Effects of acitretin: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Major Research Findings

Acitretin is a retinoid commonly used in dermatology to treat psoriasis. 5 Studies have shown that acitretin can affect cell growth and apoptosis, particularly in melanoma cells. 18 It has also been shown to inhibit cell proliferation and RANTES production in keratinocytes. 10 Moreover, research suggests that acitretin can have beneficial effects on neuronal development. 4 Acitretin has been investigated for its potential use in treating various conditions, including skin cancers, spinal cord injuries, and Alzheimer's disease. 2 7 4

Benefits and Risks

Benefit Summary

Acitretin shows promise in the treatment of certain skin conditions like psoriasis. 6 It can inhibit cell proliferation and induce apoptosis, potentially reducing the severity of psoriasis. 10 Additionally, it might have potential benefits for neuronal development and treatment of neurodegenerative diseases. 4

Risk Summary

Acitretin use is associated with potential risks, including elevated serum lipids, liver function abnormalities, and teratogenicity. 3 Moreover, it can affect peripheral nerve function, causing sensory nerve dysfunction in some individuals. 22 Careful monitoring is necessary during acitretin treatment, and patients should be informed about potential side effects.

Comparison of Studies

Commonalities

A consistent theme across multiple studies is that acitretin exhibits a range of effects on cell growth and differentiation, impacting both normal and cancerous cells. It's frequently employed in the treatment of skin conditions, particularly psoriasis.

Differences

The studies highlight the complexity of acitretin's effects, with variations in how it influences different cell types and disease processes. While some studies focus on its impact on keratinocytes in psoriasis, others explore its effects on melanoma cells or neuronal development. The specific mechanisms and consequences of acitretin's action are still under investigation.

Consistency and Discrepancies

There is a degree of consistency regarding acitretin's effectiveness in treating psoriasis, but research on its influence on neuronal function and potential side effects has yielded mixed results. Further studies are needed to fully understand its long-term effects and the possible risks associated with its use.

Considerations for Real-World Application

While acitretin shows promise for certain conditions, its use should be carefully considered and monitored by healthcare professionals. Patients should be informed about potential risks and side effects. 1 16 20 21 8

Current Limitations of Research

The understanding of acitretin's long-term effects and potential for drug-drug interactions needs further investigation. 22 4 8

Future Research Directions

Continued research is necessary to clarify the long-term effects of acitretin, investigate potential benefits in various conditions, and develop strategies to mitigate potential risks.

Conclusion

Acitretin is a retinoid with potential therapeutic benefits for certain skin conditions, but its use requires careful monitoring and consideration of potential risks. More research is needed to fully understand its long-term effects, potential applications, and optimal dosage regimens.

Literature analysis of 22 papers
Positive Content
21
Neutral Content
1
Negative Content
0
Article Type
1
1
0
1
22
1.

Low-dose acitretin is associated with fewer adverse events than high-dose acitretin in the treatment of psoriasis.

Author: PearceDaniel J, KlingerStephen, ZielKristin K, MuradEmma J, RowellRichard, FeldmanSteven R

Better tolerated
Fewer abnormalities

Lower-dose acitretin therapy (25 mg/d) appears to be better tolerated and associated with fewer laboratory abnormalities compared to the standard 50 mg/d dose. Further research is needed to confirm this finding based on data from original phase 3 trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Vemurafenib-related cutaneous side effects ameliorated by acitretin.

Author: ChonSusan Y, SambranoBrittany L, GeddesElizabeth R

Melanoma treatment
Survival improvement
Cutaneous neoplasms
Skin cancer development

Vemurafenib, a BRAF kinase inhibitor, is effective in treating metastatic melanoma but can cause cutaneous neoplasms, including squamous cell carcinomas (SCCs), keratoacanthomas (KAs), and hyperkeratotic papules. This article discusses the potential benefits and risks of using systemic retinoids for chemoprophylaxis in individuals at high risk for skin cancers.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Acitretin exhibits inhibitory effects towards UDP-glucuronosyltransferase (UGT)1A9-mediated 4-methylumbelliferone (4-MU) and propofol glucuronidation reaction.

Author: YuMing-Lian, YangYue, WangCong-Min, ZhangMeng-Meng, BaiMiao-Chun, GuoYue-Ling

Psoriasis treatment
Drug interactions

The study investigated the potential risk of drug-drug interactions associated with acitretin, a drug for the therapy of psoriasis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Cytotoxic and genotoxic effects of acitretin, alone or in combination with psoralen-ultraviolet A or narrow-band ultraviolet B-therapy in psoriatic patients.

Author: SilvaF S G, OliveiraH, MoreirasA, FernandesJ C, Bronze-da-RochaE, FigueiredoA, CustódioJ B A, Rocha-PereiraP, Santos-SilvaA

Psoriasis treatment
Genotoxic effects

Acitretin alone or in combination with narrow-band ultraviolet B (NBUVB) did not show genotoxic effects in psoriatic patients. Acitretin+PUVA showed slight genotoxic effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

[Synergistic effects of acitretin and narrow-band ultraviolet-B in inducing retinoic acid receptor gamma mRNA expression in normal human keratinocytes].

