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Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL.

Author: AsgharianAfsaneh, FosterVicki J, HarriettApril E, KrishenAlok, MetzAlan, ModellJack G, RockettCarol B, RosenthalNorman E, WightmanDonna S

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Three studies found that bupropion XL was effective in preventing the onset of seasonal affective disorder (SAD). Bupropion XL treatment was started early in the season while patients were still well.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Seasonal affective disorder (SAD) can cause significant distress and impairment. No antidepressant studies have previously attempted to prevent the onset of autumn-winter depression. METHODS: Three prospective, randomized, placebo-controlled prevention trials were conducted on 1042 SAD ...See full text at original site
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引用元：
https://doi.org/10.1016/j.biopsych.2005.07.021

データ提供：米国国立医学図書館（NLM）

Preventing Seasonal Affective Disorder: Bupropion XL Shows Promise as a Preventive Treatment

The cyclical nature of seasonal affective disorder (SAD), a type of depression that recurs during specific times of the year, can be a challenging experience. This research explores the potential of bupropion XL, a sustained-release formulation of bupropion, as a preventive treatment for SAD. The study investigates the effectiveness of bupropion XL in preventing the onset of autumn-winter depression, offering hope for individuals struggling with this seasonal pattern of depression.

Early Intervention: Bupropion XL Demonstrates Effectiveness in Preventing SAD Recurrence

The study's findings suggest that bupropion XL, when administered early in the season while patients are still well, can effectively prevent the recurrence of seasonal major depressive episodes. The observed reduction in depression recurrence rates provides strong evidence for the preventive efficacy of bupropion XL in managing SAD. This finding is particularly significant for individuals who experience frequent episodes of SAD, potentially improving their quality of life and reducing the impact of this condition.

A New Approach: Preventing Depression Before It Strikes

This study introduces a new paradigm in depression management, focusing on prevention rather than solely addressing symptoms once they appear. The research highlights the potential benefits of early intervention strategies in managing SAD, potentially reducing the severity and frequency of depressive episodes. This approach offers a more proactive and potentially less disruptive way of addressing this cyclical condition.

Dr.Camel's Conclusion

This study opens a new chapter in the management of seasonal affective disorder. The demonstrated effectiveness of bupropion XL in preventing SAD recurrence offers hope for individuals struggling with this cyclical pattern of depression. By addressing the condition early in the season, we can potentially reduce the severity and frequency of depressive episodes, improving the quality of life for individuals living with SAD.

Date :
  1. Date Completed 2006-02-07
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

16271314

DOI: Digital Object Identifier

10.1016/j.biopsych.2005.07.021

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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