Effective treatment of pain: A Synthesis of Findings from 81 Studies

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Original Abstract of the Article

Major Research Findings

Numerous studies have explored various approaches to effectively manage pain. For neuropathic pain (NP), topical capsaicin 64 has shown potential as a treatment option, demonstrating a favorable safety profile and efficacy in reducing NP. Capsaicin works by targeting the TRPV1 receptor, which is found in sensory nerve cells, leading to a reduction in pain signals.

Acupuncture 36 is another non-pharmacological treatment explored for various pain conditions, including cancer-related pain. However, the current evidence regarding its effectiveness for cancer pain is insufficient, needing further investigation.

Music therapy 30 has proven effective in reducing pain in palliative care patients, particularly when combined with autogenic relaxation techniques.

For chronic back pain, self-administered acupressure 79 has shown promising results. Its convenience and minimal side effects make it a potentially valuable approach. Furthermore, research on D-cycloserine 46 , a partial agonist of the NMDA receptor, suggests potential for treating chronic back pain.

Transcutaneous electrical nerve stimulation (TENS) 57 is commonly recommended by clinicians as an adjunct non-pharmacological treatment for chronic pain. It is often used in combination with other therapies.

In the management of chronic non-cancer pain, a combination of hypnosis and TENS 66 has been explored as a treatment strategy.

Cognitive behavioral therapy (CBT) 68 has demonstrated effectiveness in managing chronic pain, especially when delivered remotely. This approach addresses pain catastrophizing, a significant factor in chronic pain.

Addressing opioid consumption among chronic pain patients is crucial, and organizational changes 74 in pain management have shown a positive impact on reducing opioid use.

For acute abdominal pain, analgesia 15 is now recommended to be administered early on, as it effectively reduces pain without hindering diagnosis and treatment.

Research on radiofrequency technology 59 for chronic postmastectomy pain syndrome (PMPS) shows promising results, offering a potential alternative for patients who don’t respond well to medications or experience intolerable side effects.

The use of diclofenac and thiocolchicoside 52 in combination has proven effective for acute low back pain (LBP).

In managing cancer pain, a multidisciplinary approach involving various treatments is essential. These treatments include opioids 42 , non-steroidal anti-inflammatory drugs (NSAIDs) 42 , anticonvulsants 42 , antidepressants 42 , acupuncture 42 , and radiotherapy 42 . The selection of treatment should be tailored to the individual patient's needs.

The effectiveness of pain neuroscience education 49 in managing musculoskeletal chronic pain has been explored, showing potential for reducing pain and improving self-care.

Multidisciplinary pain treatment (MPT) 5 is considered a valuable approach for chronic pain management, offering significant improvement in pain intensity and quality of life.

Therapeutic Touch 56 has shown potential for back pain management in a pilot study. However, further research is needed to confirm its effectiveness.

Patient coaching 27 can increase the likelihood of medication adjustments for cancer pain, ultimately leading to better pain control.

For chronic knee pain, nettle sting 19 has emerged as a promising non-pharmacological intervention, although further research is needed to establish its efficacy.

Treatment Summary

The reviewed studies showcase a variety of treatments for different types of pain. For neuropathic pain, topical capsaicin 64 and neuromodulation 67 have shown potential, while acupuncture 36 and music therapy 30 offer non-pharmacological options.

For chronic back pain, self-administered acupressure 79 , D-cycloserine 46 , and pain neuroscience education 49 have demonstrated potential benefits.

For acute low back pain, the combined use of diclofenac and thiocolchicoside 52 has proven effective.

For chronic non-cancer pain, a multidisciplinary approach including CBT 68 , hypnosis and TENS 66 , and MPT 5 is often considered.

In cancer pain management, a multidisciplinary approach employing opioids 42 , NSAIDs 42 , anticonvulsants 42 , antidepressants 42 , acupuncture 42 , and radiotherapy 42 is crucial, with patient-tailored treatment being key.

Benefits and Risks

Benefits Summary

Research has identified various benefits of different pain management approaches. For neuropathic pain, topical capsaicin 64 has shown a favorable safety profile and effectiveness in reducing pain. For chronic back pain, self-administered acupressure 79 offers a convenient and low-risk option. Cognitive behavioral therapy 68 has demonstrated effectiveness in managing chronic pain and improving quality of life. Music therapy 30 has been shown to reduce pain in palliative care patients. Additionally, the use of diclofenac and thiocolchicoside 52 has proven effective for acute low back pain.

Risks Summary

While several treatments have shown promising results, it is crucial to acknowledge potential risks. Opioids 42 carry the risks of addiction and adverse effects. Long-term use of prednisolone 71 should be approached with caution due to potential side effects. While research continues, the optimal treatment approach for pain management remains multifaceted, and the effectiveness and safety of different treatments can vary greatly depending on the individual patient's condition and specific needs.

Comparison Between Studies

Commonalities

A common thread running through many studies is the emphasis on a multidisciplinary approach to pain management. This involves a combination of pharmacological and non-pharmacological treatments tailored to the individual patient. This multidimensional approach acknowledges that pain is complex and often involves both physical and psychological components.

Differences

The studies differ significantly in the types of pain being investigated, the specific treatment modalities explored, and the research designs employed. For example, some studies focus on acute pain, while others explore chronic pain. The specific pain management techniques also vary, ranging from pharmacological interventions to non-pharmacological approaches such as acupuncture, music therapy, or cognitive behavioral therapy. Additionally, the study designs and quality can differ, making it challenging to directly compare the results across studies.

Consistency and Contradictions in Results

While numerous studies indicate the potential benefits of various pain management approaches, there is no singular definitive solution. The most effective treatment for a given individual depends on their unique condition and preferences. Furthermore, the findings across studies can be inconsistent. For example, some research highlights the efficacy of a specific treatment, while other studies might not find the same level of effectiveness. These inconsistencies emphasize the need for ongoing research to refine our understanding of pain management and develop more targeted and effective treatments.

