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Buserelin acetate versus expectant management in the treatment of infertility associated with minimal or mild endometriosis: a randomized clinical trial.

Author: BianchiC, BianchiS, BoccioloneL, CandianiG B, FedeleL, ParazziniF, RadiciE

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Treatment with gonadotropin-releasing hormone agonists did not significantly improve the reproductive outcome of infertile women with minimal or mild endometriosis.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: We performed a randomized clinical trial to evaluate the efficacy of intranasal 400 micrograms buserelin three times daily for 6 months versus expectant management in the treatment of infertile women with pelvic endometriosis stage I or II of the revised American Fertility Society classif...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9378(92)91602-7

データ提供：米国国立医学図書館（NLM）

Buserelin Acetate vs. Expectant Management for Minimal/Mild Endometriosis

This randomized clinical trial delves into the treatment of infertility associated with minimal or mild endometriosis. The study compares the efficacy of intranasal buserelin acetate, a gonadotropin-releasing hormone (GnRH) agonist, to expectant management in women with stage I or II endometriosis. The researchers followed 71 infertile women for a median of 18 months, assessing pregnancy rates and other outcomes. The study findings indicate that while both treatment groups achieved comparable pregnancy rates, there was no significant difference in overall pregnancy rates between the buserelin-treated group and the expectant management group.

A Closer Look at GnRH Agonists for Endometriosis

The research suggests that GnRH agonists may not significantly impact the reproductive outcomes of infertile women with minimal or mild endometriosis. While both treatment groups experienced comparable pregnancy rates, the study emphasizes the need for further research to fully understand the role of GnRH agonists in managing infertility associated with endometriosis.

Navigating the Path to Parenthood with Endometriosis

This research provides valuable insights for women facing infertility associated with endometriosis. The study highlights the importance of careful consideration of treatment options, particularly the potential benefits of GnRH agonists and the need for further research to refine treatment strategies.

Dr. Camel's Conclusion

Navigating infertility with endometriosis can be like finding a hidden oasis in a vast desert – it requires persistence and a careful understanding of the different paths. While this research suggests that GnRH agonists may not dramatically improve outcomes for those with minimal or mild endometriosis, it emphasizes the need for personalized care and continued exploration of effective treatments for infertility associated with this condition.

Date :
  1. Date Completed 1992-06-26
  2. Date Revised 2019-06-15
Further Info :

Pubmed ID

1595789

DOI: Digital Object Identifier

10.1016/0002-9378(92)91602-7

Related Literature

Article Analysis
・Effective treatment of endometriosis
SNS
PICO Info
in preparation
Languages

English

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