Effective treatment of acne: A Synthesis of Findings from 171 Studies

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Original Abstract of the Article

Major Research Findings

Several studies have shown that light therapy and laser therapy are effective treatments for acne, in addition to conventional medication. 20 , 42 , 17 These therapies have the advantage of being less likely to cause side effects and have a good chance of being effective compared to traditional methods. 42 Also, it is clear that different treatments are used depending on the severity of the acne. 110 For example, topical treatment may be effective for mild to moderate acne. 158 On the other hand, more aggressive treatments such as oral medication, light therapy, and laser therapy may be needed for severe acne. 131 Furthermore, the best way to treat acne varies depending on the patient’s age, skin type, and type of acne. 60

Treatment Summary

Studies 20 , 42 , 17 have shown that light therapy and laser therapy are effective treatments for acne. Also, study 110 suggests that different treatments are used depending on the severity of the acne. Study 158 shows that topical treatment may be effective for mild to moderate acne. On the other hand, study 131 suggests that more aggressive treatment may be needed for severe acne. Study 60 suggests that the best way to treat acne varies depending on the patient’s age, skin type, and type of acne.

Benefits and Risks

Benefits Summary

Light therapy and laser therapy for acne have the advantage of being less likely to cause side effects and have a good chance of being effective compared to traditional methods. 42 Also, these therapies have the advantage of being able to choose the right method depending on the patient’s age, skin type, and type of acne. 60

Risks Summary

While light therapy and laser therapy for acne are generally safe treatments, some patients may experience side effects such as skin redness, inflammation, and pigmentation. 42 Therefore, it is important to consult with your doctor before undergoing treatment and to understand the risks and benefits fully.

Comparison Between Studies

Similarities Between Studies

Many studies have shown that light therapy and laser therapy are effective treatments for acne in addition to conventional medication. 20 , 42 , 17 It is also a common understanding that it is important to choose the right treatment based on the severity of the acne. 110

Differences Between Studies

Because the treatments used, the types of acne targeted, and the patients’ characteristics differ between studies, there is some variation in the results. 60 For example, study 158 shows the effectiveness of topical treatment for mild to moderate acne, while study 131 suggests that more aggressive treatment is needed for severe acne.

Consistency and Contradictions in the Results

Multiple studies have shown that light therapy and laser therapy are effective treatments for acne, but the treatment effects and severity of side effects vary from study to study. 42 Therefore, it is important to consult with your doctor and choose the right treatment for your situation when actually undergoing these therapies.

Precautions for Practical Applications

The best way to treat acne varies depending on the patient’s age, skin type, and type of acne. 60 Therefore, you should not decide on a treatment method yourself. It is essential to consult a doctor and receive the right treatment.

Limitations of Current Research

Research on acne treatment methods is still insufficient. 92 In particular, more research is needed on the long-term effects and safety of light therapy and laser therapy. 42

Future Research Directions

Research on acne treatment methods needs to include larger studies involving more patients and long-term follow-up studies. 62 Also, research is needed to compare the treatment effects and side effects of different types of acne. 110

Conclusion

There are a variety of treatment options for acne, including conventional medication, light therapy, and laser therapy. 42 It is important to consult with your doctor to choose the right treatment for you.

Treatment List

The following treatments are used to treat acne.