Considerations for Real-World Application

It is important to recognize that research findings are not always directly transferable to real-world settings. The effectiveness of a treatment can vary depending on individual factors, such as the specific pain condition, the individual's medical history, and their response to treatment. Additionally, it is crucial to seek guidance from healthcare professionals for personalized treatment recommendations.

Limitations of Current Research

Current research on pain management is limited by various factors. Many studies involve relatively small sample sizes, making it difficult to generalize the findings to broader populations. Research designs and methodologies can vary, making it challenging to consistently compare results. Furthermore, the complexity of pain and its varied causes makes it difficult to isolate the specific effects of a particular treatment.

Future Research Directions

Future research is crucial to advance our understanding of pain management and develop more effective and personalized treatments. Larger-scale studies with robust designs are needed to provide more definitive evidence on the effectiveness of different treatments. Additionally, further research on the underlying mechanisms of pain and the development of new therapeutic modalities is essential.

Conclusion

Pain management is a complex and multifaceted field. Research continues to uncover promising treatment options, but no single solution exists for every individual. A personalized approach that addresses both physical and psychological factors is essential for effective pain management. It is crucial to seek guidance from healthcare professionals for personalized treatment recommendations. As research progresses, we can expect to see more targeted and effective treatments for pain, ultimately improving the lives of those affected by this common and debilitating condition.

Treatment List

Topical capsaicin, acupuncture, music therapy, cognitive behavioral therapy, neuromodulation, self-administered acupressure, D-cycloserine, pain neuroscience education, diclofenac and thiocolchicoside, opioids, NSAIDs, anticonvulsants, antidepressants, radiotherapy, hypnosis, TENS, multidisciplinary pain treatment (MPT), therapeutic touch, patient coaching, and nettle sting.

Keywords
Benefit Keywords
Improved chronic pain treatment
1
Pain management
2
Improved pain
Improved physical function
Improved stiffness
3
Improve HRQL
Reduce pain intensity
5
Chronic low back pain relief
6
Reduced pain severity
7
Treatment of chronic pain
8
Enhanced pain relief
Limited adverse effects
9
Neuropathic pain relief
10
Improved function
Pain relief
11
Pain relief
12
Pain relief
14
Improved acute abdominal pain treatment
15
Fear reduction
Function improvement
16
Improved chronic low back pain treatment
18
Nettle sting acceptable
19
Reduced pain intensity
20
Pain sensation assessment
21
Chronic pain treatment
22
Acute pain management
23
Acupuncture for cancer pain
24
Pain relief
25
Improved pain control
Increased treatment adjustment
27
Maintenance of treatment gains
Practical advice and social support
Support after treatment
28
Improved pain management
29
Reduced pain
30
Neck pain treatment
31
Chronic pain treatment
32
Pain management
33
Pain reduction
34
Reduced cancer pain
36
Functional capacity
Pain reduction
37
Improved coping
Improved functioning ability
Improved mental symptoms
Improved physical symptoms
Reduced health services use
38
Chronic pain treatment
39
Function improvement
Pain reduction
40
Pain management
Treatment guidance
41
Reduced pain intensity
42
Chronic pain treatment
43
Effective treatment
Improved pain
44
Phantom limb pain treatment
45
Back pain relief
46
Pain neuroscience education
49
Neck disability improvement
Neck pain reduction
Quality of life improvement
50
Improved neuropathic pain
Pain relief
51
Improved mobility
Reduced pain
52
Reduced pain impact
53
Pain relief
Reduced medication need
54
Improved pain management
55
Pain relief
56
Chronic pain treatment
TENS
57
Improved quality of life
Reduced depression
58
Improved PMPS treatment
59
Postoperative pain management
60
Chronic non-cancer pain treatment
61
Orthodontic pain control
Pain relief
62
Post-surgical pain reduction
63
Reduced neuropathic pain
64
Improved function
Pain reduction
65
Chronic non-cancer pain treatment
66
Chronic pain treatment
67
Accessible treatment
Improved sleep
Reduced pain catastrophizing
Reduced pain intensity
68
IIPT for severe chronic pediatric pain
70
CRPS symptom control
Effective at low dose
71
Cancer pain reduction
72
Multidisciplinary care
Opioid reduction
73
Opioid reduction
74
None
75
Improved quality of life
Reduced pain interference
76
Improved QoL
Increased beta-endorphin
Reduced pain
77
Pain management
79
Effective pain management
Improved quality of life
80
Pain management
Treatment access
81
Risk Keywords
Lack of evidence
4
None mentioned
6
Adverse effects
7
Opioid risks
10
Constipation
Nausea
11
None stated
12
LBP treatment ineffectiveness
13
Insufficient evidence
Low quality studies
14
Acute abdominal pain
15
Dose-related adverse events
17
Chronic low back pain
18
Minor irritation
19
Side effects
20
Acupuncture risks
24
Opioid dependence
Opioid tolerance
26
Anorexia
Depersonalization/derealization
Drowsiness
Hallucinations
Insobriety
Myoclonic movements
Nausea/vomiting
Sedation
Somnolence
Urinary retention
34
Low evidence quality
42
Opioid dependence
43
None mentioned
45
Chronic back pain
46
High pain prevalence
69
Minor side effects
71
Further research needed
Inconclusive results
72
None
75
Limited superiority
78
Limited research
Treatment side effects
80
Literature analysis of 81 papers
Positive Content
69
Neutral Content
7
Negative Content
5
Article Type
37
17
39
31
80
2.

The treatment of chronic cancer pain in a cancer hospital in The Netherlands.

Author: de WitR, van DamF, Vielvoye-KerkmeerA, MatternC, Abu-SaadH H

Pain management

This prospective study evaluated the practice of pain treatment in Dutch cancer patients with chronic pain, examining structural resources, process components, and outcomes. The study found that a significant proportion of patients received suboptimal pain treatment, primarily due to issues with process components, such as insufficient use of strong opioids, inadequate pain education, and poor communication about pain management.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Double blind randomized placebo control trial of controlled release codeine in the treatment of osteoarthritis of the hip or knee.

