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Synthesis and pharmacological effects of new, N-substituted soft anticholinergics based on glycopyrrolate.
Author: BodorN, BuchwaldP, DaiX, JiF, MoriN, WuJ, WuW
Original Abstract of the Article :
To reduce the possibility of systemic side-effects in locally administered anticholinergics, two new N-substituted glycopyrrolate analogues designed using soft drug design approaches have been synthesized and evaluated in vitro and in vivo. Because stereospecificity is known to be important at musca...See full text at original site
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引用元:
https://doi.org/10.1211/jpp.57.11.0008
データ提供:米国国立医学図書館(NLM)
New, N-Substituted Soft Anticholinergics: A Gentle Approach to Blocking Acetylcholine
This study explores the development of new, N-substituted soft anticholinergics based on glycopyrrolate, a drug commonly used to block the effects of acetylcholine, a neurotransmitter involved in various bodily functions. The researchers designed these new compounds using a “soft drug” approach, aiming to reduce the potential for systemic side effects while maintaining therapeutic efficacy. Think of acetylcholine as a desert traveler, navigating the intricate pathways of the body, carrying vital messages. These new compounds act as gentle guardians, blocking the effects of acetylcholine at specific sites, minimizing potential disruptions to the body's overall balance.Soft Anticholinergics: A Gentle Touch in the Desert of Pharmacology
The study highlights the potential of soft drug design to create more targeted and effective anticholinergic therapies, minimizing the risk of unwanted side effects. It's like discovering a new and gentler way to navigate the desert of pharmacology, minimizing the risk of getting lost or encountering unexpected challenges. The study's findings encourage continued research into the development of soft drugs, potentially leading to more effective and safer treatments for a range of conditions.Navigating the Desert of Acetylcholine: A Search for Safe and Effective Therapies
This study showcases the power of innovative drug design in creating safer and more effective medications. It's like exploring a vast desert, where researchers seek to find the most effective pathways and minimize the risk of encountering harmful obstacles. The study's findings encourage a multi-faceted approach to drug development, ensuring that treatments are both effective and safe for patients.Dr. Camel's Conclusion
This study explores the development of new, N-substituted soft anticholinergics, offering a glimpse into the future of drug design, where gentle and targeted approaches are prioritized. It's like discovering a new and gentler way to navigate the desert of pharmacology, minimizing the risk of unwanted side effects and maximizing therapeutic benefits. The research encourages a continued focus on developing soft drugs, promising a brighter future for patient care and treatment.Date :
- Date Completed 2006-12-14
- Date Revised 2013-11-21
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