  • Topical therapy
  • Oral medication
  • Light therapy
  • Laser therapy
Keywords
Benefit Keywords
Effective acne treatment
1
Effective combination therapy
Improved acne
Improved acne symptoms
Reduced acne lesions
2
Acne treatment
Effective acne treatment
Reduced pustules
3
Effective acne treatment
Improved acne symptoms
Less expensive
Non-irritating
Well-accepted
4
Clearance of acne
Effective acne treatment
High remission rate
Improved acne
Long-lasting remission
Reduced sebum production
5
Acne prevention
Acne treatment
Effective acne treatment
Potential maintenance therapy
6
Acne treatment
Effective acne treatment
Less irritating than tretinoin
7
Improved acne vulgaris
8
Acne vulgaris treatment effective
9
Decreases comedones
Effective acne treatment
May reduce resistance
Multi-target approach
Reduced bacterial growth
Reduced epidermal cell compaction
Reduced resistance development
Reduces bacterial growth
10
Acne treatment
Combined therapies offer relief
Isotretinoin effective for acne
Isotretinoin reduces relapse
Reduced relapse risk
11
Improved actinic keratoses
Improved photodamaged skin
Lightened solar lentigines
12
Acne treatment
Improved acne QOL
Statistically significant treatment
13
Improved acne severity
Reduced acne lesions
15
Acne treatment
Effective acne treatment
Rosacea treatment
Superior tissue distribution
16
Acne treatment
Need for novel treatments
17
Acne treatment
Adapalene safe and tolerated
Effective acne treatment
Superior combination therapy
18
Improved acne treatment
Need for noninvasive treatments
Noninvasive treatment options
19
Alternative therapy needed
Improved acne treatment
Phototherapy effective
20
Reduced acne
Well tolerated
21
Conjoint analysis for preferences
Effective acne treatments
Improved acne treatment
22
Alternative to isotretinoin
Improved acne treatment
PDT for recalcitrant acne
23
Reduce erythema
24
Acne reduction
25
Lower irritation
26
Acne improvement
Safe & effective alternative
27
Acne reduction
Reduced pain
28
Acne treatment
Complementary approach
Improved QOL
No treatment deterioration
29
Improved comedonal acne
30
Reduced acne lesions
31
Acne treatment
Early onset
32
Acne treatment
Well tolerated
33
Acne scarring prevention
Acne scarring treatment
34
Improved acne treatment
Need for nonantibiotic treatments
35
Acne treatment
Adapalene safety and efficacy
Effective combination therapy
Enhanced therapeutic results
36
Acne treatment
Better tolerability
Combats resistance
Enhanced efficacy
Improved tolerability
Retinoids for early treatment
37
Effective acne treatment
Improved acne treatment
Minimizes resistance
Retinoids for anti-inflammation
38
Adapalene effective for acne
Improved acne treatment
39
Alternative therapy needed
Improved acne treatment
Phototherapy effective
40
Acne reduction
41
Acne treatment
Convenient acne treatment
Effective acne treatment
Safe acne treatment
42
Acne treatment
43
Acne treatment
Need for new treatments
44
Acne scar treatment
Improved scar appearance
Reduced complications
45
Acne treatment
Improved acne severity
46
Acne scar treatment
47
Reduced acne
48
Acne treatment
Effective combination therapy
Rapid onset of effect
Well-tolerated
49
Acne vulgaris treatment
PDT efficacy for acne
Reduced phototoxicity
50
Acne treatment
Adapalene for acne
51
Acne vulgaris treatment
52
Improved global acne severity
53
Improved acne scarring
Improved overall appearance
54
Azelaic acid effective
Cleanser effective
Salicylic acid effective
Triclosan effective
55
Azelaic acid effective
Combination effective
Erythromycin effective
56
Benzoyl peroxide effective
Clindamycin effective
57
Effective acne treatment
Reduced PIH
Reduced PIH (tazarotene)
Reduced acne
Well-tolerated
58
Acne treatment
Effective acne treatment
59
Acne treatment
Antibiotics for acne
60
Effective treatment
Lesion reduction
61
Acne treatment
Blue/red light therapy effective
COCs effective for acne
Photodynamic therapy effective
62
Effective acne treatment
Isotretinoin efficacy for acne
63
Improved acne
64
Combination therapy for acne
Decreased resistance
Improved acne treatment
65
COCs effective for acne
Low-dose isotretinoin promising
Treatment of acne
67
Increased efficacy
Multifactorial treatment
Reduced response time
Treatment of acne
68
Improved adapalene tolerance
69
Improved acne
Reduced inflammatory lesions
Reduced noninflammatory lesions
Reduced total lesions
70
Potential rosacea treatment
Treatment of papulopustular acne rosacea
71
Acne treatment
Combination therapy standard
72
Acne treatment
73
Combination therapy standard
Treatment of acne in skin of color
74
Dual-action formulation
Targets acne and aging
Treatment of acne and skin aging
75
Improved acne treatment
Improved topical drug development
76
Improved acne severity
Reduced acne lesions
77
Acne reduction
Clearer skin
78
Improved acne treatment
Modified-release minocycline
79
Acne treatment
Diverse treatment options
80
Acne treatment
81
Improved acne understanding
Low GI diet potential
Validated core outcomes
82
Reduced acne lesions
83
Effective for acne
Well tolerated
84
Reduced acne lesions
85
Acne treatment
Similar tolerance and efficacy
Treatment A effective
86
Safe and effective treatment
87
Acne treatment
Plant oils potential
88
Acne treatment
Effective facial acne treatment
89
Effective for acne erythema
Safe for acne erythema
90
ISO alternative to RA
