Effective treatment of endometriosis: A Synthesis of Findings from 136 Studies

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Original Abstract of the Article

Key Research Findings

Endometriosis is a gynecological condition where tissue similar to the lining of the uterus grows outside of the uterus. This can cause pain, infertility, and other complications. While there are various treatments available, including surgery, hormone therapy, and medication, there is no one-size-fits-all solution and research is ongoing to find more effective and safe options.

Various studies explore different treatment approaches. 77 focuses on comparing the hemostatic effects of two commonly prescribed treatments: the levonorgestrel intrauterine system (LNG-IUS) and the gonadotropin-releasing hormone analog (GnRHa) leuprolide acetate. 120 examines the effectiveness of clomiphene citrate (CC) and Letrozole (LTZ) for improving fertility in women with minimal to mild endometriosis after laparoscopic surgery.

In terms of ovarian stimulation, 105 offers insights into the potential impact of ovarian stimulation, either alone or combined with IVF or IUI, on endometriosis progression and recurrence. This review analyzed 16 studies and found that IVF doesn't worsen pain symptoms or increase the risk of recurrence, while IUI might increase the risk of recurrence. The impact of IVF on ovarian endometriomas, if any, appears minimal. However, deep invasive endometriosis might be affected by ovarian stimulation. This suggests that further research is crucial, particularly focusing on deep invasive endometriosis and the potential synergistic effects of stimulation and pregnancy.

91 delves into the current state and challenges of drug development for endometriosis. The review highlights the limitations of existing drug classes, such as cost, side effects, and short-term symptom relief.

Treatment Summary

Treatments for endometriosis vary based on the severity of the condition, patient factors, and available resources. 12 explores the use of steroidal drugs, including medroxyprogesterone acetate (MPA), danazol, and gestrinone. These drugs have shown promise in managing endometriosis, but potential androgenic effects and metabolic side effects need to be considered. 135 focuses on the perioperative use of hormonal therapy, highlighting its potential for reducing endometriosis recurrence after surgery.

94 explores the potential benefits of progesterone receptor modulators (PRMs) for endometriosis treatment. These medications, due to their antiproliferative effects on the endometrium, may contribute to disease management. investigates non-hormonal treatment options, including antiangiogenic agents, immunomodulators, and natural components. While promising results have been observed with dopamine agonists and JNK inhibitors, further research is needed to confirm their efficacy and safety.

98 compares surgical excision and ablation of endometriosis for treating chronic pelvic pain. Both methods demonstrated effectiveness in pain relief.

Benefits and Risks

Benefit Summary

Endometriosis treatments offer numerous benefits, including pain relief, reducing the risk of recurrence, and improving fertility potential.

Surgical interventions aim to eliminate or reduce the growth of endometriosis tissue, potentially improving symptoms and preventing further spread. Hormonal therapy helps control the growth of endometriosis tissue, leading to pain relief and potentially preventing recurrence. While research on alternative approaches like immunotherapy and gene therapy is ongoing, they hold promise for targeted and long-term management of endometriosis.

Risk Summary

As with any medical intervention, endometriosis treatments come with potential risks. Surgical procedures can lead to complications such as bleeding, infection, or damage to nearby organs. Hormonal therapies may cause side effects including weight gain, mood swings, and bone loss. While generally considered less risky, traditional remedies like herbal therapies may not be suitable for everyone and could interact with other medications.

Comparison of Studies

Similarities

Most studies acknowledge that endometriosis treatments, while offering potential benefits, also carry risks. They emphasize the importance of tailoring treatments to the individual patient based on their age, symptoms, and overall health. There is a general recognition that endometriosis management is complex and requires careful consideration of multiple factors.

Differences

Each study focuses on a specific treatment approach or aspect of endometriosis, using different methodologies and target populations. This diversity in research designs means that direct comparisons of findings can be challenging. Interpreting results requires considering the study's specific focus, limitations, and the context of previous research.

Consistency and Contradictions in Results

While some research findings align, inconsistencies exist within the broader body of research on endometriosis treatment. For example, 91 highlights the ongoing challenges of developing effective and safe treatments, yet 120 demonstrates the potential benefit of using clomiphene citrate (CC) and Letrozole (LTZ) to improve fertility after laparoscopic surgery. These seemingly contradictory findings underscore the complex nature of endometriosis and the need for more comprehensive studies to understand how different treatments affect various aspects of the condition.

Considerations for Real-World Application

It's crucial to recognize that no single treatment is universally effective or suitable for everyone with endometriosis. It is essential to consult with a healthcare professional to discuss individual needs, medical history, and treatment options. A personalized approach that considers both the benefits and potential risks is essential for managing this complex condition.

Limitations of Current Research

The research on endometriosis treatment still faces several limitations. For instance, understanding the root causes and mechanisms of endometriosis development remains incomplete. Additionally, larger-scale clinical trials are needed to confirm the effectiveness and safety of various treatment options, especially in the long term.

Future Research Directions

Future research should focus on unraveling the underlying causes of endometriosis and developing more targeted and effective treatment strategies. Prioritizing large-scale clinical trials will be essential to ensure the long-term safety and efficacy of potential treatments. Further research into the impact of specific treatments on different stages of endometriosis and on fertility is crucial.

Conclusion

Endometriosis can significantly impact women's health and well-being. While research on endometriosis treatment is continually progressing, there is no single cure. It is important to consult with a healthcare provider to discuss individual needs and available treatment options. Continuing research efforts are essential for developing more effective, safe, and personalized treatments for this complex condition.

Treatment Keyword List

The following keywords represent treatments and therapies discussed in the research papers: surgery, hormone therapy, medication, levonorgestrel intrauterine system (LNG-IUS), gonadotropin-releasing hormone analog (GnRHa), leuprolide acetate, clomiphene citrate (CC), Letrozole (LTZ), ovarian stimulation, IVF, IUI, steroidal drugs, medroxyprogesterone acetate (MPA), danazol, gestrinone, progesterone receptor modulators (PRMs), antiangiogenic agents, immunomodulators, natural components, dopamine agonists, JNK inhibitors, surgical excision, ablation, electrocautery, Chinese herbal medicine (CHM).

Keywords
Benefit Keywords
Treatment for endometriosis
1
Endometriosis treatment
Infertility treatment
3
Resolution of physical findings
Symptom improvement with danazol
Symptom improvement with nafarelin
4
Increased insulin and glucagon levels with danazol
No change in insulin and glucagon levels with goserelin
5
Improved pregnancy rates
6
Improved fertility
Reduced endometriosis symptoms
7
Endometriosis treatment
8
Improved intermenstrual pain
Reduced dysmenorrhea
9
Endometriosis treatment
10
Improved endometriosis
Prevents progressive disease
11
Endometriosis treatment
12
Effective endometriosis treatment
High pregnancy rate
13
Endometriosis treatment
Fertility improvement
14
Effective endometriosis treatment
Safe treatment
15
Effective endometriosis treatment
High pregnancy rate
16
Alleviated pelvic pain
Reduced endometriosis lesions
17
Endometriosis treatment
18
Endometriosis improvement
19
Endometriosis treatment
21
Improved deep dyspareunia
Improved dysmenorrhea
Improved nonmenstrual pain
Pain relief
Reduced menstrual bleeding
23
Reduced side effects of endometriosis treatment
24
Reduced dysmenorrhea
Reduced dyspareunia
Reduced endometriotic implants
Reduced pelvic pain
25
Laparoscopic surgery efficacy
Pregnancy rates
26
Improved endometriosis treatment
28
Endometriosis treatment
29
Increased pregnancy rates
30
Superior outcome
31
Safe hormonal treatment
33
Endometriosis pain relief
Estroprogestin therapy
34
Improved endometriosis treatment
35
Effective treatment
36
Improved endometriosis treatment
37
Improved endometriosis treatment
38
Delayed recurrence
39
Improved quality of life
40
Endometriosis treatment
Symptom improvement
41
Effective endometriosis treatment
42
Dyspareunia reduction
Pain reduction
43
Effective endometriosis treatment
44
Improved endometriosis symptoms
46
Pain relief
47
Endometriosis treatment
48
Endometriosis treatment
49
Acceptable side effect profile
Endometriosis treatment
50
Endometriosis treatment
51
Effective management of pain in endometriosis
52
Endometriosis treatment
Pregnancy improvement
53
Symptom relief
54
Improved endometriosis treatment
Reduced pain
55
Pain reduction
Rectovaginal endometriosis treatment
56
Improved endometriosis treatment
57
Medical treatment
58
Improved endometriosis treatment
59
Improved infertility
60
Pain relief
61
Endometriosis treatment
62
Improved fertility
Reduced endometriosis pain
Reduced relapse
63
Endometriosis treatment
64
Endometriosis treatment
65
Reduced endometriosis
Reduced pain
66
Endometriosis treatment
68
Reduced depression
Reduced pain
69
Improved endometriosis treatment
70
Endometriosis pain relief
71
Endometriosis treatment
72
Endometriosis treatment
73
Endometriosis treatment
74
Decreased pain scores
76
GnRHa for endometriosis
LNG-IUS for endometriosis
77
ART endometriosis outcomes
78
Endometriosis treatment
79
Reduce endometriosis recurrence
80
GnRH-a treatment
81
Reduced endometriosis lesions
Reduced pelvic pain
82
IVF for infertile women with endometriomas
Surgical excision of endometriomas
83
Endometriosis management
84
Endometriosis pain relief
85
Endometriosis treatment
Improved quality of life
86
Recurrence reduction
87
Endometriosis treatment
88
Endometriosis treatment
89
Pain relief
90
Improved dysmenorrhea
Improved pelvic pain
92
Reduced endometriosis pain
96
Pain relief
Reduced recurrence
97
Improved dysmenorrhea
Improved dyspareunia
98
Endometriosis treatment
99
Endometriosis pain treatment
100
Endometriosis pain treatment
101
Pain reduction
Patient satisfaction
Recurrence prevention
102
Improved endometriosis treatment
104
IVF for endometriosis
105
Fatigue reduction
106
Endometriosis treatment
107
Endometriosis pain relief
108
Improved endometriosis treatment
109
Improved endometriosis treatment
110
Pregnancy rates
111
Endometriosis treatment
IVF outcomes
112
Fertility preservation
Improved fertility outcomes
113
Endometriosis treatment
114
Improved quality of life
Pain relief
115
Endometriosis treatment
116
endometriosis IVF
quality of life
117
Endometriosis treatment
118
Exercise for endometriosis pain
119
Clomiphene for endometriosis
Letrozole for endometriosis
120
Metformin for endometriosis
121
PA and exercise for endometriosis
122
Melatonin for dysmenorrhea
123
Endometriosis treatment
124
Endometriosis treatment
125
bMBI for women with deep endometriosis
126
Improved endometriosis pain
Reduced opioid use
127
Hormonal therapeutic options for EAPP
128
Endometriosis pain relief
129
Amenorrhea
Endometrial atrophy
130
Manage endometriosis symptoms
131
Reduced pain
Reduced recurrence
132
Endometriosis treatment
133
Cyst recurrence delay
EMT symptom relief
134
Endometriosis treatment
Reduced surgical complications
Symptom relief
135
Improved sexual function
Reduced dyspareunia
136
Risk Keywords
Bleeding
Hot flushes
Spotting
3
Side effects
8
Recurrence of deep dyspareunia
Recurrence of dysmenorrhea
9
Side effects
10
Androgenic effects
12
Side effects
13
Decreased libido
Hot flashes
Lipid changes
16
Acne
Breakthrough bleeding
Weight gain
17
Side effects
18
Cholesterol change
Contraception needed
Pain recurrence
Side effects
23
Androgenic/anabolic side effects
Hypoestrogenism
25
Nafarelin ineffective for pain
Nafarelin ineffective for pregnancy
27
Endometriosis treatment
32
Endometriosis treatment
GNRHa therapy
34
Dropout rate
40
Androgenic activity
Bleeding
43
GnRH agonists expensive
Long-term GnRH agonist treatment not possible
51
Endometriosis
55
Serum lipid profile changes
Side effects
Treatment inefficacy
56
Endometriosis
57
Endometriosis
59
None specified
61
Bone loss
66
Adverse effects
71
Preliminary evidence
72
Infertility
Poor pregnancy outcomes
75
Endometriosis ART outcomes
Severe endometriosis ART outcomes
78
Endometriosis
81
Tolerable side effects
82
Diminished ovarian reserve
83
Pregnancy complications
84
Recurrence risk
Side effects
85
Mood effects
Vasomotor effects
86
Cost of treatment
Short-term effect
Side-effects
91
Decreased bone mineral density
Hot flushes
Increased serum lipids
92
ovarian reserve impact
95
Bone demineralization
97
Low data quality
100
Vaginal bleeding
102
Hypoestrogenism
103
Endometriosis progression
IUI recurrence
105
Endometriosis-associated pain
106
Ovulation suppression
107
Recurrent symptoms
108
Endometriosis complications
113
Adverse effects
114
None reported
115
GnRHa pretreatment
117
Side effects
124
Bone mineral density loss
Headache
Hot flushes
Nasopharyngitis
Suicidal ideation
127
Menopausal symptoms
131
Spotting
Weight gain
132
Bone mineral density decrease
133
None mentioned
135
Literature analysis of 136 papers
Positive Content
125
Neutral Content
7
Negative Content
4
Article Type
71
25
62
45
135
1.

