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Controversies in the treatment of metastatic prostate cancer.

Author: BlumensteinB A, CrawfordE D, DorrF A, EisenbergerM A, McLeodD G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Combination therapy with leuprolide and flutamide showed an increased progression-free survival time and survival advantage compared to leuprolide alone in patients with advanced prostate cancer, particularly those with good performance and minimal disease.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Prostate cancer is the most common cancer in American men today. Unfortunately, at the time of diagnosis, most men will have either regional or distant metastatic disease. METHODS: Six hundred three patients with advanced prostate cancer who could be examined were randomized in a double...See full text at original site
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引用元：
https://doi.org/10.1002/1097-0142(19920701)70:1+<324::aid-cncr2820701321>3.0.co;2-g

データ提供：米国国立医学図書館（NLM）

Metastatic Prostate Cancer: A Journey Through the Desert of Treatment Options

[Prostate cancer] is a common malignancy that can sometimes spread to other parts of the body. This study investigates the [efficacy of combination therapy] using [leuprolide and flutamide] for [metastatic prostate cancer]. The authors conducted a [double-blind, placebo-controlled trial] to evaluate the effectiveness of this treatment approach. Their findings suggest that [combination therapy significantly improved progression-free survival and overall survival] compared to [leuprolide alone]. This study highlights the [potential for improving treatment outcomes] by employing [a combination of therapies] to target [different aspects of the disease].

Combination Therapy: A Promising Oasis in the Desert of Metastatic Prostate Cancer

The study's findings suggest that [combination therapy with leuprolide and flutamide] may offer a [significant improvement in survival] for patients with metastatic prostate cancer. The authors emphasize the importance of [individualized treatment plans] to optimize outcomes and address the unique needs of each patient.

Navigating the Desert: Managing Metastatic Prostate Cancer

This study highlights the importance of [ongoing research and clinical trials] to evaluate new treatment options for metastatic prostate cancer. The authors emphasize the need for [continued collaboration between healthcare providers and researchers] to develop [more effective and personalized therapies] for this challenging disease.

Dr. Camel's Conclusion

The desert of metastatic prostate cancer can be a daunting journey, but this study offers a glimmer of hope in the form of combination therapy. The findings suggest that combining leuprolide and flutamide may significantly improve survival for patients with this disease. Remember, like a camel seeking a safe haven in the desert, we must rely on the collective knowledge and expertise of healthcare providers and researchers to navigate this challenging landscape and find effective treatments for our patients.

Date :
  1. Date Completed 1992-07-16
  2. Date Revised 2019-06-19
Further Info :

Pubmed ID

1600494

DOI: Digital Object Identifier

10.1002/1097-0142(19920701)70:1+<324::aid-cncr2820701321>3.0.co;2-g

Related Literature

Article Analysis
・Effective treatment of prostate cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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