ISO for photoaging
ISO for severe acne
Isotretinoin
Photoaging treatment
91
Acne treatment
COCs effective for acne
Early psychiatric support
Laser resurfacing potential
Lower benzoyl peroxide strength
Tretinoin safe for skin cancer prevention
92
Adapalene faster than isotretinoin
BPO faster than tretinoin
TOA as trial outcome
Topical acne treatments
93
Favorable efficacy/safety profile
94
Acne treatment
Inositol for acne
95
Improved tolerability
Reduced acne flare
Reduced acne lesions
Reduced erythema
Reduced sebum
96
Acne vulgaris treatment
97
Good tolerance
Improved lesion count
Reduced relapse
98
Effective for acne
Effective for skin cancer
Skin cancer treatment
100
Improved acne severity
Reduced lesion count
101
Meta-analysis of antibiotic resistance
102
Improved acne scars
103
Alternatives needed
Benzoyl peroxide + topical retinoid for acne
Combined therapy for acne
Limited antibiotic use
Oral antibiotics + topical retinoid/benzoyl peroxide for acne
104
Acne vulgaris treatment
Combined therapy for acne
Topical therapy maintenance
105
Acne treatment
106
Improved acne severity
Reduced inflammatory lesions
107
Acne treatment
109
Acne treatment
Need for novel treatments
110
Higher active ingredient concentration
Improved acne treatment
Improved tolerability (clindamycin-BP)
Reduced skin irritation
111
Acne treatment
OTC product use
Rapid resolution
112
Effective treatment for acne
Improved skin health
Phototherapy effective
Reduced pustules
Reliable and safe
113
Improved scar severity
Reduced scarring risk
114
Acne treatment
115
Acne treatment
116
Acne scar improvement
117
Acne treatment
Early treatment important
118
Reduced acne lesions
119
Low-GI diet potential
Plant-based approach
120
Effective acne treatment
Good tolerability
Rapid improvement
Reduced inflammatory acne lesion elevation
Reduced inflammatory acne lesion erythema
Reduced inflammatory acne lesion induration
121
Effective acne treatment
Improved acne symptoms
Improved appearance
Minimal side effects
Well-tolerated
122
Acne treatment
DL and FMR effective for acne
Dermal remodelling effects
123
Acne improvement
Quality of life improvement
124
Acne treatment
Alternative to drugs
Non-pharmacological therapies
Reduced antibiotic resistance
125
Commonly used
Improved acne treatment
Potentially effective
126
Acne severity reduction
Lesion reduction
Safe and well-tolerated
127
Acne treatment
Isotretinoin effective
Isotretinoin efficacy
Reduced side effects
128
AKN treatment
129
Atrophic acne scarring treatment
Diverse treatment options
Minimally invasive modalities
130
Acne improvement
Safe treatment
131
Acne treatment
Combined therapy superiority
Effective acne treatment
Hormonal treatment
Laser treatment
132
Acne treatment
Improved QoL
134
Acne treatment
Effective treatment
Lotion formulation
Tretinoin
135
Improved acne
Reduced lesion counts
136
Acne treatment
Alternative treatment
Herbal extracts
Multiple active ingredients
Potential efficacy
137
Alternative treatment
Fewer side effects
Improved acne treatment
Potential for combination therapy
138
Effective acne treatment
Safe for long-term use
Well tolerated
139
Combined technique efficacy
Improved acne scar treatment
Improved scar appearance
140
Improved hyperpigmentation
Reduced acne
141
Improved scar appearance
142
Acne treatment
Blue light therapy
143
Acne improvement
Noninflammatory lesion reduction
144
Acne improvement
145
Improved acne scarring
146
Acne improvement
147
Acne treatment
Alternative to antibiotics
Effective treatment
148
Acne treatment
Lotion formulation
PIH treatment
Potential for sensitive skin
Treats acne & PIH
149
Acne reduction
Better tolerability (CT)
Effective treatment
Improved skin moisture
150
Improved acne
151
Acne improvement
Quality of life
152
Improved atrophic post-acne scars
Improved quality of life
153
Azithromycin plus levamisole for acne
Potential for combination therapy
154
Acne treatment
Improved efficacy
Well tolerated
155
Acne scar treatment
156
Laser and topical efficacy
Treatment for PAE
Treatment options available
157
Acne treatment
158
Alternative treatment
IHM for AV
159
Reduced adverse reactions
Rose acne treatment
Symptom improvement
160
Acne reduction
161
Acne treatment
162
Acne scar treatment
Improved skin appearance
163
Acne reduction
Improved skin condition
164
Acne scar treatment
Active acne treatment
Pigmentation reduction
165
Acne treatment
Combination therapy
Needle-free delivery
166
Combination of fire needle and ALA-PDT for acne
Combination therapy
Potential for improved outcomes
167
Acne treatment
Alternative treatment options
Potential for improved tolerability
168
Acne treatment
Effective treatment
Maximize patient satisfaction
Minimize side effects
169
Acne scar treatment
Combination therapy
Potential for scar improvement
170
Reduced acne lesions
171
Risk Keywords
Erythema
Irritation
1
Cutaneous side effects
Itching (benzoyl peroxide)
Redness (benzoyl peroxide)
Scaling (benzoyl peroxide)
Skin irritation (benzoyl peroxide)
2
Not specified
3
Dryness aggravates acne
Skin dryness
4
Not specified
5
Not specified
6
Not specified
7
Skin irritation
8
Dryness
Peeling
9
Not specified
10
Isotretinoin teratogenicity
Methodological limitations in studies
Methodological variability in studies
Teratogenicity
11
Clinical meaningfulness unclear
13
Not specified
16
Antibiotic resistance
Isotretinoin safety concerns
