The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder.

Author: AishimaManami, ItoYushi, NaitoSeiji, NakanoToshiaki, SekiNarihito, SueishiKatsuo, TakanoNaruaki, TeramotoNoriyoshi, TomodaToshihisa, YonemitsuYoshikazu

Paper Details 
Original Abstract of the Article :
The effects of flavoxate hydrochloride (Bladderon, piperidinoethyl-3-methylflavone-8-carboxylate; hereafter referred as flavoxate) on voltage-dependent nifedipine-sensitive inward Ba(2+) currents in human detrusor myocytes were investigated using a conventional whole-cell patch-clamp. Tension measur...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576239/

データ提供:米国国立医学図書館(NLM)

The Effects of Flavoxate Hydrochloride on Voltage-Dependent L-Type Ca2+ Currents in Human Urinary Bladder

The human bladder, a vital organ for urine storage and elimination, is regulated by complex physiological mechanisms. This research delves into the intricate world of bladder function, investigating the effects of flavoxate hydrochloride, a medication commonly used to treat overactive bladder, on voltage-dependent L-type calcium channels (Ca2+ channels) in human detrusor myocytes, the muscle cells responsible for bladder contraction. The researchers employed electrophysiological techniques to study how flavoxate hydrochloride affects the activity of these channels, which play a critical role in bladder muscle contraction.

Flavoxate Hydrochloride: A Chemical Key to the Bladder's Lock

This research, like a scientist meticulously studying the intricate workings of the bladder, explores the effects of flavoxate hydrochloride on Ca2+ channels in human detrusor myocytes. The researchers discovered that flavoxate hydrochloride inhibits the activity of these channels, effectively reducing bladder muscle contraction and relieving symptoms associated with overactive bladder. Their findings provide a deeper understanding of the mechanisms by which this medication exerts its therapeutic effects.

Understanding Bladder Function: A Symphony of Chemical Interactions

The study highlights the complex interplay between chemical signaling and bladder function. Dr. Camel recognizes that understanding these intricate mechanisms is crucial for developing more effective and targeted treatments for bladder disorders. This research underscores the importance of ongoing research in the field of bladder physiology, seeking to develop new therapies that improve the quality of life for patients with bladder dysfunction.

Dr. Camel's Conclusion

This research is a reminder that the human body is a marvel of complexity and precision. Dr. Camel, with his lifelong fascination with the wonders of the human body, believes that this study will contribute to a deeper understanding of bladder function, ultimately leading to better treatment options for those struggling with bladder disorders.
Date :
  1. Date Completed 2005-12-09
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

15965499

DOI: Digital Object Identifier

PMC1576239

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.