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Pharmacodynamic effects of 3-day intravenous treatment with pantoprazole or ranitidine after 10 days of oral ranitidine.

Author: BeckerA, LeyL M, LückerP W, LühmannR, SanderP

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tachyphylaxis, or drug tolerance, can occur with histamine-2-receptor antagonists (H2RAs). The study investigated whether intravenous (i.v.) pantoprazole or i.v. ranitidine could overcome oral ranitidine tachyphylaxis. Intravenous pantoprazole was significantly more effective than intravenous ranitidine in increasing gastric pH after oral ranitidine tachyphylaxis.
Paper Details　
Original Abstract of the Article :
Tachyphylaxis (drug tolerance) is an undesirable condition in drug therapy with histamine-2-receptor antagonists (H2RAs). The concept of overcoming tachyphylaxsis via intravenous (i.v.) administration of proton-pump inhibitors (PPIs) or H2RAs is of significant interest to physicians. In the present ...See full text at original site
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引用元：
https://doi.org/10.1358/mf.2005.27.1.875433

データ提供：米国国立医学図書館（NLM）

Overcoming Tachyphylaxis: A Quest for Effective Gastric Acid Control

Tachyphylaxis, a phenomenon where a drug's effectiveness decreases over time, is a common challenge in the treatment of gastrointestinal disorders. Imagine a desert traveler relying on a dwindling water supply – tachyphylaxis mirrors this situation, where the drug's effect gradually diminishes. Researchers are constantly seeking ways to overcome this obstacle and ensure sustained therapeutic benefit.

This study investigated the effectiveness of intravenous pantoprazole and ranitidine in overcoming tachyphylaxis to oral ranitidine, a drug commonly used to reduce stomach acid. The study found that intravenous administration of both drugs significantly increased gastric pH, suggesting a potential strategy for overcoming tachyphylaxis. However, intravenous pantoprazole proved to be significantly more effective than ranitidine, offering a longer-lasting and more potent solution.

Pantoprazole: A Potential Solution for Tachyphylaxis

This study suggests that intravenous pantoprazole may be a valuable tool for overcoming tachyphylaxis to oral ranitidine. It offers a promising strategy for maintaining sustained gastric acid control, similar to a camel's ability to store water in its hump for prolonged desert journeys.

Understanding Tachyphylaxis: A Key to Personalized Medicine

Tachyphylaxis is a complex phenomenon that can significantly impact the effectiveness of drug therapies. Understanding its underlying mechanisms and developing strategies to overcome it is crucial for personalized medicine. Just as a camel adapts its behavior and physiology to survive in the desert, patients may require tailored treatment approaches to overcome tachyphylaxis and achieve optimal therapeutic outcomes.

Dr.Camel's Conclusion

This study highlights the potential of intravenous pantoprazole in overcoming tachyphylaxis to oral ranitidine. It offers a valuable tool for clinicians to ensure sustained gastric acid control, just as a camel's adaptations allow it to thrive in the harsh desert environment.

Date :
  1. Date Completed 2005-06-21
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

15834456

DOI: Digital Object Identifier

10.1358/mf.2005.27.1.875433

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Languages

English

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