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Tardive dyskinesia predicts prolactin response to buspirone challenge in people with schizophrenia.

Author: ConleyRobert R, KellyDeanna L, KimYoung-Hoon, LeeJung-Goo, ShimJoo-Cheol

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study evaluated prolactin response to buspirone in patients with schizophrenia, with and without tardive dyskinesia (TD). It found that patients without TD had a significantly decreased prolactin response to buspirone, suggesting a possible link between dopamine receptor sensitivity and TD.
Paper Details　
Original Abstract of the Article :
Prolactin response to buspirone was evaluated in patients with schizophrenia, with and without tardive dyskinesia (TD). Prolactin response in patients with schizophrenia without TD was significantly decreased, compared to healthy comparison subjects (F = 6.36, df = 5, p < 0.0001). Furthermore, prola...See full text at original site
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引用元：
https://doi.org/10.1176/jnp.17.2.221

データ提供：米国国立医学図書館（NLM）

Tardive Dyskinesia: A Window into Dopamine Receptor Sensitivity

The field of [neurology] seeks to understand the complex workings of the [brain] and its impact on [mental health]. This research investigates the relationship between [tardive dyskinesia] and [prolactin response] in patients with [schizophrenia]. Using a [prolactin challenge] with [buspirone], the researchers discovered that [patients with tardive dyskinesia] had a [significantly different prolactin response] compared to [patients without tardive dyskinesia]. This study sheds light on the role of [dopamine receptors] in [tardive dyskinesia] and [schizophrenia].

Unlocking the Secrets of Tardive Dyskinesia: A Deeper Understanding

The researchers concluded that [decreased dopamine receptor sensitivity] may be linked to [tardive dyskinesia]. This finding provides valuable insight into the [pathophysiology] of [tardive dyskinesia] and the potential for [future treatments] targeting [dopamine receptors].

Navigating the Sands of Mental Health: A Journey of Discovery

Imagine a traveler in the desert, seeking an oasis of understanding. This research serves as a guidepost, illuminating the complexities of [schizophrenia] and [tardive dyskinesia]. The study reveals the importance of exploring the [dopamine system] in understanding and managing these [mental health conditions].

Dr.Camel's Conclusion

This study provides a valuable insight into the relationship between [tardive dyskinesia] and [dopamine receptor sensitivity] in patients with [schizophrenia]. It encourages further research into the role of [dopamine receptors] in [neurological disorders] and the potential for developing new treatments.

Date :
  1. Date Completed 2005-06-27
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

15939977

DOI: Digital Object Identifier

10.1176/jnp.17.2.221

Related Literature

Article Analysis
・Side Effects of buspirone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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