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Nizatidine for the treatment of pediatric gastroesophageal reflux symptoms: an open-label, multiple-dose, randomized, multicenter clinical trial in 210 children.

Author: GremseDavid A, KlingDouglas F, OrensteinSusan R, PantaleonCarmela D, RotenbergKeith S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This large study supports the tolerability and effectiveness of nizatidine in children aged 5 days through 18 years with GERD. Approximately 30% of patients became asymptomatic after 8 weeks of treatment, regardless of dosing or formulation, with an overall improvement in symptoms and a decrease in antacid use.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Gastroesophageal reflux disease (GERD), which is reflux that produces damage or troubling symptoms, afflicts approximately 7% of infants and children to the extent that administration of physician-directed pharmacotherapy is warranted. OBJECTIVE: This study was designed in conjunction w...See full text at original site
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引用元：
https://doi.org/10.1016/j.clinthera.2005.04.008

データ提供：米国国立医学図書館（NLM）

Nizatidine: A Safe and Effective Treatment for Pediatric Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD), a common ailment in infants and children, can significantly impact their well-being. This research examines the tolerability and effectiveness of nizatidine in treating pediatric GERD. The authors designed a comprehensive, open-label, randomized, multicenter clinical trial to evaluate the safety and efficacy of nizatidine in various doses and formulations.

Nizatidine: A Promising Treatment for Pediatric GERD

The results of this study demonstrate the tolerability and effectiveness of nizatidine in children aged 5 days through 18 years. The researchers observed a significant reduction in reflux symptoms and a decrease in antacid use among the participants. Importantly, the study found no significant differences in tolerability or effectiveness between various nizatidine formulations, suggesting that different forms of the drug can provide comparable relief.

Managing Pediatric GERD: A Multifaceted Approach

The findings of this study offer valuable insights for healthcare providers seeking effective treatments for pediatric GERD. Nizatidine appears to be a safe and effective option for managing symptoms and improving the quality of life for children suffering from this condition. It is essential to remember that managing GERD often requires a multifaceted approach, incorporating lifestyle modifications alongside appropriate medication.

Dr. Camel's Conclusion

As a researcher, I am continually inspired by the dedication of healthcare professionals in providing safe and effective treatments for our youngest patients. This study underscores the importance of conducting rigorous research to ensure that medications are both safe and effective for children. The findings provide a valuable resource for healthcare providers in their efforts to improve the health and well-being of children with GERD.

Date :
  1. Date Completed 2005-07-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15922820

DOI: Digital Object Identifier

10.1016/j.clinthera.2005.04.008

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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