Effects of tolterodine: A Synthesis of Findings from 15 Studies

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Original Abstract of the Article

Major Research Findings

Tolterodine is a medication commonly used to treat overactive bladder (OAB). Multiple studies have investigated the effects of tolterodine. 9 found that tolterodine can increase bladder capacity. 15 reported that tolterodine improves health-related quality of life (HRQoL) in patients with OAB. 12 showed that tolterodine has a smaller impact on the central nervous system (CNS) compared to oxybutynin. 8 demonstrated that tolterodine is effective in improving OAB and urgency urinary incontinence symptoms in sexually active women. 2 indicated that tolterodine can alleviate discomfort associated with ureteral stents. 4 showed that tolterodine is effective in treating OAB symptoms in women, but may have different outcomes compared to mirabegron. 7 suggested that combining tolterodine with elocalcitol could enhance bladder function improvement. 11 showed that tolterodine combined with bladder training can effectively improve OAB symptoms. 3 found that tolterodine has a greater effect on increasing bladder capacity compared to the β3-adrenoceptor agonist, ritobegron. 1 demonstrated that tolterodine does not have a clinically significant effect on QT interval. 10 suggested that tolterodine may be more effective than oxybutynin in patients with neurogenic bladder. 14 5 found that combining tolterodine with behavioral intervention can improve patient satisfaction with OAB treatment.

Benefits and Risks

Benefits Summary

Tolterodine has shown promise in improving overactive bladder (OAB) symptoms. It can potentially reduce symptoms like frequent urination, urgency, and nighttime urination. Tolterodine may also increase bladder capacity, leading to fewer trips to the bathroom. Furthermore, combining tolterodine with behavioral therapy could enhance patient satisfaction with OAB treatment. 14 5

Risks Summary

Tolterodine can potentially cause side effects such as dry mouth, constipation, and blurred vision. However, these side effects are usually mild and often subside with continued use. 12

Comparison Across Studies

Similarities in Research

Numerous studies consistently demonstrate the effectiveness of tolterodine in improving OAB symptoms. Particularly, it shows promise in alleviating frequent urination, urgency, and nighttime urination. 9 15 12 8 2 4 7 11 3 1 10 14 13 5

Differences in Research

There are variations in the findings regarding the effects and side effects of tolterodine across studies. For instance, 12 suggests that tolterodine has less impact on the central nervous system compared to oxybutynin, while 10 suggests that tolterodine is more effective than oxybutynin in patients with neurogenic bladder. These discrepancies might stem from differences in patient populations, study designs, and other factors.

Consistency and Contradictions in Results

Numerous studies show consistent findings regarding the effectiveness of tolterodine. However, there are variations in the observed side effects across studies. This could be attributed to differences in patient demographics, study designs, and other contributing factors.

Practical Implications and Considerations

Tolterodine holds promise as a medication for alleviating OAB symptoms. However, it is crucial to remember that it can potentially cause side effects. If considering tolterodine, consult with a physician, understand the risks of side effects, and discuss appropriate strategies for managing them. 12

Limitations of Current Research

There are still areas for improvement in the research on tolterodine's effects. For example, there is limited data on the long-term effects and safety of tolterodine. Additionally, the efficacy of tolterodine can vary among individuals. Further research is needed to address these limitations.

Future Research Directions

Future research on tolterodine's effects should aim to clarify long-term efficacy, safety, and individual variability in response. It is also important to investigate the combination effects of tolterodine with other treatment modalities.

Conclusion

Tolterodine presents a promising option for improving OAB symptoms. However, it's important to consider that it can cause side effects. Consult your doctor before using tolterodine, fully understand the risks, and discuss strategies for managing any potential adverse effects. 12 14 5

Literature analysis of 15 papers
Positive Content
15
Neutral Content
0
Negative Content
0
Article Type
7
0
0
0
15
1.

Thorough QT study with recommended and supratherapeutic doses of tolterodine.

Author: MalhotraB K, GlueP, SweeneyK, AnzianoR, MancusoJ, WickerP

no QTc effect

This study evaluated the QTc effects of tolterodine in a crossover-design thorough QT study. The QTc effect of tolterodine was lower than moxifloxacin. No subject receiving tolterodine exceeded the clinically relevant thresholds of 500 ms absolute QTc or 60 ms change from baseline.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effects of terazosin and tolterodine on ureteral stent related symptoms: a double-blind placebo-controlled randomized clinical trial.

Author: TehranchiAli, RezaeiYousef, KhalkhaliHamidreza, RezaeiMahdi

Ureteral stent discomfort reduction

Terazosin plus tolterodine was more effective than placebo in reducing ureteral stent-related complications, including irritative symptoms, pain levels, and analgesic use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Comparisons of the Clinical Outcomes and Urodynamic Effects of Mirabegron versus Tolterodine Treatment for Female Overactive Bladder Syndrome: A Subgroup Analysis of a Controlled, Randomised, Prospective Study.

Author: HsiaoSheng-Mou, ChangTing-Chen, ChenChi-Hau, WuWen-Yih, LinHo-Hsiung

Overactive bladder treatment

This study compared the clinical outcomes and urodynamic effects of mirabegron and tolterodine treatment for women with overactive bladder syndrome (OAB).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Combined effects of behavioral intervention and tolterodine in patients dissatisfied with overactive bladder medication.

