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Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors.

Author: BursteinRami, JakubowskiMoshe, LevyDan

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Sumatriptan is a medication used to treat migraine headaches. Some patients report that their headache initially intensifies for 10-15 minutes after taking sumatriptan before they start to notice pain relief. A study found that 55% of patients reported this transient pain exacerbation. This may be due to sumatriptan altering the response properties of meningeal nociceptors, which are nerve cells that detect pain in the meninges, the membranes that surround the brain and spinal cord.
Paper Details　
Original Abstract of the Article :
Consistent with previous accounts, some of the patients visiting our pain clinic during the course of a migraine attack have indicated-without solicitation-that sumatriptan injection initially intensified their headache before they were able to appreciate any pain relief. In this study, those patien...See full text at original site
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引用元：
https://doi.org/10.1016/j.pain.2005.01.027

データ提供：米国国立医学図書館（NLM）

Triptans and Migraines: A Complex Interaction

Triptans, a class of medications used to treat migraine headaches, are often effective but can sometimes cause a transient worsening of pain before providing relief. This study investigates this phenomenon, exploring the potential mechanisms underlying this temporary exacerbation of pain. The study examines patient reports of pain intensification after triptan administration and investigates the effects of sumatriptan on meningeal nociceptors, nerve cells involved in pain sensation.

Understanding the Transient Exacerbation of Migraine Pain

This research provides valuable insights into the complex mechanisms underlying migraine pain and the effects of triptans on pain pathways. The study sheds light on the potential cause of transient pain intensification, suggesting that triptans may initially activate meningeal nociceptors before ultimately reducing pain. This understanding can help patients and healthcare providers better manage migraine symptoms and expectations.

Navigating the Desert of Migraine Pain

Imagine a long and arduous journey across a desert of intense migraine pain. Triptans, like oases, can provide temporary relief, but sometimes they can initially intensify the pain, making the journey even more challenging. This study explores the complex interplay between triptans and migraine pain, helping us understand the nuances of navigating this challenging landscape.

Dr.Camel's Conclusion

This research explores the complex relationship between triptans and migraine headaches, shedding light on the phenomenon of transient pain exacerbation before pain relief. The study provides insights into the potential mechanisms involved and emphasizes the importance of understanding this phenomenon for effective migraine management. It highlights the need for further research to optimize treatment strategies and improve patient outcomes.
Date :
  1. Date Completed 2005-06-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15836966

DOI: Digital Object Identifier

10.1016/j.pain.2005.01.027

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Languages

English

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