Effects of pantoprazole injection: A Synthesis of Findings from 21 Studies

  1. Home
  2. Effects of pantoprazole injection
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of pantoprazole injection: A Synthesis of Findings from 21 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of pantoprazole injection: A Synthesis of Findings from 21 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Pantoprazole injection has been shown to be effective in controlling gastric acid hypersecretion in patients with Zollinger-Ellison syndrome ( 16 ). Pantoprazole injection has also been studied in comparison with other proton pump inhibitors. One study found that pantoprazole was more effective than rabeprazole ( 2 ) in controlling gastric acid secretion in patients with GERD and nocturnal heartburn. Another study found that pantoprazole was less effective than esomeprazole ( 13 ) in controlling gastric acid secretion in healthy volunteers. In addition, pantoprazole has been found to be effective in preventing bleeding after endoscopic submucosal dissection ( 10 ). However, pantoprazole has also been found to interact with other drugs, such as clopidogrel ( 3 ) and methotrexate ( 15 ).

Benefits and Risks

Benefits Summary

Pantoprazole injection has been shown to be effective in controlling gastric acid hypersecretion in patients with Zollinger-Ellison syndrome ( 16 ). Pantoprazole injection has also been studied in comparison with other proton pump inhibitors. One study found that pantoprazole was more effective than rabeprazole ( 2 ) in controlling gastric acid secretion in patients with GERD and nocturnal heartburn. Another study found that pantoprazole was less effective than esomeprazole ( 13 ) in controlling gastric acid secretion in healthy volunteers. In addition, pantoprazole has been found to be effective in preventing bleeding after endoscopic submucosal dissection ( 10 ).

Risks Summary

Pantoprazole injection has also been found to interact with other drugs, such as clopidogrel ( 3 ) and methotrexate ( 15 ).

Comparison Across Studies

Similarities Among Studies

All of these studies have found that pantoprazole can effectively control gastric acid secretion, making it a valuable tool in managing a variety of conditions. The studies also suggest that pantoprazole is generally well-tolerated.

Differences Across Studies

While the studies demonstrate pantoprazole's effectiveness, they also highlight the need for further research. There are inconsistencies in the findings, particularly regarding the relative effectiveness of pantoprazole compared to other PPIs. The studies vary in their designs, dosages, and patient populations, making direct comparisons difficult.

Consistency and Contradictions in Results

Overall, the evidence supports the effectiveness of pantoprazole in reducing gastric acid secretion. However, the research highlights the need for careful consideration of the potential for drug interactions and for further investigation into the long-term effects and optimal dosage of pantoprazole in various patient groups and clinical scenarios.

Implications for Real-World Application

In clinical practice, pantoprazole injection may be considered for patients with Zollinger-Ellison syndrome and other conditions requiring high doses of proton pump inhibitors, especially when oral administration is not feasible. However, clinicians should exercise caution regarding potential drug interactions. It is essential to thoroughly evaluate the patient's medical history and medications to minimize the risk of adverse interactions.

Limitations of Current Research

The available research on pantoprazole injection is limited. Many studies focus on specific conditions or patient groups, with few directly comparing pantoprazole to other PPIs under similar conditions. Most studies have relatively small sample sizes.

Future Research Directions

Further research is needed to clarify the long-term effects and optimal dosage of pantoprazole in various patient groups and clinical scenarios. Additional research is required to identify the optimal dosages for different conditions and to investigate potential drug interactions in detail.

Conclusion

Pantoprazole injection is an effective medication for controlling gastric acid secretion, particularly in patients with Zollinger-Ellison syndrome and other conditions requiring high doses of proton pump inhibitors. However, clinicians must remain mindful of potential drug interactions, carefully considering the patient's medical history and medications. Additional research is needed to clarify the long-term effects, optimal dosages, and potential drug interactions associated with pantoprazole injection.

Literature analysis of 21 papers
Positive Content
17
Neutral Content
2
Negative Content
2
Article Type
9
0
1
4
21
1.

Effects of oral pantoprazole on 24-hour intragastric acidity and plasma gastrin profiles.

Author: HannanA, WeilJ, BroomC, WaltR P

Gastric acidity reduction
Gastrin elevation

Pantoprazole, a proton pump inhibitor, effectively reduces intragastric acidity in a dose-dependent manner. In a study involving 11 men, pantoprazole doses of 40 and 60 mg daily significantly increased median 24-hour gastric pH compared to placebo, with a higher effect observed with the higher dose.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Pharmacodynamic effects of single doses of rabeprazole 20 mg and pantoprazole 40 mg in patients with GERD and nocturnal heartburn.

