Effects of ATRA, acitretin and tazarotene on growth and apoptosis of Tca8113 cells.

Author: RanLiwei, TanShengshun, TanWeiming, WangWanjuan, ZengWeihui, ZhangRu

Paper Details 
Original Abstract of the Article :
To investigate the effects of ATRA, acitretin and tazarotene on the growth and apoptosis of human tongue squamous cell carcinoma cell line Tca8113. The effect of retinoids on growth of Tca8113 cells in vitro was examined by MTT assay and Trypan blue exclusion assay. Cell cycle analysis, early apopto...See full text at original site
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引用元:
https://doi.org/10.1007/BF02828205

データ提供:米国国立医学図書館(NLM)

Retinoids' Effects on Human Tongue Squamous Cell Carcinoma Cells

This study explores the potential therapeutic effects of retinoids, a class of vitamin A derivatives, on human tongue squamous cell carcinoma cells (Tca8113). The authors investigated the effects of all-trans retinoic acid (ATRA), acitretin, and tazarotene on the growth and apoptosis of these cancer cells. Their findings demonstrate that all three retinoids inhibited the growth of Tca8113 cells in a dose- and time-dependent manner. They also found that retinoids induced apoptosis in these cells, potentially through a caspase-dependent mechanism. The study highlights the promising anticancer potential of retinoids for the treatment of tongue squamous cell carcinoma.

Retinoids as Potential Anticancer Agents for Tongue Squamous Cell Carcinoma

This study provides evidence for the anticancer effects of retinoids on tongue squamous cell carcinoma cells. The study's findings suggest that retinoids, particularly acitretin, may have therapeutic potential for the treatment and prevention of this type of cancer.

Health Implications and Life Applications

Tongue squamous cell carcinoma is a serious condition, but this study offers hope for new treatment options. The study's findings highlight the potential benefits of retinoids in treating this type of cancer, potentially leading to improved patient outcomes.

Dr. Camel's Conclusion

This research is like finding a hidden spring of hope in the vast desert of cancer treatment. Retinoids, like a refreshing oasis, offer potential new avenues for combating tongue squamous cell carcinoma. This study encourages continued research into the therapeutic potential of retinoids for the treatment of various types of cancer.

Date :
  1. Date Completed 2007-10-09
  2. Date Revised 2019-11-09
Further Info :

Pubmed ID

16196285

DOI: Digital Object Identifier

10.1007/BF02828205

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