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Uridine in the prevention and treatment of NRTI-related mitochondrial toxicity.

Author: VenhoffNils, WalkerUlrich A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Nucleoside analogue reverse transcriptase inhibitors (NRTIs) are used to treat HIV infection but can cause mitochondrial toxicity. Uridine has been shown to prevent and treat mitochondrial toxicity caused by NRTIs and to improve the liver and hematopoietic toxicities of zidovudine. Uridine can be safely increased in humans to achieve concentrations that are protective in vitro. Mitocnol, a sugar cane extract that increases uridine levels, has been shown to be beneficial in HIV patients with mitochondrial toxicity and is currently being tested in clinical trials.
Paper Details　
Original Abstract of the Article :
Long-term side effects of antiretroviral therapy are attributed to the mitochondrial (mt) toxicity of nucleoside analogue reverse transcriptase inhibitors (NRTIs) and their ability to deplete mtDNA. Studies in hepatocytes suggest that uridine is able to prevent and treat mtDNA depletion by pyrimidin...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/16152713

データ提供：米国国立医学図書館（NLM）

Uridine: A Potential Solution for NRTI-Related Mitochondrial Toxicity

This study investigates the potential benefits of uridine, a naturally occurring nucleoside, in preventing and treating mitochondrial toxicity associated with nucleoside analogue reverse transcriptase inhibitors (NRTIs), a class of drugs commonly used to treat HIV. The study examines the mechanisms by which uridine may protect mitochondria from NRTI-induced damage and explores its potential as a therapeutic agent.

Uridine’s Protective Role: Safeguarding Mitochondria

The researchers demonstrate that uridine can effectively prevent and treat mitochondrial DNA depletion caused by certain NRTIs, potentially mitigating the adverse effects of these drugs on cellular function. The study highlights the potential of uridine to improve liver and hematopoietic toxicities associated with NRTIs, suggesting a broader range of protective effects beyond mitochondrial toxicity.

Managing HIV Treatment: A Balancing Act

This study underscores the importance of understanding and managing the potential side effects of HIV treatment. It highlights the need for ongoing research to develop safer and more effective treatment options, minimizing the risk of mitochondrial toxicity while maximizing the benefits of antiretroviral therapy. The study encourages further investigation into the use of uridine and other potential therapies to mitigate the adverse effects of NRTIs.

Dr.Camel's Conclusion

Just as a camel can endure long journeys through the desert, seeking out life-sustaining water sources, researchers are diligently searching for ways to mitigate the potential side effects of HIV treatment. This study offers a promising glimpse into the potential of uridine to safeguard mitochondrial health and improve the lives of individuals living with HIV.

Date :
  1. Date Completed 2005-09-29
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16152713

DOI: Digital Object Identifier

16152713

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English

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