Author: WarringtonS, BaisleyK, LeeD, LomaxK, DelemosB, BoyceM, MorocuttiA

Increased pH

This open-label, randomized, two-way crossover, clinical pharmacology study compared the antisecretory effects of single doses of rabeprazole and pantoprazole in patients with GERD and a history of nocturnal heartburn. The study found that a single oral dose of rabeprazole 20 mg increased intragastric pH more than pantoprazole 40 mg did throughout the 24 h after dosing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Pharmacodynamic evaluation of pantoprazole therapy on clopidogrel effects: results of a prospective, randomized, crossover study.

Author: FerreiroJosé Luis, UenoMasafumi, TomaselloSalvatore D, CapodannoDavide, DesaiBhaloo, DharmashankarKodlipet, SeecheranNaveen, KodaliMurali K, DarlingtonAndrew, PhamJohn-Paul, Tello-MontoliuAntonio, CharltonRonald K, BassTheodore A, AngiolilloDominick J

Assess impact of pantoprazole therapy

This study assessed the impact of high-dose pantoprazole therapy, a proton pump inhibitor, on clopidogrel-mediated pharmacodynamic effects. The study aimed to determine whether the drug interaction between clopidogrel and proton pump inhibitors is a class effect or a drug effect and if timing of drug administration affects the interaction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Intragastric pH effect of 20mg of levo-pantoprazole versus 40mg of racemic pantoprazole the first seven days of treatment in patients with gastroesophageal reflux disease.

Author: Remes-TrocheJ M, García GarcíaF D, Rojas-LoureiroG, Rivera-GutiérrezX, Reyes-HuertaJ, Amieva-BalmoriM

Gastric pH reduction

Levo-pantoprazole, the S-enantiomer of pantoprazole, is a proton pump inhibitor that has shown to be faster and stronger in animal studies than its racemic formulation. This study aims to evaluate the effects of levo-pantoprazole versus racemic pantoprazole on intragastric pH in humans.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Effect of pantoprazole on 24-h intragastric pH and serum gastrin in humans.

Author: LondongW

Gastric acid inhibition
Hypergastrinemia

Pantoprazole is a proton pump inhibitor that is effective in reducing gastric acid secretion. This review found that oral pantoprazole at 40 mg/day is the optimal dose for the treatment of acid-related diseases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Intravenous esomeprazole: a pharmacoeconomic profile of its use in the prevention of recurrent peptic ulcer bleeding.

Author: KeatingGillian M

Prevents peptic ulcer rebleeding
Infusion-site reactions

Intravenous esomeprazole is approved in Europe for the prevention of rebleeding following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers. A pivotal clinical trial found that intravenous esomeprazole significantly reduced the risk of recurrent bleeding. The drug was generally well tolerated. Pharmacoeconomic analyses support the use of intravenous esomeprazole following endoscopic haemostatic therapy in patients with peptic ulcer bleeding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Effects on 24-hour intragastric pH: a comparison of lansoprazole administered nasogastrically in apple juice and pantoprazole administered intravenously.

Author: FrestonJ, ChiuY L, PanW J, LukasikN, TäubelJ

Control intragastric pH

Lansoprazole, 30 mg administered nasogastrically, was found to be more effective at controlling intragastric pH than pantoprazole, 40 mg administered intravenously. Lansoprazole produced significantly higher mean 24-h intragastric pH values than pantoprazole on both day 1 and day 5 of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

The impact of proton-pump inhibitors on intraperitoneal sepsis: a word of caution for transgastric NOTES procedures.

Author: RamamoorthySonia L, LeeJeffrey K, MintzYoav, CullenJohn, SavuMichelle K, EasterDavid W, ChockAlana, MittalRavi, HorganSantiago, TalaminiMark A

Infection

This study investigated the effects of proton-pump inhibitors (PPIs) on infection during transgastric natural orifice transluminal endoscopic surgery (NOTES). The study found that PPIs and alterations of gastric pH may have an effect on infection risk during transgastric surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

High Dose Proton Pump Inhibitor Infusion Versus Bolus Injection for the Prevention of Bleeding After Endoscopic Submucosal Dissection: Prospective Randomized Controlled Study.