Safety and tolerance of isotretinoin
17
Not specified
18
Acne vulgaris
Medication side effects
19
Antibiotic resistance
Not specified
20
Increased pain
21
Acne vulgaris
High treatment failure
Poor compliance
22
Acne
Isotretinoin side effects
23
Pain
Severe adverse effects
25
Not specified
29
Acne vulgaris
Antibiotic resistance
35
Antibiotic resistance
Not specified
36
Not specified
37
Acne
Lack of direct comparisons
38
Acne vulgaris
Not available in Japan
39
Acne vulgaris
Antibiotic resistance
40
Not specified
42
Adverse effects
Antibiotic resistance
Bacterial resistance
Lack of response to therapies
Retinoid teratogenicity
44
None reported
45
None reported
46
Acneiform eruption
Hyperpigmentation
47
None reported
48
Not specified
49
Antibiotic resistance
Drug side effects
Phototoxic side effects
50
Not specified
51
Pain
Postinflammatory hyperpigmentation
54
Mild to moderate AE
56
Mild irritation
Skin irritation
58
Common skin disease
Compliance issues
59
Antibiotic side effects
Reduced compliance
60
Side effects
61
Benzoyl peroxide strength unclear
Dietary influence unclear
Isotretinoin psychiatric risks
Limited evidence for cyproterone acetate
Photodynamic therapy side effects
Retinoid worsening inconclusive
Spironolactone ineffective
62
Lack of comparative data
63
Not specified
65
Antibiotic resistance
Bacterial resistance
Benzoyl peroxide combinations unclear
Botanical products ineffective
Depression
Isotretinoin suicide risk
Isotretinoin timing unclear
Suicide
67
Antibiotic resistance
Increased irritation
Skin irritation
68
Skin irritation
70
Difficult rosacea treatment
Not specified
Systemic medication reluctance
71
Dryness (Hispanics)
Hyperpigmentation
Hyperpigmentation (Hispanics)
Increased dryness
Increased irritation
Increased irritation (Hispanics)
Lack of clinical studies
72
Small sample size
73
Dryness (skin of color)
Increased irritation (skin of color)
Lack of clinical studies
74
Not specified
Prevalence data lacking
75
Placebo effect in tetracyclines
Vehicle effect significance
76
Unknown comparison to alternative treatments
77
Unknown vs other treatments
78
High cost (minocycline)
No greater benefit
Safety concerns (minocycline)
79
Potential side effects
Side effects
80
Dryness
Erythema
Peeling
81
Acne heritability high
Acne persists into adulthood
Acne prevalence high
Acne severity correlates with puberty
Dietary association unclear
High economic impact
Severe acne linked to suicidal ideation
Smoking association unclear
82
Erythema
Scaling
83
Mild adverse events
85
Not specified
86
None
87
Acne prevalence high
Lack of evidence
Medication side effects
Psychosocial impact significant
88
Limited truncal acne data
89
Lack of controlled trials
RA skin irritation
Skin irritation
91
Acne impacts mental health
Dairy produce link unclear
Demodex mite role unclear
Isotretinoin monitoring needed
92
Acne
Inconsistent results
Limited study quality
Treatment selection
93
Acne psychological impact
95
Acne
96
Recurrence
97
Not reaching target dose
98
Burning pain
100
Antibiotic resistance
Bacterial resistance
102
Erythema
PIH
103
Antibiotic resistance
Long-term antibiotic risks
104
Antibiotic resistance
105
Skin irritation
106
Acne scarring common
Lack of high-quality evidence
Negative psychosocial impact
108
Application site reactions
109
Acne prevalence high
Treatment limitations
110
Increased irritation (adapalene-BP)
111
Not specified
112
Bacterial resistance
SA treatment limitations
Sensitivity
Teratogenicity
113
Small study group
114
Menstrual side effects
Serum potassium
115
Edema
Erythema
Hyperpigmentation
Pain
116
Skin darkening
117
Acne scarring common
Delayed treatment
118
Acne prevalence high
Compliance challenges
Limited research
120
Not specified
121
Not specified
122
Limited controlled studies
123
Limited evidence
Unknown long-term effects
125
Limited evidence
Unknown long-term effects
126
Compliance issues
Isotretinoin side effects
Muco-cutaneous side effects
128
Lack of consensus guidelines
130
Cheilitis
Xerostomia
131
Not specified
132
Local tolerability issues
133
Limited data on younger patients
Potential side effects
135
Adverse effects
136
Limited research
Potential interactions
Unknown side effects
137
Limited research
Unknown long-term effects
138
Cutaneous adverse events
Skin irritation
139
Individual variations
Potential side effects
140
Antibiotic resistance
143
Acne exacerbation
144
Skin burning
Skin irritation
145
Scaling
Skin irritation
147
Limited study duration
Unknown long-term effects
148
Irritant contact dermatitis
Limited data on black patients
Potential for irritation
149
Dryness
Erythema
Irritation (BA)
Limited study duration
Skin irritation
150
Increased withdrawal
151
Limited data
Unknown long-term effects
154
Need for further research
No gold standard
157
Skin irritation
158
Limited research
Potential for placebo effect
159
Adverse effects
161
Further research needed
Limited sample size
163
Crusting
Erythema
165
Limited research
Uncertain efficacy
166
Limited research
Unknown long-term effects
167
Limited research
Side effects
Unknown long-term effects
168
Limited research
Unknown long-term effects
169
Limited research
Unknown long-term effects
170
Burning
Dry skin
Irritation
Redness
Scaling
171
Literature analysis of 171 papers
Positive Content
169
Neutral Content
1
Negative Content
1
Article Type
133
19
34
29
170
1.