Author: LuoSu-ju, PengZhen-hui, ZhengYan, XuHao-xiang, ZhouShao-na, LiXiao-li, WangGuo-rong

Keratinocyte growth inhibition

Treatment with acitretin and narrow-band ultraviolet-B irradiation synergistically enhances the expression of retinoic acid receptor gamma mRNA in normal human keratinocytes.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

12.

Synergistic effects of acitretin and narrow-band UVB on inducing the expression of heparin-binding epidermal-growth-factor-like growth factor in normal human keratinocytes.

Author: LuoSuju, PengZhenhui, ZhengYan, ZhangLukun, FengYiguo, WangGuorong

Psoriasis treatment

This study investigated the effects of acitretin and narrow-band UVB (NB-UVB) on cell proliferation and HB-EGF expression in cultured normal human keratinocytes. The combination of acitretin and NB-UVB showed the strongest inhibition of keratinocyte proliferation and the highest induction of HB-EGF mRNA expression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Effects of topically applied acitretin in reconstructed human epidermis and the rhino mouse.

Author: HsiaEdward, JohnstonMichael J, HouldenRobert J, ChernWendy H, HoflandHans E J

Increased local bioavailability
Less irritation
Reduced systemic toxicity

Topical acitretin is a potential treatment for keratinization disorders. It is less irritating than other topical retinoids, such as tretinoin and tazarotene.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Effects of acitretin on spermatogenesis of rats.

Author: SengörB, BayramgürlerD, MüezzinogluB, AltintasL, BilenN, ApaydinR

No spermatogenesis effect

Acitretin, a retinoid, was investigated for its effects on spermatogenesis in rats. No statistically significant effects were observed on spermatogenesis after 8 and 16 weeks of standard or high-dose acitretin administration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

[Effects of acitretin on the expression of signaling pathway-related genes in epidermal squamous-cell carcinoma cells].

Author: CaiSui-qing, ChenLi-rong, ZhengMin

STAT3 inhibition

Acitretin, a retinoid used to treat skin cancers, inhibits the expression of STAT3, cyclin D1, and p42/44MAPK in an epidermal squamous-cell carcinoma cell line. In a study using A431 cells, acitretin downregulated the mRNA and protein levels of these signaling pathway-related genes in a time-dependent manner, suggesting that acitretin's therapeutic effect may involve modulation of these pathways.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

16.

Evidence based or theoretical concern? Pseudotumor cerebri and depression as acitretin side effects.

Author: StarlingJohn, KooJohn

Psoriasis treatment
Depression
Pseudotumor cerebri

This review examines the scientific evidence for two potential side effects of acitretin: pseudotumor cerebri and depression. There is currently a lack of strong scientific evidence to support these associations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Effects of ATRA, acitretin and tazarotene on growth and apoptosis of Tca8113 cells.

Author: RanLiwei, TanWeiming, TanShengshun, ZhangRu, WangWanjuan, ZengWeihui

Tongue squamous cell carcinoma treatment

Retinoids, including ATRA, acitretin, and tazarotene, inhibit the growth and induce apoptosis of human tongue squamous cell carcinoma cells. Acitretin showed the most potent effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

[Effects of all-trans-retinoic acid, acitretin and tazarotene on apoptosis and Bax/Bcl-2 expressions of human melanoma cells A375 and the significance].

Author: RanLi-wei, TanSheng-shun, WangWan-juan, QiuShi, LeiXiao-bing, ZengWei-hui

Apoptosis induction

Retinoids ATRA, acitretin, and tazarotene induced apoptosis in human melanoma A375 cells, possibly through the mitochondrial pathway. Acitretin showed the strongest effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

19.

Acitretin treatment in (pre)malignant skin disorders of renal transplant recipients: Histologic and immunohistochemical effects.

Author: SmitJürgen V, de SévauxRuud G L, BlokxWilleke A M, van de KerkhofPeter C M, HoitsmaAndries J, de JongElke M G J

Reduced Skin Cancers

Acitretin treatment may reduce the incidence of (pre)malignant skin lesions in renal transplant recipients. However, more research is needed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Acitretin treatment of premalignant and malignant skin disorders in renal transplant recipients: clinical effects of a randomized trial comparing two doses of acitretin.

Author: de SévauxR G L, SmitJ V, de JongE M G J, van de KerkhofP C M, HoitsmaA J

Actinic keratosis improvement
Squamous cell carcinoma reduction
Side effects

This study reviews the use of acitretin to treat premalignant and malignant skin lesions in renal transplant recipients. While acitretin can improve the appearance and number of actinic keratoses and reduce the incidence of squamous cell carcinomas, it can also cause frequent side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Effects of oral acitretin on contrast sensitivity and tear film function: a prospective study.

Author: GartaganisS P, MelaE K, GeorgakopoulosC D, GeorgiouS, MonastirliA, MerkH F, TsambaosD

Dermatoses treatment

This study found no significant ocular side effects associated with short-term oral acitretin treatment in patients with severe dermatoses.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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