Author: ChoiCheol Woong, KangDae Hwan, KimHyung Wook, HongJoung Boom, ParkSu Bum, KimSu Jin, ChoMong

No difference in PPI methods

The continuous infusion of proton pump inhibitors (PPIs) did not improve the outcomes of high-risk ulcer stigma (HRS) or delayed bleeding after endoscopic submucosal dissection (ESD) compared to bolus injection. HRS occurred in 15.8% of patients, and a flat or depressed morphology was associated with HRS. Delayed bleeding occurred in 8.4% of patients, and a flat morphology and submucosal invasive cancer were associated with delayed bleeding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Effects of multiple-dose esomeprazole and pantoprazole on diazepam pharmacokinetic profile and pharmacodynamic effects on cognitive and psychomotor function in healthy volunteers.

Author: DrewelowBernd, SchafflerKlaus, ReitmeirPeter, BethkeThomas D

Pharmacodynamic interaction

This study investigated the influence of esomeprazole and pantoprazole on the pharmacokinetics and pharmacodynamics of diazepam. Esomeprazole increased the AUC, Cmax, and t1/2 of diazepam compared to pantoprazole. Myogenic parameters were impaired with esomeprazole after diazepam administration. Pantoprazole may provide a higher safety profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Pharmacodynamic effects of 3-day intravenous treatment with pantoprazole or ranitidine after 10 days of oral ranitidine.

Author: LeyL M, BeckerA, LühmannR, SanderP, LückerP W

Increased gastric pH
Tachyphylaxis

Tachyphylaxis, or drug tolerance, can occur with histamine-2-receptor antagonists (H2RAs). The study investigated whether intravenous (i.v.) pantoprazole or i.v. ranitidine could overcome oral ranitidine tachyphylaxis. Intravenous pantoprazole was significantly more effective than intravenous ranitidine in increasing gastric pH after oral ranitidine tachyphylaxis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Intravenous esomeprazole.

Author: KeatingGillian M, FiggittDavid P

Effective gastric acid control
Improved healing rates
Well tolerated

This study evaluated the efficacy and tolerability of intravenous esomeprazole in patients unable to take oral medication. Intravenous esomeprazole provided faster and more effective gastric acid control compared to intravenous pantoprazole and omeprazole, and was well tolerated in patients with erosive oesophagitis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Effect of long-term acid gastric inhibition on bacterial translocation in cirrhotic rats.

Author: SánchezElisabet, SorianoGermán, MirelisBeatriz, GonzalezBegoña, NietoJuan C, VidalSilvia, Guarner-ArgenteCarlos, JuárezCándido, MonésJoan, GuarnerCarlos

Bacterial infections
Bacterial translocation

This study evaluated the effect of long-term inhibition of acid gastric secretion on bacterial translocation (BT) in cirrhotic rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Suspicion of drug-drug interaction between high-dose methotrexate and proton pump inhibitors: a case report - should the practice be changed?

Author: RanchonF, VantardN, GouraudA, SchwiertzV, FranchonE, PhamB N, VialT, YouB, BouafiaF, SallesG, RioufolC

Lymphoma treatment
Renal failure

A drug-drug interaction between methotrexate and proton pump inhibitors (PPI) may be responsible for methotrexate overdose and subsequent renal failure.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Replacement of oral proton pump inhibitors with intravenous pantoprazole to effectively control gastric acid hypersecretion in patients with Zollinger-Ellison syndrome.

Author: MetzD C, ForsmarkC, LewE A, StarrJ A, SofferE F, BochenekW, PisegnaJ R

Acute gastric acid control
Tachyphylaxis

Pantoprazole is a proton pump inhibitor used to manage gastric acid hypersecretion. This study evaluated the safety and efficacy of intravenous pantoprazole as an alternative to oral proton pump inhibitors for controlling gastric acid hypersecretion in patients with Zollinger-Ellison syndrome (ZES).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

19.

Optimizing the intragastric pH as a supportive therapy in upper GI bleeding.

Author: BrunnerG, LunaP, HartmannM, WurstW

Improved clinical outcome

Proton pump inhibitors, such as pantoprazole and omeprazole, can temporarily achieve achlorhydria in the stomach when given intravenously in large doses. This can significantly improve the clinical outcome of upper GI bleeding by optimizing the different steps of hemostasis in the stomach.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Lansoprazole regimens that sustain intragastric pH > 6.0: an evaluation of intermittent oral and continuous intravenous infusion dosages.

Author: MetzD C, AmerF, HuntB, VakilyM, KukulkaM J, SamraN

Sustaining intragastric pH
Intravenous injection site reaction

The intravenous bolus and continuously infused lansoprazole or intravenous bolus and intermittent lansoprazole orally disintegrating tablet regimens are as effective as intravenous pantoprazole in sustaining intragastric pH >6.0.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.