Comparison of two concentrations of tretinoin solution in the topical treatment of acne vulgaris.

Author: KrishnanG

Effective acne treatment
Erythema
Irritation

Topical retinoic acid treatment (0.05% or 0.025%) was effective in reducing facial acne symptoms in a 12-week trial. The 0.025% solution had fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Comparison of topical clindamycin phosphate, benzoyl peroxide, and a combination of the two for the treatment of acne vulgaris.

Author: TuckerS B, TausendR, CochranR, FlanniganS A

Effective combination therapy
Improved acne
Improved acne symptoms
Reduced acne lesions
Cutaneous side effects
Itching (benzoyl peroxide)
Redness (benzoyl peroxide)
Scaling (benzoyl peroxide)
Skin irritation (benzoyl peroxide)

A study comparing topical clindamycin phosphate, benzoyl peroxide, and a combination of both for treating acne vulgaris found that the combination therapy was most effective in decreasing all types of acne lesions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

[Internal versus topical tetracycline therapy of acne].

Author: SchwanitzH J, MacherE

Acne treatment
Effective acne treatment
Reduced pustules
Not specified

A study of 49 acne patients compared the effectiveness of oral and topical tetracycline treatment over an average of 4.7 months. Patients were randomly assigned to receive either oral tetracycline (1000mg daily for 5 days, then 250mg daily) or topical tetracycline (2% alcoholic solution). Both groups showed a significant decrease in pustules after treatment. The overall evaluation of both treatments by both doctors and patients was similar, indicating no significant difference in effectiveness between oral and topical tetracycline for acne.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

4.

Topical agents alone in acne. A blind assessment study.

Author: SwinyerL J, SwinyerT A, BrittM R

Effective acne treatment
Improved acne symptoms
Less expensive
Non-irritating
Well-accepted
Dryness aggravates acne
Skin dryness

A study of 118 patients with mild to moderate acne compared three treatment regimens over 16 weeks. A topical regimen of tretinoin, benzoyl peroxide, and water avoidance proved as effective as systemic tetracycline therapy with topical tretinoin, and more effective than systemic tetracycline with abradant cleansers. Dry skin was associated with a lack of improvement in all groups, suggesting its role in both acne development and treatment. The topical regimen was well-tolerated, non-irritating, and less expensive than the other two options.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Isotretinoin versus placebo in the treatment of cystic acne. A randomized double-blind study.

Author: PeckG L, OlsenT G, ButkusD, PandyaM, Arnaud-BattandierJ, GrossE G, WindhorstD B, CheripkoJ

Clearance of acne
Effective acne treatment
High remission rate
Improved acne
Long-lasting remission
Reduced sebum production
Not specified

A study of 33 patients with severe, treatment-resistant acne compared isotretinoin to placebo. The placebo group saw a 57% increase in cystic lesions, while those who switched to isotretinoin after the placebo period experienced a 98% improvement. Patients who received isotretinoin from the start had a 95% improvement. A total of 27 out of 32 patients treated with isotretinoin achieved complete clearance. The average maximum dose of isotretinoin was 1.2mg/kg/day. Eighteen patients received one 4-month course, while 15 received two courses. All patients are now in remission for an average of 38 months. Biopsies and sebum measurements during treatment showed a significant reduction in sebaceous gland size and function, suggesting that this may be the key mechanism of action for isotretinoin in treating acne.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Comparison of combined azelaic acid cream plus oral minocycline with oral isotretinoin in severe acne.

Author: GollnickH P, GraupeK, ZaumseilR P

Acne prevention
Acne treatment
Effective acne treatment
Potential maintenance therapy
Not specified

This study compared the effectiveness and safety of a combined treatment of topical 20% azelaic acid (AA) cream and oral minocycline to oral isotretinoin therapy for severe inflammatory acne (nodular papulopustular and conglobata). Additionally, the study investigated the potential of AA cream for preventing acne recurrence as a maintenance therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Topical adapalene gel 0.1% vs. isotretinoin gel 0.05% in the treatment of acne vulgaris: a randomized open-label clinical trial.

