Effects of eletriptan: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Main Research Findings

Eletriptan is a type of medication called a triptan, which is used to treat migraines. 24 reports that triptans, including eletriptan, are generally considered safe. 6 presents a systematic review investigating the effectiveness and tolerability of triptans, such as eletriptan, in treating migraines. However, 14 suggests that the use of triptans might be associated with a temporary worsening of headaches. This study indicates that triptans, like eletriptan, could potentially activate nerve cells that transmit pain signals in the brain, leading to a brief increase in headache intensity. 20 presents a case report highlighting that some patients experience a temporary intensification of headache, such as tingling or numbness, after receiving eletriptan. 25 indicates that eletriptan has a quicker absorption rate compared to other triptans, leading to faster headache relief. 9 includes a comparative study of different triptans, demonstrating that eletriptan provides faster headache relief and is well-tolerated in comparison to other triptans. 21 compares the effectiveness of eletriptan and zolmitriptan, showing that eletriptan is superior in reducing headache intensity. Additionally, provides a review of eletriptan's pharmacological action and clinical use, concluding that it is an effective and safe treatment option. 18 compares the effectiveness of eletriptan in patients who have never used triptans before with those who have, showing that it is effective even for patients new to triptan medications. Based on these research findings, eletriptan appears to be an effective medication for treating migraines. However, it's crucial to acknowledge that some individuals might experience a temporary worsening of headache, and there's a potential for interactions with other medications.

Benefits and Risks

Benefit Summary

Eletriptan has shown promise as an effective treatment for migraines. 24 , 6 , 25 , 9 , 21 , , 18 These studies demonstrate that eletriptan effectively alleviates headaches, particularly in the initial stages. Additionally, it appears to offer advantages over other triptans by reducing headache recurrence and exhibiting greater tolerability. 25 , 9 , 21 These observations position eletriptan as a valuable option for migraine treatment.

Risk Summary

Using eletriptan carries certain potential risks that should be considered. 14 , 20 One notable risk is a possible intensification of headaches after taking eletriptan. 14 This worsening of headache is generally temporary and often followed by improvement. 20 Additionally, eletriptan can interact with other medications, making it crucial to consult a physician if you're taking any other drugs. 17 Specific caution is needed when taking monoamine oxidase inhibitors. 17 Furthermore, individuals with heart or blood vessel conditions might not be suitable candidates for eletriptan. 24 It's essential to be aware of these risks when considering eletriptan treatment.

Comparison Between Studies

Commonalities

Numerous studies highlight the effectiveness of eletriptan in treating migraines. 24 , 6 , 25 , 9 , 21 , , 18 Moreover, eletriptan is generally perceived as a safe medication. 24 However, it's recognized that there's a possibility of headache worsening and interactions with other drugs. 14 , 20 , 17 These aspects should be considered as precautions when using eletriptan.

Differences

Research studies on the effectiveness and safety of eletriptan might show variations in results due to differences in research design, evaluation methods, and other factors. 6 For example, 14 suggests that eletriptan might temporarily worsen headaches, while concludes that it's a safe and effective medication. These discrepancies could be attributed to variations in participant characteristics, research design, or other factors. Further investigation is needed to fully understand eletriptan's mechanism of action, effectiveness, and safety.

Consistency and Contradictions in Findings

The research findings regarding the effectiveness and safety of eletriptan exhibit a mix of consistency and contradictions. 24 , 6 , 14 , 20 , 25 , 9 , 21 , , 18 , 17 Some studies demonstrate the effectiveness of eletriptan in treating migraines, while others indicate a potential for headache worsening. 14 , 20 While eletriptan is generally considered safe, it may not be suitable for individuals with heart or blood vessel conditions. 24 These contradictions could be due to differences in research designs, evaluation methods, or the intricate nature of the drug's mechanism of action. Further research is needed to provide a clearer understanding of eletriptan's mechanism of action, effectiveness, and safety profile.

Practical Considerations and Precautions

While eletriptan holds potential as an effective migraine treatment, its use requires careful consideration. 14 , 20 , 17 , 24 There's a risk of headache worsening and interactions with other medications. 14 , 20 , 17 It's also important to note that it may not be suitable for patients with heart or blood vessel conditions. 24 Before taking eletriptan, it's crucial to consult a doctor and receive guidance on appropriate usage based on your individual circumstances.

Limitations of Current Research

The research on eletriptan remains incomplete. 6 In particular, further research is needed to fully assess the long-term effectiveness and safety of eletriptan. 24 Additionally, there's a need for more comparative studies evaluating the effectiveness of eletriptan against other medications. 6 Additional research can provide valuable insights into eletriptan's effectiveness, safety, and comparisons with other treatment options.

Future Research Directions

Future research on eletriptan should focus on addressing several key aspects. 6 , 24 Studies evaluating the long-term effectiveness and safety of eletriptan are essential. 24 Comparative research comparing the effectiveness of eletriptan with other medications is also necessary. 6 Furthermore, understanding the mechanism of action of eletriptan and developing more effective and safe methods of administration are crucial. These research endeavors can significantly contribute to a better understanding of eletriptan's clinical value.