Author: PelosoP M, BellamyN, BensenW, ThomsonG T, HarsanyiZ, BabulN, DarkeA C

Improved pain
Improved physical function
Improved stiffness

Controlled-release codeine was effective in treating pain due to osteoarthritis of the hip or knee.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Injection therapy for subacute and chronic benign low back pain.

Author: NelemansP J, de BieR A, de VetH C, SturmansF

Lack of evidence

The effectiveness of injection therapy for chronic low back pain is unclear. More well-designed trials are needed to determine if it is beneficial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

[Therapeutic results in chronic, non-malignant pain in patients treated at a Danish multidisciplinary pain center compared with general practice. A randomized controlled clinical trial].

Author: BeckerN, SjøgrenP, OlsenA K, EriksenJ

Improve HRQL
Reduce pain intensity

Multidisciplinary pain treatment (MPT) was found to be more effective than treatment by general practitioners after initial supervision by a pain specialist in reducing pain intensity and improving health-related quality of life (HRQL) in patients with chronic non-malignant pain.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Danish

6.

Manipulation and mobilization in the treatment of chronic pain.

Author: MiorS

Chronic low back pain relief
None mentioned

Manipulation and mobilization are more effective for chronic low back pain than placebos or usual care for up to 6 months. Evidence of effectiveness for chronic neck pain, chronic soft tissue shoulder disorders, and post-traumatic headache is limited.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

The effect of antidepressant treatment on chronic back pain: a meta-analysis.

Author: SalernoStephen M, BrowningRobert, JacksonJeffrey L

Reduced pain severity
Adverse effects

Antidepressants are more effective than placebo in reducing pain severity but not functional status in chronic back pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Psychological therapies for the management of chronic and recurrent pain in children and adolescents.

Author: EcclestonC, YorkeL, MorleyS, WilliamsA C, MastroyannopoulouK

Treatment of chronic pain

More children are experiencing pain that lasts for six months or longer. While medications and physical therapy have been the main treatment approaches, psychological therapies are increasingly being used for children with chronic or recurrent pain, inspired by advancements in adult pain management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of pain after abdominal or pelvic surgery in women: a randomized, double-blind, placebo- and active-controlled parallel-group study.

Author: SinglaNeil, PongAnnpey, NewmanKenneth,

Enhanced pain relief
Limited adverse effects

A fixed combination of oxycodone and ibuprofen, two analgesic agents with different mechanisms of action, may improve pain relief in patients undergoing abdominal or pelvic surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Efficacy and safety of opioid agonists in the treatment of neuropathic pain of nonmalignant origin: systematic review and meta-analysis of randomized controlled trials.

Author: EisenbergElon, McNicolEwan D, CarrDaniel B

Neuropathic pain relief
Opioid risks

The use of opioids for neuropathic pain, a common and often treatment-resistant condition, remains controversial due to limited research, equivocal results, and uncertainty about long-term risks and benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects.

Author: FurlanAndrea D, SandovalJuan A, Mailis-GagnonAngela, TunksEldon

Improved function
Pain relief
Constipation
Nausea

Opioids are effective for pain and functional outcomes in patients with chronic noncancer pain (CNCP), particularly strong opioids. A meta-analysis of 41 randomized trials involving 6019 patients with various types of CNCP found that opioids outperformed placebo and were superior to other medications for pain relief, especially strong opioids. However, the high dropout rates highlight the need for longer-term studies and strategies to minimize side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

[Systematic review: are major opioids effective in the treatment of musculoskeletal pain?].

Author: AbásoloLydia, CarmonaLoreto

Pain relief
None stated

Major opioids have been shown to reduce pain in patients with chronic musculoskeletal disorders. A systematic review of 23 randomized controlled trials demonstrated significant improvement in pain relief in patients with osteoarthritis when oral major opioids were compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Spanish

13.

Traction for low-back pain with or without sciatica.

Author: ClarkeJ A, van TulderM W, BlombergS E I, de VetH C W, van der HeijdenG J M G, BronfortG, BouterL M

LBP treatment ineffectiveness

Traction as a single treatment for low-back pain (LBP) is probably not effective. Traction for patients with sciatica cannot be judged effective at present.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

WITHDRAWN: Injection therapy for subacute and chronic benign low-back pain.

Author: NelemansP J, de BieR A, de VetH C W, SturmansF

Pain relief
Insufficient evidence
Low quality studies

Convincing evidence is lacking on the effects of injection therapies for low back pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Analgesia in patients with acute abdominal pain.

Author: ManterolaC, AstudilloP, LosadaH, PinedaV, SanhuezaA, VialM

Improved acute abdominal pain treatment
Acute abdominal pain

For a long time, pain medication was withheld for people with acute abdominal pain until a diagnosis was made, out of concern that it might mask symptoms, alter physical findings, and delay diagnosis and treatment. However, recent studies have shown that giving pain medication early on significantly reduces pain without affecting the accuracy of diagnosis. In fact, reducing pain may make it easier to diagnose the problem.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

A randomized controlled trial of exposure in vivo for patients with spinal pain reporting fear of work-related activities.

Author: LintonSteven J, BoersmaKatja, JanssonMarkus, OvermeerThomas, LindblomKarin, VlaeyenJohan W S

Fear reduction
Function improvement

Exposure in vivo was significantly more effective than usual treatment in improving function, but not for fear or pain. Overall exposure had moderate effects on function, fear and pain intensity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Prolonged-release oxycodone enhances the effects of existing gabapentin therapy in painful diabetic neuropathy patients.