Author: IoannidesD, RigopoulosD, KatsambasA

Acne treatment
Effective acne treatment
Less irritating than tretinoin
Not specified

Topical isotretinoin and adapalene have shown effectiveness in treating acne. Both offer benefits over tretinoin, the most common acne treatment, with less irritation. They both function as retinoid agonists, but differ in how strongly they bind to specific receptors in cells.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Clinical evaluation of Double Strength Isotrexin versus Benzamycin in the topical treatment of mild to moderate acne vulgaris.

Author: MarazziP, BoormanG C, DonaldA E, DaviesH D

Improved acne vulgaris
Skin irritation

Isotretinoin/erythromycin gel given once daily showed comparable efficacy with benzoyl peroxide/erythromycin given twice daily in the treatment of mild to moderate acne vulgaris.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

A comparative trial of two retinoids commonly used in the treatment of acne vulgaris.

Author: NyiradyJ, GrossmanR M, NighlandM, BergerR S, JorizzoJ L, KimY H, MartinA G, PandyaA G, SchulzK K, StraussJ S

Acne vulgaris treatment effective
Dryness
Peeling

Tretinoin gel microsphere 0.1% and adapalene gel 0.1% demonstrate comparable efficacy in treating acne vulgaris, but tretinoin gel microsphere may have a faster onset of action in reducing comedones. While both treatments are effective, tretinoin gel microsphere is associated with higher incidences of dryness and peeling.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

A randomized, double-blind, multicenter, parallel group study to compare relative efficacies of the topical gels 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4% in the treatment of moderate acne vulgaris of the face.

Author: GuptaAditya K, LyndeCharles W, KunynetzRod A W, AminSmita, ChoiKen, GoldsteinEric

Decreases comedones
Effective acne treatment
May reduce resistance
Multi-target approach
Reduced bacterial growth
Reduced epidermal cell compaction
Reduced resistance development
Reduces bacterial growth
Not specified

Combination treatments for acne, like Benzamycin (erythromycin and benzoyl peroxide) and Stievamycin (tretinoin and erythromycin), are effective because they target different aspects of acne. Erythromycin in both treatments reduces bacteria that contribute to inflammation. Benzoyl peroxide in Benzamycin has both antibacterial and anti-comedogenic (pore-clearing) properties. Tretinoin in Stievamycin helps normalise skin cell turnover and loosen the blockage that forms comedones. Combining antibiotics can reduce the risk of resistance, and the tretinoin/erythromycin combination provides both antibacterial and cell-regulating effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Acne: comparing hormonal approaches to antibiotics and isotretinoin.

Author: LarsenTina Holst, JemecGregor B E

Acne treatment
Combined therapies offer relief
Isotretinoin effective for acne
Isotretinoin reduces relapse
Reduced relapse risk
Isotretinoin teratogenicity
Methodological limitations in studies
Methodological variability in studies
Teratogenicity

This review assessed the effectiveness of systemic treatments for severe acne, including antibiotics, anti-androgens, and retinoids. Isotretinoin showed the highest improvement (85% on average) compared to baseline, followed by tetracyclines (54%) and cyproterone acetate plus ethinyloestradiol (65%). Isotretinoin also seemed to reduce relapse risk. However, limitations such as potential teratogenicity restrict widespread use. Combined topical and systemic therapies offer relief, but future standardized studies are needed for better comparison and evidence-based recommendations.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial.

Author: KangSewon, GoldfarbMichael T, WeissJonathan S, MetzRussell D, HamiltonTed A, VoorheesJohn J, GriffithsChristopher E M

Improved actinic keratoses
Improved photodamaged skin
Lightened solar lentigines

Adapalene gel 0.1% and 0.3% were well tolerated and improved actinic keratoses, solar lentigines, and other features of photodamaged skin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Evaluating minimal clinically important differences for the acne-specific quality of life questionnaire.

Author: McLeodLori D, FehnelSheri E, BrandmanJane, SymondsTara

Acne treatment
Improved acne QOL
Statistically significant treatment
Clinical meaningfulness unclear

A study using the Acne-Specific Quality of Life Questionnaire (Acne-QoL) showed statistically significant improvements in quality of life for women with moderate acne who used a low-dose oral contraceptive (Estrostep) compared to placebo. However, the study questions whether these statistically significant results translate to meaningful improvements in daily life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Treatment of acne vulgaris with a pulsed dye laser: a randomized controlled trial.

Author: OrringerJeffrey S, KangSewon, HamiltonTed, SchumacherWendy, ChoSoyun, HammerbergCraig, FisherGary J, KarimipourDarius J, JohnsonTimothy M, VoorheesJohn J

This study evaluated the clinical efficacy of pulsed dye laser therapy for acne. The study found that pulsed dye laser therapy did not result in significant improvement of facial acne.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

15.

Combined oral contraceptive pills for treatment of acne.