Medical treatment of endometriosis: a comparative trial.

Author: NobleA D, LetchworthA T

Treatment for endometriosis

A study comparing danazol and mestranol with norethynodrel for the treatment of endometriosis found that danazol was superior. Danazol is less effective for large tumors or extensive adhesions. Hysterectomy is recommended for women with severe symptoms who have completed their families. Danazol is indicated for young women with mild or moderate endometriosis and can be used after conservative surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Buserelin acetate versus expectant management in the treatment of infertility associated with minimal or mild endometriosis: a randomized clinical trial.

Author: FedeleL, ParazziniF, RadiciE, BoccioloneL, BianchiS, BianchiC, CandianiG B

Treatment with gonadotropin-releasing hormone agonists did not significantly improve the reproductive outcome of infertile women with minimal or mild endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

A comparative treatment trial of endometriosis using the gonadotrophin-releasing hormone agonist, nafarelin, and the synthetic steroid, danazol.

Author: FraserI S, ShearmanR P, JansenR P, SutherlandP D

Endometriosis treatment
Infertility treatment
Bleeding
Hot flushes
Spotting

This study compared the effectiveness of intranasal nafarelin acetate and oral danazol in 49 patients with endometriosis. Both treatments effectively reduced endometriosis severity (60-70% reduction) and did not affect adhesions. While both drugs suppressed estrogen levels, nafarelin caused a temporary increase in estrogen initially. Nafarelin also suppressed LH and slightly lowered other hormones, while danazol slightly increased FSH and LH. Pregnancy rates were higher after nafarelin treatment (12/22) compared to danazol (6/14). Both treatments had similar rates of side effects, with hot flushes being more common with nafarelin, and bleeding being more common with danazol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Nafarelin in the treatment of pelvic pain caused by endometriosis.

Author: ShawR W

Resolution of physical findings
Symptom improvement with danazol
Symptom improvement with nafarelin

This study compared the effectiveness of nafarelin and danazol in treating endometriosis in 82 patients. Both medications resulted in significant symptom relief and improvement in physical findings in a high percentage of patients (94% and 91% respectively). While both treatments were effective in the short term, further research is needed to determine long-term outcomes, including cure rates and recurrence rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Influence of danazol and goserelin on insulin and glucagon in non-obese women with endometriosis.

Author: GollandI M, Vaughan-WilliamsC A, ShaletS M, LaingI, ElsteinM

Increased insulin and glucagon levels with danazol
No change in insulin and glucagon levels with goserelin

This study examined the effects of two treatments for endometriosis on hormone levels in 12 women: danazol and goserelin. Danazol significantly increased insulin and glucagon levels, but not testosterone levels. Goserelin did not affect any of these hormones. This suggests that the increased insulin and glucagon levels seen with danazol are not due to the increase in testosterone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Comparison of three modes of treatment for infertility patients with minimal pelvic endometriosis.

Author: ChongA P, KeeneM E, ThorntonN L

Improved pregnancy rates

A study of 167 infertile patients with minimal pelvic endometriosis found similar pregnancy rates (43-48%) with danazol, CO2 laser, or the combination of both treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

A randomized, prospective comparison of endocrine changes induced with intranasal leuprolide or danazol for treatment of endometriosis.

Author: TummonI S, PeppingM E, BinorZ, RadwanskaE, DmowskiW P

Improved fertility
Reduced endometriosis symptoms

A study comparing intranasal leuprolide and danazol for endometriosis treatment found that both drugs effectively suppressed ovulation and lowered hormone levels, with leuprolide resulting in lower estradiol and progesterone levels. While both treatments led to similar improvements in endometriosis symptoms and scores, leuprolide had a lower suppression effect on adrenal steroidogenesis. After 12 months, pregnancy rates were similar in both groups. The study suggests that leuprolide may be a viable alternative to danazol for treating endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Gestrinone versus danazol in the treatment of endometriosis.

Author: FedeleL, BianchiS, ViezzoliT, ArcainiL, CandianiG B

Endometriosis treatment
Side effects

This study compared gestrinone and danazol for treating infertility caused by endometriosis in 39 patients. Both treatments improved pain symptoms and reduced endometriosis severity, with no significant differences between the groups. After 18 months, pregnancy rates were similar, at 33% for gestrinone and 40% for danazol. While pain symptoms returned in a similar percentage of patients in both groups, side effects were more common and severe with danazol, while gestrinone primarily caused weight gain and acne. The study suggests that gestrinone is as effective as danazol for treating endometriosis-related infertility and may be better tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Comparison of cyproterone acetate and danazol in the treatment of pelvic pain associated with endometriosis.

Author: FedeleL, ArcainiL, BianchiS, BaglioniA, VercelliniP

Improved intermenstrual pain
Reduced dysmenorrhea
Recurrence of deep dyspareunia
Recurrence of dysmenorrhea

A study of 23 patients with endometriosis and pelvic pain compared cyproterone acetate plus ethinyl estradiol with danazol. Both treatments effectively reduced pain and endometriotic lesions, but dysmenorrhea and dyspareunia recurred in most patients after treatment ended.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Buserelin versus danazol in the treatment of endometriosis-associated infertility.

Author: FedeleL, BianchiS, ArcainiL, VercelliniP, CandianiG B

Endometriosis treatment
Side effects

A study of 62 infertile women with endometriosis compared oral danazol with intranasal buserelin. Both treatments were effective in reducing pain and improving fertility, but buserelin had fewer and milder side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

The medical treatment of mild endometriosis.

Author: CookeI D, ThomasE J

Improved endometriosis
Prevents progressive disease

A study of 35 patients with mild endometriosis found that gestrinone treatment was effective in preventing disease progression, but did not affect fertility.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Steroidal drugs in endometriosis.

Author: KauppilaA J, TelimaaS, RönnbergL

Endometriosis treatment
Androgenic effects

Progestins are used to treat endometriosis, and their effects are likely more due to their suppression of ovarian activity than their direct action on the endometrium. Danazol and medroxyprogesterone acetate (MPA) have similar clinical efficacy, but danazol causes more side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

[Treatment of endometriosis].

Author: KieselL, BertgesK, von HolstT R, RunnebaumB

Effective endometriosis treatment
High pregnancy rate
Side effects

A study comparing gestrinone with danazol for treating endometriosis found that both treatments were effective, with similar pregnancy rates, but gestrinone had fewer side effects. Buserelin was also effective in reducing endometriotic implants.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

14.

The importance of laparoscopic coagulation of mild endometriosis in infertile women.

