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Urodynamic effects of oxybutynin and tolterodine in conscious and anesthetized rats under different cystometrographic conditions.

Author: AngelicoPatrizia, GuarneriLuciano, LeonardiAmedeo, SironiGiorgio, TestaRodolfo, VelascoCristina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Oxybutynin and tolterodine, antimuscarinic drugs, were studied in rats to determine the experimental conditions required to reproduce their clinical pharmacological effects, particularly their ability to increase bladder capacity.
Paper Details　
Original Abstract of the Article :
Antimuscarinic agents are the most popular treatment for overactive bladder and their efficacy in man is well documented, producing decreased urinary frequency and an increase in bladder capacity. During cystometry in rats, however, the main effect reported after acute treatment with antimuscarinics...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1274333/

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of Oxybutynin and Tolterodine: A Journey Through the Bladder's Labyrinth

This research explores the urodynamic effects of oxybutynin and tolterodine, two commonly prescribed antimuscarinic medications used to treat overactive bladder. The study investigated the effects of these drugs on bladder capacity and micturition pressure in rats, examining their actions under different cystometrographic conditions.

Navigating the Labyrinth of Bladder Function

This study delves into the intricacies of bladder function, revealing the complex interplay between antimuscarinic drugs, bladder capacity, and micturition pressure. Researchers found that oxybutynin and tolterodine exhibited distinct effects on bladder function, highlighting the importance of considering the specific characteristics of each medication when designing treatment strategies for overactive bladder.

Unveiling the Mechanisms of Antimuscarinic Action

This research provides valuable insights into the mechanisms of action of antimuscarinic medications for overactive bladder. By studying the effects of oxybutynin and tolterodine under different experimental conditions, researchers gain a deeper understanding of how these drugs interact with the bladder, paving the way for more targeted and effective treatments.

Dr. Camel's Conclusion

The desert of bladder function is complex and filled with intricate pathways. This study illuminates the unique effects of oxybutynin and tolterodine, revealing the intricate mechanisms by which these antimuscarinics influence bladder capacity and micturition pressure. This research provides valuable insights for navigating the terrain of overactive bladder treatment, guiding us towards more effective and individualized approaches.

Date :
  1. Date Completed 2006-02-01
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

16216132

DOI: Digital Object Identifier

PMC1274333

Related Literature

Article Analysis
・Effects of tolterodine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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