Conclusion

Eletriptan has the potential to be an effective treatment for migraines. 24 , 6 , 25 , 9 , 21 , , 18 However, there are potential risks such as headache worsening and interactions with other medications. 14 , 20 , 17 It's important to consult a doctor before using eletriptan to receive personalized guidance on its appropriate use.

Literature analysis of 25 papers
Positive Content
23
Neutral Content
0
Negative Content
2
Article Type
3
1
2
11
25
1.

Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect.

Author: EdvinssonLars, UddmanErik, WackenforsAngelica, DavenportAnthony, LongmoreJenny, MalmsjöMalin

Cerebral vasoconstriction

Triptans, a class of drugs used to treat migraines, are potent vasoconstrictors, particularly in cerebral arteries. The study found that the vasoconstrictor potency of sumatriptan, rizatriptan, and eletriptan was directly related to their clinically relevant plasma levels in cerebral arteries. However, this relationship was not observed in coronary arteries.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Myocardial infarction after taking eletriptan.

Author: DiasAndre, FrancoEmiliana, HebertKathy, MercedesAna

Myocardial infarction risk

This case report describes a patient who experienced a non-ST-elevation myocardial infarction after taking eletriptan for a migraine. Although rare, this case suggests a possible link between eletriptan and myocardial infarction, especially in individuals with pre-existing heart conditions.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Tolerability and safety of eletriptan in the treatment of migraine: a comprehensive review.

Author: MathewNinan T, HettiarachchiJayasena, AldermanJeffrey

Migraine treatment
Cardiovascular risk

Eletriptan, a potent and selective 5-HT1B/1D agonist, was found to be safe and well-tolerated in doses of 20 mg to 80 mg in clinical trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Treatment-emergent CNS symptoms following triptan therapy are part of the attack.

Author: GoadsbyP J, DodickD W, AlmasM, DienerH-C, Tfelt-HansenP, LiptonR B, ParsonsB

Migraine treatment
Asthenia
Somnolence

Treatment-emergent central nervous system (CNS) symptoms following triptan therapy may represent the unmasking of CNS symptoms associated with the natural resolution of a migraine attack, rather than simply representing drug-related side-effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Eletriptan: pharmacological differences and clinical results.

Author: GiffinN

Faster Onset
Migraine Treatment
Reduced Cardiovascular Risk
Headache Recurrence

Eletriptan is a drug used to treat migraine headaches. It is faster acting than sumatriptan, but it has not been compared to other triptans. It is not known if it is more effective than sumatriptan for preventing headaches from returning.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Marketed oral triptans in the acute treatment of migraine: a systematic review on efficacy and tolerability.

Author: PascualJulio, MateosValentin, RoigCarles, Sanchez-Del-RioMargarita, JiménezDolores

Migraine relief
Pain reduction
Adverse events

All marketed oral triptans were significantly more effective than placebo in providing relief from moderate-to-severe migraine attacks. Fast-dissolving sumatriptan formulations showed faster onset of action, with sumatriptan 100 mg being the only triptan to achieve pain-free status within 30 minutes. Some triptans, such as sumatriptan and zolmitriptan, were associated with more frequent adverse events compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Acute management of migraine.

Author: ChowdhuryDebashish

Migraine treatment
Overuse headache

This article reviews the current treatment options for migraine headaches, including acute treatment with triptans, which are generally well-tolerated and effective in aborting attacks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Comparative aspects of triptans in treating migraine.

Author: AdelmanJ U, LewitE J

Migraine treatment
Adverse effects

Triptans, beginning with sumatriptan, have revolutionized the treatment of migraine. New triptans in several formulations will soon become available in the United States. Subcutaneous sumatriptan has the most rapid onset of action and greatest efficacy but the most adverse effects. Intranasal sumatriptan also has rapid onset of action, but at 2 hours its efficacy is comparable to that of oral zolmitriptan. Of the oral triptans, rizatriptan seems to have the greatest early efficacy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Pharmacological approaches to migraine.

Author: DienerH Ch

Treats migraine

This review summarizes new treatment options for both acute migraine attacks and migraine prophylaxis. Triptans are highly effective in treating migraine attacks. For migraine prophylaxis, beta-blockers, calcium channel blockers, and antiepileptic drugs are effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Drug dependence associated with triptans and ergot derivatives: a case/non-case study.

Author: Beau-SalinasFrédérique, Jonville-BéraAnnie Pierre, CissokoHaware, Bensouda-GrimaldiLamiae, Autret-LecaElisabeth

Drug dependence

Triptans and ergot derivatives are associated with an increased risk of drug dependence, similar to benzodiazepines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Eletriptan: a review and new perspectives.

Author: SandriniGiorgio, PerrottaArmando, NappiGiuseppe

Migraine treatment

Eletriptan is a triptan effective for acute migraine treatment. It has high bioavailability, a long half-life, and is selective for cranial arteries. Eletriptan is effective and well-tolerated in over 11,000 patients and is one of the most cost-effective migraine treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors.

