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Divalproex in the treatment of bipolar depression: a placebo-controlled study.

Author: BartolucciAl, DavisLori L, PettyFrederick

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Treating the depressed phase of bipolar disorder is tricky because typical antidepressants can sometimes trigger manic episodes or make the illness worse. This study investigates the potential of mood stabilizers, such as divalproex (effective for manic episodes), to also treat depression in bipolar disorder.
Paper Details　
Original Abstract of the Article :
The treatment of bipolar disorder in the depressed phase is complicated by a tendency for conventional antidepressant drugs to worsen the course of the illness by precipitating a manic episode or increasing cycle frequency. Thus, the potential antidepressant efficacy of mood stabilizers, such as div...See full text at original site
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引用元：
https://doi.org/10.1016/j.jad.2004.09.009

データ提供：米国国立医学図書館（NLM）

Divalproex for Bipolar Depression: A Potential Treatment Option

The treatment of [bipolar disorder] in the depressed phase is a complex challenge, as conventional antidepressants can sometimes worsen the condition. This study explores the potential antidepressant efficacy of [divalproex], a mood stabilizer commonly used for the manic phase of bipolar disorder.

Divalproex: Potential Antidepressant Effects

The study, which involved a placebo-controlled trial, found that divalproex showed potential antidepressant effects in patients with bipolar depression. This finding suggests that divalproex could potentially be used as a treatment option for both the manic and depressive phases of bipolar disorder, offering a more comprehensive approach to managing this complex condition.

Implications for Bipolar Disorder Treatment

This research adds to the growing body of evidence suggesting that mood stabilizers like divalproex may have therapeutic potential for the depressive phase of bipolar disorder. Further research is needed to confirm these findings, explore optimal dosages, and investigate potential long-term effects. This research highlights the need for continued exploration of novel treatment strategies for bipolar disorder, particularly in the depressed phase.

Dr.Camel's Conclusion

Bipolar disorder is like a desert with fluctuating temperatures: one moment it's scorching hot, the next it's bitterly cold. This research explores the potential of divalproex as a treatment strategy, like finding a reliable oasis that can help regulate these extreme shifts. While more research is needed, the findings suggest that divalproex could offer a more consistent and comfortable journey for patients battling bipolar disorder.

Date :
  1. Date Completed 2005-09-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15780695

DOI: Digital Object Identifier

10.1016/j.jad.2004.09.009

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

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