Paper Details

  1. Home
  2. Paper Details

Effects of oleoyl-estrone with dexfenfluramine, sibutramine or phentermine on overweight rats.

Author: AlemanyMarià, CabotCristina, Fernández-LópezJosé-Antonio, Ferrer-LorenteRaquel, RemesarXavier

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Combining oleoyl-estrone with either dexfenfluramine or sibutramine resulted in significant weight loss and fat reduction in overweight rats, while maintaining energy balance.
Paper Details　
Original Abstract of the Article :
We studied the combination of oleoyl-estrone with either dexfenfluramine, sibutramine or phentermine in overweight male rats treated for 10 days in order to determine whether they shared a mechanism of action. Oleoyl-estrone, dexfenfluramine and sibutramine decreased body weight and energy (essentia...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.ejphar.2005.02.044

データ提供：米国国立医学図書館（NLM）

Oleoyl-Estrone: A Potential Anti-Obesity Agent

This study investigates the potential benefits of oleoyl-estrone, a derivative of estrogen, in combination with various weight-loss medications for treating overweight rats. The researchers aimed to determine the efficacy of oleoyl-estrone in combination with dexfenfluramine, sibutramine, or phentermine in reducing body weight and improving metabolic parameters in overweight rats.

Oleoyl-Estrone: A Promising Anti-Obesity Agent

The study found that oleoyl-estrone, when combined with dexfenfluramine or sibutramine, resulted in a significant reduction in body weight and fat mass in overweight rats. These findings suggest that oleoyl-estrone could be a promising agent for treating obesity, either alone or in combination with other medications. The study also found that oleoyl-estrone improved insulin sensitivity, suggesting a potential benefit for managing metabolic disorders associated with obesity.

Navigating Obesity: Exploring New Treatment Options

This research highlights the potential of oleoyl-estrone as a novel therapeutic agent for treating obesity. The study suggests that oleoyl-estrone, either alone or in combination with other medications, could offer a promising strategy for reducing body weight and improving metabolic health. Further research is needed to validate these findings and to explore the long-term effects and safety of oleoyl-estrone in humans.

Dr. Camel's Conclusion

This study is a testament to the ongoing search for effective and safe treatments for obesity. The findings suggest that oleoyl-estrone could be a promising agent for weight loss and metabolic improvement. It is crucial to continue research to further evaluate the efficacy and safety of oleoyl-estrone in both animal models and human clinical trials.

Date :
  1. Date Completed 2005-09-01
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

15862807

DOI: Digital Object Identifier

10.1016/j.ejphar.2005.02.044

Related Literature

Article Analysis
・Effects of phentermine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.