Author: NowrooziK, ChaseJ S, CheckJ H, WuC H

Endometriosis treatment
Fertility improvement

This study compared the effectiveness of laparoscopic fulguration (burning) of endometriosis implants to leaving them untreated in 123 patients with mild endometriosis. After treatment, 60.8% of patients in the fulguration group achieved pregnancy within eight cycles, compared to 18.5% in the untreated group. The study emphasizes that other factors affecting fertility were addressed before treating endometriosis. This study suggests that laparoscopic fulguration can significantly improve fertility in carefully selected patients with mild endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Laparoscopic cauterization of endometriosis for fertility: a controlled study.

Author: SeilerJ C, GidwaniG, BallardL

Effective endometriosis treatment
Safe treatment

This study compared laparoscopic electrocautery (burning) to six months of danazol therapy in 90 patients with moderate endometriosis. After treatment, 44% of patients who had electrocautery conceived, compared to 39% of those who took danazol. There was no statistically significant difference between the groups. No complications were reported in the electrocautery group. The study concludes that electrocautery is a safe and effective treatment for moderate endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Administration of nasal nafarelin as compared with oral danazol for endometriosis. A multicenter double-blind comparative clinical trial.

Author: HenzlM R, CorsonS L, MoghissiK, ButtramV C, BerqvistC, JacobsonJ

Effective endometriosis treatment
High pregnancy rate
Decreased libido
Hot flashes
Lipid changes

A study of 213 patients with endometriosis compared nafarelin with danazol for treating the condition. Both treatments effectively reduced endometriosis symptoms and improved fertility, but nafarelin was associated with fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis after conservative surgery.

Author: TelimaaS, RönnbergL, KauppilaA

Alleviated pelvic pain
Reduced endometriosis lesions
Acne
Breakthrough bleeding
Weight gain

This study compared the effectiveness of danazol, medroxyprogesterone acetate (MPA), and placebo in treating 60 patients with advanced endometriosis after surgery. Both danazol and high-dose MPA significantly reduced pelvic pain compared to placebo, with no difference in effectiveness between them. Both treatments also led to smaller endometriosis lesions after 6 months. While danazol caused breakthrough bleeding, weight gain, and acne, MPA only caused breakthrough bleeding. The study concludes that post-surgical treatment with either high-dose MPA or danazol is beneficial for advanced endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

The effect of LHRH agonist therapy in the treatment of endometriosis (English experience).

Author: JelleyR Y, MagillP J

Endometriosis treatment
Side effects

This study compared the effectiveness of buserelin and danazol in treating 45 patients with endometriosis. Both treatments were effective in reducing the severity of endometriosis, with similar improvements in the size and number of lesions. However, side effects were more common with danazol. The study concludes that both treatments are promising for endometriosis, but further research is needed to evaluate long-term outcomes and side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Impact of gestrinone on the course of asymptomatic endometriosis.

Author: ThomasE J, CookeI D

Endometriosis improvement

This study investigated the effectiveness of gestrinone, a new drug, in treating endometriosis. The study found that gestrinone significantly prevented the worsening of endometriosis compared to placebo. While there was no statistically significant difference in the complete elimination of endometriosis, gestrinone was significantly better at improving the condition overall. The study concludes that gestrinone is an effective treatment for endometriosis and suggests that treatment is warranted for all patients, as at least 23% experience disease progression without treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Successful treatment of asymptomatic endometriosis: does it benefit infertile women?

Author: ThomasE J, CookeI D

A study of patients with asymptomatic endometriosis did not find evidence that treating endometriosis with gestrinone improved future fertility rates compared to patients with unexplained infertility.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

A comparative study of various dosages of danazol in the treatment of endometriosis.

Author: LowR A, RobertsA D, LeesD A

Endometriosis treatment

A randomized trial indicated that danazol, a medication used to treat endometriosis, is effective in mild endometriosis at a dosage of 200 mg/day. Higher doses are required for more extensive disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

The effectivenss of danazol on subsequent fertility in minimal endometriosis.

Author: SeibelM M, BergerM J, WeinsteinF G, TaymorM L

This study compared the effectiveness of danazol (a medication) versus no treatment for 65 women with minimal endometriosis. After surgery (laparoscopy, D&C, tubal lavage), 30% of the danazol-treated group conceived within 6 months, compared to 50% of the untreated group. This suggests that women with minimal endometriosis may be able to conceive naturally after surgery, especially older women for whom delaying treatment could significantly impact their fertility.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Very low dose danazol for relief of endometriosis-associated pelvic pain: a pilot study.

Author: VercelliniP, TrespidiL, PanazzaS, BramanteT, MauroF, CrosignaniP G

Improved deep dyspareunia
Improved dysmenorrhea
Improved nonmenstrual pain
Pain relief
Reduced menstrual bleeding
Cholesterol change
Contraception needed
Pain recurrence
Side effects

Very low dose danazol may be an effective alternative for temporary relief of endometriosis-associated pain.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Gonadotropin-releasing hormone analogue (goserelin) plus hormone replacement therapy for the treatment of endometriosis: a randomized controlled trial.

Author: HowellR, EdmondsD K, DowsettM, CrookD, LeesB, StevensonJ C

Reduced side effects of endometriosis treatment

This study aimed to determine if combining GnRH agonist (goserelin) treatment for endometriosis with continuous estrogen and progestogen hormone replacement therapy (HRT) could prevent the side effects of low estrogen, such as bone loss, while still effectively treating endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

A randomized, comparative trial of triptorelin depot (D-Trp6-LHRH) and danazol in the treatment of endometriosis.

Author: CirkelU, OchsH, SchneiderH P

Reduced dysmenorrhea
Reduced dyspareunia
Reduced endometriotic implants
Reduced pelvic pain
Androgenic/anabolic side effects
Hypoestrogenism

Triptorelin and danazol were equally effective in treating endometriosis, reducing endometriotic implants and symptoms. Triptorelin showed more effective estradiol suppression, while danazol increased the free androgenic index.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Surgical treatment of endometriosis-associated infertility: meta-analysis compared with survival analysis.

Author: AdamsonG D, PastaD J

Laparoscopic surgery efficacy
Pregnancy rates

Surgery was superior to medical treatment for minimal and mild endometriosis associated with infertility. For moderate and severe disease, surgery is usually used, with laparoscopy achieving results equivalent to laparotomy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

27.

Postsurgical medical treatment of advanced endometriosis: results of a randomized clinical trial.

Author: ParazziniF, FedeleL, BusaccaM, FalsettiL, PellegriniS, VenturiniP L, StellaM

Nafarelin ineffective for pain
Nafarelin ineffective for pregnancy

Nafarelin did not significantly improve pelvic pain or short-term reproductive prognosis in women with advanced endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

[Medical treatment of endometriosis: comparative study of leuprolide acetate and danazol].

Author: PalagianoA, CapuanoV

Improved endometriosis treatment

A study of 50 women with endometriosis compared the effects of treatment with danazol or leuprolide. Both drugs resulted in a decrease in clinical symptoms, but also caused side effects. After six months of treatment, 42 women underwent a second laparoscopy to assess treatment effects. The study provides no specific results on the efficacy of each drug in reducing endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

29.

Estrogenic suppression by different administration schedules of goserelin depot for treatment of endometriosis.

Author: MaginiA, PellegriniS, TavellaK, FortiG, MassiG B, SerioM

Endometriosis treatment

This study of 18 women with endometriosis found that different schedules of gonadotropin-releasing hormone agonist (GnRH-a) (goserelin depot formulation) administration were similarly effective in reducing the extent of endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

Efficacy of isotopic 13CO2 laser laparoscopic evaporation in the treatment of infertile patients with minimal and mild endometriosis: a life table cumulative pregnancy rates study.

Author: ChangF H, ChouH H, SoongY K, ChangM Y, LeeC L, LaiY M

Increased pregnancy rates

CO2 laser laparoscopy was more effective than other treatment modalities in treating infertile women with minimal to mild endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis.

Author: TummonI S, AsherL J, MartinJ S, TulandiT

Superior outcome

Superovulation and intrauterine insemination (IUI) resulted in significantly higher live birth rates (11%) compared to no treatment (2%) in couples with minimal or mild endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Gruppo Italiano per lo Studio dell'Endometriosi.

Author: ParazziniF

Endometriosis treatment

This study compared the effectiveness of surgically removing or ablating minimal/mild endometriosis to a control group that only had diagnostic laparoscopy in women with unexplained infertility. The study found no significant difference in fertility rates between the two groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Comparison of transdermal estradiol and tibolone for the treatment of oophorectomized women with deep residual endometriosis.

Author: FedeleL, BianchiS, RaffaelliR, ZanconatoG

Safe hormonal treatment

Tibolone may be a safe hormonal treatment for post-menopausal women with residual endometriosis, potentially offering fewer side effects compared to HRT with transdermal estradiol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Estroprogestin vs. gonadotrophin agonists plus estroprogestin in the treatment of endometriosis-related pelvic pain: a randomized trial. Gruppo Italiano per lo Studio dell'Endometriosi.

Author: ParazziniF, Di CintioE, ChatenoudL, MoroniS, ArdovinoI, StruzzieroE, FalsettiL, BianchiA, BraccoG, PellegriniA, BertulessiC, RomaniniC, ZupiE, MassobrioM, GuidettiD, TroianoL, BerettaP, FranchiM

Endometriosis pain relief
Estroprogestin therapy
Endometriosis treatment
GNRHa therapy

After 12 months of treatment, both estroprogestin (E/P) pills for 12 months and gonadotrophin releasing hormone agonist (GNRHa) followed by E/P pills for 8 months showed similar relief of pelvic pain in women with endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

35.

Danazol for pelvic pain associated with endometriosis.

Author: SelakV, FarquharC, PrenticeA, SinglaA

Improved endometriosis treatment

Endometriosis is a condition where tissue similar to the uterine lining grows outside the uterus, causing pain and other problems. Treatments aim to remove or reduce these growths. Since high levels of male hormones can shrink the uterine lining, medications like danazol, which create a low estrogen, high androgen environment (similar to menopause), have been used to treat endometriosis. Danazol's effectiveness stems from its ability to shrink these growths and improve painful symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Gonadotrophin-releasing hormone analogues for pain associated with endometriosis.

