Side Effects of buspirone: A Synthesis of Findings from 21 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of buspirone: A Synthesis of Findings from 21 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Main research findings

Buspirone is a medication used to treat anxiety disorders. Many studies have shown that buspirone can reduce anxiety symptoms. 2 shows that buspirone is nearly equivalent to diazepam in relieving symptoms of both anxiety and depression. In addition, buspirone has been shown to cause less cognitive impairment and confusion than diazepam. 13 indicates that buspirone may act as a partial agonist of the 5-HT1A receptor and exhibit antipsychotic and antiparkinsonian properties. Buspirone may also act as a dopamine D2 receptor antagonist, which could reduce the risk of extrapyramidal side effects.

Reasons for side effects

Buspirone works by enhancing the effects of the neurotransmitter serotonin. Serotonin is involved in many important functions, including mood, sleep, appetite, and sexual function. Buspirone is thought to reduce anxiety and depression by enhancing the effects of serotonin. However, if the effects of serotonin are too strong, side effects can occur.

Common side effects

Dizziness

Buspirone can cause dizziness. 2 indicates that dizziness has been reported as a side effect of buspirone.

Headache

Buspirone can cause headaches. 2 indicates that headaches have been reported as a side effect of buspirone.

Drowsiness

Buspirone can cause drowsiness. 2 indicates that drowsiness has been reported as a side effect of buspirone.

Nausea

Buspirone can cause nausea. 2 indicates that nausea has been reported as a side effect of buspirone.

Dry mouth

Buspirone can cause dry mouth. 2 indicates that dry mouth has been reported as a side effect of buspirone.

Constipation

Buspirone can cause constipation. 2 indicates that constipation has been reported as a side effect of buspirone.

Rash

Buspirone can cause rashes. 2 indicates that rashes have been reported as a side effect of buspirone.

Sexual dysfunction

Buspirone can cause sexual dysfunction. 5 indicates that buspirone can cause sexual dysfunction. In particular, buspirone may be associated with erectile dysfunction in men and decreased libido in women.

Insomnia

Buspirone can cause insomnia. 8 indicates that buspirone may worsen insomnia in rats exposed to stress.

Side effect management

Dizziness

Avoid driving or operating hazardous machinery while taking buspirone. Also, get up slowly to prevent dizziness.

Headache

If headaches are severe, consult your doctor.

Drowsiness

Avoid driving or operating hazardous machinery while taking buspirone.

Nausea

Eat small, frequent meals to reduce nausea. Consult your doctor as well.

Dry mouth

Drink plenty of water to reduce dry mouth.

Constipation

Eat a high-fiber diet to reduce constipation. Consult your doctor as well.

Rash

If your rash is severe, consult your doctor.

Sexual dysfunction

If you are concerned about sexual dysfunction, consult your doctor.

Insomnia

Consult your doctor before taking buspirone.

Comparison between studies

Common points among studies

Multiple studies have shown that buspirone reduces anxiety symptoms. 2 shows that buspirone is nearly equivalent to diazepam in relieving symptoms of both anxiety and depression. In addition, 13 indicates that buspirone may act as a partial agonist of the 5-HT1A receptor and exhibit antipsychotic and antiparkinsonian properties. Buspirone may also act as a dopamine D2 receptor antagonist, which could reduce the risk of extrapyramidal side effects.

Differences among studies

There may be differences in the effects and side effects of buspirone depending on the study. For example, 2 shows that buspirone is nearly equivalent to diazepam in relieving symptoms of both anxiety and depression, but 8 indicates that buspirone may worsen insomnia in rats exposed to stress. These differences in research findings could be explained by differences in study design or participant characteristics. Also, 5 indicates that buspirone can cause sexual dysfunction, but 11 suggests that buspirone may be less likely to cause sexual dysfunction compared to other antidepressants. These differences in research findings could be explained by differences in the dose of buspirone or the type of medications that buspirone is combined with.

Points to note about real-life applications

Buspirone is an effective medication for treating anxiety disorders, but it can cause side effects. When taking buspirone, follow your doctor's instructions and take it safely. In particular, avoid driving or operating hazardous machinery. Also, consult your doctor if you experience side effects such as drowsiness, dizziness, or nausea.

Current limitations of research

Not enough research has been conducted on buspirone. In particular, more research is needed on the long-term effects and safety of the drug. In addition, it is still not fully understood how buspirone works. Understanding the mechanism of action of buspirone could lead to the development of more effective and safe drugs.