Author: KlutkeCarl G, BurgioKathryn L, WymanJean F, GuanZhonghong, SunFranklin, BerrimanSandra, BavendamTamara

Bladder symptom relief
Treatment satisfaction

Tolterodine extended release plus behavioral intervention resulted in high treatment satisfaction and improved bladder diary variables in patients who had previously been treated and were dissatisfied with tolterodine or other antimuscarinics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effects of terazosin and tolterodine on ureteral stent related symptoms: a double-blind placebo-controlled randomized clinical trial.

Author: TehranchiAli, RezaeiYousef, KhalkhaliHamidreza, RezaeiMahdi

Ureteral stent discomfort reduction

Terazosin plus tolterodine was more effective than placebo in reducing ureteral stent-related complications, including irritative symptoms, pain levels, and analgesic use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Effects on bladder function of combining elocalcitol and tolterodine in rats with outflow obstruction.

Author: StrengTomi, AnderssonKarl-Erik, HedlundPetter, GratzkeChristian, BaroniEnrico, D'AmbrosioDaniele, BenigniFabio

Bladder function improvement
LUTS treatment

Elocalcitol is a secosteroid that has been shown to protect bladder contractile function in experimental models and has beneficial effects in patients with lower urinary tract symptoms (LUTS). This study investigated the effects of combining elocalcitol with an antimuscarinic on bladder dysfunction in an experimental model.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Effects of tolterodine ER on patient-reported outcomes in sexually active women with overactive bladder and urgency urinary incontinence.

Author: RogersRebecca G, BachmannGloria, ScarperoHarriette, JumadilovaZhanna, SunFranklin, MorrowJon D, GuanZhonghong, BavendamTamara

Improved HRQL
Improved OAB symptoms
Improved bladder control
Improved sexual function
Underestimated impact of OAB symptoms

This study found that tolterodine ER treatment was associated with improvements in multiple OAB- and incontinence-specific PROs in a sexually active, relatively young, and racially diverse population of women. 79% of women on tolterodine ER reported treatment benefit compared to 54% on placebo, and 78% reported treatment satisfaction compared to 59% on placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Urodynamic effects of oxybutynin and tolterodine in conscious and anesthetized rats under different cystometrographic conditions.

Author: AngelicoPatrizia, VelascoCristina, GuarneriLuciano, SironiGiorgio, LeonardiAmedeo, TestaRodolfo

Bladder capacity increase

Oxybutynin and tolterodine, antimuscarinic drugs, were studied in rats to determine the experimental conditions required to reproduce their clinical pharmacological effects, particularly their ability to increase bladder capacity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Comparison of the Effects by Obybutynin and Tolterodine on Spina Bifida Patients: A Pilot Crossover Study.

Author: KanematsuAkihiro, JohninKazuyoshi, YoshimuraKoji, ImamuraMasaaki, OgawaOsamu

Urinary storage
Adverse effects

Individualized evaluation is required for optimal choice of anticholinergics in patients with neurogenic bladder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Effects of bladder training and/or tolterodine in female patients with overactive bladder syndrome: a prospective, randomized study.

Author: SongCheryn, ParkJun Tag, HeoKyeong Ok, LeeKyu Sung, ChooMyung-Soo

Improved bladder function
OAB symptom control

This study compared the effects of bladder training and/or tolterodine as first-line treatment in female patients with overactive bladder (OAB). Combination therapy was more effective than either method alone in reducing frequency, nocturia, and urgency scores.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system.

Author: TodorovaA, Vonderheid-GuthB, DimpfelW

Overactive bladder treatment
CNS side effects
Peripheral adverse effects

This study investigated the potential CNS adverse effects of three antimuscarinic drugs, tolterodine, oxybutynin, and trospium chloride, using quantitative-topographical EEG (qEEG). Oxybutynin caused significant qEEG power reductions compared to placebo, whereas tolterodine and trospium chloride showed limited effects. The results suggest that oxybutynin carries a higher risk of CNS side effects than tolterodine or trospium chloride.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Effects of Tamsulosin and Tolterodine on double J stent-related symptoms: A double-blind, randomized, placebo-controlled trial.

Author: MoradiMahmoudreza, AbdiHossein, EbrahimiSina, RezaeeHaress, KasebKaveh

Improved general health
Reduced urinary symptoms

Tolterodine was suggested to minimize stent-related urinary symptoms and improve general health in patients with double J stent.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Effects of combined behavioral intervention and tolterodine on patient-reported outcomes.

Author: WymanJean F, KlutkeCarl, BurgioKathryn, GuanZhonghong, SunFranklin, BerrimanSandra, BavendamTamara

Improved QOL
Reduced urgency

Tolterodine extended release plus behavioral intervention led to significant reductions in urgency episodes and improvements in bladder condition, quality of life, and urgency perception in patients with overactive bladder who were dissatisfied with antimuscarinic therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

A prospective observational study of the effects of treatment with extended-release tolterodine on health-related quality of life of patients suffering overactive bladder syndrome in Sweden.

Author: PeekerRalph, SamsioeGöran, KowalskiJan, AnderssonAnn-Sofie, BergqvistAgneta

Improved HRQoL
Improved OAB symptoms

Tolterodine ER significantly improved overactive bladder (OAB) symptoms and self-perceived health-related quality of life (HRQoL).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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