Author: HannaMagdi, O'BrienCathy, WilsonMargaret C

Dose-related adverse events

This study highlights the difficulty in treating neuropathic pain, a condition that is often under-diagnosed and poorly managed. Current treatments are not always effective, with less than half of patients achieving significant pain relief and many experiencing persistent pain. The study also mentions the limitation of increasing medication doses due to potential side effects.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Motor control or graded activity exercises for chronic low back pain? A randomised controlled trial.

Author: MacedoLuciana G, LatimerJane, MaherChris G, HodgesPaul W, NicholasMichael, TonkinLois, McAuleyJames H, StaffordRyan

Improved chronic low back pain treatment
Chronic low back pain

Chronic lower back pain is a major health problem worldwide. While treatments exist, they are only modestly effective because not everyone responds. Only 25-50% of people respond to exercise, the most common type of treatment. Two popular exercise approaches are graded activity and motor control exercises. However, there are no guidelines to help doctors choose the best treatment for each patient, leading to wasted time and money on ineffective treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Nettle sting for chronic knee pain: a randomised controlled pilot study.

Author: RandallColin, DickensAndy, WhiteAdrian, SandersHilary, FoxMary, CampbellJohn

Nettle sting acceptable
Minor irritation

Research into nettle sting for chronic knee pain is acceptable to patients and general practitioners, and patients do not find the treatment more than a minor irritation. Larger rigorous studies are justified to determine the effectiveness of this ancient therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial.

Author: WuChristopher L, AgarwalShefali, TellaPrabhav K, KlickBrendan, ClarkMichael R, HaythornthwaiteJennifer A, MaxMitchell B, RajaSrinivasa N

Reduced pain intensity
Side effects

Morphine treatment resulted in a decrease in intensity of postamputation pain but was associated with a higher rate of side effects and no improvement in self-reported levels of overall functional activity and pain-related interference in daily activities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

21.

The pain quality response profile of oxymorphone extended release in the treatment of low back pain.

Author: GouldErrol M, JensenMark P, VictorTimothy W, GammaitoniArnold R, WhiteRichard E, GalerBradley S

Pain sensation assessment

This study investigated the utility of assessing the multiple components of non-neuropathic pain in an analgesic clinical trial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews.

Author: KroenkeKurt, KrebsErin E, BairMatthew J

Chronic pain treatment

Chronic pain is a common, expensive, and disabling condition that is often not treated well. Chronic pain often occurs with depression, anxiety, and other mental health conditions, making these conditions harder to treat. This article provides evidence-based guidance on medication for managing chronic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

The scientific evidence for acute pain treatment.

Author: MacintyrePamela E, WalkerSuellen M

Acute pain management

This review discusses the availability, synthesis, and incorporation into clinical practice of recent evidence related to acute pain treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

Acupuncture for cancer pain in adults.

Author: PaleyCarole A, JohnsonMark I, TashaniOsama A, BagnallAnne-Marie

Acupuncture for cancer pain
Acupuncture risks

Acupuncture is proposed as a potential treatment for cancer pain, with guidelines available for its use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Epidemiology of cancer pain.

Author: MarcusDawn A

Pain relief

Cancer pain affects about half of cancer patients, and is moderate or severe in most cases. Despite its prevalence and impact, barriers prevent effective pain management in many patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

26.

Beyond opioid patient-controlled analgesia: a systematic review of analgesia after major spine surgery.

Author: SharmaSonal, BalireddyRavi K, VorenkampKevin E, DurieuxMarcel E

Opioid dependence
Opioid tolerance

This review examines treatment options for postoperative pain control in patients undergoing spine surgery, focusing on alternatives to intravenous opioids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Influence of patient coaching on analgesic treatment adjustment: secondary analysis of a randomized controlled trial.

Author: KravitzRichard L, TancrediDaniel J, JerantAnthony, SaitoNaomi, StreetRichard L, GrennanTim, FranksPeter

Improved pain control
Increased treatment adjustment

Patient-centered tailored education and coaching (TEC) increased the likelihood of physician-directed adjustments in analgesic prescribing, leading to better cancer pain outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Internet-based aftercare for patients with back pain-a pilot study.

Author: MoessnerMarkus, SchiltenwolfMarcus, NeubauerEva

Maintenance of treatment gains
Practical advice and social support
Support after treatment

After multidisciplinary treatment for chronic back pain, innovative support concepts are needed to help patients implement behavioral changes into their daily life and manage relapses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Sensory and affective pain descriptors respond differentially to pharmacological interventions in neuropathic conditions.

Author: GilronIan, TuDongsheng, HoldenRonald R

Improved pain management

This study highlights the challenges of choosing the best pain treatment for individual patients, as the specific causes and mechanisms of pain are often difficult to identify. While animal research provides insights into pain mechanisms, it is not always applicable to humans. The study suggests that paying attention to how people describe their pain (using words) may be valuable in understanding the underlying mechanisms and developing more effective treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Music therapy reduces pain in palliative care patients: a randomized controlled trial.

Author: GutgsellKathy Jo, SchluchterMark, MargeviciusSeunghee, DeGoliaPeter A, McLaughlinBeth, HarrisMariel, MecklenburgJanice, WiencekClareen

Reduced pain

Music therapy, incorporating autogenic relaxation and live music, significantly reduced pain levels in palliative care patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Patient-oriented rehabilitation in the management of chronic mechanical neck pain: a randomized controlled trial.

Author: PaoloniM, TaverneseE, CacchioA, TattoliM, MelisL, RonconiR, SantilliV

Neck pain treatment

A patient-oriented (Pa-O) therapeutic approach, where therapies are tailored to the patient's current physical status at each session, may be beneficial for managing chronic mechanical neck pain (CMNP). This approach differs from a prescription-oriented (Pr-O) approach, where therapies are prescribed at the initial referral and remain unchanged throughout treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

The costs and consequences of adequately managed chronic non-cancer pain and chronic neuropathic pain.