Future directions for research

Research on the long-term effects and safety of buspirone is needed. Further research is also needed on how buspirone works. Understanding the mechanism of action of buspirone could lead to the development of more effective and safe drugs. In addition, research on the interactions of buspirone with other medications is also needed.

Conclusion

Buspirone is an effective medication for treating anxiety disorders, but it can cause side effects. When taking buspirone, follow your doctor's instructions and take it safely. There are many treatment options for anxiety disorders besides buspirone. Consult your doctor to find the best treatment for you.

Literature analysis of 21 papers
Positive Content
18
Neutral Content
1
Negative Content
2
Article Type
4
1
1
9
21
1.

The side effect profile of buspirone in comparison to active controls and placebo.

Author: NewtonR E, CastenG P, AlmsD R, BenesC O, MarunyczJ D

Less impairment in psychomotor function
Less sedative-hypnotic side effects
Dizziness
Headache
Nervousness

Buspirone (20 mg) was less sedative and less likely to cause lethargy or depression than diazepam (20 mg) or clorazepate (24 mg). Other side effects were similar to those of benzodiazepines, with nervousness, headache, and dizziness occurring more frequently with buspirone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

A double-blind comparison of buspirone and diazepam in outpatients with generalized anxiety disorder.

Author: FeighnerJ P, MeridethC H, HendricksonG A

Effective for anxiety and depression
Fewer side effects
Improved cognition

Buspirone (16.5 mg/day) was comparable to diazepam (15 mg/day) in relieving anxiety and depression symptoms. Buspirone showed greater improvement in impaired cognition and confusion compared to diazepam, with fewer and less severe side effects, such as sedation and drowsiness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Sexual side effects of serotonergic antidepressants: mediated by inhibition of serotonin on central dopamine release?

Author: BijlsmaElisabeth Y, ChanJohnny S W, OlivierBerend, VeeningJan G, MillanMark J, WaldingerMarcel D, OostingRonald S

Improved sexual function
Sexual dysfunction

Antidepressants increasing serotonin neurotransmission, like SSRIs, are more likely to cause sexual dysfunction. This can be mitigated by drugs that increase dopamine and noradrenaline signaling.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Psychosocial conditions and the efficacy of clinically available anxiolytics.

Author: HallerJózsef, HalászJózsef, MajercsikEszter

Improved anxiety treatment
Reduced anxiolytic side effects

Psychosocial factors significantly influence the efficacy of anxiolytics by affecting receptor properties and function. Further research is needed to optimize anxiolytic treatment by considering psychosocial factors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Tardive dyskinesia predicts prolactin response to buspirone challenge in people with schizophrenia.

Author: ShimJoo-Cheol, KimYoung-Hoon, KellyDeanna L, LeeJung-Goo, ConleyRobert R

Reduced TD risk

This study evaluated prolactin response to buspirone in patients with schizophrenia, with and without tardive dyskinesia (TD). It found that patients without TD had a significantly decreased prolactin response to buspirone, suggesting a possible link between dopamine receptor sensitivity and TD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Anxiolytic-like effects of carvacryl acetate, a derivative of carvacrol, in mice.

Author: PiresLúcio Fernandes, CostaLuciana Muratori, SilvaOskar Almeida, de AlmeidaAntonia Amanda Cardoso, CerqueiraGilberto Santos, de SousaDamião Pergentino, de FreitasRivelilson Mendes

Anxiolytic-like effect
No psychomotor retardation

Carvacryl acetate (CA) demonstrated anxiolytic-like effects in mice, comparable to diazepam. CA effectively increased time spent in open arms and light boxes, suggesting a reduction in anxiety. Unlike diazepam, CA did not cause psychomotor retardation. Further studies indicate that CA's anxiolytic effect is likely mediated through GABAergic agonist action.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Housing conditions and the anxiolytic efficacy of buspirone: the relationship between main and side effects.

Author: HallerJ, HalászJ, MakaraG B

Anxiolytic effect
Increased corticosterone

This study found that buspirone, a serotonergic anxiolytic, had delayed anxiolytic effects in rats. The anxiolytic effect was observed 4 hours after injection, but not 1 hour after injection, possibly due to corticosterone release. Individual housing enhanced the anxiolytic effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

The use of monoamine pharmacological agents in the treatment of sexual dysfunction: evidence in the literature.

