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A randomized trial of nicotine enemas for active ulcerative colitis.

Author: CourtneyEdward, EvansBrian K, GreenJohn T, HawkesNeil D, IngramJohn R, NewcombeRobert G, PillaiSuresh, RhodesJohn, SrivastavaEmmanuel D, SwiftJill L, ThomasGareth A O, WilliamsGeraint T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Six-milligram nicotine enemas were well tolerated but were not found to be efficacious for active ulcerative colitis.
Paper Details　
Original Abstract of the Article :
BACKGROUND & AIMS: Ulcerative colitis (UC) is largely a disease of nonsmokers in which transdermal nicotine improves the symptoms but often causes adverse events (AEs). Nicotine enemas cause fewer AEs and were used as supplemental treatment for active UC. METHODS: We treated 104 patients with activ...See full text at original site
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引用元：
https://doi.org/10.1016/s1542-3565(05)00849-9

データ提供：米国国立医学図書館（NLM）

Nicotine Enemas for Ulcerative Colitis: A Journey Through Unexpected Terrain

Ulcerative colitis (UC), like a fiery desert storm, can wreak havoc on the digestive system, leaving individuals experiencing debilitating symptoms. This study explores the potential of nicotine enemas as a treatment option for active UC, investigating their efficacy and safety.

A New Approach: Nicotine Enemas for Ulcerative Colitis

The researchers conducted a randomized, double-blind study to compare the effects of nicotine enemas to placebo enemas in patients with active UC. While nicotine is known to be a potential therapeutic agent in UC, the study found that nicotine enemas did not demonstrate significant efficacy in inducing clinical remission. The researchers concluded that nicotine enemas, while well-tolerated, may not be an effective treatment option for active UC.

Navigating the Desert of UC Treatment: Seeking New Pathways

This study highlights the complex and often unpredictable nature of UC treatment. Like a desert traveler who may encounter unexpected terrain, researchers continue to seek new and innovative approaches to managing this challenging condition. The study emphasizes the need for further research to explore the potential of different treatment strategies and identify those that can provide effective relief for patients with UC.

Dr.Camel's Conclusion

This study reminds us that the journey through the desert of UC treatment is often filled with unexpected twists and turns. While nicotine enemas may not have proven effective in this study, the search for new and effective treatments for UC continues. By embracing innovation and continuing to explore new avenues for treatment, we can ultimately find the most effective pathways to relief for patients with this debilitating condition.

Date :
  1. Date Completed 2006-01-13
  2. Date Revised 2019-11-09
Further Info :

Pubmed ID

16271342

DOI: Digital Object Identifier

10.1016/s1542-3565(05)00849-9

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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