Evaluation of a novel vaginal bromocriptine mesylate formulation: a pilot study.

Author: DarwishAtef M, El-GebaliIbraheem, HafezEhsan, HassanSaher B

Paper Details 
Original Abstract of the Article :
Because of the frequent side effects found with oral bromocriptine, we created two formulas of vaginal bromocriptine suppositories to compare with vaginal application of bromocriptine tablets. The formula containing bromocriptine and a releasing agent (Pluronic F127) showed an increased dissolution ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.fertnstert.2004.09.024

データ提供:米国国立医学図書館(NLM)

A Novel Vaginal Formulation of Bromocriptine Mesylate

Navigating the vast landscape of hormone-related health challenges is often like traversing a treacherous desert. In this pilot study, researchers embarked on a quest to explore a novel vaginal formulation of bromocriptine mesylate, a medication used to treat hyperprolactinemia. They aimed to evaluate the effectiveness and safety of two vaginal formulations of bromocriptine compared to the traditional vaginal tablet approach. The study revealed that a formula containing bromocriptine and a release agent (Pluronic F127) exhibited a significantly enhanced dissolution rate, leading to an effective reduction in serum prolactin levels. This discovery holds promise for improving the treatment of hyperprolactinemia.

Exploring New Avenues for Bromocriptine Delivery

This study presents a novel approach to the delivery of bromocriptine, a medication commonly used to regulate prolactin levels. The researchers found that a specially formulated vaginal suppository containing bromocriptine and a releasing agent (Pluronic F127) significantly increased the dissolution rate of the drug, leading to a more effective lowering of serum prolactin levels. This suggests that this new formulation may offer a more efficient and potentially less invasive treatment option for hyperprolactinemia.

Potential Benefits and Considerations for Vaginal Bromocriptine

The development of this novel vaginal formulation holds potential benefits for patients with hyperprolactinemia, offering a more effective and potentially less invasive treatment option. However, as with any new medication or delivery method, further research is crucial to ensure safety and efficacy. It's important to consult with a healthcare professional to determine the most suitable treatment option for your specific needs.

Dr.Camel's Conclusion

The researchers in this study have embarked on a journey through the desert of hormonal imbalances, seeking a more efficient and effective way to deliver bromocriptine. Their innovative formulation demonstrates the potential for a more tailored treatment approach for hyperprolactinemia. Remember, my friends, a journey of a thousand miles begins with a single step, and this research offers a promising step forward in the treatment of this condition.

Date :
  1. Date Completed 2005-06-07
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15820828

DOI: Digital Object Identifier

10.1016/j.fertnstert.2004.09.024

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.