Author: AndrewR, DerrySheena, TaylorRod S, StraubeSebastian, PhillipsCeri J

Chronic pain treatment

Chronic pain significantly impacts patients' lives and burdens healthcare systems and society. Recent studies highlight the negative effects of chronic pain and the positive benefits of successful treatment, making a review of the costs and consequences of chronic pain timely.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

The 2013 EAU guidelines on chronic pelvic pain: is management of chronic pelvic pain a habit, a philosophy, or a science? 10 years of development.

Author: EngelerDaniel S, BaranowskiAndrew P, Dinis-OliveiraPaulo, ElneilSuzy, HughesJohn, MesselinkEmbert J, van OphovenArndt, WilliamsAmanda C,

Pain management

Pain specialists are moving away from focusing solely on the physical source of pelvic pain and are now considering the overall mechanisms of pain, including psychological, social, and sexual factors. This shift affects how pain is classified and treated. Determining the appropriate tests to rule out treatable conditions before adopting this approach requires expertise in both pain management and traditional medical knowledge.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Ketamine for pain in adults and children with cancer: a systematic review and synthesis of the literature.

Author: BredlauAmy Lee, ThakurRajbala, KoronesDavid Nathan, DworkinRobert H

Pain reduction
Anorexia
Depersonalization/derealization
Drowsiness
Hallucinations
Insobriety
Myoclonic movements
Nausea/vomiting
Sedation
Somnolence
Urinary retention

Ketamine may be a viable option for treatment-refractory cancer pain in adults and children, although more research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Intravenous nonopioid analgesic drugs in chronic low back pain patients on chronic opioid treatment: a crossover, randomised, double-blinded, placebo-controlled study.

Author: WetzelLeonore, ZadrazilMarkus, Paternostro-SlugaTatjana, AuthriedGeorg, Kozek-LangeneckerSibylle, ScharbertGisela

Intravenous (i.v.) infusions of nonopioid analgesic drugs fail to improve pain intensity and spinal mobility in chronic low back pain (CLBP) patients on chronic opioid treatment. However, the anticipation of an i.v. infusion of nonopioid analgesic drug improves visual analogue scale (VAS) significantly.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

36.

A Cochrane systematic review of acupuncture for cancer pain in adults.

Author: PaleyCarole A, TashaniOsama A, BagnallAnne-Marie, JohnsonMark I

Reduced cancer pain

There is insufficient evidence to judge whether acupuncture is effective in treating cancer pain in adults.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Effects of visual illusion and transcutaneous electrical nerve stimulation on neuropathic pain in patients with spinal cord injury: A randomised controlled cross-over trial.

Author: ÖzkulÇağla, KılınçMuhammed, YıldırımSibel Aksu, TopçuoğluElif Yalçın, AkyüzMüfit

Functional capacity
Pain reduction

Visual illusion (VI) and transcutaneous electrical nerve stimulation (TENS) therapies were effective in reducing pain intensity, pain quality, and functional limitations in patients with spinal cord injury (SCI) and neuropathic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

39.

A randomized trial of a pain management intervention for adults receiving substance use disorder treatment.

Author: IlgenMark A, BohnertAmy S B, ChermackStephen, ConranCarly, JannauschMary, TraftonJodie, BlowFrederic C

Chronic pain treatment

This study evaluated the effectiveness of a pain management program called ImPAT for people with substance use disorders who also experience chronic pain. The program combines pain management strategies with information on how to manage pain without relying on substances.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

A Mind-Body Program for Older Adults With Chronic Low Back Pain: A Randomized Clinical Trial.

Author: MoroneNatalia E, GrecoCarol M, MooreCharity G, RollmanBruce L, LaneBridget, MorrowLisa A, GlynnNancy W, WeinerDebra K

Function improvement
Pain reduction

A mind-body program improved short-term function and long-term current and most severe pain in older adults with chronic low back pain. The functional improvement was not sustained.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

41.

From "Breakthrough" to "Episodic" Cancer Pain? A European Association for Palliative Care Research Network Expert Delphi Survey Toward a Common Terminology and Classification of Transient Cancer Pain Exacerbations.

Author: LøhreErik Torbjørn, KlepstadPål, BennettMichael I, BrunelliCinzia, CaraceniAugusto, FainsingerRobin L, KnudsenAnne Kari, MercadanteSebastiano, SjøgrenPer, KaasaStein,

Pain management
Treatment guidance

Consensus was reached on definitions and terminology for transient cancer pain exacerbations, which include more than just breakthrough cancer pain (BTCP). The classification of pain exacerbations can aid in tailored treatment approaches, considering patient input and pain pathophysiology.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Pharmacological Treatment of Pain in Cancer Patients: The Role of Adjuvant Analgesics, a Systematic Review.

Author: van den Beuken-van EverdingenMarieke H J, de GraeffAlexander, JongenJoost L M, DijkstraDenise, MostovayaIrina, VissersKris C,

Reduced pain intensity
Low evidence quality

The quality of available evidence on the effectiveness of adjuvant analgesics in the treatment of cancer pain is low.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Novel Three-Day, Community-Based, Nonpharmacological Group Intervention for Chronic Musculoskeletal Pain (COPERS): A Randomised Clinical Trial.

Author: TaylorStephanie J C, CarnesDawn, HomerKate, KahanBrennan C, HounsomeNatalia, EldridgeSandra, SpencerAnne, PincusTamar, RahmanAnisur, UnderwoodMartin

Chronic pain treatment
Opioid dependence

Chronic muscle and joint pain is a major cause of disability worldwide. While medications are often used to treat pain, their effectiveness is limited and they can have side effects, including addiction to opioids. This study looks at the effectiveness of a new group intervention program designed to help manage chronic muscle and joint pain without relying on medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

44.

Does Duration of Neuropathic Pain Impact the Effectiveness of Pregabalin?

