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Systematic review: treatment of chronic hepatitis B virus infection by pegylated interferon.

Author: ChanH L-Y, CheungA Y-K, CooksleyG, HuiA Y, SungJ J-Y

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study found that peginterferon-alpha treatment of at least 6 months should be considered as one of the first-line therapeutic options for hepatitis B virus infection.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Pegylated interferon-alpha has been shown to be more efficacious than conventional interferon in treating chronic hepatitis C. The use of peginterferon in chronic hepatitis B virus infection with positive hepatitis B e antigen has also been tested in a number of trials since 2003. AIM: ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.2005.02616.x

データ提供：米国国立医学図書館（NLM）

Pegylated Interferon: A Promising Weapon Against Chronic Hepatitis B

The fight against viral hepatitis is an ongoing battle, and the quest for effective therapies is a constant pursuit. This study reviews the efficacy and safety of pegylated interferon-alpha, a potent antiviral medication, in treating chronic hepatitis B virus infection, a persistent and potentially serious liver infection. The researchers systematically review the results of multiple clinical trials that investigated the use of pegylated interferon in this setting.

Pegylated Interferon: A Potent Force Against Hepatitis B

The review reveals that pegylated interferon-alpha outperforms lamivudine monotherapy, a commonly used treatment for chronic hepatitis B. It demonstrates that pegylated interferon can induce sustained biochemical and virological responses, akin to creating a protective oasis in the desert of viral infection, in a significant proportion of patients. The review also highlights the potential for pegylated interferon to reduce the emergence of drug-resistant mutations, a common challenge in antiviral therapy.

A Beacon of Hope: A New Era in Hepatitis B Treatment

These findings provide a glimmer of hope for patients with chronic hepatitis B virus infection. Pegylated interferon-alpha offers a potent and effective treatment option, holding the potential to significantly improve outcomes for those battling this persistent and potentially serious disease. It's like discovering a hidden spring in the desert, offering a valuable source of relief and hope.

Dr.Camel's Conclusion

This review highlights the promising role of pegylated interferon-alpha in treating chronic hepatitis B virus infection. It provides valuable insights into the efficacy and safety of this medication, offering a beacon of hope for patients seeking effective treatment options.

Date :
  1. Date Completed 2006-08-21
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

16167968

DOI: Digital Object Identifier

10.1111/j.1365-2036.2005.02616.x

SNS
PICO Info
in preparation
Languages

English

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