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Efficacy and safety of opioid agonists in the treatment of neuropathic pain of nonmalignant origin: systematic review and meta-analysis of randomized controlled trials.

Author: CarrDaniel B, EisenbergElon, McNicolEwan D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

The use of opioids for neuropathic pain, a common and often treatment-resistant condition, remains controversial due to limited research, equivocal results, and uncertainty about long-term risks and benefits.
Paper Details　
Original Abstract of the Article :
In the United States, an estimated 2 million persons have neuropathic pain that is often resistant to therapy. The use of opioids for neuropathic pain remains controversial, in part because studies have been small, have yielded equivocal results, and have not established the long-term risk-benefit r...See full text at original site
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引用元：
https://doi.org/10.1001/jama.293.24.3043

データ提供：米国国立医学図書館（NLM）

Opioids for Neuropathic Pain: A Controversial Oasis in the Desert of Chronic Pain

The [treatment of neuropathic pain] is a complex and often frustrating journey through a desert of chronic discomfort. This study examines the efficacy and safety of [opioid agonists] in managing [neuropathic pain of nonmalignant origin], a condition that affects millions worldwide. The researchers conducted a [systematic review and meta-analysis of randomized controlled trials] to evaluate the available evidence on opioid use for neuropathic pain. The study's findings provide valuable insights into the benefits and risks associated with this controversial treatment approach.

The Role of Opioids in Neuropathic Pain Management

The study found [limited evidence] to support the use of [opioid agonists] for [neuropathic pain]. The results highlight the need for [further research] to determine the appropriate role of opioids in managing this challenging condition. The study also underscores the importance of [considering individual patient factors and alternative treatment options] when prescribing opioids for neuropathic pain.

Navigating the Desert of Chronic Pain

The study's findings remind us that [neuropathic pain] is a complex condition that requires a multidisciplinary approach to treatment. This may include [pharmacotherapy, non-pharmacological therapies, and lifestyle modifications]. Close collaboration between patients and healthcare providers is crucial for finding the most effective and personalized treatment strategies.

Dr.Camel's Conclusion

As a researcher who has witnessed the profound impact of chronic pain on individuals' lives, I am deeply committed to finding effective and safe treatment options. This study highlights the need for a nuanced and evidence-based approach to [opioid use] for [neuropathic pain], recognizing both the potential benefits and risks associated with this controversial treatment. Continued research is essential to develop safer and more effective treatments for this debilitating condition.
Date :
  1. Date Completed 2005-06-24
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

15972567

DOI: Digital Object Identifier

10.1001/jama.293.24.3043

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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