Author: PérezConcepción, LatymerMark, AlmasMary, OrtizMarie, ClairAndrew, ParsonsBruce, VarvaraRoxana

Effective treatment
Improved pain

Pregabalin significantly improves pain in patients with neuropathic pain regardless of the duration of pain. This was found in a pooled analysis of 19 randomized placebo-controlled trials involving 5,783 patients with neuropathic pain conditions. Pregabalin was effective in improving pain and increasing Patient Global Impression of Change (PGIC) responders in all pain duration categories, without significant differences in treatment response between these categories.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

45.

A systematic review on the treatment of phantom limb pain with spinal cord stimulation.

Author: AiyerRohit, BarkinRobert L, BhatiaAnurag, GungorSemih

Phantom limb pain treatment
None mentioned

This study discussed the use of spinal cord stimulation (SCS) as a treatment option for phantom limb pain (PLP) when pharmacologic agents fail.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

A randomized placebo-controlled pilot study of the efficacy and safety of D-cycloserine in people with chronic back pain.

Author: SchnitzerThomas J, TorbeySouraya, HerrmannKristi, KaushalGagan, YeastedRenita, Vania ApkarianA

Back pain relief
Chronic back pain

A pilot trial of D-cycloserine for chronic back pain in 41 participants showed a trend toward better pain relief with D-cycloserine compared to placebo. While not statistically significant, the effect size was clinically meaningful, suggesting further research is warranted.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Associations between maternal characteristics and women's responses to acupuncture during labour: a secondary analysis from a randomised controlled trial.

Author: VixnerLinda, SchyttErica, MårtenssonLena B

This cohort study examined associations between maternal characteristics and response to acupuncture for labor pain. Advanced age and cervical dilation were associated with lower pain scores in close proximity to treatment. Advanced age and dysmenorrhea were associated with lower pain scores over a longer time period.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

48.

Non-pharmacological interventions for alleviating pain during orthodontic treatment.

Author: FlemingPadhraig S, StrydomHardus, KatsarosChristos, MacDonaldLci, CuratoloMichele, FudalejPiotr, PandisNikolaos

This research examines pain management during orthodontic treatment. While pharmacological approaches are common, the study explores the potential of non-pharmacological methods to prevent or alleviate pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

[Effectiveness of education based on neuroscience in the treatment of musculoskeletal chronic pain].

Author: Cuenda-GagoJ D, Espejo-AntunezL

Pain neuroscience education

This systematic review examined the effectiveness of pain neuroscience education in the treatment of musculoskeletal disorders with chronic pain. The results suggest that pain neuroscience education is effective in the short term and medium/long term for pain relief.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Spanish

50.

Manual therapy, exercise therapy or combined treatment in the management of adult neck pain - A systematic review and meta-analysis.

Author: FredinKen, LoråsHåvard

Neck disability improvement
Neck pain reduction
Quality of life improvement

Combined treatment consisting of manual therapy (MT) and exercise therapy (ET) does not seem to be more effective in reducing neck pain intensity at rest, neck disability, or improving quality of life in adult patients with grade I-II neck pain, than ET alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Antidepressants for chronic non-cancer pain in children and adolescents.

Author: CooperTess E, HeathcoteLauren C, ClinchJacqui, GoldJeffrey I, HowardRichard, LordSusan M, SchechterNeil, WoodChantal, WiffenPhilip J

Improved neuropathic pain
Pain relief

This review examines the use of antidepressants for treating chronic non-cancer pain in children. The study explores the evidence for using antidepressants in this population and the need for further research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Efficacy and safety of a fixed combination of intramuscular diclofenac 75 mg + thiocolchicoside 4 mg in the treatment of acute low back pain: a phase III, randomized, double blind, controlled trial.

Author: SprovieroEgidio, AlbamonteEmilio, CostantinoCosimo, GiossiAttilio, MancusoMaurizio, RigamontiAlberto, TornariPaolo, CaggianoGiuseppe

Improved mobility
Reduced pain

The study found that a 5-day treatment with IM diclofenac+thiocolchicoside FDC in a 4-mL volume was as effective and well tolerated as the separate injection of the two components in improving pain symptoms in patients with acute moderate-severe LBP.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Interdisciplinary team-based care for patients with chronic pain on long-term opioid treatment in primary care (PPACT) - Protocol for a pragmatic cluster randomized trial.

Author: DeBarLynn, BenesLindsay, BonifayAllison, DeyoRichard A, ElderCharles R, KeefeFrancis J, LeoMichael C, McMullenCarmit, MayhewMeghan, Owen-SmithAshli, SmithDavid H, TrinactyConnie M, VollmerWilliam M

Reduced pain impact

This study described a pragmatic clinical trial investigating the effectiveness of an interdisciplinary biopsychosocial intervention, the Pain Program for Active Coping and Training (PPACT), in reducing pain impact for patients with chronic pain in primary care settings.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

54.

Pulsed Radiofrequency Treatment for Chronic Post-Surgical Orchialgia: A Double-Blind, Sham-Controlled, Randomized Trial: Three-Month Results.

Author: HettaDiab Fuad, MahranAli Mohammed, KamalEmad Eldien

Pain relief
Reduced medication need

Pulsed radiofrequency (PRF) applied to the ilioinguinal and genitofemoral nerves was an effective treatment for chronic post-surgical orchialgia. 80% of patients in the PRF group experienced >50% pain reduction, compared to 23.33% in the sham group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

55.

Effects of Auricular Acupressure on Pain Management: A Systematic Review.

Author: YouEunhea, KimDavid, HarrisRyan, D'AlonzoKaren

Improved pain management

Almost half of hospitalized patients report experiencing pain despite receiving pain medications. Many people seek non-drug options to manage pain, including alternative therapies like auricular acupressure (AA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

56.

The effect of Therapeutic Touch on Back Pain in Adults on a Neurological Unit: An Experimental Pilot Study.

Author: MuellerGerhard, PalliChristoph, SchumacherPetra

Pain relief

This pilot study investigated the pain-relieving effect of Therapeutic Touch in adult neurologic patients with back pain. Pain improvement was found in the intervention group receiving Therapeutic Touch.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

57.