Author: MollJennifer L, BrownCandace S

Improved sexual dysfunction
Side effects

Monoaminergic agents, such as bupropion, buspirone, and ropinirole, may be effective in treating sexual dysfunction, especially those caused by serotonergic reuptake inhibitors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Incidence of sexual side effects in refractory depression during treatment with citalopram or paroxetine.

Author: LandénMikael, HögbergPer, ThaseMichael E

Sexual dysfunction

This study highlights the underreporting of sexual dysfunction in clinical trials due to the use of non-leading questions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Vilazodone does not inhibit sexual behavior in male rats in contrast to paroxetine: A role for 5-HT1A receptors?

Author: OostingRonald S, ChanJohnny S W, OlivierBerend, BanerjeePradeep

5-HT1A receptor activation
Reduced sexual side effects

This study investigates the sexual side effects of vilazodone (VLZ), a selective serotonin reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist, compared with paroxetine (PAR). VLZ showed significantly lower sexual side effects than PAR, suggesting that activation of 5-HT1A receptors may mitigate sexual side effects associated with SSRIs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effects of fluoxetine on hippocampal rhythmic slow activity and behavioural inhibition.

Author: MunnRobert G K, McNaughtonNeil

Improved behavioural inhibition
Reduced anxiety
Side effects at higher doses

Fluoxetine, a serotonin reuptake inhibitor, reduces the frequency of hippocampal rhythmic slow activity (RSA) in rats. This study suggests that serotonergic anxiolytics share some of the central actions of GABAergic anxiolytics, but at higher doses, they have distinct side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Outcomes on the pharmacopsychometric triangle in bupropion-SR vs. buspirone augmentation of citalopram in the STAR*D trial.

Author: BechP, FavaM, TrivediM H, WisniewskiS R, RushA J

Antidepressive activity
Side effects

This study compared the effectiveness of bupropion and buspirone as augmentation treatments for major depression.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

17.

Modern indications for the use of opipramol.

Author: KrystaKrzysztof, MurawiecSławomir, WarchalaAnna, ZawadaKarolina, CubałaWiesław J, WigluszMariusz S, Jakuszkowiak-WojtenKatarzyna, KrzystanekMarek, Krupka-MatuszczykIrena

Anxiety disorder treatment
Somatoform disorder treatment
Mania

Opipramol is a pharmacological agent that does not fit the classification of antidepressants, antipsychotics and anxiolytics. It has a structure related to tricyclic antidepressants but it has a different mechanism of action. Opipramol has been regarded as an effective drug in general anxiety disorders. It may also be used as a premedication in the evening prior to surgery, and it can be used to treat somatoform disorders. The latest data from literature present also certain dangers and side effects, such as mania.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties.

Author: ZazpeArturo, ArtaizInés, InnerárityAna, Del OlmoElena, CastroElena, LabeagaLuis, PazosAngel, OrjalesAurelio

Reduced extrapyramidal side effects

Activation of 5-HT(1A) receptors counteracted tacrine-induced tremulous jaw movements in rats, suggesting a role in regulating motor functions. This effect was reversed by a selective 5-HT(1A) antagonist, highlighting the potential of 5-HT(1A) agonists for treating parkinsonian tremor.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Azapirones for generalized anxiety disorder.

Author: ChessickC A, AllenM H, ThaseMe, Batista Miralha da CunhaA B C, KapczinskiF F K, de LimaM S M L, dos Santos SouzaJ J S S

GAD treatment

Azapirones are a class of drugs that work on the 5-HT1A receptor and are used to treat generalized anxiety disorder (GAD). However, conflicting results from several studies have led to ongoing research regarding their effectiveness as a first-line treatment for GAD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Buspirone in Children and Adolescents with Anxiety: A Review and Bayesian Analysis of Abandoned Randomized Controlled Trials.

Author: StrawnJeffrey R, MillsJeffrey A, CornwallGary J, MossmanSarah A, VarneySara T, KeeshinBrooks R, CroarkinPaul E

Buspirone efficacy
Anxiety treatment

This article discusses the challenges of conducting clinical trials for mood and anxiety disorders in children and adolescents. It also proposes a new approach for reanalyzing data from abandoned trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Validation StudyResearch to assess the validity and reliability of new measurement methods or diagnostic tests.

Language : English

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