Suppression of the histamine-induced wheal and flare response by fexofenadine HCl 60 mg twice daily, loratadine 10 mg once daily and placebo in healthy Japanese volunteers.

Fexofenadine: A Potent Antihistamine in Japanese Subjects

This study investigates the effects of the selective H1-receptor antagonist fexofenadine on the histamine-induced wheal and flare response in healthy Japanese volunteers, providing valuable insights into the drug's efficacy in an Asian population. The researchers conducted a double-blind, crossover study, comparing the effects of fexofenadine with loratadine, another antihistamine, and placebo. The findings highlight the potential of fexofenadine as a potent antihistamine with a rapid onset of action and a long duration of effect.

Fexofenadine: A Superior Antihistamine

The study demonstrated that fexofenadine produced significantly greater suppression of both the wheal and flare responses compared to placebo and loratadine. Furthermore, fexofenadine exhibited a significantly faster onset of action and a longer duration of effect than loratadine. These results confirm the effectiveness of fexofenadine as a potent antihistamine in Japanese subjects.

A New Understanding of Antihistamine Action

The study provides valuable insights into the mechanism of action of fexofenadine. The researchers found that the antihistamine effects of fexofenadine were significantly correlated with its peak plasma concentration, suggesting a direct relationship between drug levels and therapeutic efficacy. This understanding could inform future drug development and optimize treatment strategies for allergic reactions.

Dr.Camel's Conclusion

This research is like a refreshing breeze blowing across the desert of allergy relief. It reveals that fexofenadine is a potent and effective antihistamine, even in Japanese subjects. This research provides valuable information for clinicians, helping them to choose the most appropriate antihistamine for their patients based on individual needs and preferences.