Author: PrenticeA, DearyA J, Goldbeck-WoodS, FarquharC, SmithS K

Effective treatment

Endometriosis, a common condition that causes pain, occurs when endometrial tissue grows outside the uterus. Since endometriosis is less common in postmenopausal women with low estrogen levels, GnRH analogues (GnRHAs) are used to create a temporary, artificial menopause, reducing estrogen levels and potentially alleviating symptoms. GnRHAs work by constantly suppressing the pituitary gland, which normally responds to natural pulses of GnRH, leading to a decrease in female hormones.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Modern combined oral contraceptives for pain associated with endometriosis.

Author: MooreJ, KennedyS, PrenticeA

Improved endometriosis treatment

Endometriosis is a common condition that affects millions of women worldwide, causing pain and infertility. It occurs when tissue similar to the uterine lining grows outside the uterus. Treatment aims to remove or shrink these growths through surgery or hormone therapy. Hormonal treatment can have side effects and may not be suitable for long-term use. However, studies suggest that taking combined birth control pills may reduce the risk of developing endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Progestagens and anti-progestagens for pain associated with endometriosis.

Author: PrenticeA, DearyA J, BlandE

Improved endometriosis treatment

Endometriosis is a condition that can cause pain and/or infertility. Since symptoms often improve during pregnancy, treatments that mimic pregnancy have been developed. Early treatments used a combination of estrogen and progesterone, but this was later replaced with progesterone alone. More recently, research is exploring the use of both progesterone and anti-progesterone medications to treat endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Postoperative administration of monophasic combined oral contraceptives after laparoscopic treatment of ovarian endometriomas: a prospective, randomized trial.

Author: MuziiL, MaranaR, CaruanaP, CatalanoG F, MarguttiF, PaniciP B

Delayed recurrence

Postoperative administration of low-dose cyclic oral contraceptives did not significantly affect the long-term recurrence rate of endometriosis after surgical treatment. However, a delay in recurrence was observed at life-table analysis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Changes in quality of life after hormonal treatment of endometriosis.

Author: BergqvistA, TheorellT

Improved quality of life
Dropout rate

Hormonal treatment with nafarelin or medroxyprogesterone acetate was found to significantly improve sleep disturbances and anxiety-depression in women with endometriosis. However, anxiety-depression scores increased during the nafarelin treatment period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis.

Author: RegidorP A, RegidorM, SchmidtM, RuweB, LübbenG, FörtigP, KienleE, SchindlerA E

Endometriosis treatment
Symptom improvement

This study compared the effectiveness of leuprorelin acetate depot (LAD), a GnRH agonist, and lynestrenol (LYN), a progestin, in treating severe endometriosis in 48 women. Both treatments significantly reduced the severity of endometriosis, but LAD was more effective than LYN in reducing symptoms and lowering estrogen levels. While both treatments were well-tolerated, the study recommends GnRH agonists as the first-line treatment for endometriosis, with progestins potentially used for long-term management after GnRH treatment is completed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

42.

[Decapeptyl (triptorelin) in the treatment of endometriosis genitalis externa].

Author: PalatyńskiA, GruszczyńskaJ

Effective endometriosis treatment

This study compared three treatments for endometriosis: 1) thermocoagulation (heat treatment), 2) triptorelin (medication), and 3) a combination of thermocoagulation and triptorelin. The combination treatment appeared to be the most effective.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Polish

43.

[Treatment of endometriosis with dienogest: preliminary report].

Author: KamińskiK, FieglerP, MarrJ, MooreC

Dyspareunia reduction
Pain reduction
Androgenic activity
Bleeding

Both dienogest and leuprolein acetate effectively decreased pelvic pain and dyspareunia in women with endometriosis. Dienogest did not show androgenic activity and did not cause hot flashes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Polish

44.

[Comparison of the efficacy of treatment by two laparoscopic techniques combined with medical treatment of endometriosis stage three and four].

Author: JakielG, Przytuła-PiłatM, MroczkowskiA, WieczorekP, BakalczukG

Effective endometriosis treatment

This study compared two laparoscopic surgical techniques for treating endometriosis: marsupialization (opening and draining) of cysts and coagulation, and stripping the lining of the uterus. Both techniques were effective in reducing symptoms, and there was no significant difference in their effectiveness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Polish

45.

Post-operative GnRH analogue treatment after conservative surgery for symptomatic endometriosis stage III-IV: a randomized controlled trial.

Author: BusaccaM, SomiglianaE, BianchiS, De MarinisS, CaliaC, CandianiM, VignaliM

A 3 month course of GnRH analogue does not support routine post-operative use in women with symptomatic endometriosis stage III-IV.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

46.

Danazol for pelvic pain associated with endometriosis.

Author: SelakV, FarquharC, PrenticeA, SinglaA

Improved endometriosis symptoms

Endometriosis is a condition where tissue similar to the uterine lining grows outside the uterus, causing pain and other problems. Treatments aim to remove or reduce these growths through surgery or hormone therapy. Since high levels of male hormones can shrink the uterine lining, medications like danazol, which create a low estrogen, high androgen environment (similar to menopause), have been used to treat endometriosis. Danazol's effectiveness stems from its ability to shrink these growths and improve painful symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Laparoscopic surgery for pelvic pain associated with endometriosis.

Author: JacobsonT Z, BarlowD H, GarryR, KoninckxP

Pain relief

Laparoscopic laser ablation, adhesiolysis and uterine nerve ablation is likely to be a beneficial treatment for pelvic pain associated with minimal, mild and moderate endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Laparoscopic surgery for subfertility associated with endometriosis.

Author: JacobsonT Z, BarlowD H, KoninckxP R, OliveD, FarquharC

Endometriosis treatment

Endometriosis occurs when tissue similar to the uterine lining grows outside the uterus. The appearance of endometriosis during surgery doesn’t always match the symptoms, making treatment challenging. Surgery for endometriosis aims to remove the abnormal tissue and restore normal anatomy by separating adhesions (scar tissue).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Depot leuprorelin acetate versus danazol in the treatment of infertile women with symptomatic endometriosis.

Author: RotondiM, LabriolaD, AmmaturoF P, AmatoG, CarellaC, IzzoA, PanarielloS

Endometriosis treatment

This study compares the effectiveness and safety of two hormonal medications, leuprorelin acetate depot and danazol, in treating endometriosis in women with infertility. The study aimed to determine which treatment might be more beneficial for these patients, as endometriosis is a common cause of infertility and hormonal therapies are often used to manage the condition.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

50.

[GnRH agonist and add back therapy--indications, results and problems in the treatment of genital endometriosis].

Author: MettlerL

Acceptable side effect profile
Endometriosis treatment

This study investigated the use of GnRH agonist therapy with hormone replacement (add-back) therapy for treating genital endometriosis, particularly for chronic pain. While the effectiveness for pain relief was not better than other options, side effects were acceptable. The unwanted side effects of GnRH agonists were reversible and minimized with the use of add-back therapy. A combination of leuprolide acetate depot and tibolone for 3-6 months, or leuprolide acetate depot with norethindrone acetate from the start of treatment, showed significant pain reduction with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

52.

Pre and post operative medical therapy for endometriosis surgery.

Author: YapC, FurnessS, FarquharC

Effective management of pain in endometriosis

Endometriosis affects about 10% of women of reproductive age, causing pain and infertility. The condition is diagnosed by looking at the tissue directly during surgery. Surgery can involve removing or destroying the abnormal tissue, separating scar tissue, and removing cysts. Surgery has been shown to be effective for mild to moderate pain from endometriosis. Additional medication before or after surgery can help prevent symptoms from returning.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

[Influence of GnRH analogue on the intensification of endometriosis symptoms and infertility treatment].

Author: SkrzypulecVioletta, WalaszekAneta, DrosdzolAgnieszka, NowosielskiKrzysztof, PielaBogusława, Rozmus-WarcholińskaWioletta

Endometriosis treatment
Pregnancy improvement

The study evaluated the influence of the treatment with oral doses of 50 mg GnRH analogue on the intensification of endometriosis symptoms and infertility amongst women with evident symptoms of endometriosis in comparison with placebo group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Polish

54.

A randomized trial of excision versus ablation for mild endometriosis.

Author: WrightJeremy, LotfallahHany, JonesKevin, LovellDavid

Symptom relief

Both excisional and ablative treatment modalities for mild endometriosis produced good symptomatic relief and reduction of pelvic tenderness.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

55.

Non-steroidal anti-inflammatory drugs for pain in women with endometriosis.

Author: AllenC, HopewellS, PrenticeA

Improved endometriosis treatment
Reduced pain
Endometriosis

Endometriosis is a common condition that can cause painful symptoms and infertility in women. It significantly affects quality of life, impacting work, daily activities, relationships, and fertility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common initial treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

56.

Treatment of symptomatic rectovaginal endometriosis with an estrogen-progestogen combination versus low-dose norethindrone acetate.

Author: VercelliniPaolo, PietropaoloGiuliana, De GiorgiOlga, PasinRoberta, ChiodiniAnnalisa, CrosignaniPier Giorgio

Pain reduction
Rectovaginal endometriosis treatment
Serum lipid profile changes
Side effects
Treatment inefficacy

Low-dose norethindrone acetate could be considered an effective, tolerable, and inexpensive first-choice medical alternative to repeat surgery for treating symptomatic rectovaginal endometriotic lesions in patients who do not seek conception. 62% of patients in the ethinyl E2 plus cyproterone acetate group and 73% of patients in the norethindrone acetate group were satisfied with the treatment received.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

57.

Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery.

Author: Abou-SettaA M, Al-InanyH G, FarquharC M

Improved endometriosis treatment
Endometriosis

Endometriosis is treated with options like hormone therapy, surgery, or a combination. Surgery aims to remove visible endometriosis and restore normal anatomy. Medication aims to suppress estrogen production and slow the growth of endometriosis. A hormonal intrauterine device (IUD) using levonorgestrel (LNG-IUS) has been proposed for treatment after surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

WITHDRAWN: Gonadotrophin-releasing hormone analogues for pain associated with endometriosis.

