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Does clozapine decrease smoking?

Author: CooperThomas B, DiazFrancisco J, JosiassenRichard C, SimpsonGeorge M, de LeonJose

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Clozapine is a drug that is often used to treat schizophrenia. Studies on the effects of clozapine on smoking in patients with schizophrenia have yielded inconsistent results. This study found no significant effects of clozapine on smoking.
Paper Details　
Original Abstract of the Article :
McEvoy et al.'s study in 1999, which used cotinine levels but had limited power, suggested that clozapine treatment may be associated with a mild smoking decrease (particularly when plasma clozapine levels are > 150 ng/ml). Some naturalistic studies also suggest that clozapine treatment may be assoc...See full text at original site
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引用元：
https://doi.org/10.1016/j.pnpbp.2005.04.031

データ提供：米国国立医学図書館（NLM）

Clozapine and Smoking: Exploring a Complex Relationship

The world of psychopharmacology is a vast desert of research, where scientists seek to understand the interactions between medications and behaviors. This study delves into the relationship between clozapine, an antipsychotic medication, and smoking behavior. The researchers analyzed data from a double-blind clozapine trial involving 38 schizophrenic daily smokers. They examined whether clozapine treatment had any effect on smoking behavior, as measured by plasma cotinine levels. However, despite several different analyses, the study did not find a significant association between clozapine treatment and a decrease in smoking. This suggests that clozapine, at the doses and in the populations studied, may not have a significant effect on smoking behavior.

Clozapine and Smoking: A Complex and Uncertain Relationship

This study provides valuable data for understanding the potential effects of clozapine on smoking behavior in individuals with schizophrenia. It suggests that clozapine, at the doses and in the populations studied, may not significantly reduce smoking. This research underscores the need for further investigation to explore potential individual variations in response to clozapine and to identify factors that might influence the relationship between clozapine treatment and smoking behavior.

Navigating the Desert of Mental Health

This study emphasizes the importance of considering the complex interactions between medications and behaviors. It reminds us that the effects of medications can vary depending on individual factors and that further research is often needed to fully understand these interactions.

Dr.Camel's Conclusion

This study provides a glimpse into the desert of psychopharmacology, exploring the relationship between clozapine and smoking. It suggests that clozapine might not have a significant impact on smoking behavior in individuals with schizophrenia. This research reminds us that the interactions between medications and behaviors are complex and require further investigation to fully understand their implications.

Date :
  1. Date Completed 2005-08-26
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

15951089

DOI: Digital Object Identifier

10.1016/j.pnpbp.2005.04.031

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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