[Valaciclovir-related neuro- and nephro-toxicity in two geriatric patients].

Author: CatalanoC, ConfortoL

Paper Details 
Original Abstract of the Article :
Valaciclovir (VAL) is the L-valyl ester of acyclovir and it is quickly hydrolysed to acyclovir. Acyclovir-related nephrotoxicity is associated with high drug infusion doses and VAL-related neurotoxicity to pre-existing renal failure. We observed two geriatric patients with normal serum creatinine wh...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/15786387

データ提供:米国国立医学図書館(NLM)

Valaciclovir: A Potential Risk for Neuro- and Nephro-Toxicity in Geriatric Patients

The field of geriatric medicine faces unique challenges in managing medication use in older adults, who often experience age-related physiological changes that can influence drug metabolism and response. This study investigates the potential risks of valaciclovir, an antiviral medication used to treat herpes infections, in two geriatric patients with normal serum creatinine levels. The researchers examine the development of neurotoxicity and acute renal failure (ARF) after conventional dosing of valaciclovir.

Valaciclovir: A Cautionary Tale of Potential Adverse Effects

The study reveals that valaciclovir can pose a significant risk for neurotoxicity and ARF in some geriatric patients, even with conventional dosing. The researchers highlight the need for cautious monitoring and careful consideration of potential adverse events, particularly in older adults with pre-existing renal impairment or other underlying medical conditions.

Safeguarding Geriatric Patients: A Call for Vigilance in Medication Management

This study underscores the importance of vigilance in medication management for geriatric patients. It emphasizes the need for a thorough assessment of individual risk factors and a proactive approach to monitoring for potential adverse events. The findings highlight the importance of individualized treatment plans and close collaboration between patients, caregivers, and healthcare professionals.

Dr.Camel's Conclusion

This research on valaciclovir-related neuro- and nephro-toxicity in geriatric patients serves as a reminder of the complexities of medication management in this population. It is like navigating a treacherous sandstorm in the desert of geriatric medicine, where even seemingly safe medications can pose unexpected risks. This study emphasizes the importance of individualizing treatment plans and carefully monitoring for potential adverse events to ensure the well-being of our aging population.

Date :
  1. Date Completed 2005-06-10
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

15786387

DOI: Digital Object Identifier

15786387

Related Literature

SNS
PICO Info
in preparation
Languages

Italian

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