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Effects of fexofenadine and hydroxyzine on brake reaction time during car-driving with cellular phone use.

Author: HindmarchIan, HorikawaEtsuo, InokuchiTakatoshi, KatoMotohisa, MochizukiHideki, RidoutFran, SakuradaYumiko, TashiroManabu, YanaiKazuhiko

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the effects of fexofenadine and hydroxyzine, antihistamines, on driving performance with and without cellular phone usage. The study found that fexofenadine did not impair CNS function, even when driving while using a cell phone. Hydroxyzine, however, significantly increased sedation and slowed brake reaction time, suggesting impaired driving performance, particularly when combined with cell phone use.
Paper Details　
Original Abstract of the Article :
Antihistamines are a mainstay treatment for allergic rhinitis; however, many older agents cause adverse events, including sedation and central nervous system (CNS) impairment. Research has shown sedating effects of antihistamines on driving; currently, no known study has examined whether cellular ph...See full text at original site
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引用元：
https://doi.org/10.1002/hup.713

データ提供：米国国立医学図書館（NLM）

Antihistamines and Driving: A Camel's Journey Through the Desert of Cognition

The desert of cognition is a vast and complex landscape, with many factors influencing our ability to think clearly and react quickly. This research explores the potential impact of antihistamines on cognitive function, specifically focusing on their effects on brake reaction time (BRT) during driving. The study investigated the effects of two antihistamines, fexofenadine and hydroxyzine, on BRT in healthy volunteers while they were driving under various conditions, including driving alone, driving while completing calculations, and driving while conversing on a cell phone.

Antihistamines and Driving: A Cautionary Tale

The results showed that fexofenadine did not significantly impair BRT in any driving condition, even when the volunteers were engaged in a divided attention task involving cellular phone use. However, hydroxyzine was associated with significantly slower BRTs compared to both fexofenadine and placebo, suggesting a potential for delayed reaction times and increased risk while driving. Furthermore, cellular phone use was an additive factor, further increasing BRTs in hydroxyzine-treated volunteers.

A Camel's Guide to Safe Driving

This research highlights the importance of understanding the potential effects of medications on our cognitive function, especially when engaging in activities that require alertness and quick reactions, such as driving. It suggests that certain antihistamines, like hydroxyzine, could impair driving performance and should be used with caution, particularly when engaging in tasks that require divided attention.

Dr. Camel's Conclusion

The desert of cognition is a delicate and complex landscape, with numerous factors influencing our ability to think clearly and react swiftly. This research serves as a reminder that medications can have significant effects on our cognitive function, and it is essential to be aware of these potential impacts, especially when engaging in activities like driving that demand alertness and quick reflexes.

Date :
  1. Date Completed 2006-01-05
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

16086364

DOI: Digital Object Identifier

10.1002/hup.713

Related Literature

Article Analysis
・Effects of hydroxyzine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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