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Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial.

Author: AdamsJudith A, DeSilvioMichelle L, MillerDaniel W, RossiCarl J, ShipleyWilliam U, SlaterJerry D, ZietmanAnthony L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Men with clinically localized prostate cancer receiving high-dose conformal radiation had a lower risk of biochemical failure compared to those receiving conventional-dose radiation. This advantage was achieved without any associated increase in acute or late urinary or rectal morbidity.
Paper Details　
Original Abstract of the Article :
CONTEXT: Clinically localized prostate cancer is very prevalent among US men, but recurrence after treatment with conventional radiation therapy is common. OBJECTIVE: To evaluate the hypothesis that increasing the radiation dose delivered to men with clinically localized prostate cancer improves di...See full text at original site
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引用元：
https://doi.org/10.1001/jama.294.10.1233

データ提供：米国国立医学図書館（NLM）

High-Dose Radiation Therapy for Prostate Cancer: A Powerful Weapon in the Fight

Prostate cancer, a common malignancy, is a significant health concern for men. Imagine a desert where the sand dunes represent cancerous cells, growing and spreading. This research investigates the effectiveness of high-dose conformal radiation therapy in treating localized prostate cancer. It's like discovering a powerful weapon to combat these cancerous dunes, aiming to eradicate them and prevent their spread.

The Benefits of High-Dose Therapy: A More Effective Approach to Prostate Cancer

The researchers found that high-dose radiation therapy significantly reduced the risk of biochemical failure (reappearance of cancer) compared to conventional-dose therapy. This is like discovering a more effective weapon in the desert, one that can more effectively target and destroy the cancerous cells. The study highlights the potential of high-dose therapy to improve treatment outcomes and provide a more durable solution for patients with localized prostate cancer.

Navigating the Risks of Radiation Therapy: A Careful Balance

While high-dose therapy offers promising results, it's essential to recognize the potential for side effects, such as urinary or rectal complications. It's like encountering a patch of quicksand in the desert, requiring careful navigation. By carefully monitoring patients and managing potential side effects, healthcare providers can minimize the risks and maximize the benefits of high-dose radiation therapy.

Dr. Camel's Conclusion

The desert of prostate cancer can be a challenging terrain, but research continues to uncover new weapons to fight this disease. High-dose conformal radiation therapy offers a powerful tool for treating localized prostate cancer, potentially providing a more durable solution. By carefully navigating the risks and balancing the benefits, we can harness the power of high-dose therapy to improve treatment outcomes and offer patients a greater chance of conquering this disease.

Date :
  1. Date Completed 2005-09-15
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

16160131

DOI: Digital Object Identifier

10.1001/jama.294.10.1233

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Article Analysis
・Effective treatment of prostate cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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