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Combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris: a multicenter, investigator-blind, randomized, controlled study.

Author: , ArsonnaudStéphanie, DawsonCatherine, KangSewon, ShalitaAlan R, ThiboutotDiane M, YamauchiPaul S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Combining a topical retinoid with an antibiotic is considered an effective approach for treating acne. Adapalene, a retinoid with anti-inflammatory properties, is safe and well-tolerated. While combining adapalene with other antibiotics has shown improved results compared to antibiotics alone, a combination of adapalene and doxycycline, a common oral antibiotic for acne, has not yet been clinically studied.
Paper Details　
Original Abstract of the Article :
Combination therapy with a topical retinoid and an antibiotic is recognized as a rational and effective approach for the treatment of acne vulgaris. Adapalene, a naphthoic acid derivative with anti-inflammatory and receptor-selective retinoid properties, is safe and well tolerated. While the combina...See full text at original site
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引用元：
https://doi.org/10.1111/j.1540-9740.2005.04279.x

データ提供：米国国立医学図書館（NLM）

A Synergistic Approach: Combination Therapy for Severe Acne Vulgaris

Acne vulgaris, like a stubborn desert sandstorm, can be a persistent and challenging skin condition. This research investigates the effectiveness of combination therapy for severe acne, combining adapalene gel 0.1% with doxycycline, a commonly prescribed oral antibiotic. The authors, like skilled dermatologists, conduct a multicenter, investigator-blind, randomized, controlled study to evaluate the efficacy of this combined approach.

A Powerful Partnership: Adapalene and Doxycycline Combined for Acne Treatment

The study demonstrates the effectiveness of combining adapalene gel 0.1% with doxycycline in treating severe acne vulgaris. This combination therapy, like a team of skilled desert guides working together, provides a synergistic approach to combatting the multiple factors contributing to this condition.

A New Oasis in Acne Treatment: Hope for Clearer Skin

This research offers hope for patients seeking relief from severe acne, providing a promising treatment option with proven efficacy. Like a caravan finding a hidden oasis in a vast desert, this combination therapy can offer a path towards clearer skin and improved self-esteem.

Dr.Camel's Conclusion

This study demonstrates the effectiveness of combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris. Like a camel finding a source of water in a barren desert, this research offers hope for individuals struggling with this challenging skin condition, providing a potential pathway to clearer skin and improved self-confidence.

Date :
  1. Date Completed 2005-08-15
  2. Date Revised 2019-11-09
Further Info :

Pubmed ID

15891249

DOI: Digital Object Identifier

10.1111/j.1540-9740.2005.04279.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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