Author: ArowojoluA O, GalloM F, GrimesD A, GarnerS E

Improved acne severity
Reduced acne lesions

Combination oral contraceptives (COCs) are effective in reducing inflammatory and non-inflammatory facial acne lesions. Few differences were found in acne effectiveness between COC types.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

A topical azithromycin preparation for the treatment of acne vulgaris and rosacea.

Author: McHughR C, RiceA, SanghaN D, McCartyM A, UtterbackR, RohrbackJ M, OsborneB E, FleischerA B, FeldmanS R

Acne treatment
Effective acne treatment
Rosacea treatment
Superior tissue distribution
Not specified

Erythromycin is a commonly used treatment for acne and rosacea. Azithromycin, a newer macrolide antibiotic, has better tissue distribution and is effective for acne orally. While topical erythromycin is a standard treatment for acne, there are currently no topical azithromycin solutions available.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action.

Author: PollockB, TurnerD, StringerM R, BojarR A, GouldenV, StablesG I, CunliffeW J

Acne treatment
Need for novel treatments
Antibiotic resistance
Isotretinoin safety concerns
Safety and tolerance of isotretinoin

Acne affects a large majority of teenagers, with many seeking medical help. Concerns about antibiotic resistance in acne-causing bacteria and safety issues with oral isotretinoin highlight the need for new approaches to acne treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris: a multicenter, investigator-blind, randomized, controlled study.

Author: ThiboutotDiane M, ShalitaAlan R, YamauchiPaul S, DawsonCatherine, ArsonnaudStéphanie, KangSewon,

Acne treatment
Adapalene safe and tolerated
Effective acne treatment
Superior combination therapy
Not specified

Combining a topical retinoid with an antibiotic is considered an effective approach for treating acne. Adapalene, a retinoid with anti-inflammatory properties, is safe and well-tolerated. While combining adapalene with other antibiotics has shown improved results compared to antibiotics alone, a combination of adapalene and doxycycline, a common oral antibiotic for acne, has not yet been clinically studied.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Nonablative phototherapy for acne vulgaris using the KTP 532 nm laser.

Author: BaughWilliam P, KucabaWalter D

Improved acne treatment
Need for noninvasive treatments
Noninvasive treatment options
Acne vulgaris
Medication side effects

Acne is a common skin condition. While there are many treatments available, including topical and oral medications, there's a need for effective non-invasive treatments that reduce the risk of medication side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

An open study to determine the efficacy of blue light in the treatment of mild to moderate acne.

Author: MortonC A, ScholefieldR D, WhitehurstC, BirchJ

Alternative therapy needed
Improved acne treatment
Phototherapy effective
Antibiotic resistance
Not specified

Managing acne effectively is difficult, with the goal of achieving good results while minimizing side effects. The increasing threat of antibiotic resistance makes finding alternative therapies crucial. Phototherapy, using light to treat acne, has shown promise, with both internal and external light-based treatments being investigated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Treatment of inflammatory facial acne with the 1,450 nm diode laser alone versus microdermabrasion plus the 1,450 nm laser: a randomized, split-face trial.

Author: WangSteven Q, CountersJeff T, FlorMary E, ZelicksonBrian D

Reduced acne
Well tolerated
Increased pain

The 1,450 nm laser is an effective treatment for facial acne. A study of 20 patients found that both laser alone and microdermabrasion plus laser significantly reduced the total number of acne lesions. The study did not demonstrate increased clinical efficacy or decreased associated pain with the addition of microdermabrasion to treatment with the 1,450 nm laser.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Conjoint analysis: a novel, rigorous tool for determining patient preferences for topical antibiotic treatment for acne. A randomised controlled trial.

Author: KellettN, WestF, FinlayA Y

Conjoint analysis for preferences
Effective acne treatments
Improved acne treatment
Acne vulgaris
High treatment failure
Poor compliance

While effective treatments for acne exist, poor adherence to medication is a major factor in treatment failures. Conjoint analysis, a method used to understand patient preferences, could be helpful in improving acne treatment adherence by considering what patients value in their medications.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Effect of a single overnight topical application of miconazole nitrate paste on acne papules.

Author: FlagothierCaroline, VroomeValérie, BorgersMarcel, WangXuemin, CauwenberghGeert, PiérardGérald E

Reduce erythema

A single overnight application of miconazole nitrate paste appears to reduce the erythematous aspect of acne papules.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Photodynamic therapy of acne vulgaris using methyl aminolaevulinate: a blinded, randomized, controlled trial.

Author: WiegellS R, WulfH C

Acne reduction
Pain
Severe adverse effects

MAL-PDT proved to be an efficient treatment for inflammatory acne. The treatment was associated with severe pain during treatment and severe adverse effects after treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Cumulative irritancy comparison of topical retinoid and antimicrobial combination therapies.

