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Risperidone versus olanzapine for schizophrenia.

Author: HosalliP, JayaramM B

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Risperidone and olanzapine were found to be equally effective in treating schizophrenia. However, risperidone was associated with more movement disorders and sexual dysfunction, while olanzapine caused more weight gain.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Antipsychotic medication is a mainstay of treatment for schizophrenia and risperidone and olanzapine are the most popular treatment choice of the new generation drugs. OBJECTIVES: To determine the clinical effects, safety and cost effectiveness of risperidone compared with olanzapine fo...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD005237

データ提供：米国国立医学図書館（NLM）

Risperidone vs. Olanzapine: Navigating the Desert of Schizophrenia Treatment

Schizophrenia, like a treacherous desert, is a complex mental illness. Antipsychotic medications are essential tools for treating schizophrenia, with risperidone and olanzapine being two popular choices. This study compares these medications, exploring their effectiveness, safety, and cost-effectiveness in managing schizophrenia.

A Comparative Journey: Risperidone and Olanzapine in the Schizophrenia Desert

The researchers conducted a meta-analysis of randomized controlled trials, comparing the efficacy of risperidone and olanzapine. They found no significant difference in the short-term outcomes. However, a study sponsored by the olanzapine manufacturer favored olanzapine for longer-term relapse prevention.

Navigating the Side Effect Oasis: Choosing the Right Path

Both risperidone and olanzapine were associated with adverse effects, like a desert oasis with potential dangers. Risperidone was linked to movement disorders and sexual dysfunction, while olanzapine was associated with significant weight gain.

Dr. Camel's Conclusion

This research highlights the challenges of treating schizophrenia, similar to navigating a vast and unpredictable desert. The authors suggest the need for larger, independent, and well-designed studies to better understand the complex interplay between antipsychotic medications and schizophrenia. The comparison of risperidone and olanzapine underscores the importance of considering individual patient needs and potential side effects when choosing an antipsychotic treatment.

Date :
  1. Date Completed 2005-07-19
  2. Date Revised 2018-12-21
Further Info :

Pubmed ID

15846745

DOI: Digital Object Identifier

10.1002/14651858.CD005237

Related Literature

Article Analysis
・Effective treatment of schizophrenia
SNS
PICO Info
in preparation
Languages

English

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