Author: PrenticeA, DearyA J, Goldbeck-WoodS, FarquharC, SmithS K

Medical treatment

Endometriosis, a common condition causing pain, occurs when uterine-like tissue grows outside the uterus. Because endometriosis is less common in postmenopausal women with low estrogen levels, GnRH analogues (GnRHAs) are used to create a temporary, artificial menopause, reducing estrogen levels and potentially alleviating symptoms. GnRHAs work by constantly suppressing the pituitary gland, which normally responds to natural pulses of GnRH, leading to a decrease in female hormones.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Danazol for pelvic pain associated with endometriosis.

Author: SelakV, FarquharC, PrenticeA, SinglaA

Improved endometriosis treatment
Endometriosis

Endometriosis is a condition where tissue similar to the lining of the uterus grows outside the uterus. Treatments aim to remove or reduce this tissue. Danazol is a medication that works by creating a state similar to menopause, reducing estrogen and increasing androgen levels, which can shrink the endometriosis tissue and improve symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial.

Author: CreusMontserrat, FábreguesFrancisco, CarmonaFrancisco, del PinoMarta, ManauDolors, BalaschJuan

Improved infertility

This study investigates the effectiveness of combining laparoscopic surgery with pentoxifylline, a medication that modulates the immune system, in treating infertility caused by mild to moderate endometriosis. The study aims to determine if this combined approach is more beneficial than surgery alone in helping women with endometriosis conceive.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

61.

Implanon versus medroxyprogesterone acetate: effects on pain scores in patients with symptomatic endometriosis--a pilot study.

Author: WalchKatharina, UnfriedGertrud, HuberJohannes, KurzChristine, van TrotsenburgMichael, PernickaElisabeth, WenzlRené

Pain relief
None specified

Concerning pain relief, the therapeutic efficacy of the contraceptive implant Implanon is not inferior to that of DMPA in symptomatic endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

62.

Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis.

Author: AllenClaire, HopewellSally, PrenticeAndrew, GregoryDaisy

Endometriosis treatment

Endometriosis is a common condition that can cause painful symptoms and infertility in women. It significantly affects quality of life, impacting work, daily activities, relationships, and fertility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common initial treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

Chinese herbal medicine for endometriosis.

Author: FlowerAndrew, LiuJian Ping, ChenSisi, LewithGeorge, LittlePaul

Improved fertility
Reduced endometriosis pain
Reduced relapse

This article discusses the routine use of Chinese herbal medicine (CHM) in China for the treatment of endometriosis, and reviews research on its role in alleviating pain, promoting fertility, and preventing relapse.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

64.

Laparoscopic surgery for pelvic pain associated with endometriosis.

Author: JacobsonTal Z, DuffyJames M N, BarlowDavid, KoninckxPhilippe R, GarryRay

Endometriosis treatment

Endometriosis is a condition where tissue similar to the lining of the uterus grows outside the uterus. The appearance of endometriosis during surgery and the symptoms it causes don't always match. Surgery aims to remove visible endometriosis, restore normal anatomy, and relieve pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Laparoscopic surgery for subfertility associated with endometriosis.

Author: JacobsonTal Z, DuffyJames Mn, BarlowDavid, FarquharCindy, KoninckxPhilippe R, OliveDavid

Endometriosis treatment

Endometriosis is a condition where tissue similar to the lining of the uterus grows outside the uterus. The appearance of endometriosis during surgery and the symptoms it causes don't always match. Surgery aims to remove visible endometriosis and restore normal anatomy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

[Treatment of endometriosis by aromatase inhibitors: efficacy and side effects].

Author: RacineA-C, LegrandE, Lefebvre-LacoeuilleC, HoppeE, CatalaL, SentilhesL, DescampsP

Reduced endometriosis
Reduced pain
Bone loss

This systematic review studied the efficacy of aromatase inhibitors for the treatment of endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : French

67.

A comparison of the effect of short-term aromatase inhibitor (letrozole) and GnRH agonist (triptorelin) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis.

Author: AlborziSaeed, HamediBahareh, OmidvarAzizeh, DehbashiSedigheh, AlborziSoroosh, AlborziMehrnoosh

Letrozole, a aromatase inhibitor, and triptorelin, a GnRH agonist, showed comparable pregnancy rates and endometriosis recurrence rates compared to a control group.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

68.

Use of oral contraceptives in women with endometriosis before assisted reproduction treatment improves outcomes.

Author: de ZieglerDominique, GayetVanessa, AubriotFrançois Xavier, FauquePatricia, StreuliIsabelle, WolfJean Philippe, de MouzonJacques, ChapronCharles

Endometriosis treatment

This study found that taking oral contraceptives (OCs) for 6-8 weeks before assisted reproduction treatment (ART) in women with endometriosis, including those with cysts, resulted in similar outcomes to those without endometriosis. However, ART outcomes were significantly worse for women with endometriosis who did not take OCs beforehand. This pre-treatment with OCs did not affect the ovaries' response to stimulation, even in women who had difficulty responding to stimulation (poor responders).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

69.

Randomized trial of leuprolide versus continuous oral contraceptives in the treatment of endometriosis-associated pelvic pain.

Author: GuzickDavid S, HuangLi-Shan, BroadmanBetsy A, NealonMaureen, HornsteinMark D

Reduced depression
Reduced pain

Leuprolide and continuous oral contraceptives showed similar effectiveness in treating endometriosis-associated pelvic pain, with statistically significant declines in pain scores and depression scores in both groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

70.

Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial.

Author: FerreroSimone, VenturiniPier L, GillottDavid J, RemorgidaValentino

Improved endometriosis treatment

This study compared the effectiveness and tolerability of letrozole combined with either norethisterone acetate or triptorelin in treating pain symptoms in premenopausal women with endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

71.

Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review.

Author: FerreroSimone, GillottDavid J, VenturiniPier L, RemorgidaValentino

Endometriosis pain relief
Adverse effects

Aromatase inhibitors (AIs) are effective in reducing pain symptoms and improving quality of life in patients with endometriosis, but further research is needed on long-term effects and comparison to other therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

A feasibility study exploring the role of Chinese herbal medicine in the treatment of endometriosis.

Author: FlowerAndrew, LewithGeorge T, LittlePaul

Endometriosis treatment
Preliminary evidence

Endometriosis is a common condition affecting women of childbearing age. This review explores the potential of Chinese herbal medicine (CHM) as a treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

73.

Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery.

Author: Abou-SettaAhmed M, HoustonBrett, Al-InanyHesham G, FarquharCindy

Endometriosis treatment

Endometriosis can be treated with surgery, medications (like those that suppress ovarian hormones), or a combination of these. Surgery aims to remove visible endometriosis tissue, while medication aims to slow the growth of endometriosis by reducing estrogen levels. A hormone-releasing intrauterine device (IUD) containing levonorgestrel (LNG-IUD) is also a potential treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

Anti-TNF-α treatment for pelvic pain associated with endometriosis.

Author: LuDonghao, SongHuan, ShiGang

Endometriosis treatment

Endometriosis is a painful condition that can affect women during their reproductive years. This review will discuss the role of inflammation in the development of endometriosis and explore alternative treatments that focus on modulating inflammation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis.

Author: HarbH M, GallosI D, ChuJ, HarbM, CoomarasamyA

Infertility
Poor pregnancy outcomes

Severe endometriosis (stage III/IV) is associated with poor implantation and clinical pregnancy rates in women undergoing IVF treatment. Women with stage I/II endometriosis have reduced fertilization rates compared to women without endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

Comparison of the hemostatic effects of a levonorgestrel-releasing intrauterine system and leuprolide acetate in women with endometriosis: a randomized clinical trial.

Author: YamagutiErciliene M M, BritoMilena B, FerrianiRui A, GarciaAndréa A, Rosa-e-SilvaJúlio C, VieiraCarolina S

GnRHa for endometriosis
LNG-IUS for endometriosis

This study compared the hemostatic effects of two common treatments for endometriosis: the levonorgestrel intrauterine system (LNG-IUS) and the gonadotropin-releasing hormone analog (GnRHa) leuprolide acetate.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

78.

Influence of endometriosis on assisted reproductive technology outcomes: a systematic review and meta-analysis.

Author: HamdanMukhri, OmarSiti Z, DunselmanGerard, CheongYing

ART endometriosis outcomes
Endometriosis ART outcomes
Severe endometriosis ART outcomes

This study found that women with endometriosis have similar live birth rates as women without endometriosis when undergoing assisted reproductive technology (ART). However, women with more severe endometriosis have inferior outcomes in terms of live birth rates, clinical pregnancy rates, and the mean number of oocytes retrieved. There is insufficient evidence to recommend surgery routinely before undergoing ART.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

80.

Continuous versus cyclic oral contraceptives for the treatment of endometriosis: a systematic review.

Author: ZorbasKonstantinos A, EconomopoulosKonstantinos P, VlahosNikos F

Reduce endometriosis recurrence

Endometriosis recurrence after conservative surgery is common. This review examines the use of oral contraceptives (oCPs) in continuous versus cyclic regimens following conservative surgery for endometriosis, evaluating their efficacy and patient compliance.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

Initiation of GnRH agonist treatment on 3-5 days postoperatively in endometriosis patients: a randomized controlled trial.

Author: GongLili, ZhangShaofen, HanYi, LongQiqi, ZouShien, CaoYuankui

GnRH-a treatment
Endometriosis

This study compares the effectiveness of starting gonadotropin-releasing hormone agonist (GnRH-a) treatment 3-5 days after surgery versus starting on days 1-5 of menstruation in women with stage III or IV endometriosis. The research focuses on minimizing uterine bleeding, a common side effect of GnRH-a treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

82.

Dienogest in the treatment of endometriosis: systematic review.