Author: DosikJonathan S, GilbertRichard D, ArsonnaudStéphanie

Lower irritation

The study compared the cumulative irritation potential of adapalene gel 0.1%, tazarotene cream 0.05%, and tretinoin microsphere 0.04% when used in combination with two benzoyl peroxide/clindamycin topical gels. The results showed that adapalene had significantly lower irritation potential compared to tazarotene and tretinoin, making it a more tolerable option for topical combination therapy in the management of acne.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Azithromycin versus tetracycline in the treatment of acne vulgaris.

Author: RafieiRana, YaghoobiReza

Acne improvement
Safe & effective alternative

Azithromycin is a safe and effective alternative in the treatment of inflammatory acne.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

A pilot investigation comparing low-energy, double pass 1,450 nm laser treatment of acne to conventional single-pass, high-energy treatment.

Author: BernsteinEric F

Acne reduction
Reduced pain

Low-energy, double-pass 1,450 nm laser treatment effectively reduces acne counts and dramatically reduces the pain associated with treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

A randomized, controlled, split-face clinical trial of 1320-nm Nd:YAG laser therapy in the treatment of acne vulgaris.

Author: OrringerJeffrey S, KangSewon, MaierLisa, JohnsonTimothy M, SachsDana L, KarimipourDarius J, HelfrichYolanda R, HamiltonTed, VoorheesJohn J

Improved comedonal acne

Infrared laser therapy may improve comedonal acne.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Combined oral contraceptive pills for treatment of acne.

Author: ArowojoluA O, GalloM F, LopezL M, GrimesD A, GarnerS E

Reduced acne lesions

This review determined the effectiveness of combined oral contraceptives (COCs) for the treatment of facial acne compared to placebo or other active therapies. The review found that the three COCs evaluated in placebo-controlled trials are effective in reducing inflammatory and non-inflammatory facial acne lesions. Few differences were found between COC types in their effectiveness for treating acne.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide (Duac) and erythromycin + zinc acetate (Zineryt) in the treatment of mild to moderate facial acne vulgaris.

Author: LangnerA, Sheehan-DareR, LaytonA

Acne treatment
Early onset

This assessor-blind, randomized study compared the clinical effectiveness of two combination treatments for facial acne: clindamycin phosphate (1%) plus benzoyl peroxide (5%) (CDP + BPO) and erythromycin (4%) plus zinc acetate (1.2%) (ERY + Zn). The study found that CDP + BPO showed an earlier onset of action with a faster significant reduction in total lesion counts than ERY + Zn.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study.

Author: EnshaiehShahla, JooyaAbolfazl, SiadatAmir Hossein, IrajiFariba

Acne treatment
Well tolerated

Topical 5% tea tree oil was effective in treating mild to moderate acne vulgaris. In a randomized, double-blind clinical trial, tea tree oil gel was significantly more effective than placebo in reducing total acne lesions and acne severity index.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Combined 0.1% retinaldehyde/ 6% glycolic acid cream in prophylaxis and treatment of acne scarring.

Author: DrenoBrigitte, KatsambasAndreas, PelfiniCarlo, PlantierDaniel, JancoviciEliane, RibetVirginie, NoceraThérèse, MorinetPierre, KhammariAmir

Acne scarring prevention
Acne scarring treatment

A 0.1% retinaldehyde/6% glycolic acid (RALGA) cream was found to be effective in preventing and treating acne scarring in patients with moderate acne. In a double-blind vehicle-controlled study, patients using RALGA cream showed significant improvement in global scarring score, inflammatory lesions, and comedones after 28 days, compared to the vehicle group. After 3 months, the RALGA cream was significantly more efficient than the vehicle in reducing scarring due to erythema and hyperpigmentation improvement.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Double-blind, randomized, placebo-controlled study of a lotion containing triethyl citrate and ethyl linoleate in the treatment of acne vulgaris.

Author: CharakidaA, CharakidaM, ChuA C

Improved acne treatment
Need for nonantibiotic treatments
Acne vulgaris
Antibiotic resistance

Acne is a common problem, and while many treatments exist, both patients and doctors are often unsatisfied with the results. Antibiotic resistance is increasing due to overuse, highlighting the need for effective non-antibiotic treatments for acne.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

36.

Study results of benzoyl peroxide 5%/clindamycin 1% topical gel, adapalene 0.1% gel, and use in combination for acne vulgaris.

Author: Del RossoJames Q

Acne treatment
Adapalene safety and efficacy
Effective combination therapy
Enhanced therapeutic results
Antibiotic resistance
Not specified

A 12-week study compared the effectiveness of three acne treatments: benzoyl peroxide 5%/clindamycin 1% gel alone, this combination plus adapalene gel, and adapalene gel alone. Combination therapy is the standard of care for acne, targeting different aspects of the condition. While benzoyl peroxide/clindamycin has shown better results than either ingredient alone, adding adapalene may further improve outcomes. This study investigated the safety and effectiveness of these treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English