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Reduced oral itraconazole bioavailability by antacid suspension.

Author: LohitnavyM, LohitnavyO, SrichaiW, ThangkeattiyanonO

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Taking antacids with itraconazole reduced the rate and extent of itraconazole absorption by 75%. This is likely due to the antacids changing the pH of the stomach. Therefore, it is best to avoid taking antacids with itraconazole.
Paper Details　
Original Abstract of the Article :
AIMS: To investigate the effects of antacid suspension on oral absorption of itraconazole. METHODS: A randomized, open-labelled, two-period, crossover study with a 1-week washout period was conducted in 12 healthy Thai male volunteers. The participants were allocated in either treatment A or B in t...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2710.2005.00632.x

データ提供：米国国立医学図書館（NLM）

Impact of Antacids on Itraconazole Bioavailability: A Crossover Study

The world of pharmaceuticals is a complex one, with interactions between drugs a constant consideration. This study investigates the impact of antacids, commonly used to alleviate heartburn and indigestion, on the bioavailability of itraconazole, an antifungal medication. Using a randomized, crossover study design, the researchers explored the effects of co-administering itraconazole with antacid suspension on its absorption into the bloodstream. The findings offer valuable insights into the potential consequences of combining these two medications.

Reduced Itraconazole Absorption: A Crucial Finding

The study revealed a significant reduction in the rate and extent of itraconazole absorption when co-administered with antacid suspension. This means that the antifungal medication may not reach its target in the body effectively, potentially compromising its therapeutic efficacy. The study measured key pharmacokinetic parameters, such as time to reach maximal concentration (Tmax), maximal concentration (Cmax), and area under the curve (AUC0-infinity), all of which were significantly lower in the antacid-treated group compared to the group that received itraconazole alone.

Navigating Drug Interactions: A Wise Approach

These findings highlight the importance of careful consideration when combining medications. Patients should discuss any potential drug interactions with their healthcare providers. It is crucial to be aware of the potential for reduced drug efficacy and to consult with a healthcare professional before making any changes to medication regimens.

Dr.Camel's Conclusion

This study is a reminder that the world of pharmaceuticals is like a delicate ecosystem, where the interplay between different substances can have significant consequences. As wise camels, we must carefully consider the potential interactions of our medications and consult with our trusted oasis of knowledge, our healthcare providers, to ensure optimal health and well-being.

Date :
  1. Date Completed 2005-08-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15896236

DOI: Digital Object Identifier

10.1111/j.1365-2710.2005.00632.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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