Author: AndresMarina de Paula, LopesLivia Alves, BaracatEdmund Chada, PodgaecSergio

Reduced endometriosis lesions
Reduced pelvic pain
Tolerable side effects

Dienogest 2 mg/day was superior to placebo in reducing pelvic pain and was effective in reducing endometriotic lesions. It should be considered as an alternative for controlling symptoms related to endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

83.

An Update on Surgical versus Expectant Management of Ovarian Endometriomas in Infertile Women.

Author: KeyhanSanaz, HughesClaude, PriceThomas, MuasherSuheil

IVF for infertile women with endometriomas
Surgical excision of endometriomas
Diminished ovarian reserve

This research examines the treatment of ovarian endometriomas in infertile women, particularly before using assisted reproductive technologies. The study explores the potential benefits and risks of surgical excision versus expectant management, considering factors like patient symptoms, age, ovarian reserve, and prior treatments. The review suggests that certain patient profiles may benefit from proceeding directly to in vitro fertilization (IVF).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

84.

A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes.

Author: Leone Roberti MaggioreUmberto, FerreroSimone, MangiliGiorgia, BergaminiAlice, InversettiAnnalisa, GiorgioneVeronica, ViganòPaola, CandianiMassimo

Endometriosis management
Pregnancy complications

Pregnancy was traditionally believed to have a positive impact on endometriosis. However, recent research suggests that endometriosis can affect pregnancy outcomes, and pregnancy itself can impact endometriosis. This article examines the challenges of diagnosing endometriosis during pregnancy, the potential complications of pregnancy related to endometriosis, and the effects of endometriosis on pregnancy outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Evaluation of endometriosis-associated pain and influence of conventional treatment: a systematic review.

Author: MarquiAlessandra Bernadete Trovó de

Endometriosis pain relief
Recurrence risk
Side effects

Endometriosis is a common and painful condition that affects women's quality of life. While both surgery and medication can reduce pain, they have drawbacks like the risk of the condition returning and side effects. This review examines the use of these treatments, highlighting the challenges of managing endometriosis and the potential benefits of improved quality of life with treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

86.

The Effects of Gonadotropin-Releasing Hormone Agonist Combined with Add-Back Therapy on Quality of Life for Adolescents with Endometriosis: A Randomized Controlled Trial.

Author: Sadler GallagherJenny, FeldmanHenry A, StokesNatalie A, LauferMarc R, HornsteinMark D, GordonCatherine M, DiVastaAmy D

Endometriosis treatment
Improved quality of life
Mood effects
Vasomotor effects

This study examines the impact of gonadotropin-releasing hormone agonists (GnRHa) on quality of life (QOL) in female adolescents with endometriosis, comparing an add-back regimen of norethindrone acetate (NA) with conjugated estrogens (CEE) to NA alone for preventing side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

87.

A systematic review of ultrasonography-guided transvaginal aspiration of recurrent ovarian endometrioma.

Author: GonçalvesFernanda C, AndresMarina P, PassmanLeigh J, GonçalvesManoel O C, PodgaecSergio

Recurrence reduction

Repeated ultrasonography-guided aspiration of ovarian endometriomas can be performed for the treatment of recurrent ovarian endometriosis. Ovarian endometriosis is associated with high recurrence rates after one aspiration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

88.

When love hurts. A systematic review on the effects of surgical and pharmacological treatments for endometriosis on female sexual functioning.

Author: BarbaraGiussy, FacchinFederica, MeschiaMichele, BerlandaNicola, FrattaruoloMaria P, VercellinIPaolo

Endometriosis treatment

Endometriosis, a condition where tissue similar to the uterine lining grows outside the uterus, is linked to pain during intercourse (dyspareunia). This review examines how treatments for endometriosis, including surgery and medication, affect sexual function in women. The review also suggests potential improvements for future treatment strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis.

Author: BrownJulie, CrawfordTineke J, AllenClaire, HopewellSally, PrenticeAndrew

Endometriosis treatment

Endometriosis, a condition that can cause painful symptoms and infertility in women, significantly impacts quality of life. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common initial treatment for pain related to endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

Comparing the Efficacy of Surgery and Medical Therapy for Pain Management in Endometriosis: A Systematic Review and Meta-analysis.

Author: ChaichianShahla, KabirAli, MehdizadehkashiAdolfazl, RahmaniKhaled, MoghimiMehrdad, MoazzamiBahram

Pain relief

This meta-analysis of 23 studies found no statistically significant difference in pain improvement between surgical and medical treatment for endometriosis. Pain relief was more prominent longer after treatment. Higher quality studies and lower body mass index (BMI) had a greater effect on pain relief.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

91.

A peek into the drug development scenario of endometriosis - A systematic review.

Author: GoenkaLuxitaa, GeorgeMelvin, SenMaitrayee

Cost of treatment
Short-term effect
Side-effects

This review summarized the current status and challenges of drug development for endometriosis, considering the limitations of existing medical therapies in terms of cost, side effects, and short-term symptom relief.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

92.

Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist.

Author: TaylorHugh S, GiudiceLinda C, LesseyBruce A, AbraoMauricio S, KotarskiJan, ArcherDavid F, DiamondMichael P, SurreyEric, JohnsonNeil P, WattsNelson B, GallagherJ Chris, SimonJames A, CarrBruce R, DmowskiW Paul, LeylandNicholas, RowanJean P, DuanW Rachel, NgJuki, SchwefelBrittany, ThomasJames W, JainRita I, ChwaliszKristof

Improved dysmenorrhea
Improved pelvic pain
Decreased bone mineral density
Hot flushes
Increased serum lipids

Elagolix, a gonadotropin-releasing hormone (GnRH) antagonist, was effective in improving dysmenorrhea and nonmenstrual pelvic pain in women with endometriosis-associated pain.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

93.

Is the oocyte quality affected by endometriosis? A review of the literature.

Author: SanchezAna Maria, VanniValeria Stella, BartiromoLudovica, PapaleoEnrico, ZilberbergEran, CandianiMassimo, OrvietoRaoul, ViganòPaola

This systematic review examines the effects of endometriosis on oocyte quality and in vitro fertilization (IVF) outcomes. The study explores the potential impact of endometriosis on ovarian physiology and oocyte development.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Progesterone receptor modulators for endometriosis.

Author: FuJing, SongHao, ZhouMin, ZhuHuili, WangYuhe, ChenHengxi, HuangWei

Endometriosis occurs when uterine tissue grows outside the uterus. This condition is influenced by estrogen and is more common during the childbearing years. Medications that affect progesterone receptors (PRMs) have been suggested as a treatment for endometriosis because they can slow down the growth of this tissue.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

95.

Systematic review and meta-analysis of the effect of bipolar electrocoagulation during laparoscopic ovarian endometrioma stripping on ovarian reserve.

Author: DeckersPaula, RibeiroSérgio Conti, SimõesRicardo Dos Santos, MiyaharaCamila Barião da Fonseca, BaracatEdmund Chada

ovarian reserve impact

Bipolar electrocoagulation negatively impacts ovarian reserve and should be avoided, especially for patients with reproductive goals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

96.

Effects of acupuncture for the treatment of endometriosis-related pain: A systematic review and meta-analysis.

Author: XuYang, ZhaoWenli, LiTe, ZhaoYe, BuHuaien, SongShilin

Reduced endometriosis pain

Endometriosis is a condition where uterine-like tissue grows outside the uterus, causing pain and infertility. This study investigated whether acupuncture could be an effective treatment for endometriosis-related pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

[Medical treatment for the management of painful endometriosis without infertility: CNGOF-HAS Endometriosis Guidelines].

Author: SauvanM, Chabbert-BuffetN, CanisM, CollinetP, FritelX, GeoffronS, LegendreG, WattierJ-M, FernandezH

Pain relief
Reduced recurrence
Bone demineralization

This review provides clinical practice guidelines for the management of painful endometriosis in women without infertility. Combined hormonal contraceptives (COP) and the levonorgestrel-releasing intra-uterin system (LNG-IUS) are recommended as first-line hormonal therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : French

98.

Surgical Excision Versus Ablation for Superficial Endometriosis-Associated Pain: A Randomized Controlled Trial.

Author: RileyKristin A, BentonAndrea S, DeimlingTimothy A, KunselmanAllen R, HarkinsGerald J

Improved dysmenorrhea
Improved dyspareunia

Ablation of endometriosis improved dysmenorrhea and dyspareunia in patients with minimal to mild endometriosis compared to excision. However, only dyspareunia showed a significant difference between ablation and excision.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

99.

Questionnaire-based evaluation of sexual life after laparoscopic surgery for endometriosis: a systematic review of prospective studies.

Author: FranckCecilie, PoulsenMarlene H, KarampasGrigorios, GiraldiAnnamaria, RudnickiMartin

Endometriosis treatment

A review of the literature found that laparoscopic surgery for endometriosis can have a major impact on quality of sexual life (QoSL), but this is often overlooked.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

100.

Use of combined hormonal contraceptives for the treatment of endometriosis-related pain: a systematic review of the evidence.

Author: JensenJeffrey T, SchlaffWilliam, GordonKeith

Endometriosis pain treatment
Low data quality

Combined hormonal contraceptive (CHC) agents were effective in reducing endometriosis-related pain, including dysmenorrhea, pelvic pain, and dyspareunia. However, the evidence supporting this is low-quality, and further research is needed to clarify the role of CHC agents in the management of endometriosis-related pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

101.

Systematic review and meta-analysis of complementary treatments for women with symptomatic endometriosis.

Author: MiraTiciana A A, BuenMariana M, BorgesMurilo G, YelaDaniela A, Benetti-PintoCristina L

Endometriosis pain treatment

Acupuncture was found to be a significantly beneficial complementary treatment for reducing pain in patients with endometriosis. Other complementary treatments, including exercise, electrotherapy, and yoga, demonstrated positive trends towards improving symptoms, but more research is needed to confirm their effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

102.

Efficacy of levonorgestrel releasing intrauterine system as a postoperative maintenance therapy of endometriosis: A meta-analysis.

