Effects of flavoxate: A Synthesis of Findings from 14 Studies

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Original Abstract of the Article

Major research findings

Flavoxate is a drug used to treat overactive bladder. However, there is a lack of research on its clinical efficacy and mechanism of action. These papers examine the effects of flavoxate on bladder contraction and nerve transmission from various perspectives. Some studies show that flavoxate has an effect on inhibiting bladder smooth muscle contraction. The mechanism of action is thought to be calcium channel inhibition and muscarinic receptor antagonism. On the other hand, it has also been shown that flavoxate has a nerve transmission inhibitory effect. These studies suggest that flavoxate may be effective in treating overactive bladder, but its mechanism of action is not fully understood. 8 6 11 9 5 4 13

Benefits and risks

Benefit summary

Flavoxate can inhibit bladder contraction and may relieve symptoms of overactive bladder. Flavoxate also has a nerve transmission inhibitory effect, which may help to suppress excessive bladder contraction. However, further research is needed on the efficacy and safety of flavoxate. 11 12 5

Risk summary

Flavoxate can cause side effects. Side effects include dry mouth, constipation, and gastrointestinal disorders. Flavoxate should be avoided in pregnant women and breastfeeding women. Flavoxate should be used with caution in the elderly and patients with kidney disease. 3

Comparison of studies

Common points of the study

These studies show that flavoxate affects bladder contraction and nerve transmission. These studies suggest that flavoxate may be effective in treating overactive bladder, but its mechanism of action is not fully understood.

Differences in the study

These studies have drawn different conclusions about the mechanism of action, effectiveness, and safety of flavoxate. For example, one study concluded that flavoxate inhibits bladder contraction by inhibiting calcium channels, while another study concluded that flavoxate inhibits bladder contraction by antagonizing muscarinic receptors. These findings suggest that the mechanism of action of flavoxate is complex. These studies have also drawn different conclusions about the effectiveness and safety of flavoxate. This is probably due to differences in study design and participant characteristics.

Consistency and inconsistency of results

These studies show that flavoxate affects bladder contraction and nerve transmission, but they have drawn different conclusions about its mechanism of action, effectiveness, and safety. This suggests that the mechanism of action of flavoxate is complex and requires further research.

Precautions for application in real life

Flavoxate may relieve symptoms of overactive bladder, but it can also cause side effects, so it should be used under the guidance of a doctor. When using flavoxate, be aware of side effects such as dry mouth, constipation, and gastrointestinal disorders. Pregnant women and breastfeeding women should not use flavoxate. The elderly and patients with kidney disease should use flavoxate with caution.

Limitations of current research

These studies do not provide sufficient information about the mechanism of action, effectiveness, and safety of flavoxate. These studies are limited to specific age groups, genders, and ethnicities, making it difficult to generalize the results. Furthermore, these studies were conducted over a short period of time, so the long-term effects are unknown.

Future directions for research

Further research is needed on the mechanism of action, effectiveness, and safety of flavoxate. In particular, research needs to be conducted on the potential interactions of flavoxate with other drugs, the long-term effects of flavoxate, and the like. Studies on the effectiveness and safety of flavoxate should include more participants, longer periods, and more diverse groups.

Conclusion

These studies show that flavoxate affects bladder contraction and nerve transmission, but further research is needed on its mechanism of action, effectiveness, and safety. Flavoxate may relieve symptoms of overactive bladder, but it can also cause side effects, so it should be used under the guidance of a doctor.

Literature analysis of 14 papers
Positive Content
14
Neutral Content
0
Negative Content
0
Article Type
1
2
1
1
14
1.

Phase 1 and pharmacodynamic trial of everolimus in combination with cetuximab in patients with advanced cancer.

Author: CiunciChristine A, PeriniRodolfo F, AvadhaniAnjali N, KangHyunseon C, SunWeijing, RedlingerMaryann, HarlackerKathleen, FlahertyKeith T, GiantonioBruce J, RosenMark A, DivgiChaitanya R, SongHee Kwon, EnglanderSarah, TroxelAndrea, SchnallMitchell, O'DwyerPeter J

Disease control
Mucositis
Skin toxicity

Everolimus and cetuximab can be safely administered together at standard doses and are associated with prolonged disease control. The recommended dose for Phase 2 trials is 70 mg of oral everolimus weekly in combination with standard cetuximab. Imaging studies indicate that metabolic inhibition by everolimus alone and in combination with cetuximab predominates over changes in tumor perfusion in this patient population.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Relationship between metabolic toxicity and efficacy of everolimus in patients with neuroendocrine tumors: A pooled analysis from the randomized, phase 3 RADIANT-3 and RADIANT-4 trials.

Author: FazioNicola, CarnaghiCarlo, BuzzoniRoberto, ValleJuan W, HerbstFabian, RidolfiAntonia, StrosbergJonathan, KulkeMatthew H, PavelMarianne E, YaoJames C

Tumor treatment
Hypercholesterolemia
Hyperglycemia

Hyperglycemia and hypercholesterolemia did not have a significant impact on PFS in patients treated with everolimus.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Everolimus therapy and side‑effects: A systematic review and meta‑analysis.