Author: BursteinRami, JakubowskiMoshe, LevyDan

Migraine pain relief
Transient pain exacerbation

Sumatriptan is a medication used to treat migraine headaches. Some patients report that their headache initially intensifies for 10-15 minutes after taking sumatriptan before they start to notice pain relief. A study found that 55% of patients reported this transient pain exacerbation. This may be due to sumatriptan altering the response properties of meningeal nociceptors, which are nerve cells that detect pain in the meninges, the membranes that surround the brain and spinal cord.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

15.

The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat.

Author: HoskinKaren Lisa, LambertGeoffrey Andrew, DonaldsonCathy, ZagamiAlessandro Stefano

Migraine Treatment
Nausea Relief

Eletriptan and naratriptan may alleviate migraine-related nausea and vomiting by inhibiting cells in the nucleus tractus solitarius (NTS) through activation of 5-HT(1B/1D) receptors.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

WITHDRAWN: Eletriptan for acute migraine.

Author: SmithL A, OldmanA D, McQuayH J, MooreR A

Improved acute migraine treatment
Acute migraine

Eletriptan (Relpax), a new type of migraine medication, will soon be available by prescription. There are currently five other similar medications available, and more are under development. With so many migraine treatments, evidence-based assessments are needed to compare their effectiveness and potential risks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Pharmacokinetics and interactions of headache medications, part I: introduction, pharmacokinetics, metabolism and acute treatments.

Author: SternieriEmilio, CocciaCiro Pio Rosario, PinettiDiego, FerrariAnna

Effective headache treatment
Drug interactions

This review discusses pharmacokinetic drug-drug interactions of headache medications, focusing on acute treatments, aiming to raise awareness among physicians about potential interactions and their clinical significance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Efficacy of eletriptan in triptan-naïve patients: results of a combined analysis.

Author: MartinVincent T, ValadeDominique, AlmasMary, HettiarachchiJayasena, SikesCarolyn, AlbertKenneth S, ParsonsBruce

Headache response
Pain-free response

This study compared the efficacy and tolerability of eletriptan 20 mg, 40 mg, and 80 mg in triptan-naïve patients versus triptan-experienced patients. The study found that eletriptan has comparable efficacy versus placebo among both triptan-naïve and triptan-experienced patients.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

[Pharmacological, pharmacokinetic and clinical profile of eletriptan (Relpax), a new triptan for migraine].

Author: OmoteMasayuki

Treats migraine
Mild-to-moderate side effects

Eletriptan is a triptan medication for the treatment of migraine headaches. It works by constricting cranial blood vessels and blocking the release of pain-signaling chemicals. Eletriptan has a fast onset of action and is effective in treating migraine headaches and associated symptoms such as nausea and vomiting. It is generally well tolerated.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Japanese

20.

Triptans: actions and reactions.

Author: NahasStephanie J, SilbersteinStephen D

Headache relief
Paresthesias
Tingling
Transient headache worsening

This case study investigates a patient who experienced transient worsening of headache after subcutaneous sumatriptan administration. The case provides insight into the mechanism of action and potential side effects of sumatriptan.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Comparative efficacy of eletriptan and zolmitriptan in the acute treatment of migraine.

Author: SteinerT J, DienerH C, MacGregorE A, SchoenenJ, MuirheadsN, SikesC R

Migraine treatment

This study compared the effectiveness of eletriptan (80mg and 40mg) and zolmitriptan in treating acute migraine attacks. Eletriptan was more effective in relieving headache pain and reducing the need for rescue medication.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Hemodynamic and coronary effects of intravenous eletriptan, a 5HT1B/1D-receptor agonist.

Author: MuirD F, McCannG P, SwanL, ClarkA L, HillisW S

No coronary constriction
Increased pulmonary pressure
Increased vascular resistance

This study found that eletriptan, a 5HT1B/1D-agonist, caused no significant coronary artery constriction in patients without significant obstructive coronary artery disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Safety profile of the triptans.

Author: TepperStewart J, MillsonDavid

Cluster headache treatment
Migraine treatment
Cardiovascular events

Triptans are a class of drugs used to treat migraines and cluster headaches. They work by stimulating 5-HT(1B/1D) receptors, which are found in blood vessels in the brain. Seven triptans are available worldwide. The most common side effects are cardiovascular, but the overall safety profile of triptans is considered excellent.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

Eletriptan for the treatment of migraine in patients with previous poor response or tolerance to oral sumatriptan.

Author: FärkkiläM, OlesenJ, DahlöfC, StovnerL J, ter BruggenJ P, RasmussenS, MuirheadN, SikesC

Migraine treatment
Asthenia
Chest symptoms
Nausea
Vomiting

This study evaluated the tolerability and efficacy of eletriptan in patients who had discontinued oral sumatriptan due to lack of efficacy or intolerable adverse events. Eletriptan was effective and well tolerated in these patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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