings highlight the importance of oxidative stress in cell death and the potential of antioxidants to mitigate these effects.
Date :
- Date Completed 2005-05-17
- Date Revised 2017-11-16
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.