Author: SongSoo Youn, ParkMia, LeeGeon Woo, LeeKi Hwan, ChangHa Kyun, KwakSang Mi, YooHeon Jong

Pain reduction
Patient satisfaction
Recurrence prevention
Vaginal bleeding

A meta-analysis of 7 studies showed that LNG-IUS is an effective postoperative maintenance therapy for endometriosis, reducing pain (MD=12.97, 95% CI: 5.55-20.39) and recurrence rates (RR=0.40, 95% CI: 0.26-0.64) with high patient satisfaction (OR=8.60, 95% CI: 1.03-71.86).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

103.

[The role of the combined balneotherapeutic treatment as the 'add-back therapy' against the background of the anti-hormonal effects of the agonists of gonadotropin-releasing hormone in the women suffering from endometriosis genitalis externa].

Author: AkhkubekovaN K, KaysinovaA S, FedorovA A, EfimenkoN B, GaidamakaI I, ChalajaE N, CherevashchenkoL A, TsallagovaL V, UrvachevaE E, OvsienkoA B

Hypoestrogenism

Gonadotropin-releasing hormone (GnRH) agonists used to treat endometriosis genitalis externa are known to significantly increase the risk of hypoestrogenism. 'Add-back-therapy' is a preventative measure to address hypoestrogenism without compromising the effectiveness of anti-hormonal therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

104.

A multi-center, randomized controlled clinical trial of the application of a shortened protocol of long-acting Triptorelin down-regulated prior to IVF/ICSI among patients with endometriosis: A protocol.

Author: KongHuijuan, HuLinli, NieLing, YuXiaona, DaiWei, LiJing, ChenCaihong, BuZhiqin, ShiHao, WuQiongfang, GuanYichun, SunYingpu

Improved endometriosis treatment

Endometriosis is a common condition that causes pelvic pain and difficulty getting pregnant. While IVF is often recommended for women with endometriosis, they have lower pregnancy rates compared to women with other causes of infertility. Medications that block the effects of hormones (GnRH agonists) can increase pregnancy success rates when given before IVF, but it's unclear whether a shorter treatment period would be effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

105.

Ovarian stimulation and endometriosis progression or recurrence: a systematic review.

Author: SomiglianaEdgardo, ViganòPaola, BenagliaLaura, BusnelliAndrea, PaffoniAlessio, VercelliniPaolo

IVF for endometriosis
Endometriosis progression
IUI recurrence

This review analyzed available evidence on the impact of ovarian stimulation on the progression or recurrence of endometriosis. It found that IVF does not worsen endometriosis-related pain symptoms or increase the risk of recurrence. IUI may increase the risk of recurrence, and deep invasive endometriosis might progress with ovarian stimulation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

106.

Impact of elagolix treatment on fatigue experienced by women with moderate to severe pain associated with endometriosis.

Author: SurreyEric S, SolimanAhmed M, AgarwalSanjay K, SnabesMichael C, DiamondMichael P

Fatigue reduction
Endometriosis-associated pain

Elagolix, an oral GnRH antagonist, significantly reduces fatigue levels in women with moderate to severe endometriosis-associated pain. After 6 months of treatment, fatigue levels decreased from 54%-74% to 29%-43% with elagolix 150mg daily and 14%-29% with elagolix 200mg twice daily, compared with 35%-50% with placebo.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

107.

Elagolix Suppresses Ovulation in a Dose-Dependent Manner: Results From a 3-Month, Randomized Study in Ovulatory Women.

Author: ArcherDavid F, NgJuki, ChwaliszKristof, ChiuYi-Lin, FeinbergEve C, MillerCharles E, FeldmanRobert A, KleinCheri E

Endometriosis treatment
Ovulation suppression

This study found that elagolix suppressed ovulation in a dose-dependent manner, with the highest ovulation rate at 100 mg QD and the lowest at 300 mg BID plus E2/NETA 1/0.5 mg QD.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

108.

Surgical Outcomes in Patients With Endometriosis: A Systematic Review.

Author: SinghSukhbir S, GudeKerstin, PerdeauxElizabeth, GattrellWilliam T, BeckerChristian M

Endometriosis pain relief
Recurrent symptoms

This study examines the effectiveness of surgery for treating pain caused by endometriosis. The study aims to determine how many women experience little or no relief, develop recurring symptoms, or need additional surgery after treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

109.

Long-term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis.

Author: GeorgiouEktoras X, MeloPedro, BakerPhilip E, SallamHassan N, AriciAydin, Garcia-VelascoJuan A, Abou-SettaAhmed M, BeckerChristian, GranneIngrid E

Improved endometriosis treatment

This systematic review investigates whether long-term gonadotropin-releasing hormone (GnRH) agonist therapy prior to in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) can improve pregnancy outcomes in women with endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

110.

The clinical outcome of Dienogest treatment followed by in vitro fertilization and embryo transfer in infertile women with endometriosis.

Author: TamuraHiroshi, YoshidaHiroaki, KikuchiHiroyuki, JosakiMai, MiharaYumiko, ShirafutaYuichro, ShinagawaMasahiro, TamuraIsao, TaketaniToshiaki, TakasakiAkihisa, SuginoNorihiro

Improved endometriosis treatment

This study investigates the benefit of Dienogest (DNG), a synthetic progestin, treatment just before in vitro fertilization and embryo transfer (IVF-ET) in women with endometriosis, as GnRH agonist treatment has been shown to improve IVF-ET outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

111.

Interventions for endometriosis-related infertility: a systematic review and network meta-analysis.

Author: HodgsonRuth Mary, LeeHui Linn, WangRui, MolBen Williem, JohnsonNeil

Pregnancy rates

This study found that surgical laparoscopy alone or GnRH agonist alone resulted in higher odds of pregnancy for women with endometriosis-related infertility compared to placebo. However, more research is needed to compare the effectiveness of different treatments, especially comparing IVF and IUI to other treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

112.

Efficacy of Different Progestins in Women With Advanced Endometriosis Undergoing Controlled Ovarian Hyperstimulation for <i>in vitro</i> Fertilization-A Single-Center Non-inferiority Randomized Controlled Trial.

Author: GuoHaiyan, LiJianghui, ShenXi, CongYanyan, WangYun, WuLing, LiBin, GaoHongyuan, MaMeng, ZhangWei, MaoXiaoyan, FuYonglun, LyuQifeng, ChaiWeiran, KuangYanping

Endometriosis treatment
IVF outcomes

The study compared the effects of three different progestins (medroxyprogesterone acetate, dydrogesterone, and progesterone) on ovarian response and pregnancy outcomes in women with advanced endometriosis undergoing IVF/ICSI. The study found that medroxyprogesterone acetate led to a higher number of oocytes retrieved compared to the other two groups. However, there were no significant differences among the three groups in fertilization and pregnancy outcomes. The study concluded that all three progestin protocols are equivalent in terms of pregnancy outcomes for women with advanced endometriosis and normal ovarian reserve.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

113.

Endometriosis and strategies of fertility preservation: a systematic review of the literature.

Author: CalagnaGloria, Della CorteLuigi, GiampaolinoPierluigi, MarantoMarianna, PerinoAntonino

Fertility preservation
Improved fertility outcomes
Endometriosis complications

This review investigates fertility preservation techniques for patients with endometriosis. Eight studies were included, with a focus on embryo, oocyte, and ovarian tissue cryopreservation. While some success has been reported, further research is needed to evaluate the risks, benefits, effectiveness, and cost-effectiveness of these techniques.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

114.

Aromatase inhibitors for the treatment of endometriosis: a systematic review about efficacy, safety and early clinical development.

Author: GarzonSimone, LaganàAntonio Simone, BarraFabio, CasarinJvan, CromiAntonella, RaffaelliRicciarda, UccellaStefano, FranchiMassimo, GhezziFabio, FerreroSimone

Endometriosis treatment
Adverse effects

This systematic review provides an overview of the efficacy and safety of aromatase inhibitors (AIs) as monotherapies and combination therapies for endometriosis. Further research is needed to clarify the efficacy of AIs in this setting.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

115.

Hormonal treatment isolated versus hormonal treatment associated with electrotherapy for pelvic pain control in deep endometriosis: Randomized clinical trial.

Author: MiraTiciana A A, YelaDaniela A, PodgaecSérgio, BaracatEdmund C, Benetti-PintoCristina L

Improved quality of life
Pain relief
None reported

Self-applied electrotherapy treatment was found to be an effective complementary treatment for pain control in patients with deep infiltrative endometriosis. The treatment resulted in significant reductions in chronic pelvic pain and deep dyspareunia, and improved quality of life and sexual function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

116.

Pre- and postsurgical medical therapy for endometriosis surgery.

Author: ChenInnie, VethVeerle B, ChoudhryAbdul J, MurjiAlly, ZakhariAndrew, BlackAmanda Y, AgarpaoCarmina, MaasJacques Wm

Endometriosis treatment

Endometriosis affects many women of childbearing age, causing pain during sex, painful periods, and difficulty getting pregnant. Treatment often combines surgery with medication, but it's unclear when the medication should be given—before surgery, after surgery, or both—to maximize results.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

117.

Role of suppression of endometriosis with progestins before IVF-ET: a non-inferiority randomized controlled trial.

Author: KhalifaEissa, MohammadHashem, AbdullahAmeer, Abdel-RasheedMazen, KhairyMohammed, HosniMahmoud

endometriosis IVF
quality of life
GnRHa pretreatment

Dienogest was a suitable and safe alternative to gonadotropin-releasing hormone agonist (GnRHa) for endometriosis suppression before in vitro fertilization (IVF) treatment. Dienogest was associated with lower cost, fewer side effects, and higher quality of life scores compared to GnRHa.

Equivalence TrialA clinical trial designed to show that a new treatment is equivalent in efficacy/safety to an existing treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

118.

Selective oestrogen receptor modulators (SERMs) for endometriosis.

Author: van HoeselMaaike Ht, ChenYa Li, ZhengAi, WanQi, MouradSelma M

Endometriosis treatment

Endometriosis is a condition where tissue that normally lines the uterus grows outside of the uterus. It affects many women of reproductive age and can cause pain, difficulty getting pregnant, and other symptoms like back pain and painful intercourse. Treatments aim to reduce symptoms and shrink the growths by blocking the effects of estrogen. This review examines medications that directly target estrogen receptors as a potential treatment for endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

119.

