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Chronic depression: medication (nefazodone) or psychotherapy (CBASP) is effective when the other is not.

Author: ArnowBruce A, BanksPhillip L C, BlalockJanice A, BorianFrances E, HowlandRobert, KellerMartin B, KleinDaniel N, KocsisJames H, KornsteinSusan G, ManberRachel, MarkowitzJohn C, MillerIvan, NinanPhilip T, RothbaumBarbara O, RushA John, SchatzbergAlan F, ThaseMichael E, TrivediMadhukar H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This crossover trial found that switching from nefazodone to cognitive behavioral analysis system of psychotherapy (CBASP) or vice versa resulted in significant improvements in symptoms among chronically depressed individuals. Both treatments were equally effective, however, switching to CBASP led to less attrition due to adverse events.
Paper Details　
Original Abstract of the Article :
CONTEXT: Although various strategies are available to manage nonresponders to an initial treatment for depression, no controlled trials address the utility of switching from an antidepressant medication to psychotherapy or vice versa. OBJECTIVE: To compare the responses of chronically depressed non...See full text at original site
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引用元：
https://doi.org/10.1001/archpsyc.62.5.513

データ提供：米国国立医学図書館（NLM）

Chronic Depression: Finding the Right Path

This study embarks on a journey through the desert of chronic depression, exploring the effectiveness of different treatment approaches for those who haven't found relief with traditional methods. The researchers, like skilled desert guides, compared the effectiveness of nefazodone (a medication) and Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in individuals who had not responded to initial treatments for depression. Their findings highlight the importance of personalized treatment approaches.

A personalized approach: Medication or therapy?

The study found that both switching from nefazodone to CBASP and vice versa led to significant improvements in symptoms. The researchers concluded that these approaches could be beneficial for individuals who haven't responded to initial treatments. This suggests that finding the right combination of therapy and medication can be crucial in the treatment of chronic depression.

Navigating the desert of depression

This research emphasizes the importance of tailoring treatment strategies to the individual needs of each patient. It's a reminder that chronic depression can be complex, and a one-size-fits-all approach might not always be effective. Working closely with a qualified mental health professional to find the right treatment path can make a significant difference in the recovery journey.

Dr.Camel's Conclusion

This research offers a valuable insight into the complexities of treating chronic depression. Like a desert oasis, finding the right treatment for chronic depression requires a personalized approach. The study underscores the importance of exploring diverse treatment options and collaborating closely with mental health professionals to identify the best path toward recovery.

Date :
  1. Date Completed 2005-05-25
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

15867104

DOI: Digital Object Identifier

10.1001/archpsyc.62.5.513

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Article Analysis
・Effective treatment of depression
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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