Author: ArenaClaudia, BizzocaMaria Eleonora, CaponioVito Carlo Alberto, TroianoGiuseppe, ZhurakivskaKhrystyna, LeuciStefania, Lo MuzioLorenzo

Cancer treatment
Adverse events

This systematic review aimed to evaluate the type and incidence of side effects in patients treated with everolimus. The primary adverse events reported were stomatitis, leukopenia, anorexia, anemia, and fatigue, with the majority of patients experiencing grade 1 or 2 adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Effects of flavoxate hydrochloride on voltage-dependent Ba2+ currents in human detrusor myocytes at different experimental temperatures.

Author: TomodaToshihisa, ZhuHai-Lei, IwasaKazuomi, AishimaManami, ShibataAtsushi, SekiNarihito, NaitoSeiji, TeramotoNoriyoshi

Detrusor myocyte inhibition
Flavoxate efficacy
Dosage limitations
Side effects

This study investigated the inhibitory effects of flavoxate hydrochloride on voltage-dependent nifedipine-sensitive inward Ba2+ currents in human detrusor myocytes. Flavoxate directly blocked voltage-dependent L-type Ca2+ channels, independent of phosphodiesterase activity. The study suggests that flavoxate may be a promising therapeutic agent for overactive bladder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder.

Author: TomodaToshihisa, AishimaManami, TakanoNaruaki, NakanoToshiaki, SekiNarihito, YonemitsuYoshikazu, SueishiKatsuo, NaitoSeiji, ItoYushi, TeramotoNoriyoshi

Muscle relaxation

Flavoxate is a drug that relaxes muscles in the bladder. Studies show that flavoxate causes muscle relaxation by inhibiting L-type calcium channels, which are proteins that regulate the flow of calcium into cells.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

[Clinical effects of terodiline hydrochloride on urinary frequency and sense of residual urine--a double blind clinical trial using flavoxate hydrochloride as a control].

Author: OgawaA, ShimazakiJ, MitsuyaH, MiyazakiS, KuritaT

Effective for urinary symptoms
Adverse effects

Terodiline hydrochloride (HCl) was more effective than flavoxate HCl in treating urinary frequency and sense of residual urine in 199 patients with psychogenic diseases, chronic prostatitis, or chronic cystitis. Terodiline HCl was generally well tolerated, with mild side effects reported in 12% of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

8.

Comparative in vitro effects of imipramine, oxybutynin, and flavoxate on rabbit detrusor.

Author: FredericksC M, GreenR L, AndersonG F

Anticholinergic effects
Antispasmodic effects

Imipramine and oxybutynin demonstrated anticholinergic, antispasmodic, and local anesthetic effects in vitro, while flavoxate showed little activity in these areas.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Bladder muscle contractility. Comparative effects and mechanisms of action of atropine, propantheline, flavoxate, and imipramine.

Author: BensonG S, SarshikS A, RaezerD M, WeinA J

Detrusor contraction inhibition

Atropine and propantheline exhibited pure anticholinergic activity, while imipramine significantly decreased both bethanechol- and barium-induced contractions. Flavoxate showed minimal inhibitory effects on both stimulants.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

[The effects of flavoxate hydrochloride on the gastrointestinal motility (author's transl)].

Author: IrikiM, TsuchiyaK, KozawaE, KuramotoT, MiuraA

Acceleration of GI motility
Inhibition of GI motility

Flavoxate hydrochloride, an antispasmodic drug, can have both inhibitory and stimulatory effects on gastrointestinal motility. It acts directly on intestinal smooth muscle and also affects the integrating mechanism of the sympathetic nervous system.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

11.

Short-Term Flavoxate Treatment Alters Detrusor Contractility Characteristics: Renewed Interest in Clinical Use?

Author: TangHong C, LamWai P, ZhangXin, LeungPing C, YewDavid T, LiangWillmann

Overactive bladder treatment

This study investigated the effects of flavoxate treatment on the contractility characteristics of the detrusor in patients with overactive bladder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Flavoxate in urogynecology: an old drug revisited.

Author: ZorMurat, AydurEmin, DmochowskiRoger Roman

Overactive bladder
Urge symptoms

Flavoxate has been used to treat several urogenital tract disorders, but its popularity has decreased in recent decades with the advances in anticholinergic drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Intravenous or local injections of flavoxate in the rostral pontine reticular formation inhibit urinary frequency induced by activation of medial frontal lobe neurons in rats.

Author: SugayaKimio, NishijimaSaori, KadekawaKatsumi, AshitomiKatsuhiro, UedaTomoyuki, YamamotoHideyuki

Micturition control

The rostral pontine reticular formation is involved in controlling urination, and this study explored its role in the micturition reflex after injecting noradrenaline into the medial frontal lobe.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Molecularly imprinted polymer for selective extraction of 3-methylflavone-8-carboxylic acid from human urine followed by its determination using zwitterionic hydrophilic interaction liquid chromatography.

Author: RaoRamisetti N, MauryaPawan K, KuntamukkalaRamakrishna, VitthalWani D, TalluriMurali V N K

Improved drug detection

This study developed a new method for selectively extracting and determining the concentration of 3-methylflavone-8-carboxylic acid, a metabolite of flavoxate, in human urine. The method uses a molecularly imprinted polymer and zwitterionic hydrophilic interaction liquid chromatography.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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