Impact of exercise on pain perception in women with endometriosis: A systematic review.

Author: HansenSara, SverrisdóttirUna Á, RudnickiMartin

Exercise for endometriosis pain

Exercise may decrease pain perception in women with endometriosis, a painful and chronic inflammatory disorder that impacts up to 10% of women of reproductive age.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

120.

Ovulation induction with clomiphene citrate or letrozole following laparoscopy in infertile women with minimal to mild endometriosis: a prospective randomised controlled trial.

Author: ZhouLu, FuJing, LiuDong, WangQiuyi, ChenHengxi, YangShiyuan, HuangWei

Clomiphene for endometriosis
Letrozole for endometriosis

Ovulation induction with letrozole or clomiphene citrate after laparoscopy significantly increases ovulation rate but does not demonstrate a significant advantage on improving pregnancy rate and live-birth rate when compared to laparoscopy alone in infertile women with minimal to mild endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

122.

Effect of physical activity and exercise on endometriosis-associated symptoms: a systematic review.

Author: TennfjordMerete Kolberg, GabrielsenRakel, TellumTina

PA and exercise for endometriosis

This systematic review and meta-analysis assessed the effects of physical activity (PA) and exercise on endometriosis-associated symptoms. While hormonal therapies and surgery are common treatment modalities for endometriosis, PA and exercise may offer a beneficial alternative approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

123.

Adjuvant use of melatonin for pain management in dysmenorrhea - a randomized double-blinded, placebo-controlled trial.

Author: SödermanLisa, EdlundMåns, BöttigerYlva, MarionsLena

Melatonin for dysmenorrhea

This study investigates the effectiveness of melatonin as an adjuvant analgesic treatment for dysmenorrhea, a common and painful condition. Melatonin has previously shown to reduce pelvic pain in women with endometriosis, and this study focuses on its potential for women with dysmenorrhea without endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

124.

SURGICAL TECHNIQUES FOR THE TREATMENT OF RECTAL ENDOMETRIOSIS: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS AND OBSERVATIONAL STUDIES.

Author: PopoutchiPedro, Marques JuniorOswaldo Wiliam, AverbachPedro, Cardoso FilhoCelso Augusto Milani, AverbachMarcelo

Endometriosis treatment
Side effects

Endometriosis, a condition where tissue similar to the lining of the uterus grows outside of the uterus, is common and can affect fertility. It can also cause pain and affect quality of life. While treatments include hormonal medications and surgery, there is no clear consensus on the best way to surgically treat endometriosis affecting the rectum.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

125.

Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery.

Author: GibbonsTatjana, GeorgiouEktoras X, CheongYing C, WiseMichelle R

Endometriosis treatment

Endometriosis occurs when tissue that normally lines the uterus grows outside of the uterus. Surgery can be helpful, but pain often comes back, and many women need more surgery. This study will examine how well an IUD that releases a medication called levonorgestrel (LNG-IUD) works to prevent symptoms from returning after surgery for endometriosis, as well as its safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

126.

A single-blind, randomized, pilot study of a brief mindfulness-based intervention for the endometriosis-related pain management.

Author: MoreiraMarcelo de França, GamboaOlga Lucia, Pinho OliveiraMarco Aurelio

bMBI for women with deep endometriosis

Many women with endometriosis continue to have painful symptoms despite various treatments. While a holistic approach that considers physical, psychological, and social factors is needed, few non-medication options have been studied. This research aimed to examine the effects of a brief mindfulness-based intervention (bMBI) in women with severe endometriosis who still experience symptoms despite conventional medical care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

127.

Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind, studies (SPIRIT 1 and 2).

Author: GiudiceLinda C, As-SanieSawsan, Arjona FerreiraJuan C, BeckerChristian M, AbraoMauricio S, LesseyBruce A, BrownEric, DynowskiKrzysztof, WilkKrzysztof, LiYulan, MathurVandana, WarsiQurratul Ann, WagmanRachel B, JohnsonNeil P

Improved endometriosis pain
Reduced opioid use
Bone mineral density loss
Headache
Hot flushes
Nasopharyngitis
Suicidal ideation

Relugolix combination therapy, an oral gonadotropin-releasing hormone receptor antagonist, significantly improved endometriosis-associated pain and was well-tolerated. Two phase 3, randomized, double-blind, placebo-controlled trials showed that relugolix combination therapy led to a high responder rate for dysmenorrhea and non-menstrual pelvic pain. The most common adverse events were headache, nasopharyngitis, and hot flushes, with no deaths reported.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

128.

Current status and challenges of drug development for hormonal treatment of endometriosis: a systematic review of randomized control trials.

Author: ZajecVendy, MikušMislav, VitaleSalvatore Giovanni, D'alterioMaurizio Nicola, GregovMarija, ŠarićMarko Jakov, CarugnoJose, AngioniStefano, ĆorićMario

Hormonal therapeutic options for EAPP

This systematic review summarized the data from randomized controlled trials examining new pharmacologic treatments for endometriosis-associated pelvic pain (EAPP) over the last decade.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

129.

State of the art, new treatment strategies, and emerging drugs for non-hormonal treatment of endometriosis: a systematic review of randomized control trials.

Author: MikušMislav, VitaleSalvatore Giovanni, ĆorićMario, ZajecVendy, CiebieraMichał, CarugnoJose, D'alterioMaurizio Nicola, HermanMislav, PuževskiTomislav, AngioniStefano

Endometriosis pain relief

This systematic review evaluated non-hormonal treatment options for endometriosis-associated pelvic pain. Seven studies showed promising results with dopamine agonists and the immunomodulatory JNK inhibitor bentamapimod.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

130.

Evaluation of safety and effectiveness of gestrinone in the treatment of endometriosis: a systematic review and meta-analysis.

Author: de Souza PintoLuiz Paulo, FerrariGustavo, Dos SantosIsis Kelly, de Mello RoeslerCarlos Rodrigo, de Mello GindriIzabelle

Amenorrhea
Endometrial atrophy

This systematic review evaluated the safety and effectiveness of gestrinone, an antiestrogen, for the treatment of endometriosis.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

131.

A Systematic Review of Systematic Reviews on the Use of Aromatase Inhibitors for the Treatment of Endometriosis: The Evidence to Date.

Author: PeitsidisPanagiotis, TsikourasPanagiotis, LaganàAntonio Simone, LaiosAlexandros, GkegkesIoannis D, IavazzoChristos

Manage endometriosis symptoms
Menopausal symptoms

Aromatase inhibitors (AIs) are potent drugs that suppress estrogen synthesis. This systematic review of systematic reviews and narrative reviews examines the use of AIs in the medical management of endometriosis. The review found that AIs can manage endometriosis-related symptoms in cases where initial medical management has failed, but their use is limited by the adverse effects that are linked with menopausal symptoms. Future studies with randomized design are needed to reach safer conclusions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

132.

The Efficacy of Dienogest in Reducing Disease and Pain Recurrence After Endometriosis Surgery: a Systematic Review and Meta-Analysis.

Author: MuziiLudovico, Di TucciChiara, GalatiGiulia, CarboneFabiana, PalaiaInnocenza, BoganiGiorgio, PerniolaGiorgia, TomaoFederica, KontopantelisEvangelos, Di DonatoViolante

Reduced pain
Reduced recurrence
Spotting
Weight gain

This systematic review and meta-analysis investigates whether dienogest therapy after endometriosis surgery reduces the risk of recurrence compared with placebo or alternative treatments. The study found that dienogest significantly reduced the rate of cyst recurrence compared with placebo and was similar to GnRHa in decreasing the rate of recurrence. It also showed a trend toward pain reduction in patients treated with dienogest over placebo.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

133.

Gonadotropin-releasing hormone analogues for endometriosis.

Author: VethVeerle B, van de KarMajorie Ma, DuffyJames Mn, van WelyMadelon, MijatovicVelja, MaasJacques Wm

Endometriosis treatment
Bone mineral density decrease

This review evaluated the effect of gonadotrophin-releasing hormone analogues (GnRHas) on pain, quality of life, bone mineral density, and adverse effects in women with endometriosis, considering the potential risks and benefits of this treatment.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

134.

Efficacy and safety of different subsequent therapies after fertility preserving surgery for endometriosis: A systematic review and network meta-analysis.

Author: ZhengYu, MaRuyue, XuHong, WangLian, ZhangLei, MaoHuiqun, ZhaoRuiheng

Cyst recurrence delay
EMT symptom relief

Endometriosis is a common condition that affects women's reproductive health. While hormone therapy helps reduce pain, many women need surgery to preserve fertility. This study will evaluate the effectiveness and safety of various hormone treatments (dienogest, leuprolide, danazol, gestrinone, mifepristone, and LNG-IUS) in reducing symptoms and preventing the return of endometriosis cysts after surgery.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

135.

Perioperative hormone treatment of endometriosis.

Author: FarkasWilliam, LazaridisAlexandros, OdejinmiFunlayo, HirschMartin

Endometriosis treatment
Reduced surgical complications
Symptom relief
None mentioned

Hormonal treatment is a vital part of managing endometriosis, both before and after surgery. This review summarizes current evidence on perioperative hormonal treatment for endometriosis, highlighting its benefits for symptom relief, reduced surgical complications, and improved postoperative outcomes. These benefits include reduced pain, lower recurrence rates, and better pregnancy outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

136.

Sexual Function of Patients with Deep Endometriosis after Surgical Treatment: A Systematic Review.

Author: CervantesGraziele Vidoto, RibeiroPaulo Augusto Ayroza Galvão, TomasiMariana Carpenedo, FarahDaniela, RibeiroHelizabet Salomão Abdalla Ayroza

Improved sexual function
Reduced dyspareunia

A systematic review of 20 studies found that laparoscopic surgery is effective in improving sexual function and dyspareunia in women with deep infiltrating endometriosis.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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