Transcutaneous electrical nerve stimulation (TENS) for chronic pain - an overview of Cochrane Reviews.

Author: GibsonWilliam, WandBenedict M, MeadsCatherine, CatleyMark J, O'ConnellNeil E

Chronic pain treatment
TENS

Chronic pain, lasting more than three months, is common and difficult to treat. While medications and non-medication therapies are often used, transcutaneous electrical nerve stimulation (TENS) is a common additional treatment recommended by doctors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

[Osteopathy for chronic pain after breast cancer surgery: A monocentric randomised study].

Author: ChvetzoffGisèle, BerthierAudrey, BlancEllen, Bourne BranchuValérie, MillaretAnne, CropetClaire, PérolDavid

Improved quality of life
Reduced depression

Osteopathy may improve quality of life and reduce depression in breast cancer patients with chronic pain. While there was no difference in pain scores between the osteopathy and standard analgesic treatment groups, the osteopathy group showed improvement in overall quality of life and reduced depression scores.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

59.

Pulsed Radiofrequency on Thoracic Dorsal Root Ganglion Versus Thoracic Paravertebral Nerve for Chronic Postmastectomy Pain, A Randomized Trial: 6-Month Results.

Author: HettaDiab Fuad, MohamedSahar Abdel Baky, MohamedKawser Hofny, MahmoudTaha Abd Elrazek, EltybHanan Ahmed

Improved PMPS treatment

This study explores the use of radiofrequency technology for managing chronic neuropathic pain in patients with postmastectomy pain syndrome (PMPS), as pharmacologic treatment is not always effective or well-tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

61.

Psychological therapies for the management of chronic pain (excluding headache) in adults.

Author: WilliamsAmanda C de C, FisherEmma, HearnLeslie, EcclestonChristopher

Chronic non-cancer pain treatment

Chronic pain that isn't caused by cancer is a common and debilitating problem, affecting many adults and placing a strain on healthcare systems. Therapy aims to reduce pain, disability, and distress. This review updates previous research on this topic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

The efficacy of analgesics in controlling orthodontic pain: a systematic review and meta-analysis.

Author: ChengCaiqi, XieTian, WangJun

Orthodontic pain control
Pain relief

A meta-analysis was conducted to assess the efficacy of analgesics on the relief of pain in orthodontic treatment. The study found that ibuprofen, naproxen, and acetaminophen were effective in controlling orthodontic pain. Naproxen showed a stronger analgesic effect than ibuprofen and acetaminophen at 2 h and 6 h, and its effect lasted to 24 h.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

64.

Topical Capsaicin for the Treatment of Neuropathic Pain.

Author: SultanaAdiba, SinglaRajeev K, HeXuefei, SunYan, AlamMd Shahin, ShenBairong

Reduced neuropathic pain

Topical capsaicin is effective in reducing neuropathic pain (NP) without affecting motor and large nerve fibers involved in sensory function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

The effectiveness of manual therapy and proprioceptive neuromuscular facilitation compared to kinesiotherapy: a four-arm randomized controlled trial.

Author: ZaworskiKamil, LatosiewiczRobert

Improved function
Pain reduction

Combined therapy of manual therapy and proprioceptive neuromuscular facilitation (PNF) was more effective than traditional kinesiotherapy in improving functional ability in patients with non-specific low back pain (LBP). All treatment methods showed significant pain reduction and decreased disability.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

66.

Efficacy of a combination of hypnosis and transcutaneous electrical nerve stimulation for chronic non-cancer pain: A randomized controlled trial.

Author: Tonye-GeoffroyLouise, Mauboussin CarlosStéphanie, TuffetSophie, FromentinHélène, BerardLaurence, LeblancJudith, LarocheFrançoise

Chronic non-cancer pain treatment

Chronic pain that's not caused by cancer can severely impact quality of life. Many different treatments are used, including medication and non-medication approaches. Nurses in France often use transcutaneous electrical nerve stimulation (TENS) and hypnosis to treat chronic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

67.

Neuromodulation for Pain: A Comprehensive Survey and Systematic Review of Clinical Trials and Connectomic Analysis of Brain Targets.

Author: YamamotoKazuaki, EliasGavin J B, BeynMichelle E, ZemmarAjmal, LohAaron, SaricaCan, GermannJürgen, ParmarRoohie, WongEmily H Y, BoutetAlexandre, KaliaSuneil, HodaieMojgan, LozanoAndres M

Chronic pain treatment

Chronic pain is a major problem, and while medication and therapy are often used, some people don't find relief. This study examines different ways to stimulate the nervous system (neuromodulation) to treat chronic pain. The study explores the various types of neuromodulation and how they work, highlighting the need for more research to understand these approaches better.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Pain Prevalence During Cancer Treatment: A Systematic Review and Meta-Analysis.

Author: EvenepoelMargaux, HaenenVincent, De BaerdemaeckerTom, MeeusMira, DevoogdtNele, DamsLore, Van DijckSophie, Van der GuchtElien, De GroefAn

High pain prevalence

Pain prevalence during cancer treatment was found to be 40% (95% CI 0.29-0.51) in a meta-analysis of 12 studies, with a high degree of heterogeneity. The heterogeneity was partially explained by the method of pain measurement.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

70.

Effectiveness of a Psychosocial Aftercare Program for Youth Aged 8 to 17 Years With Severe Chronic Pain: A Randomized Clinical Trial.

Author: DoganMeltem, HirschfeldGerrit, BlankenburgMarkus, FrühwaldMichael, AhnertRosemarie, BraunSarah, MarschallUrsula, PfenningIngo, ZernikowBoris, WagerJulia

IIPT for severe chronic pediatric pain

Intensive interdisciplinary pain treatment (IIPT) is an established treatment for severe chronic pediatric pain. However, IIPT is not effective for all patients, highlighting the need for additional treatment options to address this widespread and debilitating condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

71.

