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The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder.
Author: AishimaManami, ItoYushi, NaitoSeiji, NakanoToshiaki, SekiNarihito, SueishiKatsuo, TakanoNaruaki, TeramotoNoriyoshi, TomodaToshihisa, YonemitsuYoshikazu
Original Abstract of the Article :
The effects of flavoxate hydrochloride (Bladderon, piperidinoethyl-3-methylflavone-8-carboxylate; hereafter referred as flavoxate) on voltage-dependent nifedipine-sensitive inward Ba(2+) currents in human detrusor myocytes were investigated using a conventional whole-cell patch-clamp. Tension measur...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576239/
データ提供:米国国立医学図書館(NLM)
The Effects of Flavoxate Hydrochloride on Voltage-Dependent L-Type Ca2+ Currents in Human Urinary Bladder
The human bladder, a vital organ for urine storage and elimination, is regulated by complex physiological mechanisms. This research delves into the intricate world of bladder function, investigating the effects of flavoxate hydrochloride, a medication commonly used to treat overactive bladder, on voltage-dependent L-type calcium channels (Ca2+ channels) in human detrusor myocytes, the muscle cells responsible for bladder contraction. The researchers employed electrophysiological techniques to study how flavoxate hydrochloride affects the activity of these channels, which play a critical role in bladder muscle contraction.Flavoxate Hydrochloride: A Chemical Key to the Bladder's Lock
This research, like a scientist meticulously studying the intricate workings of the bladder, explores the effects of flavoxate hydrochloride on Ca2+ channels in human detrusor myocytes. The researchers discovered that flavoxate hydrochloride inhibits the activity of these channels, effectively reducing bladder muscle contraction and relieving symptoms associated with overactive bladder. Their findings provide a deeper understanding of the mechanisms by which this medication exerts its therapeutic effects.Understanding Bladder Function: A Symphony of Chemical Interactions
The study highlights the complex interplay between chemical signaling and bladder function. Dr. Camel recognizes that understanding these intricate mechanisms is crucial for developing more effective and targeted treatments for bladder disorders. This research underscores the importance of ongoing research in the field of bladder physiology, seeking to develop new therapies that improve the quality of life for patients with bladder dysfunction.Dr. Camel's Conclusion
This research is a reminder that the human body is a marvel of complexity and precision. Dr. Camel, with his lifelong fascination with the wonders of the human body, believes that this study will contribute to a deeper understanding of bladder function, ultimately leading to better treatment options for those struggling with bladder disorders.Date :
- Date Completed 2005-12-09
- Date Revised 2018-11-13
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