Effectiveness of prednisolone in complex regional pain syndrome treatment: A systematic narrative review.

Author: KwakSang Gyu, ChooYoo Jin, ChangMin Cheol

CRPS symptom control
Effective at low dose
Minor side effects

Oral prednisolone may be effective in alleviating complex regional pain syndrome (CRPS) symptoms. However, more research with randomized controlled trials is needed to confirm this finding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

Psychological and Non-Pharmacologic Treatments for Pain in Cancer Patients: A Systematic Review and Meta-Analysis.

Author: RuanoAlejandra, García-TorresFrancisco, Gálvez-LaraMario, MorianaJuan A

Cancer pain reduction
Further research needed
Inconclusive results

This systematic review analyzed the efficacy of psychological and non-pharmacological treatments for reducing pain in cancer patients. Mindfulness-based cognitive therapy, guided imagery and progressive muscle relaxation, and emotional and symptom focused engagement (EASE) were found to be the most effective interventions. Music therapy and brief cognitive behavioral strategies require further research. Coping skills training and yoga did not show positive effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

73.

Opioid reduction for patients with chronic pain in primary care: systematic review.

Author: de KleijnLoes, PedersenJulie Rønne, Rijkels-OttersHanneke, ChiarottoAlessandro, KoesBart

Multidisciplinary care
Opioid reduction

This systematic review of controlled trials and cohort studies found that GP-supervised tapering and multidisciplinary group therapeutic sessions may be effective strategies for reducing long-term opioid treatment for patients with chronic non-cancer pain. However, due to the high risk of bias and small sample sizes of the included studies, no firm conclusions can be made.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

Organizational changes lead to a reduction in opioid consumption among chronic pain patients: A systematic review.

Author: BacheNina, GeislerAnja

Opioid reduction

A systematic review of 11 studies on organizational changes in pain treatment for patients with chronic nonmalignant pain found that implementing new follow-up procedures resulted in a reduction in opioid consumption.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

Neurodynamic exercises provide no additional benefit to extension-oriented exercises in people with chronic low back-related leg pain and a directional preference: A randomized clinical trial.

Author: Sousa FilhoLuis Fernando, Barbosa SantosMarta Maria, Matos VasconcelosDanielle Brito, SoaresErilaine Araujo, Dos SantosGabriel Henrique Freire, da Silva JúniorWalderi Monteiro

None
None

This randomized clinical trial assessed the effects of adding neurodynamic exercises to extension-oriented exercises for patients with chronic low back-related leg pain and a directional preference for lumbar extension movements. The study found no benefits in adding neurodynamic exercises, suggesting that extension-oriented exercises alone may be sufficient in this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

76.

Effect of Ear Acupuncture plus Dry Cupping on Activities and Quality of Life in the Adults with Chronic Back Pain: a Randomized Trial.

Author: MouraCaroline de Castro, ChavesErika de Cássia Lopes, NogueiraDenismar Alves, IunesDenise Hollanda, AzevedoCissa, CorrêaHérica Pinheiro, PereiraGabriela Aparecida, SilvanoHigor Magalhães, MacieiraTamara Goncalves Rezende, ChiancaTânia Couto Machado

Improved quality of life
Reduced pain interference

Ear acupuncture combined with dry cupping therapy showed greater improvement in quality of life and satisfaction with health compared to ear acupuncture alone in patients with chronic back pain. A randomized controlled trial found significant improvements in daily activities, mood, relationships, and sleep for both groups. However, the experimental group reported greater satisfaction with health and a better perception of quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

77.

The Effect of Electroacupuncture Therapy on Pain, Plasma β-Endorphin, and Quality of Life of Stage III Cervical Cancer Patients: A Randomized Control Trial.

Author: SaraswatiWita, WardaniRatih, SuhatnoSuhatno, HartonoPudjo, ImandiriArio

Improved QoL
Increased beta-endorphin
Reduced pain

Electroacupuncture (EA) combined with medical therapy showed significant benefits for stage III cervical cancer patients experiencing pain. The treatment group experienced a greater reduction in pain scores, a rise in plasma β-endorphin levels, and an improvement in quality of life compared to the control group. This highlights the potential of EA as an adjunct therapy for managing cancer pain.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

78.

Placebo Response and Media Attention in Randomized Clinical Trials Assessing Cannabis-Based Therapies for Pain: A Systematic Review and Meta-analysis.

Author: GedinFilip, BloméSebastian, PonténMoa, LalouniMaria, FustJens, RaquetteAndreé, Vadenmark LundquistViktor, ThompsonWilliam H, JensenKarin

Limited superiority

This study suggests that positive expectations may play a role in the effectiveness of medicinal cannabis for persistent pain, as the superiority of cannabinoids over placebo in clinical trials is limited.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

79.

Self-administered acupressure for veterans with chronic back pain: Study design and methodology of a type 1 hybrid effectiveness implementation randomized controlled trial.

Author: MurphySusan L, ZickSuzanna M, HarrisRichard E, SmithShawna N, SenAnanda, AlexanderNeil B, CaldararoJennifer, RomanPia, FirshtElizabeth, BelancourtPatrick, MaciaszRachael, PerzhinskyJuliette, MitchinsonAllison, KreinSarah L

Pain management

Chronic low back pain is prevalent and disabling in Veterans, but effective pain management is challenging. This study examines the potential of self-administered acupressure as a first-line treatment option for chronic low back pain in Veterans.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

81.

Psychological therapies delivered remotely for the management of chronic pain (excluding headache) in adults.

Author: RosserBenjamin A, FisherEmma, JanjuaSadia, EcclestonChristopher, KeoghEdmund, DugganGeoffrey

Pain management
Treatment access

Chronic pain, lasting over three months, is a significant problem. Traditional treatments can be difficult to access due to limited resources, location, and cost. This study looks at the potential of using technology to deliver psychological therapies for chronic pain remotely. The goal is to see if online therapy is as effective as in-person therapy for managing chronic pain.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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